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“We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.

8 – Effects of Leisure‐Time and Transport‐Related Physical Activities on the Risk of Incident and Recurrent Myocardial Infarction and Interaction With Traffic‐Related Air Pollution: A Cohort Study – Journal of the American Heart Association (free)

Commentaries: Poor air quality does not offset exercise’s heart benefits – AHA/ASA Newsroom (free) AND Why smog should not be your excuse to skip workouts – Reuters (free)

9 – Metformin and Risk of Hypertension in Taiwanese Patients With Type 2 Diabetes Mellitus – Journal of the American Heart Association (free)

“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.

10 – Sulfonylureas as second line drugs in type 2 diabetes and the risk of cardiovascular and hypoglycaemic events: population based cohort study – The BMJ (free)

Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)

Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)

Review of Guidelines for Diagnosis of Autism Spectrum Disorder

20 Jul, 2018 | 01:45h | UTC

Clinical practice guidelines for diagnosis of autism spectrum disorder in adults and children in the UK: a narrative review – BMC Psychiatry (free)

NCCN Guideline Update: Non–Small Cell Lung Cancer

20 Jul, 2018 | 01:46h | UTC

NCCN Guidelines Insights: Non–Small Cell Lung Cancer, Version 5.2018 – Journal of the National Comprehensive Cancer Network (free)

Wed, July 18 – 10 Stories of The Day!

18 Jul, 2018 | 00:35h | UTC

1 – Association of Digital Media Use With Subsequent Symptoms of Attention-Deficit/Hyperactivity Disorder Among Adolescents – JAMA (link to abstract – $ for full-text)

Commentaries: More Screen Time For Teens Linked To ADHD Symptoms – NPR (free) AND Digital media use linked to behavioral problems in kids – University of Southern California, via ScienceDaily (free) AND Screen time linked to ADHD symptoms in teens – Reuters (free) AND ADHD study links teens’ symptoms with digital media use – CNN (free) AND Expert reaction to association of digital media use and ADHD symptoms among teenagers – Science Media Centre (free)

2 – Perspective: “Is There a Doctor on the Plane?” – JAMA (free for a limited period)

Interview: “Is There a Doctor on the Plane?” (free)

3 – Guideline for the treatment of chronic lymphocytic leukaemia: A British Society for Haematology Guideline (free)

4 – Report: Open Science by Design: Realizing a Vision for 21st Century Research (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)

News Release: Report Proposes Recommendations and New Framework to Speed Progress Toward Open Science (free)

5 – Clinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation – JAMA (link to abstract – $ for full-text)

Commentaries: Are ‘breakthrough’ drugs as safe as other FDA-approved medicines? – CNN (free) AND Evidence to support ‘breakthrough’ drugs often very limited: study – Reuters (free)

6 – Head To Head: Does evidence based medicine adversely affect clinical judgment? – The BMJ (free) (via @michelaccad)

7 – Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)

Commentaries: Reporting on risks often inadequate for prebiotics, probiotics, synbiotics – ACP Internist (free) AND Probiotics studies often don’t disclose safety data or risks, report finds – STAT (free) AND Safety of Probiotic Supplements Is Not Guaranteed, Study Says – Consumer Reports (free)

“How to make an intervention safe? Don’t report the adverse events”. (via @EricTopol see Tweet)

8 – Review: Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)

Source: Critical Care Reviews Newsletter

9 – Auscultation for bowel sounds in patients with ileus: an outdated practice in the ICU? – Netherlands Journal of Critical Care (free PDF)

Editorial: It’s not a gut feeling: don’t listen to the bowels (free PDF)

Source: Critical Care Reviews Newsletter

10 – Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality – Gut (free)

Commentaries: FOB associated with rise in all-cause mortality – OnMedica (free) AND 3 key findings from Gut study on all-cause mortality associated with occult blood in stool – GI & Endoscopy (free) AND Fecal Occult Blood Flags Risks Beyond Colon Cancer – MedPage Today (free)

WHO Campaign: Seven Strategies for Ending Violence Against Children

13 Jul, 2018 | 03:05h | UTC

INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)

Fact Sheet: Violence against children – World Health Organization (free)

The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.

Thu, July 19 – 10 Stories of The Day!

19 Jul, 2018 | 01:45h | UTC

1 – A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest – New England Journal of Medicine (free)

Editorial: Testing Epinephrine for Out-of-Hospital Cardiac Arrest (free)

Commentary: Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive – University of Warwick, via EurekAlert (free)

See also: Infographic detailing result findings (free)

“A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive – but almost doubles the risk of severe brain damage for survivors of cardiac arrest”.

