RCT | In critically ill patients receiving MV, there was no difference in outcomes between different O2 saturation targets.

Oxygen-Saturation Targets for Critically Ill Adults Receiving Mechanical Ventilation – New England Journal of Medicine (link to abstract – $ for full-text)

News Release: Study finds that the most common oxygen saturation targets for hospitalized patients appear equally safe and effective – Vanderbilt University Medical Center

Related:

Effect of Low-Normal vs High-Normal Oxygenation Targets on Organ Dysfunction in Critically Ill Patients: A Randomized Clinical Trial – JAMA

Lower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine

Oxygen targets – Intensive Care Medicine (if the link is paywalled, try this one)

Thoracic Society of Australia and New Zealand Position Statement on Acute Oxygen Use in Adults: ‘Swimming between the flags’ – Respirology

Long-term mortality and health-related quality of life of lower versus higher oxygenation targets in ICU patients with severe hypoxaemia – Intensive Care Medicine

Oxygen Targets During Mechanical Ventilation in the ICU: A Systematic Review and Meta-Analysis – Critical Care Explorations

Higher versus lower oxygenation strategies in the general intensive care unit population: A systematic review, meta-analysis and meta-regression of randomized controlled trials – Journal of Critical Care

Commentary on Twitter

In this trial involving patients receiving mechanical ventilation, randomly assigned low, intermediate, or high oxygenation targets did not alter the number of ventilator-free days. @CritCareReviews https://t.co/UUxrEPRxs6 pic.twitter.com/ueUSX8ZmHG

— NEJM (@NEJM) October 24, 2022