Archives
The Lancet Series: Interstitial Lung Disease 2021.
7 Sep, 2021 | 21:37h | UTCHomepage: Interstitial Lung Disease 2021 (free registration required for all articles)
Early diagnosis of fibrotic interstitial lung disease: challenges and opportunities
Treatment of fibrotic interstitial lung disease: current approaches and future directions
Interstitial lung diseases: quo vadis?
Moving beyond usual interstitial pneumonia to define progressive fibrotic interstitial lung disease
Commentary on Twitter (thread – click for more)
🆕 The term interstitial lung disease (ILD) refers to a diverse group of inflammatory & fibrotic conditions—with fibrotic ILD being a disease subset that constitutes a major global health problem.
Read the new @TheLancet & @LancetRespirMed Series. https://t.co/zV2Vw2l4rV pic.twitter.com/AqAe4GUlmr
— The Lancet (@TheLancet) September 7, 2021
Isn’t it time to abandon ARDS? The COVID-19 lesson.
7 Sep, 2021 | 21:34h | UTCIsn’t it time to abandon ARDS? The COVID-19 lesson – Critical Care
Commentary on Twitter
#CritCare #OA #Gattinoni & #Marini: Keeping or abandoning #ARDS?
▶️ pros
▶️ conshttps://t.co/tIhusXT2S7#FOAMed #FOAMcc #BMC #COVID19 #Rx #RCT #PEEP #respiratory_failure #Personalized pic.twitter.com/M6aoiSAn3m— Critical Care (@Crit_Care) September 7, 2021
Extended intervals and extra doses of the AstraZeneca vaccine are associated with increased immunogenicity.
7 Sep, 2021 | 10:56h | UTCInvited commentary: Longer intervals and extra doses of ChAdOx1 nCoV-19 vaccine
Commentaries on Twitter
(thread – click for more)
Substudy suggests extended interval (up to 45 wks) before 2nd dose of ChAdOx1 nCoV-19 leads to increased antibody titres, offering more flexibility in vaccine schedules.
Extended interval before 3rd dose resulted in further increase in immune responses. https://t.co/J3xOwSSYMN pic.twitter.com/8GotDI4ctS
— The Lancet (@TheLancet) September 2, 2021
(thread – click for more)
New @TheLancet
The heightened immune response to longer spacing @AstraZeneca 1st -> 2nd vaccine doses and the response 3rd booster dose, with high neutralizing antibodies and T cellshttps://t.co/A2UcPVIFYP pic.twitter.com/zfYaW0T8Yf— Eric Topol (@EricTopol) September 1, 2021
Opinion | Liquid biopsy: misplaced faith in early cancer detection?
7 Sep, 2021 | 21:30h | UTCLiquid biopsy: misplaced faith in early cancer detection? – STAT
Commentary on Twitter
Opinion: "The real money isn’t in testing the relatively few people with advanced cancer, it’s in testing everyone else: those not known to have cancer." Screening liquid biopsies could become standard care before we know if they save lives https://t.co/1IAo5Kb0vm via @statnews
— Gideon Gil (@GideonGil) August 31, 2021
Defining pediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement.
7 Sep, 2021 | 21:26h | UTCDefining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statement – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New Viewpoint – Eslam et al – Defining paediatric metabolic (dysfunction)-associated fatty liver disease: an international expert consensus statementhttps://t.co/YIW0DL7u5O#NAFLD #MAFLD #fattyliver #LiverTwitter @eslamm1222 pic.twitter.com/2AIHksqIgj
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) August 6, 2021
Antibiotics use is linked to increased risk of subsequent colorectal cancer.
7 Sep, 2021 | 21:25h | UTCCommentaries:
Antibiotics linked to increased risk of colon cancer – Umea University
Study links antibiotics use and increased subsequent risk of colorectal cancer – MedicalResearch.com
[Preprint] Large cohort study in Brazil showed AstraZeneca vaccine had high overall effectiveness against severe disease to individuals up to 89 years of age. In comparison, CoronaVac had high overall effectiveness against severe disease in individuals up to 79 years.
