Archives
Systematic Review: Immunosuppressive Treatment for Proliferative Lupus Nephritis
13 Jul, 2018 | 01:15h | UTCImmunosuppressive treatment for proliferative lupus nephritis – Cochrane Library (free)
Summary: Immunosuppressive treatment for people with proliferative lupus nephritis – Cochrane Library (free)
Statement Paper: Liquid Biopsy for Advanced Non-Small Cell Lung Cancer
13 Jul, 2018 | 01:12h | UTCCommentary: IASLC Issues Statement Paper on Liquid Biopsy for Lung Cancer – The ASCO Post (free)
Google Is Training Machines to Predict When a Patient Will Die
13 Jul, 2018 | 01:11h | UTCGoogle Is Training Machines to Predict When a Patient Will Die – Bloomberg (free)
Review: Cutaneous and Mucosal Manifestations Associated with Celiac Disease
13 Jul, 2018 | 01:10h | UTCCutaneous and Mucosal Manifestations Associated with Celiac Disease – Nutrients (free)
Review: 8 Key Clinical Applications of Machine Learning in Radiology
13 Jul, 2018 | 01:09h | UTC8 key clinical applications of machine learning in radiology – Radiology Business (free)
Original article: Current Applications and Future Impact of Machine Learning in Radiology – Radiology (link to abstract – $ for full-text)
Cohort Study: Causes and Incidence of Community-acquired Serious Infections Among Young Children in South Asia
13 Jul, 2018 | 01:07h | UTCInvited Commentary: Improving management of neonatal infections (free)
Guideline: Gadolinium-Based Contrast Agents in Kidney Disease
13 Jul, 2018 | 01:08h | UTC
Study: Use of a Lower Nicotine Concentration e‐liquid May be Associated with Compensatory Behavior
13 Jul, 2018 | 01:05h | UTCCommentaries: Ex-smokers might be better off with high rather than low nicotine e-cigs – Cancer Research UK (free) AND Vapers may inhale more toxins with lower-strength e-cigarettes – NHS Choices (free)
Thu, July 12 – 10 Stories of The Day!
12 Jul, 2018 | 01:44h | UTC
1 – Guideline: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)
2 – Guideline: Brain tumours (primary) and brain metastases in adults – National Institute for Health and Care Excellence (free)
4 – Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)
Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)
5 – News Release: Trial wipes out more than 80 per cent of disease-spreading mozzie – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Government (free)
Commentary: Australian experiment wipes out over 80% of disease-carrying mosquitoes – CNN (free)
6 – Perspective: Fractional-Dose Yellow Fever Vaccination — Advancing the Evidence Base – New England Journal of Medicine (free)
Related Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)
Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)
8 – News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)
Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)
Commentaries: A painful lesson: are we repeating previous mistakes in pain management? – The Lancet Public Health (free) AND Use of illicit cannabis does not reduce chronic pain, according to new Australian study – RACGP (free)
Related: Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials – Canadian Family Physician (free) AND Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review – VA Evidence-based Synthesis Program (free) AND Cannabis products for adults with chronic neuropathic pain – Cochrane Library (free)
10 – Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Smoking Marijuana May Be Tied to Cough, Sputum Production – HealthDay (free) AND Regular marijuana use is associated with development of respiratory issues – 2 Minute Medicine (free)
Wed, July 11 – 10 Stories of The Day!
11 Jul, 2018 | 01:44h | UTC
Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)
“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.
2 – Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)
Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)
Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)
3 – Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)
Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)
Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)
5 – Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: If You Look For Atrial Fibrillation You Will Find Atrial Fibrillation – Cardiobrief (free)
Related: Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries)
6 – Review: Update on infection control practices in cancer hospitals – CA: A Cancer Journal of Clinicians (free)
7 – Review: Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free)
Commentary: Higher risk of heart defects in babies of mothers with type 1 diabetes – Karolinska Institutet, via EurekAlert (free)
10 – Consensus Report: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)
Commentaries: National Academies panel urges researchers to routinely share test results with study participants – STAT (free) AND If you give your DNA and tissues to science, should you get a peek at what they might contain? – Science (free) AND New report says individual research results should be shared with participants more often – National Academies of Sciences, Engineering, and Medicine (free)
Related Viewpoint: Return of Research Results to Study Participants: Uncharted and Untested – JAMA (free for a limited period)
Fri, July 13 – 10 Stories of The Day!
13 Jul, 2018 | 00:25h | UTC
1 – INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)
Fact Sheet: Violence against children – World Health Organization (free)
The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.
