Archives
Meta-Analysis: Little Evidence that Prophylactic Pharmacologic Treatments are Effective for Pediatric Migraine
14 Feb, 2020 | 02:04h | UTCEfficacy, Safety, and Acceptability of Pharmacologic Treatments for Pediatric Migraine Prophylaxis: A Systematic Review and Network Meta-analysis – JAMA Pediatrics (free for a limited period)
Editorial: Can We Really Stop Pediatric Migraine? Using Network Meta-analysis to Remove the Guess Work (free)
Commentary: Network Meta-Analysis: Scant Evidence That Migraine-Prevention Meds Work in Kids – NEJM Journal Watch (free)
Guidelines for the Management of Exercise-Associated Hyponatremia
13 Feb, 2020 | 08:05h | UTCSee also: Wilderness Medical Society Full List of Updated Clinical Practice Guidelines (free articles
Recommended Childhood and Adolescent Immunization Schedule: United States, 2020
13 Feb, 2020 | 08:09h | UTCRecommended Childhood and Adolescent Immunization Schedule: United States, 2020 – Pediatrics (free)
Table 3. Recommended Child and Adolescent Immunization Schedule by Medical Indication, United States, 2020 – Centers for Disease Control and Prevention (free)
Systematic Review: Water for Preventing Urinary Stones
13 Feb, 2020 | 07:58h | UTCWater for preventing urinary stones – Cochrane Library (free)
Summary: Increased water intake for preventing urinary stones – Cochrane Library (free)
Related: Fluid Intake and Dietary Factors and the Risk of Incident Kidney Stones in UK Biobank: A Population-based Prospective Cohort Study – European Urology Focus (free) AND Dietary and Pharmacologic Management to Prevent Recurrent Nephrolithiasis in Adults: A Clinical Practice Guideline From the American College of Physicians (free)
Randomized Trial: Incisional Negative Pressure Wound Therapy Does Not Reduce Deep Surgical Site Infections After Surgery for Lower Limb Fractures Associated with Major Trauma
13 Feb, 2020 | 08:02h | UTCEffect of Incisional Negative Pressure Wound Therapy vs Standard Wound Dressing on Deep Surgical Site Infection After Surgery for Lower Limb Fractures Associated With Major Trauma: The WHIST Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Incisional Negative Pressure Wound Therapy Following Surgical Repair of Lower Extremity Fractures (free)
Commentary: Expensive new wound treatment method no more effective than cheap standard dressings – University of Warwick (free)
Randomized Trial: Comparison of Different Blood Pressure Targets for Vasopressor Therapy in Older Critically Ill Patients with Vasodilatory Hypotension
13 Feb, 2020 | 08:04h | UTCEffect of Reduced Exposure to Vasopressors on 90-Day Mortality in Older Critically Ill Patients With Vasodilatory Hypotension: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Choosing the Best Blood Pressure Target for Vasopressor Therapy (free for a limited period)
Conference Presentation: Effect of Reduced Vasopressor Exposure on Mortality in Older Critically Ill Patients With Vasodilatory Hypotension (free)
Related Commentary on Twitter
No difference in mortality (as expected?) but higher incidence of severe acute renal failure with permissive hypotension in Older Critically Ill Patients With Vasodilatory Hypotension https://t.co/XyBy74WAPL congrats to the authors @JAMA_current
— Matthieu Legrand (@matthieulegrand) February 12, 2020
Cohort Study: Sedentary Behavior in Adolescence Linked to Increased Risk of Depression at 18 Years of Age
13 Feb, 2020 | 07:55h | UTC
Related Commentary on Twitter
Using accelerometers over 6 years our @TheLancetPsych study shows:
– Sedentary behaviour rises through adolescence & linked with a greater risk of #depression by age 18
– Light activity falls but is linked with reduced depression risk at 18https://t.co/k1es8wiCWj@osborn_ucl pic.twitter.com/X5TYe5swhj
— Aaron Kandola (@KandolaAaron) February 12, 2020
[Abstract Only] Randomized Trial: Plasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis
13 Feb, 2020 | 08:00h | UTCPlasma Exchange and Glucocorticoids in Severe ANCA-Associated Vasculitis – New England Journal of Medicine (link to abstract – $ for full-text)
Visual Abstract: Plasma Exchange and Glucocorticoids for ANCA-Associated Vasculitis (free)
Commentary: PEXIVAS: No benefit of plasma exchange in ANCA-associated vasculitis – Medicine Matters (free)
Study: Poor Performance of Apps Assessing Skin Cancer Risk
13 Feb, 2020 | 07:56h | UTCEditorial: The poor performance of apps assessing skin cancer risk (free)
Commentaries: Skin cancer diagnosis apps are unreliable and poorly regulated, study shows – eCancer News (free) AND Phone apps unreliable for detecting all cases of skin cancer – OnMedica (free)
NICE Guideline: Antimicrobial Prescribing for Leg Ulcer Infection
12 Feb, 2020 | 07:35h | UTCLeg ulcer infection: antimicrobial prescribing – National Institute for Health and Care Excellence (free)
Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
Related Commentary on Twitter
Using antibiotics when they're not needed means they may not work as well in the future.
