All Posts | Links Medicus - Free Medical News & Perspective

?2023 AHA/ACC/ACCP/ASPC/NLA/PCNA Guideline for the Management of Patients w/ Chronic Coronary Disease aims to provide recommendations for diagnostic evaluation, symptom relief, improvement in QoL & reduction of future #ASCVD-related events & #heartfailure in patients w/ CCD.

— American College of Cardiology (@ACCinTouch) July 20, 2023

Guideline | Laboratory analysis in the diagnosis and management of diabetes mellitus

21 Jul, 2023 | 13:50h | UTC

Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Executive Summary: Guidelines and Recommendations for Laboratory Analysis in the Diagnosis and Management of Diabetes Mellitus – Diabetes Care

Guideline Synopsis | Diagnosis and management of priapism

21 Jul, 2023 | 13:47h | UTC

Diagnosis and Management of Priapism – JAMA (free for a limited period)

Original Guideline: The Diagnosis and Management of Recurrent Ischemic Priapism, Priapism in Sickle Cell Patients, and Non-Ischemic Priapism: An AUA/SMSNA Guideline – Journal of Urology

Cohort Study | ‘Weekend Warrior’ exercise pattern is associated with similar CVD benefits to regular activity

21 Jul, 2023 | 13:46h | UTC

Accelerometer-Derived “Weekend Warrior” Physical Activity and Incident Cardiovascular Disease – JAMA (free for a limited period)

News Release: Researchers find ‘weekend warrior’ physical activity provides similar heart-related benefits as more regular exercise – Massachusetts General Hospital

Commentaries:

Good news for ‘weekend warriors’: people who do much of their exercise on a couple of days still get heart benefits – The Conversation

Weekend Warrior Physical Activity and Risk of Cardiovascular Disease – American College of Cardiology

Correspondence | Potential “healthy vaccinee bias” in a study of BNT162b2 vaccine against Covid-19

21 Jul, 2023 | 13:43h | UTC

Potential “Healthy Vaccinee Bias” in a Study of BNT162b2 Vaccine against Covid-19 – New England Journal of Medicine

Commentary from the author on Twitter (thread – click for more)

Our correspondence is out in @njem written w @VPrasadMDMPH & Ram Duriseti

We show v strong evidence of healthy vaccinee bias in an Israeli study of Pfizer booster vs covid death, which wasn't disclosed

Could explain ALL reported benefit of the booster?https://t.co/F3WeafvUnw pic.twitter.com/b29YQ0lblh

— Tracy Høeg, MD, PhD (@TracyBethHoeg) July 20, 2023

RCT | MIND diet, a hybrid of Mediterranean and DASH, shows no superiority in preventing cognitive decline

21 Jul, 2023 | 13:38h | UTC

Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

‘MIND diet,’ intended to prevent dementia, doesn’t offer significant brain benefit, trial suggests – Live Science

Revised Mediterranean Diet Shows No Significant Impact on Cognition, MRI Outcomes in Older Persons – Neurology Live

Commentary on Twitter

Original Article: Trial of the MIND Diet for Prevention of Cognitive Decline in Older Persons https://t.co/ED5Rd6oCTf #AAIC23

— NEJM (@NEJM) July 19, 2023

RCT | Half-dose Tenecteplase + later PCI if indicated seems to be viable option in older individuals when timely PCI is unavailable

21 Jul, 2023 | 13:36h | UTC

Half-Dose Tenecteplase or Primary Percutaneous Coronary Intervention in Older Patients With ST-Segment–Elevation Myocardial Infarction in STREAM-2: A Randomized, Open-Label Trial – Circulation (link to abstract – $ for full-text)

Commentary on Twitter

In the #STREAMI-2 trial of older adults w/ early-presenting STEMI, half-dose tenecteplase w/ PCI if indicated comparable to primary PCI for ECG/angio endpoints and 30d clinical efficacy but w/ higher risk of ICH @Cardio_KULeuven @CVC_UAlberta @BaineyKevin https://t.co/zFE6C1U98n pic.twitter.com/noWWhJ6y9h

— Circulation (@CircAHA) July 18, 2023

Phase 2 Trial | Maternal GBS6 vaccine shows promise in infant group B strep prevention