2 – Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)

Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)

Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)

Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)

3 – Randomized Controlled Trial of E-Counseling for Hypertension: REACH – Circulation: Cardiovascular Quality and Outcomes (free)

Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)

4 – Guideline: Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)

5 – The association between nurse staffing and omissions in nursing care: A systematic review – Journal of Advanced Nursing (free)

Commentary: Nurse staffing levels linked to reports of missed care in adult wards – NIHR Signal (free)

6 – Global Burden of Atherosclerotic Cardiovascular Disease in People Living with the Human Immunodeficiency Virus: A Systematic Review and Meta-Analysis – Circulation (free PDF)

Commentaries: HIV infection doubles risk of heart disease – University of Edinburgh, via ScienceDaily (free) AND Global Burden of HIV-Related CVD Has Tripled Over Two Decades – TCTMD (free)

7 – Report: Feeding in the first year of life – Scientific Advisory Committee on Nutrition (SACN) (free)

Commentaries: SACN publishes ‘Feeding in the first year of life’ report – Public Health England (free) AND Too many babies overfed, experts fear – BBC (free)

8 – Contrary to common belief, randomised controlled trials inevitably produce biased results – LSE Impact Blog (free)

Original Article: Why all randomised controlled trials produce biased results – Annals of Medicine (free)

Source: Nature Briefing Newsletter

9 – CBT for anxiety: new meta-analysis confirms significant improvements to target symptoms – The Mental Elf (free) (via @AllenFrancesMD)

Original article: Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials – Depression and Anxiety (free)

10 – Are electronic nicotine delivery systems helping cigarette smokers quit? Evidence from a prospective cohort study of U.S. adult smokers, 2015–2016 – PLOS One (free)

Commentaries: More Than 90 Percent Of Smokers Using E-cigarettes Still Smoking A Year Later – Georgia State University (free) AND Study casts doubt on effectiveness of e-cigs for smoking cessation – National Institutes of Health (free) AND Vaping May Not Help Smokers Kick the Habit – MedPage Today (free registration required)

Mon, July 16 – 10 Stories of The Day!

16 Jul, 2018 | 00:01h | UTC

1 – Effects of aspirin on risks of vascular events and cancer according to bodyweight and dose: analysis of individual patient data from randomised trials – The Lancet (free)

Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)

Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”

2 – Vulnerability to snakebite envenoming: a global mapping of hotspots – The Lancet (free)

Commentaries: Addressing the global challenge of snake envenoming – The Lancet (free) AND New study maps the areas where people are most vulnerable to death following snakebite – London School of Tropical Medicine (free) AND New study finds 93 million people vulnerable to death from snakebites – Institute for Health Metrics and Evaluation (free)

3 – Association of Inferior Vena Cava Filter Placement for Venous Thromboembolic Disease and a Contraindication to Anticoagulation With 30-Day Mortality – JAMA Network Open (free)

Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)

“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)

4 – 2018 EULAR recommendations for physical activity in people with inflammatory arthritis and osteoarthritis – Annals of Rheumatic Disease (free)

5 – 2018 Guidelines of the Taiwan Society of Cardiology, Taiwan Society of Emergency Medicine and Taiwan Society of Cardiovascular Interventions for the management of non ST-segment elevation acute coronary syndrome – Journal of the Formosan Medical Association (free)

6 – CVIT expert consensus document on primary percutaneous coronary intervention (PCI) for acute myocardial infarction (AMI) in 2018 – Japanese Association of Cardiovascular Intervention and Therapeutics (free)

7 – Machine learning of toxicological big data enables read-across structure activity relationships (RASAR) outperforming animal test reproducibility – Toxicological Sciences (free)

Commentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)

8 – Review: Cardiac rehabilitation: A class 1 recommendation – Cleveland Clinic Journal of Medicine (free)

9 – Hypertension Among Youths — United States, 2001–2016 – Centers for Disease Control and Prevention (free)

Commentaries: 800,000 More Adolescents Classified as Hypertensive Under New Guidelines – NEJM Physician’s First Watch (free) AND New guidelines label 795K more US children as hypertensive – Cardiovascular Business (free)

10 – Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study – American Journal of Clinical Nutrition (free for a limited period)

Commentaries: Study finds no significant link between whole dairy products and heart disease, stroke – News Medical (free) AND Full-fat dairy may actually benefit heart health – Medical News Today (free)

Related Studies: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)