Today, we've published final guidance that sets out an antimicrobial prescribing strategy for adults with leg ulcer infection.https://t.co/4UIa6VcHr8 pic.twitter.com/Wk3V93Ycp7
— NICE (@NICEComms) February 11, 2020
Wed February 12 – 10 Stories of The Day!
12 Feb, 2020 | 10:21h | UTC
1 – COVID-19: WHO Names Disease Caused by the Novel Coronavirus / SARS-CoV-2: New Designation of the Virus Itself / + Latest Articles, News & Perspectives – 12 February 2020 Edition
World Health Organization COVID-19 Situation Report:
COVID-19: WHO Names Disease Caused by the Novel Coronavirus:
- WHO Director-General’s remarks at the media briefing on 2019-nCoV on 11 February 2020 – World Health Organization (free)
- Commentaries: Disease caused by the novel coronavirus officially has a name: Covid-19 – STAT (free) AND Coronavirus disease named Covid-19 – BBC (free) AND New Coronavirus Disease Officially Named COVID-19 By The World Health Organization – NPR (free) AND What’s in a Name? Why WHO’s Formal Name for the New Coronavirus Disease Matters – TIME (free)
“…we had to find a name that did not refer to a geographical location, an animal, an individual or group of people, and which is also pronounceable and related to the disease. Having a name matters to prevent the use of other names that can be inaccurate or stigmatizing. It also gives us a standard format to use for any future coronavirus outbreaks.”
SARS-CoV-2 (Severe Acute Respiratory Syndrome Coronavirus 2): International Committee on Taxonomy of Viruses Designates the Virus Itself:
“It’s official: severe acute respiratory syndrome coronavirus 2 (#SARSCoV2) causes coronavirus disease 2019 (#COVID19)” (via @TheLancetInfDis see Tweet)
Latest Articles:
- Viewpoint: Preparation for Possible Sustained Transmission of 2019 Novel Coronavirus: Lessons From Previous Epidemics – JAMA (free)
- Correspondence: On the use of corticosteroids for 2019-nCoV pneumonia – The Lancet (free)
- Special Collection: Coronavirus (2019-nCoV): evidence relevant to critical care – Cochrane Library (free articles)
- Emerging novel Coronavirus (2019-nCoV) – Current scenario, evolutionary perspective based on genome analysis and recent developments – Veterinary Quaterly (free)
Selected News & Perspectives:
- New Coronavirus Has A Name – COVID-19; But As WHO Convenes Global Research Forum Many Other Unknowns Remain – Health Policy Watch (free)
- The Best Defense Against Disturbing New Diseases – The Atlantic (free)
- Deaths from newly named coronavirus disease top 1,000 – CIDRAP (free)
- At least 500 Wuhan medical staff infected with coronavirus – South China Morning Post (free)
- The coronavirus cruise ship quarantine is a scary public health experiment – VOX (free)
- 2,000 People Are Stranded on a U.S. Cruise Ship After 4 Countries Reject Entry Over Coronavirus Fears – TIME (free)
- The First Signs Are Emerging That China’s Coronavirus Containment Could Be Working – TIME (free)
- Coronavirus Researchers Are Using High-Tech Methods to Predict Where the Virus Might Go Next – TIME (free)
- Hospitals, governments need more data to prepare for the new coronavirus outbreak – STAT (free)
- Factbox: Latest on coronavirus spreading in China and beyond – Reuters (free)
- Exclusive: Coronavirus outbreak may be over in China by April – expert – Reuters (free)
- Coronavirus may be over soon in China, expert says, as WHO warns of global threat – Reuters (free)
- Coronavirus emergency ‘holds a very grave threat’ for world: WHO – Reuters (free)
- WHO brands coronavirus ‘public enemy number one’ – Reuters (free)
- Coronavirus ‘could infect 60% of global population if unchecked’ – The Guardian (free)
- Coronavirus should be seen as ‘public enemy number one’, says WHO – The Guardian (free)
