Archives
Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms
17 Jul, 2019 | 09:19h | UTCThe Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)
Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)
Related Commentary on Twitter
The term "Alzheimer Clinical Syndrome", as opposed to "probable Alzheimer disease", distinguishes the biology from the associated clinical syndrome. https://t.co/9RwdaTEpUR
— JAMA Neurology (@JAMANeuro) July 16, 2019
Post‐intensive Care Syndrome: Its Pathophysiology, Prevention, and Future Directions
17 Jul, 2019 | 08:59h | UTCPost‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)
Related Reviews: Post-intensive care outpatient clinic: is it feasible and effective? A literature review – Revista Brasileira de Medicina Intensiva (free) AND Post-intensive Care Syndrome: an Overview – Journal of Translational Internal Medicine (free) AND Optimizing Post-Intensive Care Unit Rehabilitation – Turkish Thoracic Journal (free)
Guidelines for Moderate Drinking Based on The Presence or Absence of Facial Flushing
17 Jul, 2019 | 09:04h | UTC“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”
Editorial: Lithium as the Drug of Choice for Maintenance Treatment in Bipolar Disorder
17 Jul, 2019 | 09:39h | UTCLithium as the drug of choice for maintenance treatment in bipolar disorder – Acta Psychiatrica Scandinavica (free) (via @J_F_Hayes)
Original Article: A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder – Acta Psychiatrica Scandinavica (free)
Tue July 16 – 10 Stories of The Day!
16 Jul, 2019 | 09:53h | UTC
1 – Healing the Professional Culture of Medicine – Mayo Clinic Proceedings (free)
Related: Understanding organisational culture for healthcare quality improvement – The BMJ (free)
2 – State of The Art Review: Pre-eclampsia: pathophysiology and clinical implications – The BMJ (free for a limited period)
Commentaries: Reduced work hours for trainee doctors not seen to compromise care – Reuters (free) AND Capping medical residency hours does not hamper new doctors’ quality of training – Harvard Medical School (free) AND Is an 80-Hour Workweek Enough to Train a Doctor? – Harvard Business Review (free)
Commentaries: New stillbirth risk figures help women’s decisions on timing delivery – Queen Mary University of London (free) AND Higher risk of stillbirth in longer pregnancies, study finds – PLOS (free) AND Expert reaction to study on longer pregnancies and risk of stillbirth – Science Media Centre (free)
Related Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Related Randomized Trials: Labor Induction vs. Expectant Management in Low-Risk Nulliparous Women (free) AND Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free)
Related WHO Recommendations: Induction of Labor at or Beyond Term (free)
5 – Hartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Farewell to Hartmann’s Procedure? – MedPage Today (free registration required)
6 – Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
7 – Association of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
8 – Viewpoint: The Ketogenic Diet for Obesity and Diabetes—Enthusiasm Outpaces Evidence – JAMA Internal Medicine (free for a limited period)
Related Consensus Statement: Very-low-calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases (free)
9 – Association of Screen Time and Depression in Adolescence – JAMA Pediatrics (free for a limited period)
Commentaries: Expert reaction to a study on screen time and depression in adolescents – Science Media Centre (free) AND Increasing social media use tied to rise in teens’ depressive symptoms, study says – CNN (free)
10 – Association of Silent Myocardial Infarction and Sudden Cardiac Death – JAMA Cardiology (free for a limited period)
Commentaries: Frequency of Left Ventricular Scars at Autopsy in Persons Dying Suddenly of Coronary Artery Disease With or Without Earlier Myocardial Infarction – JAMA Cardiology (free for a limited period) AND Nearly half of sudden cardiac death victims had prior, undetected MI – Cardiovascular Business (free) AND Silent MI Often Precedes Sudden Cardiac Death, Finnish Data Confirm – TCTMD (free)
Healing the Professional Culture of Medicine
16 Jul, 2019 | 09:51h | UTCHealing the Professional Culture of Medicine – Mayo Clinic Proceedings (free)
Related: Understanding organisational culture for healthcare quality improvement – The BMJ (free)
“Not Initiating is Not the Same Thing as Discontinuing” – Update on Acetylsalicylic Acid for Primary Prevention of Cardiovascular Disease
17 Jul, 2019 | 08:40h | UTCSee also: Acetylsalicylic acid for primary prevention of cardiovascular events – Canadian Family Physician (free)
Related: A Practical Approach to Low-Dose Aspirin for Primary Prevention (free) AND Aspirin for Primary Prevention: Is This the End of the Road? (free) AND Evidence evolving on aspirin as prevention – ACP Internist (free)
