Archives
Meta-analysis: Outcomes of endotracheal suctioning in non-vigorous neonates born through meconium-stained amniotic fluid
22 Jan, 2021 | 08:04h | UTC
Commentary on Twitter
Outcomes of non-endotracheal suctioning (non-ETS) versus ETS in non-vigorous meconium-stained neonates = no difference
Published in @ADC_FN https://t.co/raRs4uj73o pic.twitter.com/AAGQiKyc5a
— Evidence-Based Neo (@EBNEO) June 25, 2020
Contradicting earlier trials, Tocilizumab did not improve outcomes, with signs of harm, in patients with severe Covid-19
21 Jan, 2021 | 01:46h | UTCCommentaries: Conflicting COVID-19 results for Roche arthritis drug show more trials needed – Reuters AND Covid-19: Arthritis drug trial for severe illness is stopped early after increase in deaths – The BMJ
Related research (study and commentaries): [Preprint] Randomized trial: Arthritis drugs improve survival in critically ill patients with Covid-19
Meta-analysis of randomized trials: Closed incision negative pressure wound therapy decreases surgical site infections compared to standard dressings after revision total joint arthroplasty, but not primary total joint arthroplasty
22 Jan, 2021 | 08:02h | UTCClosed Incision Negative Pressure Wound Therapy for Elective Hip and Knee Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – Journal of Arthroplasty (link to abstract – $ for full-text)
Randomized trial of Irinotecan and Cetuximab with or without Vemurafenib in BRAF-Mutant metastatic colorectal cancer
22 Jan, 2021 | 07:57h | UTCCommentary: Triple chemotherapy combination improves metastatic colorectal cancer outcomes – SWOG AND Three Drugs Top Two for BRAF+ Metastatic Colorectal Cancer – MedPage Today
Randomized trial: Benralizumab effects on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma
22 Jan, 2021 | 07:59h | UTCOnset of effect and impact on health-related quality of life, exacerbation rate, lung function, and nasal polyposis symptoms for patients with severe eosinophilic asthma treated with benralizumab (ANDHI): a randomised, controlled, phase 3b trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Commentary on Twitter
NEW Research—#Benralizumab significantly reduced exacerbation risk by 49% vs placebo (RR estimate 0·51, 95% CI 0·39–0·65; p≤0·0001) over the 24-week treatment period in patients with severe eosinophilic #asthma
The ANDHI study from Tim Harrison & co https://t.co/bQwikpQZvc pic.twitter.com/sS9ab0Mo1R
— The Lancet Respiratory Medicine (@LancetRespirMed) January 4, 2021
Final overall survival results of the IDEA Collaboration: 3 vs 6 months of adjuvant chemotherapy for Stage III Colon Cancer
22 Jan, 2021 | 07:58h | UTCOriginal article: Effect of duration of adjuvant chemotherapy for patients with stage III colon cancer (IDEA collaboration): final results from a prospective, pooled analysis of six randomised, phase 3 trials – The Lancet Oncology (link to abstract – $ for full-text)
Commentary on Twitter
https://twitter.com/NatRevClinOncol/status/1334157879767568384
‘A bloody mess’: Confusion reigns over naming of new COVID variants
21 Jan, 2021 | 01:27h | UTC‘A bloody mess’: Confusion reigns over naming of new COVID variants – Nature
[Preprint] South African COVID-19 variant escapes neutralization by antibodies in COVID-19 convalescent plasma
21 Jan, 2021 | 01:28h | UTCSARS-CoV-2 501Y.V2 escapes neutralization by South African COVID-19 donor plasma – bioRxiv
Commentaries: Expert reaction to preprint reporting that the South African SARS-CoV-2 variant 501Y.V2 escapes neutralisation by COVID-19 donor plasma – Science Media Centre AND S.Africa virus strain poses ‘re-infection risk’: study – MedicalXpress
5 reasons to wear a mask even after you’re vaccinated
21 Jan, 2021 | 01:24h | UTC5 Reasons to Wear a Mask Even After You’re Vaccinated – Kaiser Health News
COVID’s toll on smell and taste: what scientists do and don’t know
21 Jan, 2021 | 01:26h | UTCCOVID’s toll on smell and taste: what scientists do and don’t know – Nature
Multi-organ point-of-care ultrasound for COVID-19 (PoCUS4COVID): international expert consensus
21 Jan, 2021 | 01:19h | UTC
Vaccinology in the post−COVID-19 era
21 Jan, 2021 | 01:24h | UTCVaccinology in the post−COVID-19 era – Proceedings of the National Academy of Sciences
Cohort study: Recipients of hematopoietic stem-cell transplantation who develop COVID-19 have poor overall survival
21 Jan, 2021 | 01:18h | UTC
Randomized trial: Similar outcomes with lower vs. higher oxygenation targets for acute hypoxemic respiratory failure
21 Jan, 2021 | 01:16h | UTCLower or Higher Oxygenation Targets for Acute Hypoxemic Respiratory Failure – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Even though supplemental oxygen is used for the treatment of patients with hypoxemic respiratory failure, the most effective oxygenation targets are not known. In this randomized trial, a lower oxygenation target did not result in lower mortality than a higher target.