- China launches coronavirus ‘close contact detector’ app – BBC (free)
- Australian scientists grow live coronavirus virus – News Medical (free)
- How AI Is Tracking the Coronavirus Outbreak – Wired (free)
- Cruise ship coronavirus infections double, exceeding the total for any country but China – The Washington Post (free)
- There’s No Specific Drug That Kills Coronavirus. But Doctors Have Ways To Treat It – Reuters (free)
Related: NICE Antimicrobial prescribing guidelines (resource covering many common conditions) AND NICE Summary of antimicrobial prescribing guidance – managing common infections (free PDF)
News Release: New report: a roadmap to improve virtual care in Canada – Canadian Medical Association (free)
4 – Effect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: Not Ready for Prime Time (free for a limited period)
Commentaries: Trial pours cold water on combo treatment for MRSA bacteremia – CIDRAP (free) AND Trial shows using two drugs not better than one when treating MRSA blood infections – University of Melbourne (free)
5 – Association of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock – JAMA (free for a limited period)
Editorial: Microaxial Left Ventricular Assist Devices: In Search of an Appropriate Indication (free for a limited period)
Commentary: High-tech pump may increase risk of death and bleeding, study finds – Yale News (free)
6 – Dexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related: Meta-Analysis: Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients with Moderate to Severe Acute Respiratory Distress Syndrome (free resources on the subject)
7 – Scrutinizing the effects of digital technology on mental health – Nature (free)
8 – Diet and Kidney Function: a Literature Review – Current Hypertension Report (free)
9 – Diagnosis and Treatment of Parkinson Disease: A Review – JAMA (free for a limited period)
Related Clinical Review Audio: Parkinson Disease (free)
Editorial: Palliative Programs for Persons With Parkinsonism—The Next Frontier (free for a limited period)
Commentaries: Palliative Care Improves Quality of Life, Symptom Burden of Patients With Parkinson Disease – AJMC (free) AND Palliative care could benefit people with Parkinson’s – OnMedica (free)
Randomized Trial: Among Patients with MRSA Bacteremia, the Addition of an Antistaphylococcal β-lactam to Standard Therapy Does Not Improve Outcomes
12 Feb, 2020 | 07:29h | UTCEffect of Vancomycin or Daptomycin With vs Without an Antistaphylococcal β-Lactam on Mortality, Bacteremia, Relapse, or Treatment Failure in Patients With MRSA Bacteremia: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Combination Therapy for Methicillin-Resistant Staphylococcus aureus Bacteremia: Not Ready for Prime Time (free for a limited period)
Commentaries: Trial pours cold water on combo treatment for MRSA bacteremia – CIDRAP (free) AND Trial shows using two drugs not better than one when treating MRSA blood infections – University of Melbourne (free)
Related Commentary on Twitter
Adding an antistaphylococcal β-lactam to standard #antibiotic therapy w vancomycin or daptomycin did not improve a primary composite outcome of mortality, persistent #bacteremia, relapse, or Tx failure in pts with #MRSA bacteremia https://t.co/UpyCz3Ss4F #VisualAbstract
— JAMA (@JAMA_current) February 12, 2020
Virtual Care: Recommendations for Scaling up Virtual Medical Services
12 Feb, 2020 | 07:32h | UTCVirtual care: Recommendations for Scaling up Virtual Medical Services – Canadian Medical Association (free PDF)
News Release: New report: a roadmap to improve virtual care in Canada – Canadian Medical Association (free)
[Abstract Only] Randomized Trial: Dexamethasone for the Treatment of Acute Respiratory Distress Syndrome
