Archives
Cohort study: SARS-CoV-2 infection rates of antibody-positive vs. antibody-negative health-care workers – previous infection was associated with 84% lower risk of (re)infection
12 Apr, 2021 | 01:30h | UTCCommentary: Correlates of protection from SARS-CoV-2 infection – The Lancet
Commentary on Twitter
💥SIREN STUDY💥 @TheLancet
Previous SARS-CoV-2 infection
provides protection similar to or even better than currently used vaccines
📌84% risk reduction(RR) for reinfection
📌93% RR for those w symptomatic infections
📌B.1.1.7 circulate during the studyhttps://t.co/uQ3M9yahAv pic.twitter.com/leQCNbmHQO— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) April 10, 2021
Perspective | They Tested Negative for Covid. Still, They Have Long Covid Symptoms.
13 Apr, 2021 | 05:23h | UTCThey Tested Negative for Covid. Still, They Have Long Covid Symptoms. – Kaiser Health News
Commentary on Twitter
Scary: Many people have tested negative for SARSCoV2, yet they developed Long Covid. What's to blame? Haphazard testing protocols, delays & difficulties accessing tests & poor quality of many of the tests on the market. All have have left people without proof of infection. https://t.co/KH3QYkbbKW pic.twitter.com/MVuRhWoHle
— delthia ricks 🔬 (@DelthiaRicks) April 12, 2021
Prone position in intubated, mechanically ventilated patients with COVID-19: a multi-centric study of more than 1000 patients
12 Apr, 2021 | 01:23h | UTC
Commentary on Twitter
Prone position in #COVID19, use & effect:
➡️PP widely adopted, the more severe the respiratory failure, the more frequent the use
➡️PP improved oxygenation in most (better V/Q matching?)
➡️mortality of O2-Non-Responders significantly higher@Crit_Care https://t.co/Q2Z15a8Pvr pic.twitter.com/CZqshIfJrg— M Velia Antonini (@FOAMecmo) April 7, 2021
[Preprint] Pfizer vaccine less effective for SARS-CoV-2 variant B.1.351
12 Apr, 2021 | 01:26h | UTCCommentaries: South African variant may evade protection from Pfizer vaccine, Israeli study says – Reuters AND Israeli data shows South African variant able to ‘break through’ Pfizer vaccine – The Times of Israel
Related: Another study indicates SARS-CoV-2 variant B.1.351, but not variant B.1.1.7, has partial resistance to neutralizing antibodies generated by natural infection or mRNA vaccination AND SARS-CoV-2 variants B.1.351 and P.1 can escape from therapeutic antibodies and evade antibodies induced by infection or mRNA vaccination AND B.1.351 strain of SARS-CoV-2 neutralization titer reduced 8- to 9-fold for Pfizer and AstraZeneca vaccinees. Convalescent plasma and therapeutic antibodies were less effective against this variant as well.
Another study shows intravenous radiocontrast use is not associated with reduced kidney function
12 Apr, 2021 | 00:44h | UTCCommentaries: Radiocontrast Exposure Safe for Kidney Function – HCP Live AND Exposure to contrast on CTPA doesn’t cause long-term kidney injury – AuntMinnie
Related: ACR/NKF Consensus Statement: “The Risk of Acute Kidney Injury Developing in Patients with Reduced Kidney Function Following Exposure to Intravenous Iodinated Contrast Media has Been Overstated” (Guideline and commentaries)
Commentary on Twitter (thread – click for more)
Our new paper in @JAMAInternalMed: is IV contrast nephrotoxic? Lots of studies say no, but have ⬆️risk of confounding: people who get contrast ≠ people who don't get it. We used a natural experiment to try to overcome this bias https://t.co/XWEEohAvK0 1/5
— Robert Goulden (@EMrobg) April 5, 2021
AHA Policy Statement: Reducing Nontraumatic Lower-Extremity Amputations by 20% by 2030
12 Apr, 2021 | 00:48h | UTCCommentary: AHA issues policy statement on reducing lower-extremity amputations – ACP Diabetes AND AHA Seeks to Drive Down Amputations 20% by 2030 – TCTMD
M-A: Treatment for bleeding esophageal varices in people with decompensated liver cirrhosis
12 Apr, 2021 | 00:39h | UTCRelated Cochrane Reviews: M-A: Secondary prevention of variceal bleeding in adults with previous esophageal variceal bleeding due to decompensated liver cirrhosis AND Primary prevention of variceal bleeding in people with oesophageal varices due to liver cirrhosis: a network meta‐analysis – Cochrane Library
Concussion in para sport: the first position statement of the Concussion in Para Sport (CIPS) Group
12 Apr, 2021 | 00:37h | UTC
Commentary on Twitter
The ink is still wet .. fresh out in @BJSM_BMJ. Para athletes suffer concussions too, but specific guidelines for care did not exist .. until now ‼️ Open access ➡️ https://t.co/ld1BENeoho pic.twitter.com/lkwsa8HsKd
— Evert Verhagen (@EvertVerhagen) April 10, 2021
[Preprint] Efficacy and safety of CoronaVac in healthcare professionals in Brazil
