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BREAKING NEWS: The #Ebola outbreak in #DRC constitutes a public health emergency of international concern, citing concerning geographical expansion of the virus: WHO Director-General, @DrTedros following the IHR Emergency Committee’s recommendation #alert

— World Health Organization (WHO) (@WHO) July 17, 2019

Randomized Trial: Total vs. Partial Knee Replacement in Patients with Osteoarthritis

18 Jul, 2019 | 10:41h | UTC

The clinical and cost-effectiveness of total versus partial knee replacement in patients with medial compartment osteoarthritis (TOPKAT): 5-year outcomes of a randomised controlled trial – The Lancet (free)

Invited Commentary: Partial versus total knee replacement for knee osteoarthritis – The Lancet (free)

Meta-Analysis: Preventable Patient Harm Across Medical Care Settings

18 Jul, 2019 | 10:54h | UTC

Prevalence, severity, and nature of preventable patient harm across medical care settings: systematic review and meta-analysis – The BMJ (free)

Editorial: Preventable harm: getting the measure right (free)

Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)

Related Commentary on Twitter

Around one in 20 patients are affected by preventable harm in medical care, of which around 12% causes permanent disability or death, finds a study published by @bmj_latest today – take a look at the research https://t.co/oHxTBlh4s1 and linked editorial https://t.co/MBW6moT3pE pic.twitter.com/gxoL4V435w

— BMJ Group (@bmj_company) July 18, 2019

Cohort Study: Impact of Community Based Screening for Hypertension in Older Adults

18 Jul, 2019 | 10:46h | UTC

Impact of community based screening for hypertension on blood pressure after two years: regression discontinuity analysis in a national cohort of older adults in China – The BMJ (free)

Commentary: The power of awareness – The BMJ Opinion (free)

Three Large Studies Tested the Effects of Universal HIV Testing and Treatment

18 Jul, 2019 | 10:38h | UTC

Original Studies: Universal Testing, Expanded Treatment, and Incidence of HIV Infection in Botswana – New England Journal of Medicine (free) AND Effect of Universal Testing and Treatment on HIV Incidence — HPTN 071 (PopART) – New England Journal of Medicine (free) AND HIV Testing and Treatment with the Use of a Community Health Approach in Rural Africa – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries: Intensive Anti-H.I.V. Efforts Meet With Mixed Success in Africa – The New York Times (10 articles per month are free) AND HIV Incidence: Effect of Universal Testing and Treatment – MedicalResearch.com (free) AND New HIV program increased viral suppression, decreased new infections in Botswana – Harvard T.H. Chan School of Public Health (free)

International Registry: 16.6% of Patients with Takotsubo Syndrome Have Underlying Malignancy

18 Jul, 2019 | 10:15h | UTC

Clinical Features and Outcomes of Patients With Malignancy and Takotsubo Syndrome: Observations From the International Takotsubo Registry – Journal of the American Heart Association (free)

Editorial: Is Transient Takotsubo Syndrome Associated With Cancer? Why, and With What Implications for Oncocardiology? (free)

Commentary: Cancer Rates High in Patients with Takotsubo Syndrome – NEJM Journal Watch (free)

New Blood Test Seems Promising for the Diagnosis of Alzheimer’s Disease

18 Jul, 2019 | 09:49h | UTC

Association of Extracellular Vesicle Biomarkers With Alzheimer Disease in the Baltimore Longitudinal Study of Aging – JAMA Neurology (free for a limited period)

Commentaries: Scientists close in on blood test for Alzheimer’s – STAT (free) AND Predicting Alzheimer’s – Blood markers close in on helping determine who will develop Alzheimer’s disease – MedPage Today (free registration required)

“What good will that do without a cure?” (from STAT)

Meta-Analysis: Menstrual Cup Use, Leakage, Acceptability, Safety, and Availability

18 Jul, 2019 | 10:05h | UTC

Menstrual cup use, leakage, acceptability, safety, and availability: a systematic review and meta-analysis – The Lancet Public Health (free)

Commentaries: Inserting informed choice into global menstrual product use and provision – The Lancet Public Health (free) AND Menstrual Cups: Study Finds They’re Safe To Use — And People Like Them – NPR (free) AND Menstrual cups ‘as reliable as tampons’ – BBC (free) AND A Better Way to Manage Your Period? Try the Menstrual Cup, Scientists Say – The New York Times (free)

The Lancet Psychiatry Commission: A Blueprint for Protecting Physical Health in People with Mental Illness

18 Jul, 2019 | 09:19h | UTC

The Lancet Psychiatry Commission: a blueprint for protecting physical health in people with mental illness – The Lancet Psychiatry (free registration required)

Executive Summary and Podcast: A blueprint for protecting physical health in people with mental illness (free summary, audio and other resources)

Commentaries: Global commission into health inequities of mental illness gives blueprint for change – NICM Health Research Institute at Western Sydney University (free) AND People with mental illness experience poorer physical health, and the gap may be getting worse, experts say – ABC News (free) AND Why people with mental illness may face poorer physical health and early death – CNN (free)

Related Commentary on Twitter (Thread – Click for More)

Our new @TheLancetPsych Commission #BlueprintMPH tackles the growing health inequalities associated with mental illness – presenting a 'blueprint for protecting physical Health in people with mental illness" https://t.co/l6P3owTnq9 across 5 different Parts, as follows (thread): pic.twitter.com/lCiKvQbzQK

— Joseph Firth (@JosephFirthUoM) July 16, 2019

Wed July 17 – 10 Stories of The Day!

17 Jul, 2019 | 10:52h | UTC

1 – Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.

