Archives
Assessing heart failure risk: waist-to-height ratio outperforms BMI in HFrEF patients
31 Mar, 2023 | 13:49h | UTCCommentary: Study Debunks Obesity Paradox in HF, Encourages BMI Alternatives – TCTMD
RCT | Early postpartum IUD placement noninferior vs. placement at 6-8 weeks for complete expulsion, but not for partial expulsion
31 Mar, 2023 | 13:48h | UTCEarly vs Interval Postpartum Intrauterine Device Placement: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
News Release: Study: Risk of IUD Expulsion in Early Postpartum Placement – UC San Diego Health
Commentary: IUD Placement at Two to Four Weeks Postpartum Noninferior – HealthDay
Related:
Commentary on Twitter
Early IUD placement at 2 to 4 weeks postpartum compared with 6 to 8 weeks postpartum was noninferior for complete expulsion, but not partial expulsion. https://t.co/VMfWce3JJd pic.twitter.com/vdLrhCXa5Q
— JAMA (@JAMA_current) March 23, 2023
SCAI/HRS Expert consensus statement on transcatheter left atrial appendage closure
31 Mar, 2023 | 13:44h | UTCSCAI/HRS Expert Consensus Statement on Transcatheter Left Atrial Appendage Closure – JSCAI
Key Points: Consensus Statement on Transcatheter LA Appendage Closure – American College of Cardiology
Commentaries:
SCAI/HRS Consensus Document Covers the Ins and Outs of LAAO – TCTMD
M-A | Effects of statin therapy on glycemic control and insulin resistance
31 Mar, 2023 | 13:45h | UTCRelated:
Cohort study: Statin therapy initiation linked to increased risk of diabetes progression.
Meta-Analysis: Medications that Reduce or Increase the Risk of New Onset Diabetes
Observational Study Points to an Increased Risk of Diabetes Among Patients Using Statins
Cohort Study: Statin Use Associated with a 38% Higher Risk of Incident Type 2 Diabetes
Study shows clinical instability and severity are predictors for psychiatric hospitalization
31 Mar, 2023 | 13:42h | UTCCommentaries:
New study reveals clinical instability predicts psychiatric hospitalization – MedicalXpress
Instability, Clinical Severity Predict Hospitalization Risk for Psychiatric Illness – HCP Live
Update | Optimal oxygen and mean arterial blood pressure targets after cardiac arrest
31 Mar, 2023 | 13:41h | UTC
Commentary on Twitter
O2/MAP after CA? NO clear benefit from deviating from
🩸MAP >65-70 mmHg, if impaired 🧠autoregulation as high as 85-90
💨 PaO2 75-97 mmHg; more liberal O2 may be best if reliable monitoring difficult (ie transport or in ED)
More evidence needed (coming)
🖇️ https://t.co/ujsz09tDSJ pic.twitter.com/fft8Q1turt— Intensive Care Medicine (@yourICM) March 21, 2023
M-A | Incidence and prognostic role of pleural effusion in patients with pulmonary embolism
31 Mar, 2023 | 13:40h | UTC
SR | Etiologies of vertigo in the elderly
31 Mar, 2023 | 13:38h | UTCVertigo in the Elderly: A Systematic Literature Review – Journal of Clinical Medicine
RCT | Comparing exemestane dose regimens in early-stage ER+ breast cancer
31 Mar, 2023 | 13:37h | UTCEfficacy of Alternative Dose Regimens of Exemestane in Postmenopausal Women With Stage 0 to II Estrogen Receptor–Positive Breast Cancer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentary on Twitter
Exemestane 25 mg (Exe) 3x/week (TIW) in compliant patients is comparable to daily dosing in reducing circulating estradiol; a weekly dose was less effective. Toxicity similar in all arms, suggesting Exe TIW may be used in breast cancer prevention. https://t.co/2NugINVrim #BCS
— JAMA Oncology (@JAMAOnc) March 23, 2023
Cohort Study | Subclinical coronary atherosclerosis and risk for myocardial infarction
31 Mar, 2023 | 13:36h | UTCSubclinical Coronary Atherosclerosis and Risk for Myocardial Infarction in a Danish Cohort: A Prospective Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Related:
Cohort Study: Coronary Artery Calcium and Long-Term Risk of Death, Myocardial Infarction, and Stroke
USPSTF Statement: Risk Assessment for Cardiovascular Disease With Nontraditional Risk Factors
The 10-Year Prognostic Value of Zero and Minimal CAC
Review | Exercise in octogenarians: how much is too little?