12 Apr, 2021 | 01:17h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1381366467665391619
Ketogenic diet reduces alcohol withdrawal symptoms in humans and alcohol intake in rodents
12 Apr, 2021 | 00:36h | UTC
Commentary onTwitter
NIH study found evidence that a ketogenic diet (high fat, low carbohydrate and protein) can have beneficial effects on inpatients managing alcohol withdrawal and on reducing alcohol drinking in those with an alcohol use disorder.https://t.co/IBiQ6hZY5i#NIDAscience @NIAAAnews
— NIDAnews (@NIDAnews) April 9, 2021
RCT: Effect of High-frequency (10-kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
9 Apr, 2021 | 03:18h | UTCAuthor Interview: Effect of High-Frequency (10 kHz) Spinal Cord Stimulation in Patients With Painful Diabetic Neuropathy
Commentary on Twitter
Thrilled to see our publication out today in @JAMANeuro using #SCS to treat #diabetic #pain. 86% of patients with over 50% pain relief at 6 months with better sleep and walking! #progress #needherscience #neuromodulation @UAMSneurosurg @UAMSPain @uamshealth https://t.co/TJQPHsHvSa
— Dr. Erika Petersen (@ErikaPetersenMD) April 5, 2021
Consensus Document: Management of ureteric and bladder injury
12 Apr, 2021 | 00:29h | UTC
Viewpoint | Reducing Low-Value Care and Improving Health Care Value
9 Apr, 2021 | 03:23h | UTCReducing Low-Value Care and Improving Health Care Value – JAMA (free for a limited period)
Papers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine
12 Apr, 2021 | 01:20h | UTCPapers Confirm Rare Thrombocytopenia Link to AstraZeneca Vaccine – TCTMD
Study 1: Thrombotic Thrombocytopenia after ChAdOx1 nCov-19 Vaccination – New England Journal of Medicine
Study 2: Thrombosis and Thrombocytopenia after ChAdOx1 nCoV-19 Vaccination – New England Journal of Medicine
Japanese doctors perform world’s first living donor lung transplant to a Covid-19 patient
12 Apr, 2021 | 01:12h | UTCJapanese doctors perform world’s first living donor lung transplant to a Covid-19 patient – CNN
EMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine
12 Apr, 2021 | 01:18h | UTCEMA Reviews Link Between Blood Clots and Johnson & Johnson Vaccine – Health Policy Watch
See also: Johnson & Johnson’s COVID-19 vaccine under scrutiny at EMA after 4 ‘serious cases’ of unusual blood clots – Fierce Pharma AND J&J COVID-19 vaccine under EU review over blood clots, AstraZeneca probe grows – Reuters
Chinese COVID-19 vaccine maintains protection in variant-plagued Brazil
12 Apr, 2021 | 01:14h | UTCChinese COVID-19 vaccine maintains protection in variant-plagued Brazil – Science
Original study: [Preprint] CoronaVac is 50% effective for reducing symptomatic SARS-CoV-2 infection after the first dose in the setting of high P.1 variant transmission in Brazil (study and commentary on Twitter)
Guidelines of care for the management of actinic keratosis
9 Apr, 2021 | 03:20h | UTC
Short Review | How to use antihistamines
9 Apr, 2021 | 03:13h | UTCHow to use antihistamines – Canadian Medical Association Journal
AstraZeneca vaccine: Blood clots are “extremely rare” and benefits outweigh risks, regulators conclude
9 Apr, 2021 | 03:33h | UTC
A guide to Plan S: the open-access initiative shaking up science publishing
9 Apr, 2021 | 03:11h | UTCA guide to Plan S: the open-access initiative shaking up science publishing – Nature
Related: Open-access Science Funders Announce Price Transparency Rules for Publishers (several resources on the subject) AND A new mandate highlights costs, benefits of making all scientific articles free to read – Science
Comprehensive Review | Pneumonia
9 Apr, 2021 | 03:14h | UTCPneumonia – Nature Reviews Disease Primers (free for a limited period)
Try this link if the above is paywalled.
ESC Position Statement: Diagnosis and treatment of cardiac amyloidosis
8 Apr, 2021 | 08:49h | UTC
Commentary on Twitter (thread – click for more)
ESC position paper on diagnosis & treatment of cardiac amyloidosis published today simultaneously at EHJ & EJHF. https://t.co/ad7xn7c1MYhttps://t.co/pZ6tOWICpn@escardio @ESC_Journals @ehj_ed @MarcoMetra
Thread👇🏻(1/7) pic.twitter.com/ngsscfd0pB— Pablo Garcia-Pavia (@dr_pavia) April 7, 2021
Phase 2 RCT: Inhaled budesonide shows promise for the treatment of early COVID-19
12 Apr, 2021 | 01:24h | UTC
Commentary on Twitter
NEW Research— Early administration of inhaled budesonide reduced the likelihood of needing urgent medical care and reduced time to recovery after early #COVID19
RCT from Mona Bafadhel & colleagues https://t.co/6cJogJs7rp pic.twitter.com/C1dhmTcexP
— The Lancet Respiratory Medicine (@LancetRespirMed) April 10, 2021
RCT: New shorter regimens of benznidazole monotherapy and in combination with fosravuconazole for treatment of Chagas disease
8 Apr, 2021 | 08:47h | UTC