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Alcohol minimum unit pricing in Scotland led to substantial decrease in alcohol-attributable deaths and hospitalizations

29 Mar, 2023 | 13:28h | UTC

Evaluating the impact of alcohol minimum unit pricing on deaths and hospitalisations in Scotland: a controlled interrupted time series study – The Lancet

News Release: Minimum unit pricing for alcohol associated with a 13% decrease in deaths from alcohol consumption in Scotland – Lancet

Commentaries:

Expert reaction to study looking at alcohol-related deaths and hospitalisations in Scotland since the minimum unit pricing for alcohol policy was introduced – Science Media Centre

Minimum pricing averts alcohol deaths, study claims – BBC

Scotland’s minimum pricing linked to 13% drop in alcohol-related deaths, study finds – The Guardian

Commentary on Twitter (thread – click for more)

Minimum unit pricing for #alcohol was introduced in Scotland in 2018 (50p per unit) with the aim of reducing alcohol consumption in the heaviest drinkers.

A new study analyses the impact of the policy on alcohol-specific hospitalisations and deaths. https://t.co/ehoHjbc8lw

— The Lancet (@TheLancet) March 21, 2023

M-A | Aggressive IV hydration may increase mortality risk in severe acute pancreatitis

29 Mar, 2023 | 13:26h | UTC

Summary: This systematic review and meta-analysis investigated the outcomes of aggressive and non-aggressive intravenous hydration in patients with severe and non-severe acute pancreatitis (AP). The study included nine randomized controlled trials with a total of 953 participants.

The findings revealed that aggressive intravenous hydration significantly increased mortality risk in severe AP cases, and fluid-related complication risk in both severe and non-severe AP cases. However, the study has some limitations, as only one study with 249 participants was judged to have a low risk of bias in all domains, while the remaining eight studies had non-low risk of bias, raising concerns about the reliability of the findings.

Despite these concerns, the findings still suggest that more conservative intravenous fluid resuscitation protocols for AP may be preferable. Further research with more rigorous study designs is needed to provide robust evidence on the effectiveness of different intravenous hydration strategies in treating acute pancreatitis.

Article: Comparison of clinical outcomes between aggressive and non-aggressive intravenous hydration for acute pancreatitis: a systematic review and meta-analysis – Critical Care

Summary: Injections of anti-vascular endothelial growth factor for advanced diabetic retinopathy – Cochrane Library

Phase 2b RCT | Liposomal irinotecan plus fluorouracil/leucovorin for patients with previously treated metastatic biliary tract cancer

29 Mar, 2023 | 13:14h | UTC

Treatment With Liposomal Irinotecan Plus Fluorouracil and Leucovorin for Patients With Previously Treated Metastatic Biliary Tract Cancer: The Phase 2b NIFTY Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)

Commentary on Twitter

Final analysis of NIFTY trial demonstrates significant improvement of PFS & OS with use of nal-IRI plus 5-FU/LV compared to 5-FU/LV in patients with previously treated advanced biliary tract cancer. https://t.co/WrZ3GtXYxP #GICSM pic.twitter.com/BqxSbBG9dv

— JAMA Oncology (@JAMAOnc) March 23, 2023

Podcast | Diabetes updates

29 Mar, 2023 | 13:09h | UTC

#387: Diabetes Updates with Dr. Marie McDonnell: New Tools for the New Rules – The Curbsiders

Cohort Study | Evaluating 5 creatinine-based formulas for eGFR estimation in older patients

29 Mar, 2023 | 13:12h | UTC

Concordance and Discrepancies Among 5 Creatinine-Based Equations for Assessing Estimated Glomerular Filtration Rate in Older Adults – JAMA Network Open

Commentary on Twitter

5 commonly-used creatinine-based equations provided different eGFR estimates in older adults in Sweden. BIS equation outperformed others in predicting 15-year mortality, but its accuracy was reduced in subgroups of low muscle mass and high age. https://t.co/DOJmp4HzZn