12 Feb, 2020 | 07:24h | UTCDexamethasone treatment for the acute respiratory distress syndrome: a multicentre, randomised controlled trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Related: Meta-Analysis: Assessment of Therapeutic Interventions and Lung Protective Ventilation in Patients with Moderate to Severe Acute Respiratory Distress Syndrome (free resources on the subject)
Related Commentary on Twitter
#Dexamethasone is associated with a substantial reduction in duration of mechanical #ventilation and all-cause 60-day #mortality in patients with #ARDS
New RCT from Jesús ViIlar and colleagues https://t.co/b4sW2K0RwG pic.twitter.com/MBbeSWBo55
— The Lancet Respiratory Medicine (@LancetRespirMed) February 10, 2020
Diet and Kidney Function: A Literature Review
12 Feb, 2020 | 07:21h | UTCDiet and Kidney Function: a Literature Review – Current Hypertension Report (free)
Observational Study: Higher Risk of Death and Major Bleeding with Intravascular Microaxial Left Ventricular Assist Device vs. Intra-aortic Balloon Pump Among Patients with Acute MI Complicated by Cardiogenic Shock
12 Feb, 2020 | 07:27h | UTCAssociation of Use of an Intravascular Microaxial Left Ventricular Assist Device vs Intra-aortic Balloon Pump With In-Hospital Mortality and Major Bleeding Among Patients With Acute Myocardial Infarction Complicated by Cardiogenic Shock – JAMA (free for a limited period)
Editorial: Microaxial Left Ventricular Assist Devices: In Search of an Appropriate Indication (free for a limited period)
Commentary: High-tech pump may increase risk of death and bleeding, study finds – Yale News (free)
Related Commentary on Twitter (Thread – Click for More)
Major paper published by @JAMA_current today that uses real-world data to examine outcomes among patients undergoing PCI for AMI who received mechanical circulatory support, comparing the Impella to IABP (and to medical therapy) (1/9) https://t.co/EsoRfSj1eH
— Joseph Ross (@jsross119) February 10, 2020
Debate: Scrutinizing the Effects of Digital Technology on Mental Health
12 Feb, 2020 | 07:23h | UTCScrutinizing the effects of digital technology on mental health – Nature (free)
Review: Diagnosis and Treatment of Parkinson Disease
12 Feb, 2020 | 07:20h | UTCDiagnosis and Treatment of Parkinson Disease: A Review – JAMA (free for a limited period)
Related Clinical Review Audio: Parkinson Disease (free)
Tue February 11 – 10 Stories of The Day!
11 Feb, 2020 | 02:55h | UTC
1 – Noncommunicable Diseases Progress Monitor 2020 – World Health Organization (free PDF)
Related Publications: Tackling NCDs: “Best buys” and other recommended interventions for the prevention and control of noncommunicable diseases – World Health Organization (free PDF) AND Bridging the Gap on NCDs: From global promises to local progress – Policy brief – NCD Alliance (free PDF)
Commentary: Countries Falling Behind In Meeting Noncommunicable Disease Control Targets – Health Policy Watch (free)
Commentary: Researchers recommend early walking in a brace for Achilles tendon rupture – University of Warwick (free)
5 – Editor’s Note: A Successful but Underused Strategy for Reducing Low-Value Care: Stop Paying for It – JAMA Internal Medicine (free for a limited period)
Original Study: Comparison of Payment Changes and Choosing Wisely Recommendations for Use of Low-Value Laboratory Tests in the United States and Canada – JAMA Internal Medicine (free for a limited period)
Commentaries: Dialysis Modalities Found to Offer Similar Survival – Renal & Urology News (free) AND UL study reveals ‘identical’ survival for kidney dialysis patients using different treatments – University of Limerick (free)
7 – Alex Nowbar’s weekly journal review, 7 February 2020 – The BMJ Opinion (free)
Alex Nowbar reviews the latest research from the top medical journals.