31 Mar, 2023 | 13:34h | UTCExercise in Octogenarians: How Much Is Too Little? – Annual Reviews of Medicine
Cohort Study | Diffusing capacity strongly predicts all-cause mortality in individuals with COPD
31 Mar, 2023 | 13:31h | UTCDiffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease – Annals of the American Thoracic Society (link to abstract – $ for full-text)
Commentary: Diffusing capacity ‘strongly predicted’ mortality in COPD patients – Healio (free registration required)
Commentary on Twitter
Diffusing Capacity and Mortality in Chronic Obstructive Pulmonary Disease
🔗 https://t.co/F5Hqkx65hn pic.twitter.com/up0psKKE3i
— Annals of the ATS (@AnnalsATS) January 10, 2023
RCT | Pulsed oral azithromycin vs. 6-week oral doxycycline for moderate to severe meibomian gland dysfunction
31 Mar, 2023 | 13:33h | UTCPulsed Oral Azithromycin vs 6-Week Oral Doxycycline for Moderate to Severe Meibomian Gland Dysfunction: A Randomized Clinical Trial – JAMA Ophthalmology (link to abstract – $ for full-text)
Commentary: 3-Week MGD treatment equivalent to 6-week course in efficacy and adverse events – Ophthalmology Times
Commentary on Twitter
A 3-week course of weekly oral azithromycin was equivalent to a 6-week course of oral doxycycline in treating moderate to severe meibomian gland dysfunction. https://t.co/nE312KxGki pic.twitter.com/xWmqYWby7j
— JAMA Ophthalmology (@JAMAOphth) March 23, 2023
M-A | Impact of axillary lymph node dissection and sentinel lymph node biopsy on upper limb morbidity in breast cancer patients
31 Mar, 2023 | 13:30h | UTC
SR | Nonopioid pharmacological management of acute low back pain
31 Mar, 2023 | 13:27h | UTC
Review | The failed peripheral nerve block
31 Mar, 2023 | 13:28h | UTCThe failed peripheral nerve block – BJA Education
RCT | Efficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention
31 Mar, 2023 | 13:26h | UTCEfficacy and safety of garadacimab, a factor XIIa inhibitor for hereditary angioedema prevention (VANGUARD): a global, multicentre, randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary on Twitter (thread – click for more)
Hereditary angioedema is a rare disease associated with unpredictable, recurrent angioedema attacks that can be life-threatening.
