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M-A: Continuation of antidepressants vs. sequential psychological interventions to prevent relapse in depression.

8 Jul, 2021 | 08:50h | UTC

Continuation of Antidepressants vs Sequential Psychological Interventions to Prevent Relapse in Depression: An Individual Participant Data Meta-analysis – JAMA Psychiatry (link to abstract – $ for full-text)

Commentaries: Cognitive Therapy While Tapering Antidepressants May Be Alternative to Maintenance Medication – Psychiatric News Alert AND Psychotherapy Can Prevent Relapse When Discontinuing Antidepressants – Mad in America

 

Commentary on Twitter

 

M-A: Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19 – “The 4% absolute risk reduction in mortality from 25% to 21% with IL-6 inhibition added to glucocorticoids may not translate to patients with a lower baseline mortality risk and likely do not justify the additional expense and risk for toxicities for patients hospitalized with modest oxygen requirements and a stable clinical course (from editorial)”.

7 Jul, 2021 | 09:02h | UTC

Association Between Administration of IL-6 Antagonists and Mortality Among Patients Hospitalized for COVID-19: A Meta-analysis – JAMA

Editorial: IL-6 Receptor Antagonist Therapy for Patients Hospitalized for COVID-19: Who, When, and How? – JAMA

Commentaries: Interleukin-6 antagonists improve outcomes in hospitalised COVID-19 patients – King’s College London AND WHO advises 2 monoclonal antibodies for severe COVID – CIDRAP

 

Commentary on Twitter (thread – click for more)

https://twitter.com/msh_manu/status/1412473073715056645

 

Clinical guidelines for female lower urinary tract symptoms.

8 Jul, 2021 | 08:44h | UTC

Clinical Guidelines for Female Lower Urinary Tract Symptoms – International Journal of Urology

 

Guideline on the peri-operative management of patients with sickle cell disease.

8 Jul, 2021 | 08:46h | UTC

Guideline on the peri-operative management of patients with sickle cell disease – Anaesthesia

 

A living WHO guideline on drugs for covid-19 – interleukin-6 receptor blockers are now recommended for patients with severe or critical covid-19.

7 Jul, 2021 | 09:03h | UTC

A living WHO guideline on drugs for covid-19 – The BMJ

 

Commentary on Twitter

 

Wear a mask if you’re vaccinated? Why the WHO and CDC don’t have the same guidance.

7 Jul, 2021 | 08:58h | UTC

Wear a mask if you’re vaccinated? Why the WHO and CDC don’t have the same guidance – C|Net

Related: WHO urges fully vaccinated people to continue to wear masks as delta Covid variant spreads. AND What the science says about lifting mask mandates – “Wearing masks should probably be one of the last things we stop doing”. AND CDC says fully vaccinated Americans can go indoors and outdoors without masks.

 

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – “These are the first drugs found to be effective against COVID-19 since corticosteroids were recommended by WHO in September 2020”.

7 Jul, 2021 | 09:00h | UTC

WHO recommends life-saving interleukin-6 receptor blockers for COVID-19 and urges producers to join efforts to rapidly increase access – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

Pediatric telehealth in the COVID-19 pandemic era and beyond.

7 Jul, 2021 | 08:56h | UTC

Pediatric Telehealth in the COVID-19 Pandemic Era and Beyond – Pediatrics

 

RCOG Guidance: Coronavirus (COVID-19) Vaccination in Pregnancy.

7 Jul, 2021 | 08:53h | UTC

Coronavirus (COVID-19) Vaccination in Pregnancy – Royal College of Obstetricians & Gynaecologists

See also: Resources and FAQs – Royal College of Obstetricians & Gynaecologists

 

Commentary on Twitter

 

SAEM Guidelines for reasonable and appropriate care in the emergency department (GRACE): Recurrent, low-risk chest pain in the emergency department.

7 Jul, 2021 | 08:48h | UTC

Guidelines for reasonable and appropriate care in the emergency department (GRACE): Recurrent, low-risk chest pain in the emergency department – Academic Emergency Medicine

News release: SAEM publishes GRACE guidelines for recurrent, low-risk chest pain care in the ED – Society for Academic Emergency Medicine

Invited commentaries: GRACE-recurrent low-risk chest pain: A user’s guide AND Navigating uncertainty with GRACE: Society for Academic Emergency Medicine’s guidelines for reasonable and appropriate care in the emergency department

 

M-A: Convalescent plasma is safe but does not improve outcomes in the treatment of COVID-19.

7 Jul, 2021 | 08:52h | UTC

Systematic review and meta-analysis of randomised controlled trials testing the safety and efficacy of convalescent plasma in the treatment of coronavirus disease 2019 (COVID-19): Evidence-base for practise and implications for research – Transfusion Medicine

 

WHO pledges extensive commitments towards women’s empowerment and health.

7 Jul, 2021 | 08:49h | UTC

WHO pledges extensive commitments towards women’s empowerment and health – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCT: Cardiovascular and renal outcomes with Efpeglenatide (a GLP-1 receptor agonist) in Type 2 Diabetes.

