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New study in @Health_Affairs: data suggest that the 15 states and DC that mandated mask-wearing in public between 4/8 and 5/15 averted as many as 230,000–450,000 #covid19 cases.

Wear your mask. Keep your distance. It's not politics; it's science. https://t.co/JUQNJg5DqH

— Zeke Emanuel (@ZekeEmanuel) June 17, 2020

Diabetes and COVID-19: Risks, Management, and Learnings from Other National Disasters

18 Jun, 2020 | 09:08h | UTC

Diabetes and COVID-19: Risks, Management, and Learnings from Other National Disasters – Diabetes Care

Podcast: A Look at SARS-CoV-2 Transmission

18 Jun, 2020 | 09:05h | UTC

Audio Interview: A Look at SARS-CoV-2 Transmission – New England Journal of Medicine

Study: Household Secondary Attack Rate of COVID-19 and Associated Determinants

18 Jun, 2020 | 09:04h | UTC

Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study – The Lancet Infectious Diseases

Invited Commentary: Household studies provide key insights on the transmission of, and susceptibility to, SARS-CoV-2 – The Lancet Infectious Diseases

Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure

18 Jun, 2020 | 09:07h | UTC

Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure – JAMA Internal Medicine

Invited Commentary: Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention – JAMA Internal Medicine

ACP Update Alert: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination with Azithromycin for the Prophylaxis or Treatment of COVID-19?

18 Jun, 2020 | 08:59h | UTC

Update Alert: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians – Annals of Internal Medicine

WHO To Include Dexamethasone in Updated COVID-19 Care Guidelines; Drops Hydroxychloroquine from Massive Solidarity Trial

18 Jun, 2020 | 09:02h | UTC

World Health Organization to Include Dexamethasone In Updated COVID-19 Care Guidelines; Drops Hydroxychloroquine From Massive Solidarity Trial – Health Policy Watch

Position Paper: Guidance on Diagnosis, Prevention and Treatment of Thromboembolic Complications in COVID-19

18 Jun, 2020 | 09:03h | UTC

Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: a position paper of the Brazilian Society of Thrombosis and Hemostasis and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy – Hematology, Transfusion and Cell Therapy

CDC Report: Characteristics Associated with Hospitalization Among Patients with COVID-19

18 Jun, 2020 | 08:57h | UTC

Characteristics Associated with Hospitalization Among Patients with COVID-19 — Metropolitan Atlanta, Georgia, March–April 2020 – Centers for Disease Control and Prevention

Commentary: Black Patients With COVID-19 in Atlanta More Likely to Be Hospitalized: CDC – Reuters

The Pandemic Reality of COVID-19 Clinical Trials

18 Jun, 2020 | 08:52h | UTC

‘We’ve got to be able to move more quickly.’ The pandemic reality of COVID-19 clinical trials – Science

COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance

18 Jun, 2020 | 08:54h | UTC

COVID-19 Clinical Trials: A Teachable Moment for Improving Our Research Infrastructure and Relevance – Annals of Internal Medicine

Huge Open-access Journal Deal Inked by University of California and Springer Nature

18 Jun, 2020 | 08:51h | UTC

Huge open-access journal deal inked by University of California and Springer Nature – Science

Related: UC Terminates Subscriptions with World’s Largest Scientific Publisher in Push for Open Access (several resources on the subject)

No Symptoms in 37% of COVID-19 Nursing Home Patients, Research Finds

18 Jun, 2020 | 08:56h | UTC

No symptoms in 37% of COVID-19 nursing home patients, research finds – CIDRAP

Original Study: Asymptomatic SARS-CoV-2 infection and COVID-19 mortality during an outbreak investigation in a skilled nursing facility – Clinical Infectious Diseases

Podcast: Social Determinants of Health

18 Jun, 2020 | 08:47h | UTC

#220 Social Determinants of Health with Karen DeSalvo MD – The Curbsiders Internal Medicine Podcast

Guideline and Checklist for Reporting Randomized Trials that Use an Adaptive Design

18 Jun, 2020 | 08:50h | UTC

The Adaptive designs CONSORT Extension (ACE) statement: a checklist with explanation and elaboration guideline for reporting randomised trials that use an adaptive design – The BMJ

Related Commentary on Twitter

https://twitter.com/bmj_latest/status/1273352249134198789

Study Commentary: Fluconazole During Pregnancy – Is It Safe?

