Archives
Perspective: Breathing Tubes Fail to Save Many Older Patients
24 Jun, 2018 | 19:30h | UTCBreathing Tubes Fail to Save Many Older Patients – The New York Times (10 articles per month are free)
“One-third of patients over age 65 die in the hospital after they are put on ventilators. Doctors are beginning to wonder if the procedure should be used so often”.
Retrospective Observational Study: Basal Insulin Analogs vs NPH Insulin for Type 2 Diabetes
24 Jun, 2018 | 19:27h | UTCAssociation of Initiation of Basal Insulin Analogs vs Neutral Protamine Hagedorn Insulin With Hypoglycemia-Related Emergency Department Visits or Hospital Admissions and With Glycemic Control in Patients With Type 2 Diabetes – JAMA (free for a limited period)
Editorial: Revisiting NPH Insulin for Type 2 Diabetes: Is a Step Back the Path Forward? (free for a limited period)
Clinical Review Audio: Health Care Spending Gone Wild: Using Expensive Insulin Analogs With Few Clinical Advantages (free)
“Long-acting insulin analogs not associated with reduced hypoglycemia-related ED visits or hospital admissions when compared with NPH insulin, despite costing 5-10x as much” (via @jsross119 see Tweet)
Report: Effects of Sodium and Potassium Intake on Chronic Disease Outcomes and Risks
22 Jun, 2018 | 02:53h | UTCSee also: Evidence Summary (free PDF) AND Full Report (free PDF)
Randomized Trial: Sodium Bicarbonate for Patients with Severe Metabolic Acidemia in the ICU
24 Jun, 2018 | 19:26h | UTCSodium bicarbonate therapy for patients with severe metabolic acidaemia in the intensive care unit (BICAR-ICU): a multicentre, open-label, randomised controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: BICAR-ICU – The Bottom Line (free)
“This study will reassure clinicians that already use sodium bicarbonate for correcting metabolic acidaemia, that this may delay and/or reduce the requirement for RRT. Equally, for those that opt to avoid sodium bicarbonate, there is no compelling evidence to change practice”
Meta-Analysis: Determinants of Clinical Outcomes in Patients with Angina but Without Obstructive Coronary Artery Disease
24 Jun, 2018 | 19:23h | UTCCommentaries: Outcomes in Patients With Angina but Without Obstructive CAD – American College of Cardiology (free)
NICE Guideline: Hearing Loss in Adults
22 Jun, 2018 | 02:52h | UTC
Meta-Analysis: Disease-modifying Anti-rheumatic Drugs Not Effective for Osteoarthritis
22 Jun, 2018 | 02:51h | UTCCommentary: OA: DMARDs fail to relieve pain in meta-analysis – Univadis (free registration required)
Review: What’s New in Severe Pulmonary Embolism?
22 Jun, 2018 | 02:40h | UTCWhat’s new in severe pulmonary embolism? – Intensive Care Medicine (free for a limited period) (via @srrezaie)
Randomized Trial: Sodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss
22 Jun, 2018 | 02:49h | UTCSodium Thiosulfate for Protection from Cisplatin-Induced Hearing Loss – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Sodium Thiosulfate for Cisplatin-Induced Hearing Loss (free)
Commentaries: New drug halves hearing loss in children following cancer treatment – Cancer Research UK, via ScienceDaily (free) AND Otoprotectant Guards Against Cisplatin-Induced Hearing Loss – Medscape (free registration required) AND Antioxidant Cuts Hearing Loss in Cisplatin-Treated Kids – MedPage Today (free registration required)
EULAR 2018: NSAIDs Account for Large Part of Osteoarthritis-CVD Link
22 Jun, 2018 | 02:50h | UTCNSAIDs Account for Large Part of Osteoarthritis-CVD Link, Study Suggests – TCTMD (free)
Review: Acute Myocardial Infarction in Young Women
22 Jun, 2018 | 02:38h | UTCRelated Review: Young Women With Acute Myocardial Infarction: Current Perspectives – Circulation: Cardiovascular Quality and Outcomes (free)
Related Guideline: Acute Myocardial Infarction in Women: A Scientific Statement From the American Heart Association – Circulation (free)
This Mediterranean Diet Study Was Hugely Impactful. The Science Just Fell Apart
22 Jun, 2018 | 02:39h | UTCThis Mediterranean diet study was hugely impactful. The science just fell apart – VOX (free)
See Related Retraction and Republication: PREDIMED Study on Mediterranean Diet (free article and commentaries)
Perspective: To Fight Burnout, Organize
22 Jun, 2018 | 02:38h | UTCTo Fight Burnout, Organize – New England Journal of Medicine (free)
“The social determinants of health — and physicians’ sense of powerlessness in the face of them — seem crucially missing from the discussion of burnout”.