7 Jul, 2021 | 08:45h | UTC

Cardiovascular and Renal Outcomes with Efpeglenatide in Type 2 Diabetes – New England Journal of Medicine

Commentary: Efpeglenatide Cuts Risk of CV Events and Kidney Disease in High-Risk T2D Patients, Regardless of SGLT2 Status – AJMC

 

New WHO recommendations for screening to prevent cervical cancer – the new guideline recommends an HPV DNA based test every 5 years as the preferred method, rather than visual inspection with acetic acid (VIA) or cytology (Pap smear).

7 Jul, 2021 | 08:51h | UTC

News release: New recommendations for screening and treatment to prevent cervical cancer – World Health Organization

See guidance: WHO guideline for screening and treatment of cervical pre-cancer lesions for cervical cancer prevention – World Health Organization

 

Commentary on Twitter (thread – click for more)

 

RCT: Daratumumab-based treatment for immunoglobulin light-chain amyloidosis.

7 Jul, 2021 | 08:44h | UTC

Daratumumab-Based Treatment for Immunoglobulin Light-Chain Amyloidosis – New England Journal of Medicine

 

RCT: An antibiotic-prescribing feedback to high-volume primary care physicians led to significant reductions in total and prolonged-duration antibiotic prescriptions, as well as drug costs.

7 Jul, 2021 | 08:47h | UTC

Effect of Antibiotic-Prescribing Feedback to High-Volume Primary Care Physicians on Number of Antibiotic Prescriptions: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)

Commentary: Studies highlight impact of clinician feedback on antibiotic prescribing – CIDRAP

 

Commentary on Twitter (thread – click for more)

 

RCT: Pectoral nerve blocks for breast augmentation surgery.

7 Jul, 2021 | 08:41h | UTC

Pectoral Nerve Blocks for Breast Augmentation Surgery: A Randomized, Double-blind, Dual-centered Controlled Trial – Anesthesiology (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Similar long-term survival after combined epidural–general anesthesia vs. general anesthesia alone.

7 Jul, 2021 | 08:39h | UTC

Long-term Survival after Combined Epidural–General Anesthesia or General Anesthesia Alone: Follow-up of a Randomized Trial – Anesthesiology

See also: Delirium in Older Patients after Combined Epidural–General Anesthesia or General Anesthesia for Major Surgery: A Randomized Trial – Anesthesiology

 

Commentary on Twitter

 

A critical review on altmetrics: can we measure the social impact factor?

7 Jul, 2021 | 08:42h | UTC

A critical review on altmetrics: can we measure the social impact factor? – Insights into Imaging

Related: Altmetric Score Has a Stronger Relationship With Article Citations Than Journal Impact Factor and Open Access Status: A Cross-Sectional Analysis of 4,022 Sports Science Articles – Journal of Orthopaedic & Sports Physical Therapy (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: A prevention program for insomnia in at-risk adolescents.

7 Jul, 2021 | 08:38h | UTC

A Prevention Program for Insomnia in At-risk Adolescents: A Randomized Controlled Study – Pediatrics (link to abstract – $ for full-text)

Commentaries: Using a program to combat teen insomnia – Contemporary Pediatrics AND Cognitive behavioral program may prevent insomnia in at-risk adolescents – Medicom

 

Opinion | Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality.

6 Jul, 2021 | 10:18h | UTC

Fractionation of COVID-19 vaccine doses could extend limited supplies and reduce mortality – Nature Medicine

 

Commentary on Twitter

 

RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.

6 Jul, 2021 | 10:16h | UTC

Ivermectin to prevent hospitalizations in patients with COVID-19 (IVERCOR-COVID19) a randomized, double-blind, placebo-controlled trial – BMC Infectious Diseases

Commentary: Ivermectin: balance of evidence shows no significant benefit against Covid-19 – MSN News

Related: Ivermectin for the treatment of COVID-19: A systematic review and meta-analysis of randomized controlled trials – “IVM did not reduce all-cause mortality, length of stay or viral clearance in RCTs in COVID-19 patients with mostly mild disease”. AND Ivermectin is the new hydroxychloroquine, take 2 – “Ivermectin shouldn’t be used to treat COVID-19 outside of the context of a well-designed clinical trial”. AND Therapeutics and COVID-19 | WHO guideline update advises Ivermectin should only be used to treat COVID-19 within clinical trials AND RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19

 

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians.

6 Jul, 2021 | 10:21h | UTC

Choosing Wisely for COVID-19: ten evidence-based recommendations for patients and physicians – Nature Medicine

 

M-A: Incidence and Relapse of Idiopathic Nephrotic Syndrome.

7 Jul, 2021 | 08:37h | UTC

Incidence and Relapse of Idiopathic Nephrotic Syndrome: Meta-analysis – Pediatrics (link to abstract – $ for full-text)

 

Editorial | Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions.

6 Jul, 2021 | 10:14h | UTC

Do not just sit there, do something … but do no harm: the worrying aspects of COVID-19 experimental interventions – Intensive Care Medicine

 

Commentary on Twitter

 

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