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RCT | Atogepant outperforms placebo in reducing migraines over 12 weeks

2 Aug, 2023 | 13:56h | UTC

Atogepant for the preventive treatment of chronic migraine (PROGRESS): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

RCT | Lazertinib offers 20.6-month of median PFS in EGFR-mutated NSCLC vs 9.7 months with gefitinib

2 Aug, 2023 | 13:55h | UTC

Lazertinib Versus Gefitinib as First-Line Treatment in Patients With EGFR-Mutated Advanced Non–Small-Cell Lung Cancer: Results From LASER301 – Journal of Clinical Medicine

 

RCT | Camrelizumab-rivoceranib outperforms sorafenib as first-line therapy for unresectable HCC

2 Aug, 2023 | 13:53h | UTC

Camrelizumab plus rivoceranib versus sorafenib as first-line therapy for unresectable hepatocellular carcinoma (CARES-310): a randomised, open-label, international phase 3 study – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Case Report | Post-myocardial infarction free-wall rupture: rapid diagnosis and management

2 Aug, 2023 | 13:52h | UTC

Post-Myocardial Infarction Free-Wall Rupture: Rapid Diagnosis and Management – JACC: Case Reports

 

Commentary on Twitter

 

M-A | High-volume disease, T stage 4 show largest docetaxel benefit in prostate cancer

2 Aug, 2023 | 13:51h | UTC

Which patients with metastatic hormone-sensitive prostate cancer benefit from docetaxel: a systematic review and meta-analysis of individual participant data from randomised trials – The Lancet Oncology

Commentaries:

Meta-analysis of the Addition of Docetaxel to ADT in Metastatic Hormone-Sensitive Prostate Cancer – The ASCO Post

Disease Volume and T Stage Affect Docetaxel/ADT Efficacy in Prostate Cancer – Cancer Network

 

Commentary on Twitter

 

Cohort Study | Depression at any life stage linked to increased dementia incidence

2 Aug, 2023 | 13:49h | UTC

Association of Early-, Middle-, and Late-Life Depression With Incident Dementia in a Danish Cohort – JAMA Neurology (link to abstract – $ for full-text)

Commentary: Depression Over Adulthood May Increase Risk of Dementia – Psychiatric News Alert

 

RCT | Maternal egg intake in early neonatal period does not impact infant egg allergy risk

2 Aug, 2023 | 13:47h | UTC

Effect of Maternal Egg Intake During the Early Neonatal Period and Risk of Infant Egg Allergy at 12 Months Among Breastfeeding Mothers: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

RCT | Baricitinib demonstrates efficacy in treatment-resistant juvenile idiopathic arthritis

2 Aug, 2023 | 13:45h | UTC

Baricitinib in juvenile idiopathic arthritis: an international, phase 3, randomised, double-blind, placebo-controlled, withdrawal, efficacy, and safety trial – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT | Platelet-rich plasma injections lack efficacy in 52-week ankle osteoarthritis study

2 Aug, 2023 | 13:43h | UTC

Platelet-Rich Plasma Injections for the Treatment of Ankle Osteoarthritis – The American Journal of Sports Medicine

 

RCT | Early vs. delayed intrauterine balloon tamponade: no difference in severe postpartum hemorrhage

2 Aug, 2023 | 13:42h | UTC

Efficacy of early intrauterine balloon tamponade for immediate postpartum hemorrhage after vaginal delivery: a randomized clinical trial – The American Journal of Obstetrics and Gynecology (link to abstract  – $ for full-text)

 

Consensus Paper | Diagnosis and management of infective endocarditis in adults

1 Aug, 2023 | 14:34h | UTC

Guidelines for Diagnosis and Management of Infective Endocarditis in Adults: A WikiGuidelines Group Consensus Statement – JAMA Network Open

 

Review | Futility in clinical trials

1 Aug, 2023 | 14:32h | UTC

Futility in Clinical Trials – JAMA (free for a limited period)

 

Study | AI use in lung cancer screening enhances prediction of lung cancer death, CVD death, and all-cause death

1 Aug, 2023 | 14:31h | UTC

AI Body Composition in Lung Cancer Screening: Added Value Beyond Lung Cancer Detection – Radiology (free for a limited period)

Commentary: Study: AI Assessment of Chest CT May Predict Multiple Mortality Risks – Diagnostic Imaging

 

Opinion | Bad science needs to be called out: the medical profession loses trust when bad studies are used to promote policy

1 Aug, 2023 | 14:29h | UTC

Bad Science Needs to Be Called Out – Sensible Medicine

Related: Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 

Critical Appraisal | Did Republicans die more during the pandemic bc they didn’t get the vax?