— NEJM (@NEJM) January 21, 2021
Allocating scarce intensive care resources during the COVID-19 pandemic: practical challenges to theoretical frameworks
21 Jan, 2021 | 01:22h | UTC
COVID-19 testing: One size does not fit all
21 Jan, 2021 | 01:21h | UTCCOVID-19 testing: One size does not fit all – Science
Commentary on Twitter
COVID-19 testing: One size does not fit all https://t.co/zduxAcrMAA An excellent article by @michaelmina_lab and Kristian Andersen discussing the differences between diagnostic testing, surveillance testing and screening testing.
— Carlos del Rio (@CarlosdelRio7) January 8, 2021
State of the art review: Management of non-alcoholic fatty liver disease
21 Jan, 2021 | 01:13h | UTCManagement of non-alcoholic fatty liver disease – The BMJ
Thrombolytic strategies versus standard anticoagulation for acute deep vein thrombosis of the lower limb
21 Jan, 2021 | 01:10h | UTCSummary: Thrombolysis for treatment of acute deep vein thrombosis – Cochrane Library
Randomized trial: Oral Rimegepant for preventive treatment of migraine
21 Jan, 2021 | 01:04h | UTCOral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial – The Lancet (link to abstract – $ for full-text)
Commentary: Rimegepant bests placebo for preventing migraine – MedicalXpress
Against placebo? It would be interesting to know how this new drug works against other established treatments.
Randomized trial: In pediatric acute CNS infections, 3% Hypertonic saline is superior to 20% Mannitol for reducing intracranial pressure
21 Jan, 2021 | 01:08h | UTCRandomized Clinical Trial of 20% Mannitol Versus 3% Hypertonic Saline in Children With Raised Intracranial Pressure Due to Acute CNS Infections – Pediatric Critical Care Medicine (link to abstract – $ for full-text)
Commentary on Twitter
Feature w/#VisualAbstract
RCT of 20% mannitol vs. 3% hypertonic saline in children w/raised ICP due to acute CNS infections: Which is superior?
Rameshkumar, @drarunbansal, Jayashree 🇮🇳: https://t.co/ZGWaPMhPvr
Editorial by Argent 🇿🇦: https://t.co/BsbZKsEG03#PedsICU @WFPICCS pic.twitter.com/5asM9HNQaN
— Pediatric Critical Care Medicine (@PedCritCareMed) December 21, 2020
Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder
21 Jan, 2021 | 01:03h | UTCA Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Repeated Ketamine Infusions Reduce Symptom Severity in Individuals With Chronic Post-Traumatic Stress Disorder – Mount Sinai AND Repeated Ketamine Infusions May Rapidly Reduce Chronic PTSD Symptoms – Psychiatry News Alert
Commentary on Twitter
Patients with chronic PTSD given repeated infusions of ketamine over 2 weeks showed significantly greater symptom improvement than those given a psychoactive placebo control infusion, the first evidence of efficacy.
Learn More: https://t.co/qqcIsNfCHC pic.twitter.com/r7Bggz4cIj— Journals of The American Psychiatric Association (@APAPubJournals) January 5, 2021
Meta-analysis: Perioperative systemic dexamethasone reduces length of stay in total joint arthroplasty
21 Jan, 2021 | 01:52h | UTCPerioperative Systemic Dexamethasone Reduces Length of Stay in Total Joint Arthroplasty: A Systematic Review and Meta-Analysis of Randomized Controlled Trials – The Journal of Arthroplasty (link to abstract – $ for full-text)
Acute flaccid myelitis: Cause, diagnosis, and management
21 Jan, 2021 | 00:58h | UTCAcute flaccid myelitis: cause, diagnosis, and management – The Lancet (free registration required)
Randomized non-inferiority study: Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection
21 Jan, 2021 | 01:01h | UTCLong-acting cabotegravir and rilpivirine dosed every 2 months in adults with HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study – The Lancet (link to abstract – $ for full-text)
Commentary (thread – click for more)
Long-acting cabotegravir and rilpivirine dosed every 2 months in adults with #HIV-1 infection (ATLAS-2M), 48-week results: a randomised, multicentre, open-label, phase 3b, non-inferiority study: https://t.co/4SdfnRRCje
— The Lancet (@TheLancet) December 21, 2020
Podcast: MGUS, Myeloma, and Immunology
21 Jan, 2021 | 00:53h | UTCMGUS, Myeloma, and Immunology – The Curbsiders Internal Medicine Podcast