7 Sep, 2021 | 10:54h | UTC
Annual Update in Intensive Care and Emergency Medicine 2021 – Covid articles.
7 Sep, 2021 | 10:50h | UTCSecondary infections in critically ill patients with COVID-19
Tracheostomy for COVID-19: evolving best practice
See also: Non-Covid articles
Case series: COVID-19 mRNA vaccination leading to CNS inflammation.
7 Sep, 2021 | 10:49h | UTCCOVID-19 mRNA vaccination leading to CNS inflammation: a case series – Journal of Neurology
Opinion | Video: Immunity is the only way through a pandemic (w/Dr. Monica Gandhi).
7 Sep, 2021 | 10:45h | UTCImmunity Is The Only Way Through A Pandemic (w/Dr. Monica Gandhi) – ZDoggMD
CDC report: Hospitalization rates for Covid-19 were 10 times higher among unvaccinated than among fully vaccinated adolescents.
7 Sep, 2021 | 10:52h | UTCCommentaries:
More kids hospitalized with Covid-19 in states with lower vaccination rates, CDC report finds – CNN
Child COVID hospital cases up in low-vaccination states – CIDRAP
Commentary on Twitter
From late June to mid-August, there was a 10x increase in the rate of hospitalizations among children ages 0-4 with #COVID19 while the #DeltaVariant was widely circulating. It is critical for children to #maskup and get vaccinated if eligible. Learn more: https://t.co/aHC1vYdKVG. pic.twitter.com/uUeNPG6d5r
— CDC (@CDCgov) September 3, 2021
[Not published yet] Sinovac booster shot reverses drop in antibody activities against Delta-study.
7 Sep, 2021 | 10:47h | UTCSinovac booster shot reverses drop in antibody activities against Delta-study – Reuters
Commentary on Twitter
A booster dose of Sinovac Biotech's COVID-19 vaccine reversed a decline in antibody activities against the Delta variant, a study showed, easing some concerns about its longer-term immune response to the highly contagious strain of the virus. https://t.co/QdmMYVBrvl
— Reuters Health (@Reuters_Health) September 6, 2021
Medical, ethical, and legal aspects of end-of-life dilemmas in the intensive care unit.
7 Sep, 2021 | 10:37h | UTC
Cohort study: Serum markers of brain injury can predict good neurological outcome after out-of-hospital cardiac arrest.
7 Sep, 2021 | 10:41h | UTC
Commentary on Twitter
Established/novel blood brain injury markers early predict good neuro-outcome/absence of pathological prognostic findings post CA
🧠NSE/S100B may prevent premature WLST
🧠NFL highest predictive capacity
Here visual abstract, full results #FOAMcc @yourICM https://t.co/3klcew33bD pic.twitter.com/1agsFCw6RF— Intensive Care Medicine (@yourICM) September 4, 2021
Tube feeding for people with severe dementia: making decisions.
7 Sep, 2021 | 10:39h | UTCTube feeding for people with severe dementia: making decisions – Evidently Cochrane
Annual Update in Intensive Care and Emergency Medicine 2021 – Non-Covid articles.
7 Sep, 2021 | 10:43h | UTCAdvanced management of intermediate-high risk pulmonary embolism
Pathophysiology and clinical implications of the veno-arterial PCO2 gap
To prone or not to prone ARDS patients on ECMO
Management of acute metabolic acidosis in the ICU: sodium bicarbonate and renal replacement therapy
Acute kidney injury in ECMO patients
Still a place for aortic counterpulsation in cardiac surgery and patients with cardiogenic shock?
See also: Covid articles
ESPEN practical guideline: Clinical nutrition in chronic intestinal failure.
7 Sep, 2021 | 10:32h | UTCESPEN practical guideline: Clinical nutrition in chronic intestinal failure – Clinical Nutrition
Podcast: Febrile Infants (based on the new AAP Guideline).
