Archives
[Preprint] RCT: Additional heterologous vs. homologous booster vaccination in immunosuppressed patients without SARS-CoV-2 antibody seroconversion after primary mRNA vaccination.
9 Sep, 2021 | 09:55h | UTC
Commentary on Twitter (thread – click for more)
https://twitter.com/hildabast/status/1435720202147143680
AstraZeneca bosses warn against rush for boosters – “giving the most vulnerable, who may not have built up a full immune response from the first two, a third, top-up dose is “sensible”. But any decision to give a third, booster jab “to large swathes of the population”, to extend their protection from the first two, must be based on clinical data”.
9 Sep, 2021 | 09:59h | UTCAstraZeneca bosses warn against rush for boosters – BBC
Commentary on Twitter (thread – click for more)
"Moving too quickly to boost across the entire adult population will deprive us of these insights, leaving this important decision to rest on limited data," Mr Soriot and Sir Mene write.https://t.co/xTAk7yyu5G
— The Sharing Scientist (@ScienceShared) September 8, 2021
WHO appeals for countries to postpone COVID-19 vaccine boosters until 2022 to prioritize vaccinating the most at-risk people around the world who are yet to receive their first dose.
9 Sep, 2021 | 10:00h | UTCSee also:
WHO chief urges halt to booster shots for rest of the year – Associated Press
WHO extends moratorium on booster COVID vaccine doses – CIDRAP
Perspective | The plan to stop every respiratory virus at once – “The benefits of ventilation reach far beyond the coronavirus. What if we stop taking colds and flus for granted, too?”
9 Sep, 2021 | 09:54h | UTCThe Plan to Stop Every Respiratory Virus at Once – The Atlantic
Related:
Recommendations for ventilation of indoor spaces to reduce COVID-19 transmission.
We studied how to reduce airborne COVID spread in hospitals. Here’s what we learnt.
WHO: Roadmap to improve and ensure good indoor ventilation in the context of COVID-19
CDC releases new ventilation guidelines for indoor environments to reduce Covid-19 risk
Balancing incentives and disincentives for vaccination in a pandemic.
9 Sep, 2021 | 09:52h | UTCBalancing incentives and disincentives for vaccination in a pandemic – Nature Medicine
A large observational study suggests eating a plant-rich diet could reduce the risk of developing severe COVID-19.
9 Sep, 2021 | 09:51h | UTCEating a plant rich diet reduces risk of developing COVID-19 – King’s College London
Original study: Diet quality and risk and severity of COVID-19: a prospective cohort study – Gut
Emoji are proposed as a powerful way for patients and doctors to communicate.
9 Sep, 2021 | 09:06h | UTCOriginal article: Emoji for the Medical Community—Challenges and Opportunities – JAMA (free for a limited period)
Commentary on Twitter (thread – click for more)
1/ Our @JAMA_current paper is out today describing the need for Emojis in Medicine.
A thread.
It might seem silly at first, but here’s why it's important. At the core of what we do as doctors is listen to patients, so we can care and treat for them. https://t.co/I1zEBsPcWv— Shuhan He 🫀🫁 (@shuhanhemd) September 7, 2021
The Lancet Series: Out-of-hospital cardiac arrest 2021.
9 Sep, 2021 | 09:07h | UTCHomepage: Out-of-hospital cardiac arrest 2021 (free registration required for both articles)
Cardiopulmonary resuscitation in special circumstances
Brain injury after cardiac arrest
Commentary on Twitter (thread – click for more)
Early recognition and response to cardiac arrest are crucial.
This Series of two papers extends previous reviews published in The Lancet. Out-of-hospital cardiac arrest 2021: https://t.co/AdZsriZFxx pic.twitter.com/mlwyCzayPn
— The Lancet (@TheLancet) September 8, 2021
RCT: A Seven-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales was noninferior to a 14-days course.
9 Sep, 2021 | 09:03h | UTC
Commentary on Twitter
SHORTEN RCT 🔥🔥🔥@CMIJournal
Seven versus 14-days course of antibiotics for the treatment of bloodstream infections by Enterobacterales
7-day course of antibiotics as the preferential treatment for eBSI, as long as the source is properly controlled https://t.co/pyaOMl52us pic.twitter.com/wK1sgeMe36— Antibiotic Steward Bassam Ghanem 🅱️C🆔🅿️🌟 (@ABsteward) September 8, 2021
Editorial | Anticholinergic drugs and dementia: time for transparency in the face of uncertainty.
9 Sep, 2021 | 08:57h | UTCSystematic review: Anticholinergic burden (prognostic factor) for prediction of dementia or cognitive decline in older adults with no known cognitive syndrome – Cochrane Library
Commentary on Twitter
Anticholinergic drugs may double the risk of developing dementia. What should we be doing right now?
Editorial with @JenMStevenson for @CochraneLibrary published todayhttps://t.co/808wSGPUtm— Henry Woodford (@woodford_henry) September 8, 2021
RCT: No benefit from Cyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis.
9 Sep, 2021 | 08:59h | UTCCyclophosphamide added to glucocorticoids in acute exacerbation of idiopathic pulmonary fibrosis (EXAFIP): a randomised, double-blind, placebo-controlled, phase 3 trial – The Lancet Respiratory Medicine (link to abstract – $ for full-text)
Review: Management of severe traumatic brain injury in regions with limited resources.
9 Sep, 2021 | 08:56h | UTCManagement of severe traumatic brain injury in regions with limited resources – Brain Injury
Perspective | Rethinking medication adherence.
