Archives
Opinion: “Proposed British guidelines reject useless chronic fatigue syndrome treatments”
19 Nov, 2020 | 09:22h | UTCProposed British guidelines reject useless chronic fatigue syndrome treatments – STAT
NICE Draft Guideline: Myalgic encephalomyelitis (or 6 encephalopathy)/chronic fatigue syndrome: diagnosis and management
#AHA20 [not published yet] Randomized trial: After drug-eluting stent implantation, one-month dual antiplatelet therapy (DAPT) followed by aspirin monotherapy was noninferior to 6-12 months of DAPT
19 Nov, 2020 | 09:21h | UTCCommentary: Latest Post-DES Drug Trial Tests Aspirin Monotherapy After 1 Month of DAPT – TCTMD
NICE Guideline: Acute coronary syndromes
19 Nov, 2020 | 09:24h | UTCAcute coronary syndromes – National Institute for Health and Care Excellence
Visual summary: STEMI
Visual summary: NSTEMI/unstable angina
Visual summary: Cardiac rehabilitation and secondary prevention
Review: Fluid administration and monitoring in ARDS. Restrictive vs. liberal strategy of fluid administration, assessment of fluid responsiveness, and other topics are discussed
19 Nov, 2020 | 09:19h | UTCFluid administration and monitoring in ARDS: which management? – Intensive Care Medicine
Commentary on Twitter
Fluid administration & monitoring in #ARDS:
➡️ pathophysiology
➡️ fluid therapy
➡️ fluid balance & outcome
➡️ restrictive vs liberal strategy?
➡️ assessing responsiveness
➡️ origin of positive balance & correction
➡️ approach according to ARDS cause/timinghttps://t.co/wIt305B1Ci pic.twitter.com/54whmo7OmC— Intensive Care Medicine (@yourICM) November 12, 2020
Perspective: More people can access surgery. That’s great for them, awful for the planet
19 Nov, 2020 | 09:18h | UTCMore People Can Access Surgery. That’s Great For Them, Awful For The Planet – NPR
Original article: Climate change: challenges and opportunities to scale up surgical, obstetric, and anaesthesia care globally – The Lancet Planetary Health
Related: Effects of Surgery on A Warming Planet: Can Anesthesia Go Green? (commentaries and articles on the subject)
Lessons from Europe, where cases are rising but schools are open
18 Nov, 2020 | 09:18h | UTCLessons From Europe, Where Cases Are Rising But Schools Are Open – NPR
11th Ebola outbreak in the Democratic Republic of the Congo declared over
19 Nov, 2020 | 09:15h | UTC
Chinese Covid-19 vaccine candidate (CoronaVac) appears safe and induces an immune response in healthy volunteers in phase 1/2 clinical trial
18 Nov, 2020 | 09:19h | UTCCommentaries: Covid-19: Chinese vaccine ‘successful in mid-stage trials’ – BBC AND Expecting the unexpected with COVID-19 vaccines – The Lancet Infectious Diseases
Commentary on Twitter
NEW—Chinese #COVID19 vaccine candidate (CoronaVac) based on inactivated SARS-CoV-2 virus appears safe & induces an immune response in healthy volunteers: finding from a randomised, double-blind, placebo-controlled, phase 1/2 clinical trial @TheLancetInfDis https://t.co/0AC0fP53dI pic.twitter.com/W3gMdqLzTG
— The Lancet (@TheLancet) November 18, 2020
Estimation of US children’s educational attainment and years of life lost associated with primary school closures during the Covid-19 pandemic
18 Nov, 2020 | 09:15h | UTC
#AHA20 – Two studies show lower rate of atrial fibrillation recurrence with catheter cryoballoon ablation than with antiarrhythmic drug therapy
18 Nov, 2020 | 09:11h | UTCStudy 1: Cryoballoon Ablation as Initial Therapy for Atrial Fibrillation – New England Journal of Medicine
Commentaries: EARLY AF and STOP AF Put Electrophysiology at a Crossroads – Medscape (free registration required) AND EARLY-AF: First-line Ablation Beats Meds for Recent Paroxysmal A-fib – TCTMD
Commentary on Twitter (thread – click for more)
NEJM published 2 RCTs of #AFib ablation vs AF drugs.
The rub was that the ablation was done EARLY in the course.
Practice had been to try drugs first then do ablation.