18 Jun, 2020 | 08:46h | UTC

Fluconazole During Pregnancy – Is It Safe? – Journal Feed

Original Study: Oral fluconazole use in the first trimester and risk of congenital malformations: population based cohort study – The BMJ

[Abstracts Only] Studies: Effect of Continuous Glucose Monitoring on Hypoglycemia in Patients with Type 1 Diabetes

18 Jun, 2020 | 08:42h | UTC

Study 1: Effect of Continuous Glucose Monitoring on Glycemic Control in Adolescents and Young Adults With Type 1 Diabetes: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Study 2: Effect of Continuous Glucose Monitoring on Hypoglycemia in Older Adults With Type 1 Diabetes: A Randomized Clinical Trial – JAMA

Commentaries: Variable CGM benefits in high-risk subgroups – medwire News AND Continuous Glucose Monitoring Reduces Hypoglycemia in Older Adults with Type 1 Diabetes – University of North Carolina School of Medicine

Study Commentary: Haloperidol for Headache – THE HA Study RCT

18 Jun, 2020 | 08:44h | UTC

Haloperidol for Headache – THE HA Study RCT – Journal Feed

Original Study: Treatment of Headache in the Emergency Department: Haloperidol in the Acute Setting (THE-HA Study): A Randomized Clinical Trial – The Journal of Emergency Medicine (link to abstract – $ for full-text)

Thu June 18 – 10 Stories of The Day!

18 Jun, 2020 | 09:14h | UTC

1 – Genomewide Association Study of Severe Covid-19 with Respiratory Failure – New England Journal of Medicine

Commentary: Study ties blood type to COVID-19 risk; O may help, A hurt – Associated Press

2 – Community Use Of Face Masks And COVID-19: Evidence From A Natural Experiment Of State Mandates In The US – Health Affairs

Commentary: Face mask requirements may have prevented 450,000 coronavirus cases – BGR

3 – Diabetes and COVID-19: Risks, Management, and Learnings from Other National Disasters – Diabetes Care

4 – Prone Positioning in Awake, Nonintubated Patients With COVID-19 Hypoxemic Respiratory Failure – JAMA Internal Medicine

Invited Commentary: Prone Positioning in Awake, Nonintubated Patients With COVID-19: Necessity Is the Mother of Invention – JAMA Internal Medicine

5 – Audio Interview: A Look at SARS-CoV-2 Transmission – New England Journal of Medicine

6 – Household secondary attack rate of COVID-19 and associated determinants in Guangzhou, China: a retrospective cohort study – The Lancet Infectious Diseases

Invited Commentary: Household studies provide key insights on the transmission of, and susceptibility to, SARS-CoV-2 – The Lancet Infectious Diseases

7 – Guidance on diagnosis, prevention and treatment of thromboembolic complications in COVID-19: a position paper of the Brazilian Society of Thrombosis and Hemostasis and the Thrombosis and Hemostasis Committee of the Brazilian Association of Hematology, Hemotherapy and Cellular Therapy – Hematology, Transfusion and Cell Therapy

8 – World Health Organization to Include Dexamethasone In Updated COVID-19 Care Guidelines; Drops Hydroxychloroquine From Massive Solidarity Trial – Health Policy Watch

9 – Update Alert: Should Clinicians Use Chloroquine or Hydroxychloroquine Alone or in Combination With Azithromycin for the Prophylaxis or Treatment of COVID-19? Living Practice Points From the American College of Physicians – Annals of Internal Medicine

10 –COVID-19 Updates / 18 June 2020 Edition

18 June 2020 Edition – COVID-19/SARS-CoV-2 Latest Articles, Guidelines, News & Perspectives (several free resources)

Randomized Trial: Dexamethasone Reduces Death by Up to One Third in Patients with Severe COVID-19

17 Jun, 2020 | 02:49h | UTC

Low-cost dexamethasone reduces death by up to one third in hospitalised patients with severe respiratory complications of COVID-19 – Recovery Trial

Commentaries: Coronavirus breakthrough: dexamethasone is first drug shown to save lives – Nature AND WHO welcomes preliminary results about dexamethasone use in treating critically ill COVID-19 patients – World Health Organization AND Major study finds common steroid reduces deaths among patients with severe Covid-19 – STAT AND Dexamethasone reduces death in hospitalised patients with severe respiratory complications of COVID-19 – University of Oxford AND Coronavirus: Dexamethasone proves first life-saving drug – BBC

Related Commentary on Twitter

Dexamethasone reduced deaths by 1/3rd in ventilated patients (rate ratio 0.65 [95% CI 0.48 to 0.88]; p=0.0003) and by 1/5th in patients receiving oxygen only (0.80 [0.67 to 0.96]; p=0.0021). No benefit in patients not requiring respiratory support (1.22 [0.86 to 1.75; p=0.14).

— Peter Horby @peterhorby.bsky.social (@PeterHorby) June 16, 2020