See also: Episode List
9 – Intermittent fasting – NEJM Journal Watch (free audio)
“Intermittent fasting has salutary effects. Listen how Dr. Mark P. Mattson, co-author of a recent NEJM review on the topic, assesses the practice — and how he’s managed to skip breakfast for the past 30 years or so.”
For those interested in the subject, we suggest the reading of the recent review by Dr. Mark P. Mattson: Effects of Intermittent Fasting on Health, Aging, and Disease – New England Journal of Medicine ($)
10 – Novel Coronavirus (2019-nCoV) Latest Articles, Guidelines, News & Perspectives / 11 February 2020 Edition
See also: WHO: Novel Coronavirus (2019-nCoV) Situation Report – 10 February 2020 (free PDF)
Top Articles / Articles in High Impact Journals:
- Report 4: Severity of 2019-novel coronavirus (nCoV) – Imperial College London (free PDF) AND Summary: Severity of 2019-novel coronavirus (nCoV) (free) Commentary: Expert reaction to report on the severity of the novel coronavirus, as posted on the MRC Centre for Global Infectious Disease Analysis website – Science Media Centre (free)
- Critical care management of adults with community-acquired severe respiratory viral infection – Intensive Care Medicine (free)
- Persistence of coronaviruses on inanimate surfaces and its inactivation with biocidal agents – The Journal of Hospital Infection (free) AND Commentaries: How long coronaviruses persist on surfaces and how to inactivate them – Ruhr-Universität Bochum (free) AND Scientists Predict Coronavirus May Live For Up To Nine Days On Surfaces – Forbes (free)
- Therapeutic options for the 2019 novel coronavirus (2019-nCoV) – Nature Reviews Drug Discovery (free)
- The Rate of Underascertainment of Novel Coronavirus (2019-nCoV) Infection: Estimation Using Japanese Passengers Data on Evacuation Flights – Journal of Clinical Medicine (free PDF)
- Hand‐Hygiene Mitigation Strategies Against Global Disease Spreading through the Air Transportation Network – Risk Analysis (free) AND Commentary: To slow an epidemic, focus on handwashing – Massachusetts Institute of Technology (free)
Other Articles:
- Mission impossible? WHO director fights to prevent a pandemic without offending China – Science (free)
- What next for the coronavirus response? – The Lancet (free)
- What to do next to control the 2019-nCoV epidemic? – The Lancet (free)
- 2019-nCoV transmission through the ocular surface must not be ignored – The Lancet (free)
- 2019-nCoV epidemic: what about pregnancies? – The Lancet (free)
- Coronavirus epidemic: preparing for extracorporeal organ support in intensive care – The Lancet Respiratory medicine (free)
- Coronavirus: global stocks of protective gear are depleted, with demand at “100 times” normal level, WHO warns – The BMJ (free)
- In Beijing, coronavirus 2019-nCoV has created a siege mentality – The BMJ (free)
- The mental health of medical workers in Wuhan, China dealing with the 2019 novel coronavirus – The Lancet Psychiatry (free)
- Imaging changes in patients with 2019-nCov – European Radiology (free)
Preprints:
- Forecasting the Wuhan coronavirus (2019-nCoV) epidemics using a simple (simplistic) model – update (Feb. 8, 2020) – medRxiv (free PDF)
- Transmission and epidemiological characteristics of Novel Coronavirus (2019-nCoV)-Infected Pneumonia(NCIP):preliminary evidence obtained in comparison with 2003-SARS – medRxiv (free)
Selected News & Perspectives:
- China nCoV cases top 40,000, with more tied to French cluster – CIDRAP (free)