Pre-eclampsia: Pathophysiology and Clinical Implications
16 Jul, 2019 | 09:50h | UTCState of The Art Review: Pre-eclampsia: pathophysiology and clinical implications – The BMJ (free for a limited period)
Observational Study: Reductions in Residency Work Hours Not Associated with Worse Outcomes for Patients or Declines in the Quality of Physician Training
16 Jul, 2019 | 09:48h | UTCCommentaries: Reduced work hours for trainee doctors not seen to compromise care – Reuters (free) AND Capping medical residency hours does not hamper new doctors’ quality of training – Harvard Medical School (free) AND Is an 80-Hour Workweek Enough to Train a Doctor? – Harvard Business Review (free)
Meta-Analysis: Risks of Stillbirth and Neonatal Death with Advancing Gestation at Term
16 Jul, 2019 | 09:46h | UTCCommentaries: New stillbirth risk figures help women’s decisions on timing delivery – Queen Mary University of London (free) AND Higher risk of stillbirth in longer pregnancies, study finds – PLOS (free) AND Expert reaction to study on longer pregnancies and risk of stillbirth – Science Media Centre (free)
Related Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Related Randomized Trials: Labor Induction vs. Expectant Management in Low-Risk Nulliparous Women (free) AND Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free)
Related WHO Recommendations: Induction of Labor at or Beyond Term (free)
[Abstract Only] Randomized Trial: Hartmann’s Procedure vs. Sigmoidectomy with Primary Anastomosis for Perforated Diverticulitis with Purulent or Fecal Peritonitis
16 Jul, 2019 | 09:45h | UTCHartmann’s procedure versus sigmoidectomy with primary anastomosis for perforated diverticulitis with purulent or faecal peritonitis (LADIES): a multicentre, parallel-group, randomised, open-label, superiority trial – The Lancet Gastroenterology & Hepatology (link to abstract – $ for full-text)
Commentary: Farewell to Hartmann’s Procedure? – MedPage Today (free registration required)
Related Commentary on Twitter
https://twitter.com/LancetGastroHep/status/1136845295432585216?
Viewpoint: The Ketogenic Diet for Obesity and Diabetes—Enthusiasm Outpaces Evidence
16 Jul, 2019 | 09:40h | UTCThe Ketogenic Diet for Obesity and Diabetes—Enthusiasm Outpaces Evidence – JAMA Internal Medicine (free for a limited period)
Related Consensus Statement: Very-low-calorie Ketogenic Diet (VLCKD) in the Management of Metabolic Diseases (free)
Study: Health Lifestyle May Reduce the Incidence of Dementia Even in Patients with High Genetic Risk
16 Jul, 2019 | 09:42h | UTCAssociation of Lifestyle and Genetic Risk With Incidence of Dementia – JAMA (free for a limited period)
Commentaries: Healthy lifestyle reduces dementia risk even in those with genetic risk factors – NHS Choices (free) AND Healthy lifestyle may offset genetic risk of dementia – University of Exeter (free) AND Genes vs. lifestyle: Study ‘undermines fatalistic view of dementia’ – Medical News Today (free) AND Healthy living may help offset genetic risk of dementia: study – Reuters (free) AND Healthy lifestyle may cut risk of dementia regardless of genes – The Guardian (free)
[Abstract Only] Meta-Analysis: Benefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease
16 Jul, 2019 | 09:43h | UTCBenefits and Harms of Oral Anticoagulant Therapy in Chronic Kidney Disease: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Non-vitamin K oral anticoagulants appear superior to vitamin K antagonists in early-stage CKD – ACP Internist (free) AND Evidence Favors NOACs for Anticoagulation in Early Chronic Kidney Disease – NEJM Journal Watch (free)
Perspective: An Example of Low Value Health Care—Time to Talk About Money and Opportunity Cost
16 Jul, 2019 | 09:23h | UTCAn example of low value health care—time to talk about money and opportunity cost- The BMJ Opinion (free)
Study: Silent Myocardial Infarction Often Precedes Sudden Cardiac Death
16 Jul, 2019 | 09:25h | UTCAssociation of Silent Myocardial Infarction and Sudden Cardiac Death – JAMA Cardiology (free for a limited period)
Commentaries: Frequency of Left Ventricular Scars at Autopsy in Persons Dying Suddenly of Coronary Artery Disease With or Without Earlier Myocardial Infarction – JAMA Cardiology (free for a limited period) AND Nearly half of sudden cardiac death victims had prior, undetected MI – Cardiovascular Business (free) AND Silent MI Often Precedes Sudden Cardiac Death, Finnish Data Confirm – TCTMD (free)
Study: Association of Screen Time and Depression in Adolescence
16 Jul, 2019 | 09:27h | UTCAssociation of Screen Time and Depression in Adolescence – JAMA Pediatrics (free for a limited period)
Commentaries: Expert reaction to a study on screen time and depression in adolescents – Science Media Centre (free) AND Increasing social media use tied to rise in teens’ depressive symptoms, study says – CNN (free)