9 Sep, 2021 | 08:55h | UTCRethinking Medication Adherence – Therapeutics Initiative
Review: Heart failure with mid-range or mildly reduced ejection fraction.
9 Sep, 2021 | 08:52h | UTCHeart failure with mid-range or mildly reduced ejection fraction – Nature Reviews Cardiology (free for a limited period)
Commentary on Twitter
In a new Review, Lars Lund et al. discuss the epidemiology, clinical profile, prognosis and potential treatment of patients with #HeartFailure with mid-range or mildly reduced ejection fraction (HFmrEF) https://t.co/npDGByESCj pic.twitter.com/dWcRZLJGHW
— Nature Reviews Cardiology (@NatRevCardiol) September 8, 2021
Spread of Delta SARS-CoV-2 variant driven by a combination of immune escape and increased infectivity.
7 Sep, 2021 | 21:49h | UTCOriginal article: SARS-CoV-2 B.1.617.2 Delta variant replication and immune evasion – Nature
Radiation‐induced cardiovascular disease: review of an underrecognized pathology.
9 Sep, 2021 | 08:54h | UTC
Pancreatic Cancer: A Review.
9 Sep, 2021 | 08:51h | UTCPancreatic Cancer: A Review – JAMA (free for a limited period)
Cochrane review: evidence is insufficient to draw meaningful conclusions if SARS‐CoV‐2-specific monoclonal antibodies are effective in the treatment of COVID-19.
7 Sep, 2021 | 21:51h | UTCOriginal review: SARS‐CoV‐2‐neutralising monoclonal antibodies for treatment of COVID‐19 – Cochrane Library
Chile authorizes Sinovac vaccine for kids of 6 and older.
7 Sep, 2021 | 21:45h | UTCChile authorizes Sinovac vaccine for kids of 6 and older – Associated Press
Kids and COVID: why young immune systems are still on top.
7 Sep, 2021 | 21:46h | UTCKids and COVID: why young immune systems are still on top – Nature
Study shows high effectiveness of the Pfizer mRNA COVID-19 vaccine in pregnancy.
7 Sep, 2021 | 21:48h | UTCEffectiveness of the BNT162b2 mRNA COVID-19 vaccine in pregnancy – Nature Medicine
Commentaries on Twitter
NEW: Estimated vaccine effectiveness in #pregnancy from 7 through to 56 d after second dose was 96% (95% CI; 89–100%) for any documented infection, 97% (91–100%) for infections with documented symptoms & 89% (43–100%) for #COVID19-related hospitalization. https://t.co/bm950wUWGL
— All Source Pregnancy (@PregnancyAll) September 7, 2021
The Pfizer-BioNTech mRNA COVID-19 vaccine was estimated to have high vaccine effectiveness in pregnant women, which is similar to the effectiveness estimated in the general population, according to a @NatureMedicine paper. https://t.co/oz5zn7zNdq pic.twitter.com/9IP5ocxzXs
— Nature Portfolio (@NaturePortfolio) September 7, 2021
Recent cannabis use linked to increased risk of myocardial infarction in young adults: a cross-sectional study.
7 Sep, 2021 | 21:38h | UTCNews release: Recent cannabis use linked to heart attack risk in younger adults – Canadian Medical Association Journal
Commentary: Young adult cannabis consumers nearly twice as likely to suffer from a heart attack, research shows – CNN
[Preprint] M-A of 12.011.447 individuals finds individuals previously infected with SARS-CoV-2 had an 81% reduction in odds of a reinfection.
7 Sep, 2021 | 21:42h | UTC
Commentary on Twitter
A new systematic review of over 12 million people from 54 studies at up to 8 months following Covid. >90% prevalence of IgG antibodies, reinfection 0.2% (an 81% risk reduction) https://t.co/ljir4DV1zU ("did not examine evidence for immunity against the new variants") pic.twitter.com/pT7A2KA9FV
— Eric Topol (@EricTopol) September 7, 2021
AAP flu recommendations allow for coadministration with COVID-19 vaccine.
7 Sep, 2021 | 21:44h | UTCNews release: AAP flu recommendations allow for coadministration with COVID-19 vaccine – American Academy of Pediatrics
Technical report: Recommendations for Prevention and Control of Influenza in Children, 2021–2022 – American Academy of Pediatrics
Commentary on Twitter
The 2021-’22 @AmerAcadPeds flu policy emphasizes the importance of flu vaccination during the SARS-CoV-2 pandemic, allows for coadministration with COVID-19 vaccine. https://t.co/usLaO276Ku pic.twitter.com/EaL5vocxMm
— AAP News (@AAPNews) September 7, 2021
Supplement: Current Issues in Venous Thromboembolism.
7 Sep, 2021 | 21:36h | UTCHomepage: Current Issues in Venous Thromboembolism – Postgraduate Medicine
Editorial: Current issues in venous thromboembolism
A review of upper extremity deep vein thrombosis
Outpatient treatment of emergency department patients diagnosed with venous thromboembolism
Venous thromboembolism prophylaxis in high-risk orthopedic and cancer surgery
Prophylaxis and treatment of COVID-19 related venous thromboembolism
Challenges in the diagnostic approach of suspected pulmonary embolism in COVID-19 patients
Post-hospital discharge venous thromboembolism prophylaxis in medically ill patients
Radiologic mimics of pulmonary embolism
A comprehensive review of DOACs for cancer associated VTE prophylaxis or treatment