- “Containment” Is Objective Says WHO Head As New Coronavirus Clusters Emerge in France & UK; WHO Team Lands In China – Health Policy Watch (free)
- Over 30 Antiviral Drugs Being Tested Against Against Novel Coronavirus – As WHO Convenes Global Innovation Forum – Health Policy Watch (free)
- Coronavirus Is Bad. Comparing It to the Flu Is Worse – Wired (a few articles per month are free)
- Opinion: Africa is not fully ready for coronavirus – Devex (free)
- Global Solidarity, Collaboration and Urgent Action Needed to Defeat the New Coronavirus Outbreak – TIME (free)
- Coronavirus cases outside China ‘could be spark’ for bigger fire, says WHO – Reuters (free)
- Here is what WHO experts are watching on the coronavirus’ spread – Reuters (free)
- Countries rush to build diagnostic capacity as coronavirus spreads – Reuters (free)
- Fluctuating funding and flagging interest hurt coronavirus research, leaving crucial knowledge gaps – STAT (free)
- Wilson and Halabi: How global health rules are being challenged by coronavirus – Ottawa Citizen (free)
- Misinformation on the coronavirus might be the most contagious thing about it – The Guardian (free)
Randomized Trial: Palliative Care Associated with Benefits Among Patients with Parkinson Disease
12 Feb, 2020 | 07:18h | UTCEditorial: Palliative Programs for Persons With Parkinsonism—The Next Frontier (free for a limited period)
Commentaries: Palliative Care Improves Quality of Life, Symptom Burden of Patients With Parkinson Disease – AJMC (free) AND Palliative care could benefit people with Parkinson’s – OnMedica (free)
Report: Noncommunicable Diseases Progress Monitor 2020
11 Feb, 2020 | 02:27h | UTCNoncommunicable Diseases Progress Monitor 2020 – World Health Organization (free PDF)
Related Publications: Tackling NCDs: “Best buys” and other recommended interventions for the prevention and control of noncommunicable diseases – World Health Organization (free PDF) AND Bridging the Gap on NCDs: From global promises to local progress – Policy brief – NCD Alliance (free PDF)
Commentary: Countries Falling Behind In Meeting Noncommunicable Disease Control Targets – Health Policy Watch (free)
Critical Care Management of Adults with Community-acquired Severe Respiratory Viral Infection
11 Feb, 2020 | 02:25h | UTC
Randomized Trial: Plaster Cast vs. Functional Brace for Non-surgical Treatment of Achilles Tendon Rupture
11 Feb, 2020 | 02:22h | UTCCommentary: Researchers recommend early walking in a brace for Achilles tendon rupture – University of Warwick (free)
Related Commentary on Twitter
https://twitter.com/TheLancet/status/1225812357642846208
A Successful but Underused Strategy for Reducing Low-Value Care: Stop Paying for It
11 Feb, 2020 | 02:20h | UTCEditor’s Note: A Successful but Underused Strategy for Reducing Low-Value Care: Stop Paying for It – JAMA Internal Medicine (free for a limited period)
Original Study: Comparison of Payment Changes and Choosing Wisely Recommendations for Use of Low-Value Laboratory Tests in the United States and Canada – JAMA Internal Medicine (free for a limited period)
Randomized Trial: Prophylactic Biological Mesh Reinforcement vs. Standard Closure of Stoma Site
11 Feb, 2020 | 02:24h | UTC
Related Commentary on Twitter
Stoma closure, with mesh or without?
New huge multicenter RCT @TheLancet
Hernia at 2y :
Mesh group 12%, control 20%No difference on wound problems/adverse events.https://t.co/t1umAl7IdN#hernia #herniasurgery #SoMe4Surgery
— Ville Sallinen (@villesallinen) February 7, 2020