2 – Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)

Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)

Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)

News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)

3 – Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis – JAMA (free for a limited period)

Editorial: Government Regulation of Sepsis Care (free for a limited period)

Commentaries: First Ever State Sepsis Regulation in U.S. Tied to Lower Death Rates – University of Pittsburg (free) AND Regulations That Mandate Sepsis Care Appear To Have Worked In New York – NPR (free)

4 – Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)

Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – MedicalResearch.com (free)

5 – The prevention and management of sudden cardiac arrest in athletes – Canadian Medical Association Journal (free)

Commentary: Sudden cardiac arrest in athletes: Prevention and management – Joule Inc. (free)

6 – Editorial: Lithium as the drug of choice for maintenance treatment in bipolar disorder – Acta Psychiatrica Scandinavica (free) (via @J_F_Hayes)

Original Article: A systematic review and meta‐analysis of clinical predictors of lithium response in bipolar disorder – Acta Psychiatrica Scandinavica (free)

7 – Editorial: The Challenge of Defining Alzheimer Disease Based on Biomarkers in the Absence of Symptoms – JAMA Neurology (free for a limited period)

Original Article: Prevalence of Biologically vs Clinically Defined Alzheimer Spectrum Entities Using the National Institute on Aging–Alzheimer’s Association Research Framework – JAMA Neurology (free)

8 – Korean Alcohol Guidelines for Moderate Drinking Based on Facial Flushing – Korean Journal of Family Medicine (free PDF)

“individuals with flushing reaction should maintain an alcohol consumption level half of that for non-flushers.”

9 – Post‐intensive care syndrome: its pathophysiology, prevention, and future directions – Acute Medicine & Surgery (free) (via @NydahlPeter)

10 – Update on acetylsalicylic acid for primary prevention of cardiovascular disease: Not initiating is not the same thing as discontinuing – Canadian Family Physician (free)

[Abstract Only] Study: Artificial Intelligence System Could Guide Pancreatic Cyst Management and Avoid 60% to 74% of Surgeries

18 Jul, 2019 | 09:38h | UTC

A multimodality test to guide the management of patients with a pancreatic cyst – Science Translational Medicine (link to abstract – $ for full-text)

Commentaries: Test shown to improve accuracy in identifying precancerous pancreatic cysts – Johns Hopkins Medicine (free) AND Machine Learning Guides Pancreatic Cyst Management in Patients – American Association for the Advancement of Science (free) AND An experimental AI system can predict when pancreatic cysts will become cancerous – STAT (free)

Meta-Analysis: Antiplatelet Therapy After Noncardioembolic Stroke

17 Jul, 2019 | 10:47h | UTC

Antiplatelet Therapy After Noncardioembolic Stroke: An Individual Patient Data Network Meta-Analysis – Stroke (free)

Source: EvidenceAlerts

“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.

Cohort Study: State-Mandated Protocolized Sepsis Care Linked to Lower Mortality

17 Jul, 2019 | 10:36h | UTC

Association Between State-Mandated Protocolized Sepsis Care and In-hospital Mortality Among Adults With Sepsis – JAMA (free for a limited period)

Editorial: Government Regulation of Sepsis Care (free for a limited period)

Commentaries: First Ever State Sepsis Regulation in U.S. Tied to Lower Death Rates – University of Pittsburg (free) AND Regulations That Mandate Sepsis Care Appear To Have Worked In New York – NPR (free)

The Prevention and Management of Sudden Cardiac Arrest in Athletes

17 Jul, 2019 | 09:44h | UTC

The prevention and management of sudden cardiac arrest in athletes – Canadian Medical Association Journal (free for a limited period)

Commentary: Sudden cardiac arrest in athletes: Prevention and management – Joule Inc. (free)

Related Commentary on Twitter

Does screening athletes prevent sudden cardiac arrest? A @StMikesHospital review published in CMAJ finds uncertain benefit: https://t.co/JsvrGhJHPx #hearthealth #cardiology #sportsmedicine pic.twitter.com/d6bb0n8gl7

— CMAJ (@CMAJ) July 15, 2019

Cohort Study: Shorter Time to Endovascular Recanalization in Acute Ischemic Stroke is Associated with Better Outcomes

17 Jul, 2019 | 10:46h | UTC

Association Between Time to Treatment With Endovascular Reperfusion Therapy and Outcomes in Patients With Acute Ischemic Stroke Treated in Clinical Practice – JAMA (free for a limited period)

Editorial: Endovascular Therapy for Acute Ischemic Stroke Treated in Clinical Practice (free for a limited period)

Video Summary: Association Between Time to Treatment With Endovascular Reperfusion Therapy and Acute Ischemic Stroke Outcomes (free)

News Release: Treating stroke patients just 15 minutes earlier can save lives – UCLA (free)

Randomized Trial: Flexible Family Visitation Hours in The ICU Do Not Reduce the Incidence of Delirium Compared with Restricted Visitation

17 Jul, 2019 | 10:23h | UTC

Effect of Flexible Family Visitation on Delirium Among Patients in the Intensive Care Unit: The ICU Visits Randomized Clinical Trial – JAMA (free for a limited period)

Editorial: Psychological Consequences of Admission to the ICU: Helping Patients and Families (free for a limited period)

Author Interview: Do Flexible Family Visitation Hours Reduce Delirium in ICU Patients? – MedicalResearch.com (free)

Related Commentary on Twitter

In this 1685-patient cluster-crossover RCT, flexible family visitation did not significantly reduce @ICU_delirium compared with restricted visitation. https://t.co/Wg2QoXvu0F pic.twitter.com/thFJ4WqsS1

— Delirium in the ICU (@ICU_delirium) July 16, 2019

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