— JAMA Network Open (@JAMANetworkOpen) March 23, 2023

A syndrome-specific antibiotic stewardship intervention reduced antipseudomonal antibiotic use in diabetic foot infections

29 Mar, 2023 | 13:10h | UTC

Impact of a syndrome-specific antibiotic stewardship intervention on antipseudomonal antibiotic use in inpatient diabetic foot infection management – Antimicrobial Stewardship & Healthcare Epidemiology

Podcast | Pears in primary aldosteronism, mineralocorticoid receptor antagonists, and renovascular hypertension

29 Mar, 2023 | 13:07h | UTC

#386 Primary Aldosteronism, MRAs, and Renovascular Hypertension: NephMadness Pod Crawl 2023 – The Curbsiders

RCT | Effects of Docetaxel as a radiosensitizer in patients with head and neck cancer, unsuitable for cisplatin-based chemoradiation

29 Mar, 2023 | 13:05h | UTC

Results of Phase III Randomized Trial for Use of Docetaxel as a Radiosensitizer in Patients With Head and Neck Cancer, Unsuitable for Cisplatin-Based Chemoradiation – Journal of Clinical Oncology (link to abstract – $ for full-text)

Editorial: Good Radiosensitizer Hunting – Journal of Clinical Oncology

Commentaries:

Docetaxel Added to Radiation Provides DFS, OS Benefit in Cisplatin-Ineligible HNSCC – OncLive

Docetaxel as a Radiosensitizer in Cisplatin-Ineligible Patients With Locally Advanced Head and Neck Cancer – The ASCO Post

Summary: Local steroid injection for carpal tunnel syndrome – Cochrane Library

Commentary on Twitter

https://twitter.com/CochraneUK/status/1621853332003344385

Cohort Study | Associations between betablockers and psychiatric and behavioral outcomes

29 Mar, 2023 | 12:57h | UTC

Associations between β-blockers and psychiatric and behavioural outcomes: A population-based cohort study of 1.4 million individuals in Sweden – PLOS Medicine

News Release: Use of β-blockers linked with reductions in violence – News Medical/PLOS

Commentaries:

Beta blockers: how these common heart medications may reduce the risk of violence – The Conversation

Expert reaction to study looking at beta-blockers and lower rates of violence – Science Media Centre

M-A | Factors associated with post-treatment control of viral load in HIV-infected patients

29 Mar, 2023 | 12:56h | UTC

Factors Associated with Post-treatment Control of Viral Load in HIV-Infected Patients: A Systematic Review and Meta-analysis – International Journal of Infectious Diseases

Plasma D-Dimer may be useful in the diagnosis of periprosthetic joint infection

29 Mar, 2023 | 12:33h | UTC

Plasma D-Dimer Is Noninferior to Serum C-Reactive Protein in the Diagnosis of Periprosthetic Joint Infection – The Journal of Bone and Joint Surgery (link to abstract – $ for full-text)

News Release: D-dimer blood test shows value in detecting prosthetic joint infections – Wolters Kluwer

AHA Scientific Statement | Interpreting incidentally identified variants in genes associated with heritable cardiovascular disease

28 Mar, 2023 | 15:12h | UTC

Interpreting Incidentally Identified Variants in Genes Associated With Heritable Cardiovascular Disease: A Scientific Statement From the American Heart Association – Circulation: Genomic and Precision Medicine

News Release: Genetic tests unexpectedly find genes linked to heart disease — now what? – AHA Newsroom

CDC report reveals escalating Candida auris transmission and resistance in the US

28 Mar, 2023 | 15:10h | UTC

Worsening Spread of Candida auris in the United States, 2019 to 2021 – Annals of Internal Medicine

News Release: Increasing Threat of Spread of Antimicrobial-resistant Fungus in Healthcare Facilities – Centers for Disease Control and Prevention

Commentaries:

CDC reports dramatic increase in US Candida auris cases – CIDRAP

Cases and transmission of highly contagious fungal infections see dramatic increase between 2019 and 2021 – American College of Physicians

An emerging fungal threat spread at an alarming rate in US health care facilities, study says – CNN

Case reports: Multidrug-resistant Candida auris infections in critically ill Covid-19 patients

Candida auris: A Review of Recommendations for Detection and Control in Healthcare Settings

Global Epidemiology of Emerging Candida Auris (reviews and commentaries on the subject)

The superbug Candida auris is giving rise to warnings — and big questions – STAT

Candida Auris – “A Mysterious Infection, Spanning the Globe in a Climate of Secrecy” (reviews and commentaries on the subject)

Commentary on Twitter

New Annals of Internal Medicine study finds cases of deadly fungus, Candida auris, rose drastically between 2019 and 2021. Increase included treatment resistant strains: https://t.co/J3SkmfWDr5 @CDCgov pic.twitter.com/ZJBRqMIOy1

— Annals of Int Med (@AnnalsofIM) March 21, 2023

M-A | Risk factors associated with post−COVID-19 condition

28 Mar, 2023 | 15:07h | UTC

Risk Factors Associated With Post−COVID-19 Condition: A Systematic Review and Meta-analysis – JAMA Internal Medicine

Editorial: While Waiting for a Randomized Clinical Trial of Nirmatrelvir for Prevention of Post–COVID-19 Condition – JAMA Internal Medicine

Commentary:

Meta-analysis reveals risk, protective factors for long COVID – CIDRAP

Long Covid: University of East Anglia study finds women more likely affected – BBC

People who catch Omicron are less likely to get Long Covid

28 Mar, 2023 | 15:04h | UTC

People who catch Omicron are less likely to get Long Covid – Science

Alcohol minimum unit pricing in Scotland led to substantial decrease in alcohol-attributable deaths and hospitalizations

M-A | Aggressive IV hydration may increase mortality risk in severe acute pancreatitis

Review | Recompensation in cirrhosis: current evidence and future directions

SR | Diagnostic accuracy of heart auscultation for detecting valve disease

SR | Effect of antenatal corticosteroid administration-to-birth interval on maternal and newborn outcomes

FIGO Good Practice Recommendations on the use of progesterone in the management of recurrent first-trimester miscarriage

Review | Supplemental oxygen and noninvasive ventilation

M-A | Effects of dexmedetomidine on postoperative sleep quality

SR | Anti‐vascular endothelial growth factor for proliferative diabetic retinopathy

Phase 2b RCT | Liposomal irinotecan plus fluorouracil/leucovorin for patients with previously treated metastatic biliary tract cancer

Podcast | Diabetes updates

Cohort Study | Evaluating 5 creatinine-based formulas for eGFR estimation in older patients

A syndrome-specific antibiotic stewardship intervention reduced antipseudomonal antibiotic use in diabetic foot infections

Podcast | Pears in primary aldosteronism, mineralocorticoid receptor antagonists, and renovascular hypertension

RCT | Effects of Docetaxel as a radiosensitizer in patients with head and neck cancer, unsuitable for cisplatin-based chemoradiation

Consensus Paper | Diagnosis and treatment of anticancer drug-induced interstitial lung disease

Cohort Study | Risk of liver fibrosis associated with long-term methotrexate therapy may be overestimated

SR | Local corticosteroid injection versus placebo for carpal tunnel syndrome

Cohort Study | Associations between betablockers and psychiatric and behavioral outcomes

M-A | Factors associated with post-treatment control of viral load in HIV-infected patients

Plasma D-Dimer may be useful in the diagnosis of periprosthetic joint infection

AHA Scientific Statement | Interpreting incidentally identified variants in genes associated with heritable cardiovascular disease

CDC report reveals escalating Candida auris transmission and resistance in the US

M-A | Risk factors associated with post−COVID-19 condition

People who catch Omicron are less likely to get Long Covid

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