New study data support the use of garadacimab as a potential prophylactic therapy in adolescents and adults: https://t.co/xlxoA3J3sh 🧵 pic.twitter.com/VqCOHnaQAp
— The Lancet (@TheLancet) March 6, 2023
RCT | Zavegepant 10 mg nasal spray vs. placebo for the acute treatment of migraine
31 Mar, 2023 | 13:24h | UTCSafety, tolerability, and efficacy of zavegepant 10 mg nasal spray for the acute treatment of migraine in the USA: a phase 3, double-blind, randomised, placebo-controlled multicentre trial – The Lancet Neurology (link to abstract – $ for full-text)
Methodology and Design of Platform Trials | A meta-epidemiological study
31 Mar, 2023 | 13:22h | UTCRelated:
Platform trials: the future of medical research? – The Lancet Respiratory Medicine
Platform Trials — Beware the Noncomparable Control Group – New England Journal of Medicine
Review | Management of immune related endocrinopathies following immune checkpoint inhibitor therapy for cancer
31 Mar, 2023 | 13:23h | UTCRelated:
Palliative care in the intensive care unit: not just end-of-life care
31 Mar, 2023 | 13:21h | UTCPalliative Care in the Intensive Care Unit: Not Just End-of-life Care – Intensive Care Research
M-A | Exploring the efficacy of psychotherapies for depression
31 Mar, 2023 | 13:19h | UTC
RCT | Drain usage may increase the length of hospital stay following lumbar arthrodesis
31 Mar, 2023 | 13:18h | UTCCommentary: Wound drains increase hospital los after lumbar surgery? – Orthopedics This Week
ICU Burnout Crisis | Meta-analysis reveals over 40% prevalence in medical professionals
30 Mar, 2023 | 14:30h | UTCHigh-level burnout in physicians and nurses working in adult ICUs: a systematic review and meta-analysis – Intensive Care Medicine (if the link is paywalled, try this one)
Related:
AAP Clinical Report | Physician health and wellness.
M-A | Physicians suffering burnout are twice as likely to be involved in patient safety incidents.
Systematic Review | Predictors of burnout among healthcare providers.
Physician Well-being 2.0: Where Are We and Where Are We Going? – Mayo Clinic Proceedings
Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Hospital administration response to physician stress and burnout – Journal of Hospital Practice
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution) – Forbes
Physician Burnout: A Global Crisis
The Burnout Crisis in American Medicine – The Atlantic
Physician burnout costs up to $17B a year, task force says – HealthcareDive
Systematic Review: Prevalence of Burnout Among Physicians
Association Between Physician Burnout and Patient Safety, Professionalism, and Patient Satisfaction
Commentary on Twitter
High-level burnout in adult ICUs physicians & nurses, SR/MA
➡️ prevalence > 40% in all #ICU HCWs, 41% physicians/44% nurses
➡️ #COVID19? ⬆️ burnout only in nurses
Preventive/therapeutic measures to improve well-being crucial as a consensual definitio.
🖇️ https://t.co/kUcZ7P9iqz pic.twitter.com/owqC1W5yLu— Intensive Care Medicine (@yourICM) March 28, 2023
Updated WHO Guidelines | COVID-19 boosters no longer routinely recommended for low-risk groups
30 Mar, 2023 | 14:33h | UTCSummary: The WHO’s Strategic Advisory Group of Experts on Immunization (SAGE) has revised its COVID-19 vaccination roadmap in light of the Omicron variant and widespread population immunity. The revised roadmap prioritizes protecting those at the highest risk of severe disease and death while maintaining resilient health systems. It introduces cost-effectiveness considerations for vaccinating lower-risk individuals, such as healthy children and adolescents, and presents revised booster dose recommendations.
Priority groups are categorized as high, medium, and low, based on factors like risk of severe disease and death. People in the high-priority group, consisting of older adults, individuals with significant comorbidities or immunocompromising conditions, pregnant persons, and frontline health workers, are advised to receive additional boosters 6 or 12 months after the last dose. The medium priority group, which includes healthy adults without comorbidities and children with comorbidities, is recommended to receive primary series and first booster doses. However, SAGE no longer routinely recommends additional boosters for this group due to limited public health gains.
For the low-priority group, encompassing healthy children and adolescents, vaccination decisions should take into account factors such as disease prevalence and cost-effectiveness. It is important to note that the public health benefits of vaccinating healthy children and adolescents are considerably lower compared to established essential vaccines for children, like rotavirus, measles, and pneumococcal conjugate vaccines.
News Release: SAGE updates COVID-19 vaccination guidance – World Health Organization
Commentaries:
No More COVID-19 Boosters for Healthy People, WHO Experts Recommend – Health Policy Watch
WHO vaccine advisers update COVID vaccine recommendations – CIDRAP