Meta-analysis: Hemodynamic Goal-directed Therapy and Postoperative Kidney Injury
16 Jul, 2019 | 09:21h | UTC
Regimens to Treat Multidrug-resistant Tuberculosis: Past, Present and Future Perspectives
16 Jul, 2019 | 09:20h | UTCRelated: WHO Consolidated Guidelines on Drug-resistant Tuberculosis Treatment (free) AND Randomized Trial: 9-month Treatment for Multi-drug Resistant TB is as Effective as 24-month Treatment (free)
Guideline: Bowel Preparation for Colonoscopy
16 Jul, 2019 | 09:17h | UTC
An Asian Consensus on Standards of Diagnostic Upper Endoscopy for Neoplasia
16 Jul, 2019 | 09:16h | UTCAn Asian consensus on standards of diagnostic upper endoscopy for neoplasia – Gut (free)
Review: Diagnostic Evaluation of Bronchiectasis
16 Jul, 2019 | 09:19h | UTCDiagnostic evaluation of bronchiectasis – Respiratory Medicine (free)
Related Guidelines: British Thoracic Society Guideline for bronchiectasis in adults – Thorax (free) AND Bronchiectasis (non-cystic fibrosis), acute exacerbation: antimicrobial prescribing – National Institute for Health and Care Excellence (free) AND European Respiratory Society guidelines for the management of adult bronchiectasis (free)
Guideline for the Medical Management of Pediatric Luminal Crohn’s Disease
16 Jul, 2019 | 09:12h | UTC
Mon July 15 – 10 Stories of The Day!
14 Jul, 2019 | 20:09h | UTC
1 – Clinical Practice: Measles – New England Journal of Medicine (free)
2 – Optimized Treatment of ST-Elevation Myocardial Infarction: The Unmet Need to Target Coronary Microvascular Obstruction as Primary Treatment Goal to Further Improve Prognosis – Circulation Research (free) (via @gonzaeperez)
3 – For the sake of doctors and patients, we must fix hospital culture – The BMJ Opinion (free)
Related: Speaking up to prevent harm: A systematic review of the safety voice literature – Safety Science (free)
“When hospitals fail to create a culture where doctors and nurses can speak up patients pay the price.”
4 – 2 years of calorie restriction and cardiometabolic risk (CALERIE): exploratory outcomes of a multicentre, phase 2, randomised controlled trial – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Moderate calorie restriction in young and middle-aged adults significantly reduces heart and metabolic risk factors independent of weight loss – NIH News Releases (free) AND Cutting calories improves health markers even in slim adults, study reports – Diabetes.co.uk (free) AND Cutting Just 300 Calories Per Day May Keep Your Heart Healthy – NPR (free) AND Cutting about 300 calories a day might benefit your heart, study finds – CNN (free)
5 – Viewpoint: Redefining the Physician’s Role in Cost-Conscious Care: The Potential Role of the Electronic Health Record – JAMA (free for a limited period)
“Displaying price information in EHRs could mark the next step in the transformation of the practice of medicine… The next generation of EHRs should include prices for the majority of medical products and services: medications, laboratory testing, surgical procedures, and physician visits.”
6 – Industry Payments and Physician Prescribing – JAMA Internal Medicine (free for a limited period)
Original Studies: Association of Biologic Prescribing for Inflammatory Bowel Disease With Industry Payments to Physicians – JAMA Internal Medicine (free for a limited period) AND Association Between Industry Payments to Physicians and Gabapentinoid Prescribing – JAMA Internal Medicine (free for a limited period)
7 – Urinary Tract Infections Affect Millions. The Cures Are Faltering. – The New York Times (10 articles per month are free)
“As the infections become increasingly resistant to antibiotics, some standard treatments no longer work for an ailment that was once easily cured.”
8 – Review: Diaphragmatic dysfunction – Pulmonology (free)
Source: Critical Care Reviews Newsletter
Related reviews: Toxicities of chimeric antigen receptor T cells: recognition and management – Blood (free) AND Toxicity and management in CAR T-cell therapy – Molecular Therapy Oncolytics (free) AND New drugs, new toxicities: severe side effects of modern targeted and immunotherapy of cancer and their management – Critical Care (free) AND CAR T-Cell Therapy – What do you need to know for the ED? – emDocs (free) AND Managing the toxicities of CAR T‐cell therapy – Hematological Oncology (free)
Source: Critical Care Reviews Newsletter
For the Sake of Doctors and Patients, We Must Fix Hospital Culture
14 Jul, 2019 | 19:56h | UTCFor the sake of doctors and patients, we must fix hospital culture – The BMJ Opinion (free)
Related: Speaking up to prevent harm: A systematic review of the safety voice literature – Safety Science (free)
“When hospitals fail to create a culture where doctors and nurses can speak up patients pay the price.”