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Research: Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With NOACs

27 Dec, 2017 | 21:08h | UTC

Early Recurrence and Major Bleeding in Patients With Acute Ischemic Stroke and Atrial Fibrillation Treated With Non–Vitamin‐K Oral Anticoagulants (RAF‐NOACs) Study – Journal of the American Heart Association (free)

“Composite rates of recurrence and major bleeding were 12.4% in patients who initiated NOACs within 2 days after acute stroke, 2.1% in those who initiated NOACs between 3 and 14 days, and 9.1% in patients who initiated NOACs >14 days after acute stroke. Future randomized studies to assess timing of initiation and choice of agent in patients with acute stroke and AF are warranted”.

 


WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage

27 Dec, 2017 | 21:06h | UTC

Updated WHO Recommendation on Tranexamic Acid for the Treatment of Postpartum Haemorrhage (free PDF)

Commentary: Updated WHO recommendation on intravenous tranexamic acid for the treatment of post-partum haemorrhage – The Lancet Global Health (free)

 


Systematic Review: Interventions to Increase the Number of Tuberculosis Cases Being Diagnosed

27 Dec, 2017 | 21:02h | UTC

Interventions to increase tuberculosis case detection at primary healthcare or community-level services – Cochrane Library (free)

Summary: Interventions to increase the number of tuberculosis cases being diagnosed – Evidently Cochrane (free)

Commentary: Cochrane review of effectiveness of strategies to improve access to treatment for TB – Liverpool School of Tropical Medicine, via EurekAlert (free)

 


Monitoring Universal Health Coverage Within the Sustainable Development Goals

27 Dec, 2017 | 21:05h | UTC

Monitoring universal health coverage within the Sustainable Development Goals: development and baseline data for an index of essential health services – The Lancet Global Health (free)

Invited Commentary: Towards a meaningful measure of universal health coverage for the next billion (free)

See related report on Universal Health Coverage in our December 15th issue (see #1)

 

 


Guidelines: Strategies to Eliminate Mother-To-Child Transmission of Syphilis

27 Dec, 2017 | 21:04h | UTC

Revisiting strategies to eliminate mother-to-child transmission of syphilis – The Lancet Global Health (free)

Related World Health Organization Guidelines: WHO guideline on syphilis screening and treatment for pregnant women (free PDF) AND Global guidance on criteria and processes for validation: Elimination of Mother-to-Child Transmission of HIV and Syphilis (free)

 


Research: Neurocognitive Deficits in Head and Neck Cancer Survivors

27 Dec, 2017 | 21:00h | UTC

Association of Neurocognitive Deficits With Radiotherapy or Chemoradiotherapy for Patients With Head and Neck Cancer – JAMA Otolaryngology-Head & Neck Surgery (link to abstract – $ for full-text)

Commentaries: Head and neck cancer survivors have long-lasting cognitive problems – Reuters (free) AND Thinking Abilities May Decline After Treatment For Head and Neck Cancers – MedicalResearch (free)

 


Last Month in Oncology with Dr Bishal Gyawali: November 2017

27 Dec, 2017 | 20:58h | UTC

Last Month in Oncology with Dr Bishal Gyawali: November 2017 – eCancer News (free)

 


Review: What Works in Inclusion Health

27 Dec, 2017 | 21:01h | UTC

Review: What works in inclusion health: overview of effective interventions for marginalised and excluded populations – The Lancet (free registration required)

Related Article: Morbidity and mortality in homeless individuals, prisoners, sex workers, and individuals with substance use disorders in high-income countries: a systematic review and meta-analysis – The Lancet (free) AND Commentary: Inclusion health: addressing the causes of the causes (free)

 


Medication Adherence: Evidence Review

27 Dec, 2017 | 20:54h | UTC

Medication adherence: evidence review – Evidently Cochrane (free)

 


What Makes a Systematic Review “Complex”?

27 Dec, 2017 | 20:57h | UTC

What makes a systematic review “complex”? – The BMJ Opinion (free)

 


Systematic Review: Smoking Cessation Interventions for Smokers with Current Depression

27 Dec, 2017 | 20:56h | UTC

Psychological, pharmacological, and combined smoking cessation interventions for smokers with current depression: A systematic review and meta-analysis – PLOS One (free)

 


Review: Transcatheter Mitral Valve Therapies

27 Dec, 2017 | 20:53h | UTC

Transcatheter Mitral Valve Therapies: The Next Frontier – American College of Cardiology, Latest in Cardiology (free)

 


Review: New Trends in Anaphylaxis

27 Dec, 2017 | 20:51h | UTC

New trends in anaphylaxis – Allergo Journal International (free)

 


Research: Association Between Treatment by Substitute Doctors and 30-Day Mortality

27 Dec, 2017 | 20:53h | UTC

Association Between Treatment by Locum Tenens Internal Medicine Physicians and 30-Day Mortality Among Hospitalized Medicare Beneficiaries – JAMA (link to abstract – $ for full-text)

Commentaries: Substitute Doctors Are Becoming More Common. What Do We Know About Their Quality of Care? – Harvard Business Review (free) AND Doctor out sick? A substitute physician is no worse for patients’ health – STAT (free) AND When the Doctor’s Away – Harvard Medical School, via NewWise (free) AND Mortality rates similar, readmissions lower in hospital patients cared for by locum tenens – ACP Internist (free)

