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Systematic Review: Bisphosphonates in Multiple Myeloma

29 Dec, 2017 | 19:36h | UTC

Bisphosphonates in Multiple Myeloma – Cochrane Library (free summary)

Original article: Bisphosphonates in multiple myeloma: an updated network meta-analysis – Cochrane Library (free)

 


Review – Genitourinary Syndrome of Menopause: Management Strategies for the Clinician

29 Dec, 2017 | 19:34h | UTC

Genitourinary Syndrome of Menopause: Management Strategies for the Clinician – Mayo Clinic Proceedings (free)

 


Clinicians Brace for AI to Transform Medicine

29 Dec, 2017 | 19:33h | UTC

Clinicians Brace for AI to Transform Medicine – MedPage Today (free registration required)

 


Review: Phenobarbital Monotherapy for Alcohol Withdrawal

29 Dec, 2017 | 19:32h | UTC

Phenobarbital monotherapy for alcohol withdrawal: Reloaded – PulmCrit (free)

Related review: Management of Acute Alcohol Withdrawal Syndrome in Critically Ill Patients – Pharmacotherapy (free)

Related systematic review: Patient Outcomes Associated With Phenobarbital Use With or Without Benzodiazepines for Alcohol Withdrawal Syndrome: A Systematic Review – Hospital Pharmacy (link to abstract – $ for full-text)

 


CRISPR-ing Humans in 2018

29 Dec, 2017 | 17:49h | UTC

“CRISPR-ing humans in 2018: gearing up for many clinical trials X3” (RT @EricTopol see Tweet)

– CRISPR in 2018: Coming to a Human Near You – MIT Technology Review (free)

– In 2018, We Will CRISPR Human Beings – GIZMODO (free)

– Human CRISPR Trials Will Happen in 2018. They’ll Look Like This – BigThink (free)

Related: Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)

 


Review: CT for the Evaluation of Lung Disease in Alpha-1 Antitrypsin Deficiency

29 Dec, 2017 | 19:33h | UTC

The Role of Computed Tomography for the Evaluation of Lung Disease in Alpha-1 Antitrypsin Deficiency – Chest (free)

 


Meta-Analysis: Implementation Strategies for Blood Pressure Control in Hypertensive Patients

29 Dec, 2017 | 17:46h | UTC

Comparative Effectiveness of Implementation Strategies for Blood Pressure Control in Hypertensive Patients: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Meta-Analysis: It Takes a Team to Optimize Hypertension Tx – MedPage Today (free registration required) AND Blood pressure control best achieved with a multilevel, multicomponent approach – American College of Physicians, via EurekAlert (free)

 


Research: Association of GERD With Malignancy of the Upper Aerodigestive Tract

29 Dec, 2017 | 17:50h | UTC

Association of Gastroesophageal Reflux With Malignancy of the Upper Aerodigestive Tract in Elderly Patients – JAMA Otolaryngology-Head &Neck Surgery (link to abstract – $ for full-text)

Commentaries: GERD Associated With Increased Risk of Malignancy of the Upper Aerodigestive Tract – MedicalResearch (free) AND First-of-its-kind study of upper aerodigestive cancers – MedicalXpress (free) AND Chronic Heartburn Tied to Higher Odds for Head, Neck Cancers – Drugs.com (free)

 


Performance Improvement: Insulin Dosing Error in a Patient With Severe Hyperkalemia

29 Dec, 2017 | 17:48h | UTC

Insulin Dosing Error in a Patient With Severe Hyperkalemia – JAMA (free)

 


Research: Regional Variation of CT Imaging and the Risk of Nephrectomy

29 Dec, 2017 | 17:45h | UTC

Regional Variation of Computed Tomographic Imaging in the United States and the Risk of Nephrectomy – JAMA Internal Medicine (free)

Editorial: Use of Advanced Imaging Tests and the Not-So-Incidental Harms of Incidental Findings (free)

Commentary: Trunk Imaging Tied to Higher Nephrectomy Risk – MedPage Today (free registration required)

“The remarkable number of unnecessary CT scans and their downstream risk from incidental findings” (via @EricTopol see Tweet)

 


Why Doctors Keep Doing Expensive Procedures That Don’t Work

29 Dec, 2017 | 17:41h | UTC

Why American doctors keep doing expensive procedures that don’t work – VOX (free)

“The proportion of medical procedures unsupported by evidence may be nearly half”.

 


Research: Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices

29 Dec, 2017 | 17:43h | UTC

Safety of Magnetic Resonance Imaging in Patients with Cardiac Devices – The New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: MRI scan safe for most people with older pacemakers, defibrillators – Reuters (free) AND Even Thoracic MRI Safe for ‘Legacy’ ICDs, Pacemaker Systems: Large Cohort Study – Medscape (free registration required) AND MRIs safe with older pacemakers, study finds – MedicalXpress (free)

 


Meta-Analysis: Calcium or Vitamin D Supplementation and Fracture Incidence in Older Adults

29 Dec, 2017 | 17:08h | UTC

Association Between Calcium or Vitamin D Supplementation and Fracture Incidence in Community-Dwelling Older Adults: A Systematic Review and Meta-analysis – JAMA (free)

Commentaries: Do Vitamin D, Calcium Supplements Cut Fracture Risk in Older Patients? – MPR (free) AND Vitamin D and Calcium Don’t Prevent Bone Fractures – The New York Times (10 articles per month are free) AND Calcium And Vitamin D Supplements Still Do Not Prevent Fractures – American Council on Science and Health (free)