EARLY AF and STOP AF studied the procedure early. #AHA20 Thread and my column >>— John Mandrola, MD (@drjohnm) November 18, 2020
[Preprint] Study suggests immunity to the Coronavirus may last years
18 Nov, 2020 | 09:20h | UTCImmunological memory to SARS-CoV-2 assessed for greater than six months after infection – bioRxiv
Commentaries: Immunity to the Coronavirus May Last Years, New Data Hint – New York Times AND Could coronavirus immunity last YEARS? Study finds even survivors who had mild COVID-19 are protected for at least 8 months and their immune ‘memory’ may last MUCH longer – Daily Mail AND COVID-19: Study Suggests Durable Immune Response After SARS-CoV-2 Infection – NEJM Journal Watch
Commentary from the author on Twitter (thread – click for more)
1/ Our pre-print on immune memory to SARS-CoV-2 is out today. To our knowledge, this is the largest such study for any acute infection.
The upshot is that there is substantial immune memory after COVID-19.
Lots of stuff in this manuscript.https://t.co/lSAyZp0XiK@SetteLab
— Prof. Shane Crotty (@profshanecrotty) November 17, 2020
ATS Guideline: Home oxygen therapy for adults with chronic lung disease
18 Nov, 2020 | 09:13h | UTC
#AHA20 – Randomized trial: Among patients with recurrent pericarditis, Rilonacept was associated with lower risk of pericarditis recurrence than placebo
18 Nov, 2020 | 09:04h | UTCPhase 3 Trial of Interleukin-1 Trap Rilonacept in Recurrent Pericarditis – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Rilonacept Prevents Recurrent Pericarditis: RHAPSODY – TCTMD AND Rilonacept inHibition of interleukin-1 Alpha and beta for recurrent Pericarditis: a pivotal Symptomatology and Outcomes stuDY – RHAPSODY – American College of Cardiology AND Trial shows drug effective in 96% of patients with recurrent pericarditis – Cleveland Clinic
Commentary on Twitter
Patients with recurrent pericarditis were treated with the interleukin-1 trap rilonacept. Those who had a response were randomly assigned to receive continued rilonacept or placebo. Rilonacept led to a significantly lower risk of pericarditis recurrence than placebo. #AHA20
— NEJM (@NEJM) November 17, 2020
#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and CKD. Diarrhea, genital mycotic infections, volume depletion, and diabetic ketoacidosis were more common with sotagliflozin than with placebo
18 Nov, 2020 | 09:08h | UTCSotagliflozin in Patients with Diabetes and Chronic Kidney Disease – New England Journal of Medicine (link to abstract – $ for full-text)
#AHA20 – RCT: Sotagliflozin improved cardiovascular outcomes in patients with Diabetes and Recent Worsening Heart Failure. Diarrhea and severe hypoglycemia were more common with sotagliflozin than with placebo
18 Nov, 2020 | 09:06h | UTCSotagliflozin in Patients with Diabetes and Recent Worsening Heart Failure – New England Journal of Medicine (link to abstract – $ for full-text)
The ‘Ten Commandments’ for the 2020 ESC Guidelines on Sports Cardiology and Exercise in Patients with Cardiovascular Disease
18 Nov, 2020 | 09:03h | UTCOriginal Guideline and commentary: 2020 ESC Guidelines on sports cardiology and exercise in patients with cardiovascular disease
Opinion: A new important study supports wider use of the polypill
18 Nov, 2020 | 09:01h | UTCRichard Smith: A new important study supports wider use of the polypill – The Lancet
Original study and commentaries: Randomized trial: A polypill comprising statins, multiple blood pressure lowering drugs, and aspirin prevents cardiovascular events among patients at intermediate cardiovascular risk
Commentary on Twitter
"We seem now to have good evidence that the polypill can reduce cardiovascular events and deaths by at least a third and probably by half in those who take the polypill regularly" @Richard56 discusses a new study in @NEJM https://t.co/B2tkN4pkDP
— The BMJ (@bmj_latest) November 17, 2020
Surveillance of wastewater revealed peaks of SARS-CoV-2 preceding those of hospitalized patients with COVID-19
17 Nov, 2020 | 09:53h | UTC
Systematic review: Management of primary headaches in pregnancy
18 Nov, 2020 | 09:00h | UTCManagement of Primary Headaches in Pregnancy – Agency for Healthcare Research and Quality
Full report: Management of Primary Headaches in Pregnancy
Evidence Summary: Management of Primary Headaches in Pregnancy
CDC Report: Multiple COVID-19 outbreaks linked to a wedding reception