 


Guideline: Role of Bone-Modifying Agents in Metastatic Breast Cancer

27 Dec, 2017 | 20:46h | UTC

Role of Bone-Modifying Agents in Metastatic Breast Cancer: An American Society of Clinical Oncology–Cancer Care Ontario Focused Guideline Update – Journal of Clinical Oncology (free)

 


Review – SDHx mutations: beyond pheochromocytomas and paragangliomas

27 Dec, 2017 | 20:44h | UTC

SDHx mutations: beyond pheochromocytomas and paragangliomas – European Journal of Endocrinology (free)

 


Guideline: Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma

27 Dec, 2017 | 20:45h | UTC

Sentinel Lymph Node Biopsy and Management of Regional Lymph Nodes in Melanoma: American Society of Clinical Oncology and Society of Surgical Oncology Clinical Practice Guideline Update – Journal of Clinical Oncology (free)

 


Review – 18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids?

27 Dec, 2017 | 20:43h | UTC

18-Oxocortisol and 18-hydroxycortisol: is there clinical utility of these steroids? – European Journal of Endocrinology (free)

 


Systematic Review: Is Treatment With Corticosteroids Beneficial for People With Pneumonia?

26 Dec, 2017 | 23:35h | UTC

Is treatment with corticosteroids beneficial and safe for people with pneumonia? – The Cochrane Library (free)

Related: Corticosteroids for Pneumonia: Ready for Primetime? – emDocs (free)

“Corticosteroid therapy reduced mortality and morbidity in adults with severe CAP; the number needed to treat for an additional beneficial outcome was 18 patients (95% CI 12 to 49) to prevent one death. Corticosteroid therapy reduced morbidity, but not mortality, for adults and children with non-severe CAP”

 


Research: Effect of High-Intensity Exercise on Motor Symptoms in Patients With Parkinson Disease

26 Dec, 2017 | 23:33h | UTC

Effect of High-Intensity Treadmill Exercise on Motor Symptoms in Patients With De Novo Parkinson Disease: A Phase 2 Randomized Clinical Trial – JAMA Neurology (link to abstract – $ for full-text)

Commentaries: Exercise May Aid Parkinson’s Disease, but Make It Intense – The New York Times (10 articles per month are free) AND High-Intensity Exercise May Cut Parkinson’s Motor Symptoms – Medscape (free registration required) AND Vigorous Exercise May Hold Benefit in Early Parkinson’s – MedPage Today (free registration required) High-intensity exercise delays Parkinson’s progression – Northwestern University, via ScienceDaily (free)

 


Tracking Universal Health Coverage: 2017 Global Monitoring Report

26 Dec, 2017 | 23:36h | UTC

Tracking Universal Health Coverage: 2017 Global Monitoring Report – Joint Report from the World Bank and the World Health Organization (free PDF)

Press Release: World Bank and WHO: Half the world lacks access to essential health services, 100 million still pushed into extreme poverty because of health expenses (free)

Infographic: Tracking Universal Health Coverage: 2017 Global Monitoring Report (free)

Commentaries: Healthcare costs are pushing millions into extreme poverty. This outrage must end – World Economic Forum (free) AND Almost 100 million people a year ‘forced to choose between food and healthcare’ – The Guardian (free)

 


Research: Association between microcephaly, Zika virus infection, and other risk factors in Brazil

26 Dec, 2017 | 23:30h | UTC

Association between microcephaly, Zika virus infection, and other risk factors in Brazil: final report of a case-control study – The Lancet Infectious Diseases (link to abstract – $ for full-text) (via @Onisillos)

Commentaries: Zika virus, not vaccine or insecticide, linked to birth defects in Brazil – STAT (free) AND Study bolsters Zika-microcephaly link, rules out others – CIDRAP (free)

 


Research: Estimates of Global Seasonal Influenza-Associated Respiratory Mortality

26 Dec, 2017 | 23:34h | UTC

Estimates of global seasonal influenza-associated respiratory mortality: a modelling study – The Lancet (link to abstract – $ for full-text)

Commentaries: Respiratory diseases linked to seasonal flu claim thousands of lives every year – UN health agency (free) AND Up to 650 000 people die of respiratory diseases linked to seasonal flu each year – World Health Organization (free) AND CDC says more people die of influenza worldwide than some experts have estimated – PBS NewsHour (free)

 


Review – Healthcare-Acquired Infections: Prevention Strategies

26 Dec, 2017 | 23:29h | UTC

Healthcare-acquired infections: prevention strategies – Internal Medicine Journal (free)

Source: Hospital Medicine Virtual Journal Club

 


Research: Associations Between Fast Food and Physical Activity Environments and Adiposity in Mid-Life

26 Dec, 2017 | 23:31h | UTC

Associations between fast food and physical activity environments and adiposity in mid-life: cross-sectional, observational evidence from UK Biobank – The Lancet Public Health (free)

Commentaries: The built environment and obesity in UK Biobank: right project, wrong data? – The Lancet Public Health (free) AND Living near exercise facilities linked to lower BMI and smaller waists – OnMedica (free) Living near physical activity facilities linked to smaller waistline, lower BMI and lower body fat percentage – London School of Hygiene & Tropical Medicine (free)

 


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