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Meta-analysis of randomized controlled trials: Drug treatment for panic disorder with or without agoraphobia.

20 Jan, 2022 | 09:06h | UTC

Drug treatment for panic disorder with or without agoraphobia: systematic review and network meta-analysis of randomised controlled trials – The BMJ

 


Study shows that the retinal age gap might be a potential biomarker of aging linked to increased mortality risk.

20 Jan, 2022 | 09:04h | UTC

Retinal age gap as a predictive biomarker for mortality risk – British Journal of Ophthalmology (link to abstract – $ for full-text)

News Release: Difference between retina’s biological age and person’s real age linked to heightened death risk – BMJ

 

Commentary on Twitter

 


Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update.

20 Jan, 2022 | 08:57h | UTC

Use of Adjuvant Bisphosphonates and Other Bone-Modifying Agents in Breast Cancer: ASCO-OH (CCO) Guideline Update – Journal of Clinical Oncology

 

Commentary on Twitter

 


Systematic Review: Prevalence, incidence and survival of heart failure.

20 Jan, 2022 | 09:00h | UTC

Prevalence, incidence and survival of heart failure: a systematic review – Heart

 


O-RADS MRI Risk Stratification System: Guide for Assessing Adnexal Lesions from the ACR O-RADS Committee.

20 Jan, 2022 | 08:59h | UTC

O-RADS MRI Risk Stratification System: Guide for Assessing Adnexal Lesions from the ACR O-RADS Committee – Radiology

 


Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis.

20 Jan, 2022 | 08:52h | UTC

Consensus recommendations on managing the selected comorbidities including cardiovascular disease, osteoporosis, and interstitial lung disease in rheumatoid arthritis – Medicine

 


Review: Evaluating the patient with a pulmonary nodule.

20 Jan, 2022 | 08:56h | UTC

Evaluating the Patient With a Pulmonary Nodule: A Review – JAMA (free for a limited period)

Author Interview: Evaluation and Management of Patients With Pulmonary Nodules

 


Consensus Statement: Exercise/physical activity in individuals with Type 2 Diabetes.

20 Jan, 2022 | 08:51h | UTC

Exercise/Physical Activity in Individuals with Type 2 Diabetes: A Consensus Statement from the American College of Sports Medicine – Medicine & Science in Sports & Exercise

 

Commentary from the author on Twitter

 


Review: Diagnosis and treatment of polycystic ovary syndrome.

20 Jan, 2022 | 08:54h | UTC

Diagnosis and Treatment of Polycystic Ovary Syndrome – JAMA (free for a limited period)

 


How do we make decisions for the most immature babies, with their families?

20 Jan, 2022 | 08:49h | UTC

How do we make decisions for the most immature babies, with their families? – Neonatal Research

 


Cumulative 5-year results of a randomized controlled trial comparing biological Mesh with primary perineal wound closure after extralevator abdominoperineal resection.

20 Jan, 2022 | 08:40h | UTC

Cumulative 5-year Results of a Randomized Controlled Trial Comparing Biological Mesh With Primary Perineal Wound Closure After Extralevator Abdominoperineal Resection (BIOPEX-study) – Annals of Surgery (link to abstract – $ for full-text)

 


Consensus statement on hemostatic management, anticoagulation, and antiplatelet therapy in liver transplantation.

20 Jan, 2022 | 08:47h | UTC

Consensus Statement on Hemostatic Management, Anticoagulation, and Antiplatelet Therapy in Liver Transplantation – Transplantation

 


Expert consensus for plasma and platelet transfusion practice in critically ill children.

20 Jan, 2022 | 08:44h | UTC

Executive Summary of Recommendations and Expert Consensus for Plasma and Platelet Transfusion Practice in Critically Ill Children: From the Transfusion and Anemia EXpertise Initiative—Control/Avoidance of Bleeding (TAXI-CAB) – Pediatric Critical Care Medicine

 


Review: Cannabis-based medicines and medical cannabis for chronic neuropathic pain.

20 Jan, 2022 | 08:39h | UTC

Cannabis-Based Medicines and Medical Cannabis for Chronic Neuropathic Pain – CNS Drugs

Related:

Cannabinoid metabolites as inhibitors of major hepatic CYP450 enzymes, with implications for cannabis-drug interactions.

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain.

The International Cannabis Toolkit (iCannToolkit): a multidisciplinary expert consensus on minimum standards for measuring cannabis use.

Cannabis products are being sold as sleep remedies – here’s the evidence about their effectiveness.

Guideline: Medical cannabis or cannabinoids for chronic pain.

Cannabis and Cannabinoid Analgesia position statement – “Due to the lack of high-quality clinical evidence, the IASP does not currently endorse general use of cannabis and cannabinoids for pain relief.”

NICE Guideline: Cannabis-Based Medicinal Products

Consensus recommendations for perioperative management of cannabis and cannabinoid-based medicine users

Living Systematic Review on Cannabis and Other Plant-Based Treatments for Chronic Pain – Agency for Healthcare Research and Quality

Short Review: Drug Interactions with Cannabinoids

Meta-Analysis: Cannabinoids Not Effective for Cancer-Related Pain

 


Systematic Review: School closures during social lockdown and mental health, health behaviors, and well-being among children and adolescents during the first Covid-19 wave.