17 Nov, 2020 | 09:51h | UTCCommentaries: CDC: One wedding led to 177 cases of COVID-19 and 7 deaths because attendees refused to wear masks and physically distance – Business Insider AND Maine wedding outbreak offers a cautionary Covid-19 tale for the holidays – CNN AND Maine Wedding Gives Half Of The Guests Coronavirus, Outbreak Leads To 177 Covid-19 Cases And 7 Deaths – Forbes
[Press release – not published yet] Moderna’s COVID-19 vaccine candidate shows 94.5% protection in an interim analysis of the phase 3 COVE study
17 Nov, 2020 | 09:55h | UTCPress release: Moderna’s COVID-19 Vaccine Candidate Meets its Primary Efficacy Endpoint in the First Interim Analysis of the Phase 3 COVE Study
See also: Moderna Announces Longer Shelf Life for its COVID-19 Vaccine Candidate at Refrigerated Temperatures
Commentaries: What Moderna’s Covid-19 vaccine results mean for ending the pandemic – Vox AND Moderna follows Pfizer with exciting vaccine news – how to read these dramatic developments – The Conversation AND Moderna’s COVID Vaccine Is 95% Effective – Independent NIH-Appointed Board Assessment – Higher Storage Temperature Make It Even Better News – Health Policy Watch AND Moderna’s Vaccine News “Encouraging” But Won’t Solve Immediate Problem of Virus Surge in Europe & Americas – WHO – Health Policy Watch AND COVID vaccine excitement builds as Moderna reports third positive result – Nature AND Moderna’s Covid-19 vaccine is strongly effective, early look at data show – STAT AND With strong data on two Covid-19 vaccines, we have more answers about the road ahead — and questions too – STAT AND Early data show Moderna’s COVID vaccine 94.5% effective – CIDRAP AND A Note Of Caution On Moderna’s Promising Covid-19 Vaccine News – Forbes AND Promising Interim Results from Clinical Trial of NIH-Moderna COVID-19 Vaccine – NIH News Releases AND Moderna: Covid vaccine shows nearly 95% protection – BBC AND Latest vaccine success is good news but high price may restrict access – The Guardian AND ‘Just beautiful’—Another COVID-19 vaccine, from newcomer Moderna, succeeds in large-scale trial – Science AND Moderna trial success gives world more hope in race to end pandemic – Reuters AND Expert reaction to Moderna announcement of its phase 3 vaccine interim results – Science Media Centre
CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic
17 Nov, 2020 | 09:48h | UTCCommentary: ER Data Indicates the Pandemic Is Harming Children’s Mental Health – U.S. News
Commentary on Twitter
New @CDCMMWR suggests that the #COVID19 pandemic may be negatively impacting children’s mental health. The proportion of emergency room visits for mental health concerns in children & adolescents increased substantially this past Mar.-Oct. Read the report: https://t.co/9FyLoCzrza pic.twitter.com/fIXMIZg7KK
— CDC (@CDCgov) November 12, 2020
CDC Report: 9% readmitted after Covid-19 hospitalization. Risk factors were age ≥65 y, chronic medical conditions, recent hospitalization before Covid-19, and discharge to a skilled nursing facility or with home health care
17 Nov, 2020 | 09:46h | UTCCommentary: 9 percent readmitted after index COVID-19 hospitalization – MedicalXpress AND One in 11 coronavirus patients discharged from a hospital is readmitted within two months, suggesting long-lasting effects of the infection, CDC report warns – Daily Mail
Commentary on Twitter
A new @CDCMMWR finds 9% of the more than 100,000 patients discharged after being hospitalized for #COVID19 were readmitted to the same hospital within 2 months. Learn more: https://t.co/s96NXLxQUE. pic.twitter.com/ugJq9f1gHP
— CDC (@CDCgov) November 9, 2020
The Great Coronavirus Pandemic of 2020—7 Critical Lessons
17 Nov, 2020 | 09:42h | UTCThe Great Coronavirus Pandemic of 2020—7 Critical Lessons – JAMA
Commentary on Twitter
1. Build Resilient Health Systems
2. Leadership and Public Trust Matter
3. Science and Public Health Matters
4. Biomedical Research and Development Matters
5. Equity Matters
6. Evidence-Based Law Matters
7. Global Institutions Matter https://t.co/czxGwyAGCn @LawrenceGostin— JAMA (@JAMA_current) November 16, 2020
Review: Prone positioning for patients with hypoxic respiratory failure related to COVID-19
17 Nov, 2020 | 09:41h | UTC
Commentary on Twitter
What's the evidence for prone positioning for patients with respiratory distress related to #COVID19? A new review answers pressing questions about this common intervention: https://t.co/dh15AuUpD0 #ICU #CriticalCare pic.twitter.com/Y8TzactS70
— CMAJ (@CMAJ) November 11, 2020