2 – Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)
Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)
Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)
Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)
3 – Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)
4 – Infographic: Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)
5 – The right diet can boost potency of cancer drugs – Nature News (free)
Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)
Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)
“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)
6 – Report: Research into physiotherapy for musculoskeletal conditions – NIHR Dissemination Centre (free PDF)
This new NIHR report brings together key research relevant to those delivering musculoskeletal physiotherapy services.
7 – Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)
This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.
8 – Research Methods & Reporting: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians – The BMJ (free)
9 – Anticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)
Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)
10 – Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Stopping the Alteplase Indication Creep – Emergency Medicine Literature of Note (free) AND Alteplase unlikely to reduce disability after mild stroke without disabling deficits – 2 Minute Medicine (free) AND Lytic No Better Than Aspirin for Mild Ischemic Stroke – MedPage Today (free registration required)
Tue, July 10 – 10 Stories of The Day!
10 Jul, 2018 | 00:01h | UTC
Editorial: Treating nosocomial pneumonia: what’s new (free)
Related Guidelines: International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)
Source: Critical Care Reviews Newsletter
2 – Guideline: Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)
See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)
3 – Draft Statement: Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)
Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)
“The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”
4 – Oposition to Breast-Feeding Resolution by U.S. Stuns World Health Officials – The New York Times (10 articles per month are free)
5 – Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals
6 – Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)
Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group. (more on this study in Richard Leeman’s review above)
Original study: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries)
Related commentaries: Viewpoint: Placebo Effect of the Heart (free) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free)
Related research: Research: Physiology-Stratified Analysis of ORBITA (free research and commentaries)
8 – Richard Smith: Reducing global road traffic crashes and injuries – The BMJ Opinion (free)
Related reports: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) AND Save LIVES: a road safety technical package (free) AND Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF) AND Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)
9 – Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)
10 – Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)
Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)
Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)
WHO Report: Low Quality Healthcare is Increasing the Burden of Illness and Health Costs Globally
6 Jul, 2018 | 09:57h | UTCNews Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)
Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)
Mon, July 9 – 10 Stories of The Day!
9 Jul, 2018 | 00:11h | UTC
1 – Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) (via @CritCareReviews)
Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)
2 – WHO Manual: Preventing disease through a healthier and safer workplace – World Health Organization (free PDF)
Source: International Health Policies Newsletter
3 – Clinical Update: Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)
Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)
4 – Seriously, Juice Is Not Healthy – The New York Times (10 articles per month are free)
“Would you take a multivitamin if it contained 10 teaspoons of sugar? No. Then why are you drinking juice?” (via @NYTHealth see Tweet)
5 – Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)
6 – The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)
Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)
Related Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)
Source: Critical Care Reviews Newsletter
8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)
Related: Ebola virus outbreak likely over in Congo, WHO says – NBC News (free) AND Good news: the Ebola outbreak in DRC is contained – VOX (free)
9 – Use of ‘smart drugs’ on the rise – Nature (free)
Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)
Commentaries: Folic acid linked to healthy brain development through childhood – Reuters (free) AND Folic Acid Fortification May Have Role in Sustaining Mental Health – AJMC (free) AND Prenatal Exposure to Folic Acid Appears to Promote Healthy Brain Development – Psychiatric News Alert (free) AND Perinatal Folic Acid May Protect Against Serious Mental Illness in Young People – MedicalResearch.com (free)
Guideline: Endocrine Disorders in Survivors of Childhood Cancer
6 Jul, 2018 | 09:56h | UTCCommentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)
Study: Risk-Stratified Screening for Breast Cancer
6 Jul, 2018 | 09:55h | UTCEditorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)
Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)
Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)
Review: Heart Failure with Preserved Ejection Fraction
6 Jul, 2018 | 09:54h | UTC
Review: Anemia and Iron Deficiency in Heart Failure
6 Jul, 2018 | 09:52h | UTCAnemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)
Perspective: Hidden Conflicts?
6 Jul, 2018 | 09:51h | UTCHidden conflicts? – Science Magazine (free for a limited period)
““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)
Cohort Study: Direct Oral Anticoagulants vs Warfarin
6 Jul, 2018 | 09:49h | UTCCommentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)
Study: Species-Specific Activity of Antibacterial Drug Combinations
6 Jul, 2018 | 09:48h | UTCSpecies-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)
Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)
Overview of Guidelines for the Management of Non-Specific Low Back Pain in Primary Care
6 Jul, 2018 | 09:50h | UTC
Randomized Trial: Antibiotic Prophylaxis for Patients with Neurogenic Bladder and Repeated Urinary Tract Infections
6 Jul, 2018 | 09:47h | UTCInvited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)
Guideline: Antibiotic Use in Adults with Community-acquired Pneumonia
6 Jul, 2018 | 09:46h | UTCRelated Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)
Review: Management of Myocardial Infarction with Nonobstructive Coronary Arteries
6 Jul, 2018 | 09:44h | UTC