21 Jul, 2023 | 13:34h | UTC

Potential for Maternally Administered Vaccine for Infant Group B Streptococcus – New England Journal of Medicine

Commentary: Maternal strep B vaccine slashes risk of infection among infants – CIDRAP

Phase 1 Trial | Zilebesiran demonstrates potential as prolonged-action hypertension therapeutic

21 Jul, 2023 | 13:32h | UTC

Zilebesiran, an RNA Interference Therapeutic Agent for Hypertension – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Experimental Shot Given Every Six Months Controlled High Blood Pressure in Early Trial – HealthDay

RCT | Molecular screening for bacterial vaginosis does not significantly reduce preterm birth rates

21 Jul, 2023 | 13:31h | UTC

Effectiveness and Costs of Molecular Screening and Treatment for Bacterial Vaginosis to Prevent Preterm Birth: The AuTop Randomized Clinical Trial – JAMA Pediatrics

See also: Visual Abstract

Cohort Study | Bipolar disorder associated with a 6-fold higher mortality risk from external causes

21 Jul, 2023 | 13:29h | UTC

Cause-specific excess mortality after first diagnosis of bipolar disorder: population-based cohort study – BMJ Mental Health

News Release: Bipolar disorder linked to 6-fold heightened risk of early death from external causes – BMJ Newsroom

Systematic Review | Medical treatment of eosinophilic esophagitis

21 Jul, 2023 | 13:27h | UTC

Medical treatment of eosinophilic esophagitis – Cochrane Library

Summary: Medical treatments for eosinophilic esophagitis – Cochrane Library

M-A | Efficacy of elimination diets in eosinophilic esophagitis

RCT | Dupilumab in adults and adolescents with eosinophilic esophagitis

A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide – Annals of Medicine

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions – Gastroenterology

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

IDSA 2023 Guidance on the treatment of antimicrobial resistant gram-negative infections

20 Jul, 2023 | 11:15h | UTC

Infectious Diseases Society of America 2023 Guidance on the Treatment of Antimicrobial Resistant Gram-Negative Infections – Clinical Infectious Diseases

USPSTF Statement | Evidence lacking for lipid disorders screening in asymptomatic children and adolescents

20 Jul, 2023 | 11:13h | UTC

Screening for Lipid Disorders in Children and Adolescents: US Preventive Services Task Force Recommendation Statement – JAMA

Evidence Report: Screening for Lipid Disorders in Children and Adolescents: Updated Evidence Report and Systematic Review for the US Preventive Services Task Force – JAMA

Editorial: Still “on the Fence” About Universal Childhood Lipid Screening: The USPSTF Reaffirms an I Statement – JAMA

Patient Page: Screening for Lipid Disorders in Children and Adolescents – JAMA

Commentary: USPSTF: Screening Kids for Lipid Disorders Still Needs More Data – TCTMD

Study | Large language models show potential for medical question answering capabilities

20 Jul, 2023 | 11:12h | UTC

Large language models encode clinical knowledge – Nature

News Release: Benchmarking AI’s ability to answer medical questions – Nature Publishing Group

Commentary: Expert reaction to study presenting Med-PaLM, a large language model (LLM) for answering medical questions, and a benchmark for assessing how well LLMs can answer medical questions – Science Media Centre

Review | Management of severe acute respiratory distress syndrome

20 Jul, 2023 | 11:10h | UTC

Management of severe acute respiratory distress syndrome: a primer – Critical Care

RCT | Hearing intervention fails to impact 3-year cognitive decline in older adults

20 Jul, 2023 | 11:09h | UTC

Hearing intervention versus health education control to reduce cognitive decline in older adults with hearing loss in the USA (ACHIEVE): a multicentre, randomised controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary on Twitter

#AAIC23 While hearing aids did not have an impact on cognitive decline over 3 years in a general population, treating hearing loss protected against cognitive decline in older adults at greater risk of dementia, finds a new trial: https://t.co/1UjGgDf5m5 pic.twitter.com/kuujeekCWW

— The Lancet (@TheLancet) July 18, 2023