Archives
Benefits of mRNA COVID vaccines outweigh rare heart risks, says WHO.
12 Jul, 2021 | 03:02h | UTCBenefits of mRNA COVID vaccines outweigh rare heart risks, says WHO – Reuters
See also: EU finds potential link between heart inflammation and mRNA COVID shots – Reuters AND Heart inflammation link to Pfizer and Moderna jabs – BBC
Ranitidine absolved? FDA study finds Ranitidine does not convert to carcinogen NDMA, regardless of diet.
12 Jul, 2021 | 01:36h | UTCEditorial: Ranitidine and Risk of N-Nitrosodimethylamine (NDMA) Formation
Commentary: Ranitidine: FDA finds no evidence of elevated NDMA, regardless of diet
Commentaries on Twitter
Despite ranitidine (zantac) being pulled from market last year, a new study from the FDA did not find evidence that it increases concentrations of the carcinogenic metabolite people were worried about (i.e., it's probably safe). From @JAMA_current https://t.co/AdRic2GdXS
— Zack Williams, PhD (@QuantPsychiatry) June 28, 2021
In this crossover, randomized clinical trial, oral ranitidine did not significantly increase 24-hour urinary excretion of NDMA when administered with a noncured-meats diet or a cured-meats diet. https://t.co/EszRvfJOFJ
— JAMA (@JAMA_current) June 28, 2021
AHA Scientific Statement: Assessing and Addressing Cardiovascular Health in People Who Are Transgender and Gender Diverse.
12 Jul, 2021 | 01:43h | UTCNews release: Discrimination, stress linked to poorer heart health in transgender, gender diverse adults – American Heart Association
Clinical Practice Guideline for Postoperative Rehabilitation in Older Patients With Hip Fractures.
12 Jul, 2021 | 01:39h | UTCRelated: Guideline for the perioperative management of hip fractures 2020
Review: Lipoprotein(a) and cardiovascular diseases.
12 Jul, 2021 | 01:33h | UTCLipoprotein(a) and Cardiovascular Diseases – JAMA (free for a limited period)
Review: Diagnosis and Management of Infertility.
12 Jul, 2021 | 01:34h | UTCDiagnosis and Management of Infertility: A Review – JAMA (free for a limited period)
Commentary on Twitter
Although success rates vary by age and diagnosis, accurate diagnosis and effective therapy along with shared decision-making can facilitate achievement of fertility goals in many couples treated for #infertility https://t.co/7nR0nuFC3K
— JAMA (@JAMA_current) July 9, 2021
RCT: Another study shows that non-antibiotic outpatient treatment in mild acute diverticulitis is safe.
12 Jul, 2021 | 01:29h | UTCEfficacy and Safety of Non-Antibiotic Outpatient Treatment in Mild Acute Diverticulitis (DINAMO-study): A Multicentre, Randomised, Open-Label, Non-Inferiority Trial – Annals of Surgery (link to abstract – $ for full-text)
Related: State of the Art Review: Management of colonic diverticulitis AND Treatment of Uncomplicated Acute Diverticulitis Without Antibiotics: A Systematic Review and Meta-analysis – Diseases of the Colon & Rectum AND Antibiotics Do Not Reduce Length of Hospital Stay for Uncomplicated Diverticulitis in a Pragmatic Double-Blind Randomized Trial – Clinical Gastroenterology and Hepatology AND Randomized Trial: Antibiotic Avoidance Associated with Similar Long-term Outcomes in Uncomplicated Diverticulitis
Commentary on Twitter
Another (final?) nail in the coffin for antibiotics in uncomplicated diverticulitis? DINAMO study from Spain – Outpatient treatment with antibiotics versus symptomatic Tx.
No difference in hospitalization rate or revisits to ER.https://t.co/wOc3tBGfxr @AnnalsofSurgery
— Ville Sallinen (@villesallinen) July 9, 2021
Landmark research integrity survey finds questionable practices are surprisingly common.
12 Jul, 2021 | 01:32h | UTCLandmark research integrity survey finds questionable practices are surprisingly common – Science (a few articles per month are free)
Original studies (preprint): Prevalence of questionable research practices, research misconduct and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv AND Prevalence of responsible research practices and their potential explanatory factors: a survey among academic researchers in The Netherlands – MetaArXiv
Related: Opinion | Time to assume that health research is fraudulent until proven otherwise?