 


Research: Restless Legs Syndrome and Total and Cardiovascular Mortality Among Women

29 Dec, 2017 | 17:09h | UTC

Prospective study of restless legs syndrome and total and cardiovascular mortality among women – Neurology (free)

Commentaries: Restless legs syndrome may raise cardiovascular death risk – Medical News Today (free) AND Restless Legs Syndrome Linked to Higher CV Death in Women – Medscape (free registration required)

 


What We Mean When We Say Evidence-Based Medicine

29 Dec, 2017 | 17:10h | UTC

What We Mean When We Say Evidence-Based Medicine – The New York Times (10 articles per month are free)

 


How Big Tech is Going After Your Health Care

29 Dec, 2017 | 17:05h | UTC

How Big Tech is Going After Your Health Care – The New York Times (10 articles per month are free)

 


Research: Association of Short-term Exposure to Air Pollution With Mortality in Older Adults

29 Dec, 2017 | 17:06h | UTC

Association of Short-term Exposure to Air Pollution With Mortality in Older Adults – JAMA (link to abstract – $ for full-text)

Commentaries: Short-term exposure to low levels of air pollution linked with premature death among US seniors – Harvard T.H. Chan School of Public Health, via EurekAlert (free) AND Even ‘Safe’ Levels of Air Pollution Tied to Higher Mortality – Medscape (free registration required) AND Low-Level Pollution Exposures Increase Death Risk Among Elderly – MedPage Today (free registration required)

 


Hearing Aids Make Communication Easier for People With Mild Hearing Loss

29 Dec, 2017 | 17:02h | UTC

Hearing aids make communication easier for people with mild hearing loss – NIHR Signal (free)

See original article: Hearing aids for mild to moderate hearing loss in adults – Cochrane Library (link to abstract – $ for full-text) AND Summary: Hearing aids for mild to moderate hearing loss in adults (free) AND Commentary: Hearing aids: evidence, equity and rationing – Evidently Cochrane (free)

 

 


Review: Alternative Therapeutics for Self-Limiting Infections

29 Dec, 2017 | 17:00h | UTC

Alternative therapeutics for self-limiting infections—An indirect approach to the antibiotic resistance challenge – PLOS Biology (free)

Commentary: Paper suggests antibiotic alternatives should focus on mild infections – CIDRAP (free)

Related review: Alternatives to antibiotics—a pipeline portfolio review – The Lancet Infectious Diseases (free)

 


Review: Re-Emerging and Newly Recognized Sexually Transmitted Infections

29 Dec, 2017 | 17:04h | UTC

Re-emerging and newly recognized sexually transmitted infections: Can prior experiences shed light on future identification and control? – PLOS Medicine (free) (via @greg_folkers)

 


Research: Internet-Accessed STI testing

29 Dec, 2017 | 16:57h | UTC

Internet-accessed sexually transmitted infection (e-STI) testing and results service: A randomised, single-blind, controlled trial – PLOS Medicine (free)

Commentary: Introducing internet-based testing for sexually transmitted infections doubles testing uptake in South London boroughs – London School of Hygiene & Tropical Medicine (free)

 


Research: Varenicline Use Tied to Elevated Risk for Cardiovascular Hospitalizations

29 Dec, 2017 | 16:59h | UTC

Varenicline Use Tied to Elevated Risk for Cardiovascular Hospitalizations – American Journal of Respiratory and Critical Care Medicine (link to abstract – $ for full-text).

Commentaries: Smoking Cessation Drug May Increase Risk of Adverse Cardiovascular Event – American Thoracic Society, via NewsWise (free) AND Varenicline Use Tied to Elevated Risk for Cardiovascular Hospitalizations – Physician’s First Watch (free) AND Varenicline May Increase Cardiovascular Risk – MedPage Today (free registration required)

“Observational study found 34% higher rates of CV events after starting stop-smoking drug” (from MedPage Today)

 


Advancing the Role of Nurses and Midwives

29 Dec, 2017 | 17:01h | UTC

Advancing the role of nurses and midwives in Ireland: Pioneering transformation of the health workforce for noncommunicable diseases in Europe (2017) – World Health Organization (free PDF)

News release: Learning from Ireland: expanding the role of nurses and midwives to improve health outcomes (free)

 


Research: Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression

29 Dec, 2017 | 16:58h | UTC

Efficacy and Safety of Transcranial Direct Current Stimulation as an Add-on Treatment for Bipolar Depression: A Randomized Clinical Trial – JAMA Psychiatry (link to abstract – $ for full-text)

Commentary: Electrical Stimulation Works as Add-On in Bipolar Depression – MedPage Today (free registration required)

“Small RCT in BD I and II (n=59): active tDCS showed superior improvement versus sham in change in HDRS-17 scores at week 6 (βint = −1.68; NNT = 5.8; 3.3-25.8) and response rates (67.6% vs 30.4%; NNT = 2.69; 1.84-4.99)” (RT @psychopharmacol see Tweet)

 


Meta-Analysis of the Procedural Risks of Carotid Endarterectomy and Carotid Artery Stenting Over Time

29 Dec, 2017 | 16:56h | UTC

Meta-analysis of the procedural risks of carotid endarterectomy and carotid artery stenting over time – British Journal of Surgery (free)

 


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