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Study: Meta-Analysis of 150K patients. NSAIDs are unlikely to be the cause of post-operative bleeding complications. This literature remains consistent across types of NSAIDs and operations. https://t.co/1bpSyblWzb

— Skeptical Scalpel (@Skepticscalpel) January 28, 2021

RCT: Cognitive prehabilitation reduces the incidence of postoperative delirium among older adults undergoing major noncardiac surgery

4 Mar, 2021 | 08:12h | UTC

Effect of Cognitive Prehabilitation on the Incidence of Postoperative Delirium Among Older Adults Undergoing Major Noncardiac Surgery: The Neurobics Randomized Clinical Trial – JAMA Surgery (link to abstract – $ for full-text)

Commentaries: Ohio State study finds playing brain games before surgery helps improve recovery – Ohio State University Medical Center AND Cognitive Exercises May Lower Risk for Postoperative Delirium – HealthDay

Commentary on Twitter

Results of a 268-patient prospective randomized-controlled clinical trial show patients meeting at least minimum compliance with a preoperative cognitive exercise intervention had a decreased incidence of postoperative delirium https://t.co/QZUCfef6bf #VisualAbstract pic.twitter.com/jDbsfDSWxV

— JAMA Surgery (@JAMASurgery) November 11, 2020

RCT: Inspiratory muscle training with an electronic resistive loading device improves prolonged weaning outcomes

4 Mar, 2021 | 08:10h | UTC

Inspiratory Muscle Training With an Electronic Resistive Loading Device Improves Prolonged Weaning Outcomes in a Randomized Controlled Trial – Critical Care Medicine (link to abstract – $ for full-text)

Commentaries on Twitter

In 101 patients on MV, inspiratory muscle training vs T-piece led to better maximal inspiratory pressure, weaning success, and 60d-survival.
Thanks to @CritCareReviews https://t.co/8RR9e8nDVm

— Peter Nydahl (@NydahlPeter) January 2, 2021

Inspiratory muscle training in patients on prolonged weaning increases muscle strength and is associated with a higher 60d survival rate and successful weaning. Another contribution from Brazilian physiotherapy! Kudos to @brunoguimaraesp and team! https://t.co/LEw7vGSZey

— Angelo Roncalli (@curso_vm) December 25, 2020

Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group

4 Mar, 2021 | 08:13h | UTC

Management of congenital nephrotic syndrome: consensus recommendations of the ERKNet-ESPN Working Group – Nature Reviews Nephrology

RCT: Following high-risk surgery, automated closed-loop oxygen administration promotes a higher time within range as compared to standard manual administration

4 Mar, 2021 | 08:05h | UTC

Automated closed-loop versus standard manual oxygen administration after major abdominal or thoracic surgery: an international multicentre randomised controlled study – European Heart Journal (link to abstract – $ for full-text)

RCT: Laparoscopic anterior resection with or without transanal tube for rectal cancer patients

4 Mar, 2021 | 08:02h | UTC

Laparoscopic anterior resection with or without transanal tube for rectal cancer patients – A multicenter randomized controlled trial – The American Journal of Surgery (link to abstract – $ for full-text)

M-A: Effect of dietary carbohydrate and lipid modification on clinical and anthropometric parameters in nonalcoholic fatty liver disease

4 Mar, 2021 | 08:07h | UTC

Effect of dietary carbohydrate and lipid modification on clinical and anthropometric parameters in nonalcoholic fatty liver disease: a systematic review and meta-analysis – Nutrition Reviews (link to abstract – $ for full-text)

RCT: No effect from Vitamin D and/or Marine n-3 fatty acid supplementation on changes in migraine frequency and severity

4 Mar, 2021 | 08:04h | UTC

Effect of Vitamin D and/or Marine n-3 Fatty Acid Supplementation on Changes in Migraine Frequency and Severity: A randomized placebo-controlled trial – The American Journal of Medicine (link to abstract – $ for full-text)

NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms

3 Mar, 2021 | 08:55h | UTC

NIH halts trial of COVID-19 convalescent plasma in emergency department patients with mild symptoms – National Institutes of Health

The vaccine race against the coronavirus variants, explained

3 Mar, 2021 | 08:52h | UTC

The vaccine race against the coronavirus variants, explained – Vox

WHO Guideline recommends against Hydroxychloroquine to prevent Covid-19

3 Mar, 2021 | 08:56h | UTC

A living WHO guideline on drugs to prevent covid-19 – The BMJ

Commentaries: WHO advises against hydroxychloroquine to curb COVID-19 – CIDRAP AND WHO panel issues strong advice against hydroxychloroquine for COVID-19 – Reuters

Commentary on Twitter

The anti-inflammatory drug hydroxychloroquine should NOT be used to prevent infection in people who do not have #COVID19, according to the latest WHO clinical care guidance https://t.co/Oi2NJQMwiZ pic.twitter.com/0UQr78hNk4

— World Health Organization (WHO) (@WHO) March 2, 2021

COVID-19 research in critical care: the good, the bad, and the ugly

3 Mar, 2021 | 08:49h | UTC

COVID-19 research in critical care: the good, the bad, and the ugly – Intensive Care Medicine

Commentary on Twitter

Challenges, achievements, directions of critical care research in #pandemic, from early small #COVID19 studies (incomplete/inconsistent data), to large-scale registries, through overlapping/competing & underpowered trials, often with poor LMIC involvement.https://t.co/EyEui4pKPi pic.twitter.com/jUDXAVaD5z

— Intensive Care Medicine (@yourICM) March 1, 2021

More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil

3 Mar, 2021 | 08:53h | UTC

More transmissible and evasive SARS-CoV-2 variant growing rapidly in Brazil – Imperial College London

Original study (preprint): Genomics and epidemiology of a novel SARS-CoV-2 lineage in Manaus, Brazil

Commentaries: Covid Brazil variant ‘may spread more easily’ – BBC AND Brazil coronavirus variant: what is it and why is it a concern? An expert explains – The Conversation

Covid-19: Single dose of Pfizer and Oxford vaccines cuts risk of hospital admission by 80% in over 80s, data suggest

3 Mar, 2021 | 08:51h | UTC

Covid-19: Single dose of Pfizer and Oxford vaccines cuts risk of hospital admission by 80% in over 80s, data suggest – The BMJ

Commentary on Twitter

Both the Pfizer BioNTech and the Oxford AstraZeneca vaccines are highly effective in reducing covid-19 infections and protecting against severe disease in older adults, preliminary data show https://t.co/THSv5kiIVt

— The BMJ (@bmj_latest) March 2, 2021