Editorial: Aducanumab for Alzheimer’s disease?
12 Jul, 2021 | 01:15h | UTCAducanumab for Alzheimer’s disease? – The BMJ
Related: FDA approvement of Alzheimer’s drug sparks controversy among doctors.
Commentary on Twitter
Our editorial for @bmj_latest on the controversial #Aducanumab approval and what it means for patients, clinicians and researchers.
With @seb_walsh, Richard Milne @ethicsWCS, Carol Brayne @CamPubHealth https://t.co/mnhh4F1gKK— Richard Merrick (@r_merrick) July 9, 2021
RCT: Traditional plaster casting immobilization not superior to removable brace in adults with an ankle fracture.
12 Jul, 2021 | 01:22h | UTCNews release: Cast no better than brace for broken ankles – University of Warwick
Review: most common joint procedures not backed by high quality evidence – “Urgent need exists to prioritize research into common orthopedic interventions”.
12 Jul, 2021 | 01:26h | UTCNews release: Most common joint procedures not backed by high quality evidence – The BMJ
Original study: Common elective orthopaedic procedures and their clinical effectiveness: umbrella review of level 1 evidence – The BMJ
Commentary on Twitter
This review of the 10 most common elective orthopaedic procedures suggests that most of these procedures recommended by national guidelines and used by surgeons have insufficient readily available, high quality evidence on their clinical effectivenesshttps://t.co/63B7XEXeyh
— The BMJ (@bmj_latest) July 10, 2021
RCT: CoronaVac showed efficacy of 83.5% for preventing symptomatic SARS-CoV-2 infection.
9 Jul, 2021 | 10:22h | UTCInvited commentary: CoronaVac: more data for regulators and policy makers
Commentary on Twitter
NEW—Interim analysis from phase 3 trial suggests efficacy of 2 doses of #CoronaVac is 83.5% against symptomatic #COVID19. More research is needed to confirm efficacy in the long term, in a more diverse group, and against emerging #variants of concern.
🔗 https://t.co/TN5b6wwclc pic.twitter.com/4zOvJFIIOH
— The Lancet (@TheLancet) July 8, 2021
Recommendations for including or reviewing patient reported outcome endpoints in grant applications.
12 Jul, 2021 | 01:12h | UTC
Viewpoint | 7-1-7: an organizing principle, target, and accountability metric to make the world safer from pandemics.
9 Jul, 2021 | 10:21h | UTC
Commentary on Twitter
#COVID19 makes it possible and necessary to review lessons learnt and develop a framework to prepare for future epidemics, writes Thomas Frieden et al.
In this Viewpoint, they propose a 7-1-7 target for outbreak detection, notification, and response: https://t.co/TACjUplpmF pic.twitter.com/4uaxxgxJq2
— The Lancet (@TheLancet) July 7, 2021
Consensus Statement: Guidance for health care leaders during the recovery stage of the COVID-19 pandemic.
9 Jul, 2021 | 10:20h | UTCCommentary: Experts issue pandemic-recovery guidance for health leaders – CIDRAP
Commentary on Twitter
32 experts in healthcare, health leadership, and public health from 17 countries collaborated to create a novel evidence- and expertise-informed framework of leadership imperatives during the recovery stage of the #COVID19 pandemic https://t.co/3gDKZIERBv
— JAMA Network Open (@JAMANetworkOpen) July 8, 2021
Reduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization.
9 Jul, 2021 | 10:16h | UTCReduced sensitivity of SARS-CoV-2 variant Delta to antibody neutralization – Nature
Commentaries: Study highlights need for full Covid vaccination to protect against Delta variant – STAT AND How does the Delta variant dodge the immune system? Scientists find clues. – The New York Times
Commentary on Twitter (thread – click for more)
Just published @Nature
Delta variant protection by mRNA and AZ vaccines requires 2-doses, little neutralizing antibody (nAb) with 1-dose, and insufficient nAb with prior covidhttps://t.co/TOgJdMe0g6 pic.twitter.com/KWLb9rBZ44— Eric Topol (@EricTopol) July 8, 2021
CDC: Use of mRNA COVID-19 vaccine after reports of myocarditis among vaccine recipients – “Continued use of mRNA COVID-19 vaccines in all recommended age groups will prevent morbidity and mortality from COVID-19 that far exceed the number of cases of myocarditis expected”.