19 Jan, 2022 | 09:00h | UTC

School Closures During Social Lockdown and Mental Health, Health Behaviors, and Well-being Among Children and Adolescents During the First COVID-19 Wave: A Systematic Review – JAMA Pediatrics

Editorial: Pandemic Recovery for Children—Beyond Reopening Schools – JAMA Pediatrics

Commentary: More Behavioral Issues Reported in Children When School Is Virtual – Psychiatric News Alert

Related:

M-A: Child and youth mental health problems have doubled during COVID-19.

Adolescents’ recreational screen time doubled during pandemic, affecting mental health.

More data on the harmful effects of the COVID-19 pandemic on the mental health of adolescents.

COVID has caused ‘mass trauma,’ worsening mental health globally.

COVID’s mental-health toll: how scientists are tracking a surge in depression

CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic

WHO: COVID-19 disrupting mental health services in most countries

 

Commentary on Twitter (thread – click for more)

https://twitter.com/benryanwriter/status/1483482171000111111

 


M-A: Association of Sodium-Glucose Cotransporter 2 Inhibitors with cardiovascular outcomes in patients with Type 2 Diabetes and other risk factors for cardiovascular disease.

20 Jan, 2022 | 08:42h | UTC

Association of Sodium-Glucose Cotransporter 2 Inhibitors With Cardiovascular Outcomes in Patients With Type 2 Diabetes and Other Risk Factors for Cardiovascular Disease: A Meta-analysis – JAMA Network Open

 

Commentary on Twitter

 


COVID-19 testing infographics.

19 Jan, 2022 | 08:59h | UTC

COVID-19 testing infographics – British Society for Immunology

 

Commentary on Twitter

 


Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find.

19 Jan, 2022 | 08:53h | UTC

News Release: Placebo effect accounts for more than two-thirds of COVID-19 vaccine adverse events, researchers find – Beth Israel Deaconess Medical Center

Original Study: Frequency of Adverse Events in the Placebo Arms of COVID-19 Vaccine Trials: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: ‘Nocebo effect’: two-thirds of Covid jab reactions not caused by vaccine, study suggests – The Guardian

 


The pandemic’s true death toll: millions more than official counts.

19 Jan, 2022 | 08:57h | UTC

The pandemic’s true death toll: millions more than official counts – Nature

Related:

We can be confident there have been far more than 5 million global Covid deaths – “Estimating ‘excess’ fatalities, a more robust analysis method, puts the pandemic’s grim toll between 10m and 19m people”.

Global Covid-19 deaths surpass five million.

Effects of the Covid-19 pandemic on life expectancy and premature mortality in 2020 – this time series analysis showed there were more than 28 million excess years of life lost in 2020 in 31 countries.

Under-reporting of deaths limits our understanding of true burden of covid-19.

Study shows COVID-19 has caused the biggest decrease in life expectancy since World War II.

Just how do deaths due to COVID-19 stack up?

Tracking excess mortality across countries during the COVID-19 pandemic with the World Mortality Dataset.

Exploring the gap between excess mortality and COVID-19 deaths in 67 countries.

Report: Three new estimates of India’s all-cause excess mortality during the COVID-19 Pandemic – pandemic death toll estimated to be between 3.4 million and 4.9 million excess deaths.

COVID-19 has caused 6.9 million deaths globally, more than double what official reports show

 

Commentary on Twitter

 


RCT: In non–critically ill hospitalized patients with COVID-19, the use of a P2Y12 Inhibitor (ticagrelor in 63% of patients and clopidogrel in 37%) in addition to a therapeutic dose of heparin did not improve survival free of organ support compared to therapeutic heparin alone.

19 Jan, 2022 | 08:56h | UTC

Effect of P2Y12 Inhibitors on Survival Free of Organ Support Among Non–Critically Ill Hospitalized Patients With COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Antiplatelet Therapy in Patients With COVID-19—More Is Less? – JAMA

Commentary: Adding a P2Y12 Inhibitor Does Not Improve Outcomes in COVID-19 – HealthDay

 


Opinion: The COVID-Risk social contract is under negotiation.

19 Jan, 2022 | 08:48h | UTC

The COVID-Risk Social Contract Is Under Negotiation – The Atlantic (a few articles per month are free)

 


Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries.

19 Jan, 2022 | 08:50h | UTC

Disruptions in maternal health service use during the COVID-19 pandemic in 2020: experiences from 37 health facilities in low-income and middle-income countries – BMJ Global Health

 

Commentary from one of the authors on Twitter (thread – click for more)

 


WHO says there’s no evidence healthy children and adolescents need Covid boosters.

19 Jan, 2022 | 08:46h | UTC

WHO says there’s no evidence healthy children and adolescents need Covid boosters – CNBC

 


Opinion: The world won’t be able to boost its way out of the coronavirus pandemic.

19 Jan, 2022 | 08:47h | UTC

The world won’t be able to boost its way out of the coronavirus pandemic – Politico

 


RCT: In critically ill adults, using a balanced multielectrolyte solution did not lower the risk of death or acute kidney injury compared to standard saline.

19 Jan, 2022 | 08:41h | UTC

Balanced Multielectrolyte Solution versus Saline in Critically Ill Adults – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Australian study set to guide the treatment of critically ill patients worldwide – George Institute for Global Health

Related:

BaSICS RCT: Among critically ill patients requiring fluid therapy, treatment with a balanced solution did not lead to reduced mortality compared to a 0.9% saline solution.

BaSICS RCT: Among critically ill patients requiring fluid therapy, there was no difference in mortality with slower (333 mL/h) vs. faster (999 mL/h) intravenous fluid bolus rates.

Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline

 

Commentary on Twitter

https://twitter.com/NEJM/status/1483540959518281730

 


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