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Guideline: Nonpharmacological treatment of persistent postconcussion symptoms in adults.

10 Nov, 2021 | 07:07h | UTC

Nonpharmacological Treatment of Persistent Postconcussion Symptoms in Adults: A Systematic Review and Meta-analysis and Guideline Recommendation – JAMA Network Open

Invited commentary: Advances in Clinical Management of Persistent Postconcussion Symptoms—The Danish National Clinical Guideline – JAMA Network Open

Commentary on Twitter

Based on low certainty of evidence or based on consensus, new guideline provides recommendations for commonly applied non-pharmacological interventions to treat persistent post-concussion symptoms in adults. https://t.co/CM1pbMqRXN

— JAMA Network Open (@JAMANetworkOpen) November 9, 2021

Consensus Document: Non-invasive imaging in coronary syndromes.

10 Nov, 2021 | 07:11h | UTC

Non-invasive Imaging in Coronary Syndromes — Recommendations of the European Association of Cardiovascular Imaging and the American Society of Echocardiography, in Collaboration with the American Society of Nuclear Cardiology, Society of Cardiovascular Computed Tomography and Society for Cardiovascular Magnetic Resonance – European Heart Journal: Cardiovascular Imaging

Consensus Document: Multimodality imaging in patients with heart failure and preserved ejection fraction.

10 Nov, 2021 | 07:09h | UTC

Multimodality imaging in patients with heart failure and preserved ejection fraction: an expert consensus document of the European Association of Cardiovascular Imaging – European Heart Journal: Cardiovascular Imaging

RCT: One-time flexible sigmoidoscopy screening is associated with long-term reduction in colorectal cancer incidence and mortality.

10 Nov, 2021 | 07:04h | UTC

Long-Term Follow-up of the Italian Flexible Sigmoidoscopy Screening Trial – Annals of Internal Medicine

Commentaries:

Flexible sigmoidoscopy associated with long-term reduction in colorectal cancer incidence, mortality – ACP Internist

Flexible sigmoidoscopy screening associated with long-term reduction in colorectal cancer incidence and mortality – American College of Physicians

Review: Cardiogenic shock after acute myocardial infarction.

10 Nov, 2021 | 07:03h | UTC

Cardiogenic Shock After Acute Myocardial Infarction: A Review – JAMA (free for a limited period)

Perspective: Life lessons after a career in intensive care medicine.

10 Nov, 2021 | 06:54h | UTC

Life lessons after a career in intensive care medicine – Intensive Care Medicine

Commentary on Twitter

Reflections/lessons from a life in #ICU:
1⃣work with people you like/love
2⃣take sabbaticals to recharge
3⃣prioritize family = those you love most
4⃣live every day as having terminal disease: focus on what most important@JRandallCurtis1 #ICMfromtheInside https://t.co/X2GKXRM3rf pic.twitter.com/ytx1eMLkMW

— Intensive Care Medicine (@yourICM) November 8, 2021

Large observational study suggests prolactin-increasing antipsychotics are associated with increased risk of breast cancer (OR=1.56 for over 5 years of exposure); prolactin-sparing antipsychotics (including clozapine, quetiapine, or aripiprazole), on the other hand, were not associated with increased risk.

10 Nov, 2021 | 06:57h | UTC

Antipsychotic use and risk of breast cancer in women with schizophrenia: a nationwide nested case-control study in Finland – The Lancet Psychiatry (link to abstract – $ for full-text)

Commentary: Choosing between antipsychotics to reduce the risk of breast cancer in women with schizophrenia – The Mental Elf

Commentary on Twitter

Nested case-control study: ≥5 years exposure to prolactin-sparing APDs was not associated with an increased risk of breast cancer vs.<1 year exposure (aOR=1.19; 0.90–1.58). The opposite was observed with APDs that increase prolactin (aOR=1.56; 1.27–1.92) https://t.co/LwCVyTH051

— P𝘧OL (@psychopharmacol) September 12, 2021

M-A: Among patients with acute intracerebral hemorrhage, interventions to lower blood pressure within 7 days of the onset had no overall benefit on functional recovery, despite reducing bleeding.

10 Nov, 2021 | 06:55h | UTC

Early lowering of blood pressure after acute intracerebral haemorrhage: a systematic review and meta-analysis of individual patient data – Journal of Neurology, Neurosurgery & Psychiatry

Cohort study: In utero exposure to 17α-hydroxyprogesterone caproate linked to increased risk of cancer in offspring.

10 Nov, 2021 | 06:59h | UTC

In utero exposure to 17α-hydroxyprogesterone caproate and risk of cancer in offspring – American Journal of Obstetrics and Gynecology (link to abstract – $ for full-text)

Commentary: Drug used to prevent miscarriage increases risk of cancer in offspring – The University of Texas Health Science Center at Houston

Review: Uremic Encephalopathy.