1 Aug, 2023 | 14:28h | UTC

Did Republicans die more during the pandemic bc they didn’t get the vax? – By Dr. Vinay Prassad

Related: Bad Science Needs to Be Called Out – Sensible Medicine

Original Study: Excess Death Rates for Republican and Democratic Registered Voters in Florida and Ohio During the COVID-19 Pandemic – JAMA Internal Medicine

 

ESPEN Updated Guideline | Clinical nutrition in the intensive care unit

1 Aug, 2023 | 14:27h | UTC

ESPEN practical and partially revised guideline: Clinical nutrition in the intensive care unit – Clinical Nutrition

 

AAP Policy Statement | Pediatric organ donation and transplantation: across the care continuum

1 Aug, 2023 | 14:26h | UTC

Pediatric Organ Donation and Transplantation: Across the Care Continuum – Pediatrics

News Release: Policy underscores role of medical home in pediatric organ donation, transplantation – AAP News

Commentary: Pediatric Organ Donation and Transplantation: What Primary Care Providers and Families Should Know – AAP Journal Blog

 

European consensus-based interdisciplinary guideline for invasive cutaneous squamous cell carcinoma

1 Aug, 2023 | 14:24h | UTC

Part 1: Diagnostics and prevention – European Journal of Cancer

Part 2: Treatment – European Journal of Cancer

 

International Study | Postoperative acute kidney injury affects one in five patients after major surgery

1 Aug, 2023 | 14:23h | UTC

Epidemiology of surgery associated acute kidney injury (EPIS-AKI): a prospective international observational multi-center clinical study – Intensive Care Medicine

 

Commentary on Twitter

 

Novel therapeutics for management of lupus nephritis: what is next?

1 Aug, 2023 | 14:22h | UTC

Novel Therapeutics for Management of Lupus Nephritis: What Is Next? – Kidney Medicine

Related: Consensus document of the Spanish Group for the Study of the Glomerular Diseases (GLOSEN) for the diagnosis and treatment of lupus nephritis – Nefrología

 

Nonrandomized Controlled Trial | Long-term survival of 80% in selected colorectal cancer patients post liver transplant

1 Aug, 2023 | 14:20h | UTC

Long-Term Survival, Prognostic Factors, and Selection of Patients With Colorectal Cancer for Liver Transplant: A Nonrandomized Controlled Trial – JAMA Surgery (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Review | Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options

1 Aug, 2023 | 14:19h | UTC

Non-alcoholic fatty liver disease: pathophysiological concepts and treatment options – Cardiovascular Research

Related:

From NAFLD to MASLD | New consensus changes fatty liver disease terminology to avoid stigmatization

Nonalcoholic fatty liver disease from a primary care perspective – Diabetes, Obesity and Metabolism

AASLD practice guidance on the clinical assessment and management of nonalcoholic fatty liver disease – Hepatology

Management of NAFLD in primary care settings – Liver International

Updated S2k Clinical Practice Guideline on Non-alcoholic Fatty Liver Disease (NAFLD) issued by the German Society of Gastroenterology, Digestive and Metabolic Diseases (DGVS) – Zeitschrift für Gastroenterologie

AGA Clinical Practice Update | Diagnosis and management of nonalcoholic fatty liver disease in lean individuals.

Quality standards for the management of non-alcoholic fatty liver disease (NAFLD): consensus recommendations from the British Association for the Study of the Liver and British Society of Gastroenterology NAFLD Special Interest Group – The Lancet Gastroenterology & Hepatology (free registration required)

Nonalcoholic Fatty Liver Disease and Cardiovascular Risk: A Scientific Statement From the American Heart Association – Arteriosclerosis, Thrombosis, and Vascular Biology

Advancing the global public health agenda for NAFLD: a consensus statement – Nature Reviews Gastroenterology & Hepatology

Clinical Care Pathway for the Risk Stratification and Management of Patients With Nonalcoholic Fatty Liver Disease – Gastroenterology

Non-alcoholic fatty liver disease: A patient guideline – JHEP Reports

 

Phase 1 Trial | NI006 shows potential for cardiac amyloid depletion in transthyretin amyloid cardiomyopathy

1 Aug, 2023 | 14:17h | UTC

Phase 1 Trial of Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Amyloid Removal Looks Possible in ATTR Cardiomyopathy Imaging Trial – TCTMD

Antibody NI006 for Depletion of Cardiac Transthyretin Amyloid – American College of cardiology

 

Review | Revisiting resistant hypertension

1 Aug, 2023 | 14:16h | UTC

Revisiting resistant hypertension: a comprehensive review – Internal Medicine Journal

Related: Resistant hypertension: A stepwise approach – Cleveland Clinic Journal of Medicine

Podcast: #390 Resistant Hypertension – The Curbsiders

 

M-A | Updated evidence supports incisional negative pressure wound therapy for surgical site infection prevention

1 Aug, 2023 | 14:15h | UTC

Incisional negative pressure wound therapy for the prevention of surgical site infection: an up-to-date meta-analysis and trial sequential analysis – eClinicalMedicine

 

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