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Stop digoxin? #JACC paper reports discontinuation has worse outcomes among hospitalized patients with #HFrEF receiving contemporary guideline-directed medical therapies. https://t.co/8oGnNSbfH5 @DCVAMC @gcfmd pic.twitter.com/VntWsVsvLv

— JACC Journals (@JACCJournals) July 31, 2019

[Abstract Only] Randomized Trial: Little Added Benefit of Antidepressants in Youth with Depression Treated with Cognitive Behavioral Therapy

1 Aug, 2019 | 08:50h | UTC

The addition of fluoxetine to cognitive behavioural therapy for youth depression (YoDA-C): a randomised, double-blind, placebo-controlled, multicentre clinical trial – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentaries: Psychotherapy should be first-line treatment for depression in young people, trial finds – by Orygen, the National Centre of Excellence in Youth Mental Health (free) AND Psychotherapy should be first option to treat depression in young people, study says – UPI (free)

Publication Trends of Systematic Reviews and Randomized Clinical Trials

1 Aug, 2019 | 07:46h | UTC

Assessment of Publication Trends of Systematic Reviews and Randomized Clinical Trials, 1995 to 2017 – JAMA Internal Medicine (free for a limited period)

Invited Commentary: Meta-analysis Metastasis – JAMA Internal Medicine (free)

Observational Study Suggests Use of Acid-Suppressing Drugs May Increase the Risk of Allergies

1 Aug, 2019 | 07:37h | UTC

Country-wide medical records infer increased allergy risk of gastric acid inhibition – Nature Communications (free)

Commentaries: Stomach-protecting medicines can trigger allergies – Medical University of Vienna (free) AND Acid-Suppressing Drugs Tied to Later Use of Anti-Allergy Drugs – NEJM Journal Watch (free) AND Your heartburn drugs may be giving you allergies, study suggests – CNN (free)

Wed July 31 – 10 Stories of The Day!

31 Jul, 2019 | 02:14h | UTC

1 – Cardiac arrhythmias in the emergency settings of acute coronary syndrome and revascularization: an European Heart Rhythm Association (EHRA) consensus document, endorsed by the European Association of Percutaneous Cardiovascular Interventions (EAPCI), and European Acute Cardiovascular Care Association (ACCA) – EP Europace (free for a limited period)

2 – New Protocol For HIV Prevention Drug Reduces The Number Of Pills Required – Kaiser Health News (free)

Related Guidelines: British Guidelines on the Use of HIV Pre–exposure Prophylaxis (PrEP) (several guidelines on the subject) AND USPSTF Statement: Preexposure Prophylaxis for the Prevention of HIV Infection (free guideline and commentaries)

“both organizations now endorse a strategy that requires taking just four pills timed to a specific sexual encounter — two within two to 24 hours before sex and one on each of the two following days… The new strategy, called “2-1-1” or “on-demand” PrEP, is becoming popular overseas but has gotten little traction in the United States thus far.”

3 – Acupuncture as Adjunctive Therapy for Chronic Stable Angina: A Randomized Clinical Trial – JAMA Internal Medicine (free)

Commentary: Expert reaction to study looking at acupuncture as an added treatment for angina – Science Media Centre (free)

4 – Doctors: How Job Stress Can Age Us – The New York Times (10 articles per month are free)

Related Study: Physician-Training Stress and Accelerated Cellular Aging – Biological Psychiatry (link to abstract – $ for full-text) AND Commentary: New doctors’ DNA ages six times faster than normal in first year – University of Michigan (free)

5 – Placental growth factor testing to assess women with suspected pre-eclampsia: a multicentre, pragmatic, stepped-wedge cluster-randomised controlled trial – The Lancet (free)

Commentaries: Placental growth factor testing for suspected pre-eclampsia – The Lancet (free) AND Placental growth factor testing can speed up diagnosis of pre-eclampsia – NIHR Signal (free)

6 – Association of Early Interventions With Birth Outcomes and Child Linear Growth in Low-Income and Middle-Income Countries: Bayesian Network Meta-analyses of Randomized Clinical Trials – JAMA Network Open (free)

7 – The impact of occupational shift work and working hours during pregnancy on health outcomes: a systematic review and meta-analysis – American Journal of Obstetrics & Gynecology (link to abstract – for full-text)

Commentary: Night shifts, long hours linked to miscarriages and preterm births – Reuters (free)

8 – Liberal versus restrictive red blood cell transfusion strategy in sepsis or septic shock: a systematic review and meta-analysis of randomized trials – Critical Care (free)

Related Systematic Review: Transfusion thresholds and other strategies for guiding allogeneic red blood cell transfusion – Cochrane Library (free)

9 – Association between complications and death within 30 days after noncardiac surgery – Canadian Medical Association Journal (free)

Commentaries: In Noncardiac Surgery, the Post-Op Period Is Riskiest – NEJM Journal Watch (free) AND Most deaths related to noncardiac surgery occur after surgery and after discharge from hospital – Canadian Medical Association Journal (free) AND Riskiest time for surgery patients is not in the operating room – Reuters (free)

“Among adults undergoing noncardiac surgery, 99.3% of deaths occurred after the procedure and 44.9% of deaths were associated with 3 complications: major bleeding, myocardial injury and sepsis.”

10 – Infection rate among nutritional therapies for acute pancreatitis: A systematic review with network meta-analysis of randomized controlled trials – PLOS One (free)

[Abstract Only] Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases

1 Aug, 2019 | 07:23h | UTC

Cigarette Smoking, Smoking Cessation, and Long-Term Risk of 3 Major Atherosclerotic Diseases – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentaries: Smoking cessation study supports ‘never too early, never too late’ – ACP Internist (free) AND Study Quantifies Smoking’s Strong Link to Peripheral Artery Disease – Johns Hopkins Bloomberg School of Public Health (free)

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