9 Jul, 2021 | 10:17h | UTC
Commentary on Twitter
In a new @CDCMMWR, the Advisory Committee on Immunization Practices recommends everyone 12 & older get a #COVID19 vaccine. The benefits of vaccination in preventing illness & death outweigh the rare risk of heart inflammation after vaccination. More: https://t.co/iPjbhU5jeV. pic.twitter.com/IggrZ4DX7L
— CDC (@CDCgov) July 6, 2021
After the pandemic: perspectives on the future trajectory of COVID-19.
9 Jul, 2021 | 10:18h | UTCAfter the pandemic: perspectives on the future trajectory of COVID-19 – Nature
Perspective | “‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality”.
9 Jul, 2021 | 10:13h | UTC‘Too good to be true’: Doubts swirl around trial that saw 77% reduction in COVID-19 mortality – Science (a few articles per month are free)
Will COVID become a disease of the young? – “A growing share of infections among unvaccinated youths in countries with high vaccination rates is putting the spotlight on the role of young people in the pandemic”.
9 Jul, 2021 | 10:14h | UTCWill COVID become a disease of the young? – Nature
AHA Scientific Statement: Diagnosis and Management of Myocarditis in Children.
9 Jul, 2021 | 10:10h | UTCNews release: Viruses are the most common cause of myocarditis in children, experts offer guidance – American Heart Association
Top Things to Know: Diagnosis and Management of Myocarditis in Children
2021 ACR Guideline for the Management of ANCA–Associated Vasculitis.
9 Jul, 2021 | 10:09h | UTC
WHO: Countries urged to reopen with caution as world surpasses four million COVID deaths.
9 Jul, 2021 | 10:12h | UTCSee also: WHO: World at perilous point in pandemic – CIDRAP
Related commentary on Twitter (thread – click for more)
I’m struggling with how best to stress how fragile the global situation is, so I’ll be blunt:
Each week >2.6 million cases and >53,000 deaths are reported to @WHO
Reported, meaning that there are many others.
Stop and think about that.
(Short thread⬇️) pic.twitter.com/OyQK98DkjR
— Maria Van Kerkhove (@mvankerkhove) July 6, 2021
M-A: Acid suppression medications during hospitalization is a risk factor for recurrence of Clostridioides difficile infection.
9 Jul, 2021 | 09:59h | UTC
RCT: MRI can cut overdiagnoses in prostate-cancer screening by half.
9 Jul, 2021 | 10:03h | UTCMRI-Targeted or Standard Biopsy in Prostate Cancer Screening – New England Journal of Medicine (link to abstract – $ for full-text)
News release: MRI can cut overdiagnoses in prostate-cancer screening by half – Karolinska Institutet
Related articles: RCT: MRI-targeted biopsy safely reduces the need for biopsy in more than one-third of men at risk for prostate cancer AND Meta-Analysis: Negative Predictive Value of MRI in the Detection of Clinically Significant Prostate Cancer AND Study: MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis AND Review: The Use of MRI and PET Imaging Studies for Prostate Cancer Management AND Meta-Analysis: MRI plus Targeted Biopsy vs. Systematic Biopsy Alone for the Diagnosis of Prostate Cancer AND Cochrane Review: MRI Pathway vs. Systematic Biopsy for Detecting Prostate Cancer AND Meta-analysis: Clinical Utility of MRI in the Decision-making Process Before Radical Prostatectomy AND Research: Biparametric MRI (simpler, faster) May Be Used to Exclude Aggressive Disease and Avoid Unnecessary Biopsies in Men with Clinical Suspicion of Prostate Cancer AND Research: MRI-Targeted or Standard Biopsy for Prostate-Cancer Diagnosis AND Multiparametric MRI in the Detection of Clinically Significant Prostate Cancer