Guideline: Diagnosis and Management of Adhesive Small Bowel Obstruction
22 Jun, 2018 | 02:35h | UTC
NICE Guideline: Dementia
22 Jun, 2018 | 02:34h | UTC
Review: Managing Patients with Chronic Cough
22 Jun, 2018 | 02:37h | UTCSee also recently published CHEST guidelines on the management of cough in specific populations: Classification of Cough as a Symptom in Adults and Management Algorithms (free) AND Pharmacologic and Nonpharmacologic Treatment for Acute Cough Associated With the Common Cold (free) AND Cough Due to TB and Other Chronic Infections (free) AND Chronic Cough Due to Gastroesophageal Reflux in Adults (free) AND Symptomatic Treatment of Cough Among Adult Patients With Lung Cancer (free) AND Cough in the athlete (free) AND Occupational and Environmental Contributions to Chronic Cough in Adults (free) AND Treatment of Unexplained Chronic Cough (free) AND Use of Management Pathways or Algorithms in Children With Chronic Cough (free) AND Management of Children With Chronic Wet Cough and Protracted Bacterial Bronchitis (free)
Register-Based Retrospective Cohort: Stress-Related Disorders Associated With Subsequent Autoimmune Disease
22 Jun, 2018 | 02:32h | UTCAssociation of Stress-Related Disorders With Subsequent Autoimmune Disease – JAMA (link to abstract – $ for full-text)
Commentaries: Association of Stress-Related Disorders With Subsequent Autoimmune Disease – University of Iceland (free) AND Stress disorders tied to increased risk of autoimmune diseases – Reuters (free) AND Does Psychological Stress Trigger Autoimmune Disorders? – MedPage Today (free registration required)
Cohort Study: The Association of Lifetime Alcohol use with Mortality and Cancer Risk
22 Jun, 2018 | 02:33h | UTCCommentaries: Risks of cancer and mortality by average lifetime alcohol intake – PLOS, via ScienceDaily (free) AND Drinking Alcohol Can Raise Cancer Risk. How Much Is Too Much? – NPR (free) AND Light drinkers at a lower combined risk of earlier death or developing cancer – The Conversation (free) AND Expert reaction to the association between lifetime drinking and mortality and cancer risk – Science Media Centre (free)
Related Meta-analysis: Risk Thresholds for Alcohol Consumption (free study, editorial and commentaries)
Cohort Study: Pancreatic Cancer Following Incident Diabetes
22 Jun, 2018 | 02:31h | UTCPancreatic Cancer Following Incident Diabetes in African Americans and Latinos: The Multiethnic Cohort – Journal of the National Cancer Institute (link to abstract – $ for full-text)
Commentaries: Diabetes may be an early manifestation of pancreatic cancer – eCancer News (free) AND Recent-onset diabetes linked to pancreatic cancer for some minorities – UPI (free) AND Diabetes after 50 could be early sign of pancreatic cancer, study says – CNN (free)
Pharmacoepidemiological Study: Association of Antidepressant Use With Drug-Related Extrapyramidal Symptoms
22 Jun, 2018 | 02:28h | UTCAssociation of Antidepressant Use With Drug-Related Extrapyramidal Symptoms: A Pharmacoepidemiological Study – Journal of Clinical Psychopharmacology (link to abstract – $ for full-text)
Commentaries: Incidence of Extrapyramidal Symptoms Higher With Certain Antidepressants – MPR (free) AND Antidepressants tied to Parkinson’s-like symptoms – Univadis (free registration required)
“Observational study: Incidence of EPSs with antidepressants. RRs: duloxetine, 5.68; mirtazapine, 3.78; citalopram, 3.47; escitalopram, 3.23; paroxetine, 3.07; sertraline, 2.57; venlafaxine, 2.37; bupropion, 2.31; and fluoxetine, 2.03 (all significant)” (via @psychopharmacol see Tweet)
Study: Autologous vs Prosthetic Breast Reconstruction
22 Jun, 2018 | 02:29h | UTCLong-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction – JAMA Surgery (free for a limited period)
Invited Commentary: Autologous vs Prosthetic Breast Reconstruction: Where Do We Stand? (free for a limited period)
Author Interview: Long-term Patient-Reported Outcomes in Postmastectomy Breast Reconstruction (free audio)
Commentaries: Breast reconstruction more satisfying than implants after cancer, survey says – UPI (free) AND Flap vs Implant for Breast Reconstruction: How to Choose – MedPage Today (free registration required) AND Study explores satisfaction, quality of life after breast reconstruction – Brigham and Women’s Hospital, via MedicalXpress (free)
Perspective: Sleep Disorders Associated With Alzheimer’s Disease
22 Jun, 2018 | 02:17h | UTCSleep Disorders Associated With Alzheimer’s Disease: A Perspective – Frontiers in Neuroscience (free)
Disease Outbreak News: Ebola Outbreak in Congo ‘Largely Contained’, says WHO
22 Jun, 2018 | 02:30h | UTCDisease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)
Commentary: Ebola outbreak in Congo ‘largely contained’, says WHO – Reuters (free)
Perspective: New Foundation Revives Debate About Health Research Funded by Big Tobacco
22 Jun, 2018 | 02:17h | UTCNew Foundation Revives Debate About Health Research Funded by Big Tobacco – JAMA (free for a limited period)
Related Viewpoint: The Philip Morris International–Funded Foundation for a Smoke-Free World – JAMA (free for a limited period)
Review: Surgical Treatment of Obesity
22 Jun, 2018 | 02:14h | UTCSurgical treatment of obesity – F1000 Research (free)