7 Sep, 2021 | 10:31h | UTC#33: Febrile Infants – When Babies Are Too Hot – The Cribsiders
Original guideline:
AAP Guideline: Evaluation and management of well-appearing febrile infants 8 to 60 days old.
Commentaries:
Landmark Febrile Neonate, Febrile Infant Guideline from the AAP – JournalFeed
Small Talk – Hot Off The Presses: The Latest AAP Guidelines for the Febrile Neonate – emDocs
Related:
Things We Do for No Reason: Lumbar Punctures in Low-Risk Febrile Infants with Bronchiolitis
Care of the adult cancer patient at the end of life: ESMO Clinical Practice Guidelines.
7 Sep, 2021 | 10:34h | UTCCare of the adult cancer patient at the end of life: ESMO Clinical Practice Guidelines – ESMO Open
More data showing increased risk of hospitalization with SARS-CoV-2 delta variant.
6 Sep, 2021 | 11:12h | UTCHospitalisation associated with SARS-CoV-2 delta variant in Denmark – The Lancet Infectious Diseases
Podcast: The Best of Liver Tests.
7 Sep, 2021 | 10:29h | UTC#293 The Best of Liver Tests with Dr. Elliot Tapper – The Curbsiders
The resurgence of SARS-CoV-2 infection in a highly vaccinated health system workforce; vaccine effectiveness against infection was reduced from above 90% from March through June to 65% in July.
6 Sep, 2021 | 11:09h | UTCRelated:
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Commentary on Twitter (thread – click for more)
💥 NEW DATA💥
1/ "Resurgence of SARS-CoV-2 Infection in a Highly Vaccinated Health System Workforce" published today in @NEJM details ↓ in vaccine effectiveness against INFECTION among @UCSDHealth employees – from 95%+ in the spring to 65% in July
👉🏽 https://t.co/wMgjoLgJzS pic.twitter.com/lgOwlEqUQG
— Christopher A. Longhurst, MD (@CALonghurst) September 1, 2021
RCT: Early treatment of COVID-19 with anakinra guided by soluble urokinase plasminogen receptor plasma levels.
6 Sep, 2021 | 11:11h | UTC
Commentary on Twitter
The SAVE-MORE phase 3 study demonstrates the efficacy of anakinra, an IL-1α/β inhibitor, in patients with COVID-19 and high serum levels of soluble plasminogen activator receptor, according to a @NatureMedicine paper. https://t.co/aM5teLMipK pic.twitter.com/bTVNqbBOcv
— Nature Portfolio (@NaturePortfolio) September 3, 2021
Large surveillance study finds severe adverse events after COVID-19 mRNA vaccination are rare.
6 Sep, 2021 | 11:02h | UTCSurveillance for Adverse Events After COVID-19 mRNA Vaccination – JAMA
Editorial: Safety Surveillance of COVID-19 mRNA Vaccines Through the Vaccine Safety Datalink – JAMA
Commentaries:
mRNA COVID vaccines not tied to serious side effects – CIDRAP
Researchers find no serious health effects linked to mRNA COVID-19 vaccines – News Medical
Commentary on Twitter
Concerned about the safety of mRNA vaccines? This study of 6.2 million people who got 11.8 million doses is immensely reassuring. https://t.co/nUIqTacl0g pic.twitter.com/JBvenRVrRc
— David Juurlink (@DavidJuurlink) September 4, 2021
Systematic review: evaluation of dietary patterns and all-cause mortality.
6 Sep, 2021 | 10:43h | UTCEvaluation of Dietary Patterns and All-Cause Mortality: A Systematic Review – JAMA Network Open
Commentary on Twitter (thread – click for more)
Great to see work focused on diet patterns (rather than single nutrient/foods)
Nutrient-dense diet patterns, regardless of pattern label/name (Med Diet, DASH, HEI, "plant-based"), were associated with significantly lower risk of death
Commonalities?👇https://t.co/yQxo4lNJNQ
— Stephan van Vliet (@vanvlietphd) September 1, 2021