10 Nov, 2021 | 06:49h | UTC

Uremic Encephalopathy – Kidney International

M-A: In adults with sepsis or septic shock, metabolic resuscitation with vitamin C, glucocorticoids, vitamin B1, or combinations of these drugs was not associated with decreased long-term mortality. Adding glucocorticoid to other treatments shortened the duration of vasopressor therapy and ICU stay.

10 Nov, 2021 | 06:52h | UTC

Effect of adjunctive vitamin C, glucocorticoids, and vitamin B1 on longer-term mortality in adults with sepsis or septic shock: a systematic review and a component network meta-analysis – Intensive Care Medicine

Sepsis treatment: Another trial shows no benefit from the combination of Vitamin C, Thiamine, and Hydrocortisone

The VITAMINS Randomized Clinical Trial: Vitamin C, Hydrocortisone, and Thiamine Not beneficial for Patients with Sepsis

Commentary on Twitter

Metabolic resuscitation in sepsis/septic shock with
💉vitamin C
💉glucocorticoids
💉vitamin B1
or their combinations not proven to⬇️long-term mortality.
NMA suggests association high dose/very high dose vit C & decreased mortality (low certainty).#FOAMcc https://t.co/tB2KKRjtzc pic.twitter.com/uns9rcmDbA

— Intensive Care Medicine (@yourICM) November 9, 2021

Practice Review: COVID-19 rapid diagnostics.

9 Nov, 2021 | 01:52h | UTC

COVID-19 rapid diagnostics: practice review – Emergency Medicine Journal

Provocative study suggests that persistent physical symptoms after COVID-19 infection may be associated more with the belief in having been infected with SARS-CoV-2 than with having laboratory-confirmed COVID-19 infection.

9 Nov, 2021 | 01:46h | UTC

Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Test Results With Persistent Physical Symptoms Among French Adults During the COVID-19 Pandemic – JAMA Internal Medicine

Author Interview: Association of Self-reported COVID-19 Infection and SARS-CoV-2 Serology Results With Persistent Physical Symptoms – JAMA Internal Medicine

Commentaries: Expert reaction to study looking at the association of self-reported COVID-19 infection and SARS-CoV-2 serology test results with persistent physical symptoms – Science Media Centre

Update to post-acute sequelae of SARS-CoV-2 infection: Caring for the ‘long-haulers’.

Systematic Review: Short-term and long-term rates of postacute sequelae of SARS-CoV-2 infection.

WHO Consensus: A clinical case definition of post COVID-19 condition (Long Covid).

Characterizing long COVID: a living systematic review.

Long Covid – The illness narratives.

New guidelines to help doctors manage long COVID patients published.

M-A: More than 50 long-term effects of COVID-19. (several articles on the subject)

Commentary on Twitter

Except for anosmia, persistent symptoms after COVID-19 may be more related to the belief of having had #COVID19 than to actual SARS-Co-V2 infection. Clinicians and researchers should also consider general mechanisms that may not be specific to #SARSCoV2 https://t.co/IdSh5GhdQ6

— JAMA Internal Medicine (@JAMAInternalMed) November 8, 2021

How protein-based COVID vaccines could change the pandemic.

9 Nov, 2021 | 01:41h | UTC

How protein-based COVID vaccines could change the pandemic – Nature

Review: Antineutrophil cytoplasmic antibody-associated interstitial lung disease.

10 Nov, 2021 | 06:46h | UTC

Antineutrophil cytoplasmic antibody-associated interstitial lung disease: a review – European Respiratory Review

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

9 Nov, 2021 | 01:43h | UTC

We can be confident there have been far more than 5 million global Covid deaths – The Guardian

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care.

9 Nov, 2021 | 01:44h | UTC

Regional lymphadenopathy following COVID-19 vaccination: Literature review and considerations for patient management in breast cancer care – European Journal of Cancer

2 Case Series and Guidance | Lymphadenopathy in COVID-19 Vaccine Recipients

Axillary lymphadenopathy at the time of COVID-19 vaccination: ten recommendations from the European Society of Breast Imaging.

Covid-19: Schedule breast screening before vaccine or 4 to 6 weeks after to avoid false positives, says guidance

Actions to transform USPSTF methods to mitigate systemic racism in clinical preventive services.

9 Nov, 2021 | 01:24h | UTC

Actions to Transform US Preventive Services Task Force Methods to Mitigate Systemic Racism in Clinical Preventive Services – JAMA

Commentary: USPSTF Proposes Strategies to Mitigate Racism in Preventive Care – HealthDay

Not all Covid waves look the same. Here’s a snapshot of the Delta surge.

9 Nov, 2021 | 01:28h | UTC

Not all Covid waves look the same. Here’s a snapshot of the Delta surge – STAT

Commentary on Twitter

If you know someone on the fence about vaccination, show them this https://t.co/ndPLhpLlh4 pic.twitter.com/L6RLwHyGCi

— David Juurlink (@DavidJuurlink) November 8, 2021