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Opinion | Controlling the control arm in metastatic castration-resistant prostate cancer trials: best standard of care or the minimum standard of care?

23 Feb, 2022 | 10:03h | UTC

Controlling the Control Arm in Metastatic Castration-Resistant Prostate Cancer Trials: Best Standard of Care or the Minimum Standard of Care? – Journal of Clinical Oncology

 


Systematic Review: Weekly versus tri‐weekly paclitaxel with carboplatin for first‐line treatment in women with epithelial ovarian cancer.

23 Feb, 2022 | 10:05h | UTC

Weekly versus tri‐weekly paclitaxel with carboplatin for first‐line treatment in women with epithelial ovarian cancer – Cochrane Library

Summary: Does weekly dosing of paclitaxel improve survival, compared with tri-weekly dosing of paclitaxel in the initial treatment of ovarian cancer? – Cochrane Library

 


M-A: Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections.

23 Feb, 2022 | 10:07h | UTC

Diagnostic accuracy of point-of-care tests in acute community-acquired lower respiratory tract infections. A systematic review and meta-analysis – Clinical Microbiology and Infection

 


Review: Pruritus in pregnancy.

23 Feb, 2022 | 09:59h | UTC

Pruritus in Pregnancy – American Journal of Clinical Dermatology

 


Diagnostic test interpretation: hypernatremia.

23 Feb, 2022 | 10:02h | UTC

Hypernatremia – JAMA (free for a limited period)

 


Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches.

23 Feb, 2022 | 10:01h | UTC

Clinical management of chronic kidney disease-associated pruritus: current treatment options and future approaches – Clinical Kidney Journal

 


A Review of existing therapies for Actinic Keratosis: current status and future directions.

23 Feb, 2022 | 09:58h | UTC

A Review of Existing Therapies for Actinic Keratosis: Current Status and Future Directions – American Journal of Clinical Dermatology

 


Leukonychia: What can white nails tell us?

23 Feb, 2022 | 09:57h | UTC

Leukonychia: What Can White Nails Tell Us? – American Journal of Clinical Dermatology

 


AGA clinical practice update on de-prescribing of proton pump inhibitors.

22 Feb, 2022 | 10:12h | UTC

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Related:

Deprescribing proton pump inhibitors guideline

Review: Deprescribing Proton Pump Inhibitors

 


RCT: Full endoscopic discectomy non-inferior to open discectomy in patients with sciatica.

22 Feb, 2022 | 10:11h | UTC

Full endoscopic versus open discectomy for sciatica: randomised controlled non-inferiority trial – The BMJ

Commentary: Full-endoscopic transforaminal discectomy is “an effective alternative” to open microdiscectomy in treating sciatica – Spinal News International

 


Meta-analysis finds low risk of a second allergic reaction to SARS-CoV-2 mRNA vaccines in patients with an allergic reaction with the first dose.

22 Feb, 2022 | 10:05h | UTC

Risk of Second Allergic Reaction to SARS-CoV-2 Vaccines: A Systematic Review and Meta-analysis – JAMA Internal Medicine

 

Commentary on Twitter

 


New practical aspects of Sweet Syndrome.

23 Feb, 2022 | 09:56h | UTC

New Practical Aspects of Sweet Syndrome – American Journal of Clinical Dermatology

 


UK unveils game plan for ‘living with COVID’.

22 Feb, 2022 | 09:56h | UTC

UK unveils game plan for ‘living with COVID’ – CIDRAP

See also:

All you need to know about the end of Covid rules in England – The Guardian

‘Living with Covid’ strategy could do more harm than good, say businesses and unions – The Guardian

 


Opinion by Dr. Eric Topol | Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed.

22 Feb, 2022 | 10:07h | UTC

Why one-shot after a Covid-19 infection should suffice to be considered fully-vaxxed – The Guardian

 

Commentary from the author on Twitter (thread – click for more)

 


Why does the Omicron sub-variant spread faster than the original?

22 Feb, 2022 | 09:55h | UTC

Why does the Omicron sub-variant spread faster than the original? – Nature

Related:

Conflicting reports raise questions about whether any monoclonals work against Omicron’s sister variant.

Covid-19: What do we know about omicron sublineages?

We regret to inform you that we are now discussing subvariants – Vox

Sudden rise of more transmissible form of Omicron catches scientists by surprise.

Omicron’s sister variant spreads faster. So why did the one we call Omicron hit first?

[Preprint] Study suggests SARS-CoV-2 Omicron subvariants BA.2 is even more transmissible than the original variant.

BA.2 is like Omicron’s sister. Here’s what we know about it so far – The Conversation

 


PCRRT position paper on prescribing kidney replacement therapy in critically sick children with acute liver failure.

22 Feb, 2022 | 08:48h | UTC

PCRRT Expert Committee ICONIC Position Paper on Prescribing Kidney Replacement Therapy in Critically Sick Children With Acute Liver Failure – Frontiers in Pediatrics

 


[Preprint] A large-scale observational study in Chile found CoronaVac (an inactivated SARS-CoV-2 vaccine) was associated with an effectiveness of 74.5% against infection, 91.0% against hospitalization, and 93.8% against ICU admission in children aged 6 to 16 years.

22 Feb, 2022 | 09:58h | UTC

Effectiveness of an Inactivated SARS-CoV-2 Vaccine in Children and Adolescents: A Large-Scale Observational Study – Preprints with The Lancet

Commentary: Full schedule of CoronaVac vaccine shown to be highly effective in children – News Medical

 


Raw and cooked vegetable consumption and risk of cardiovascular disease: a study of 400,000 adults in UK Biobank.

22 Feb, 2022 | 09:51h | UTC

Raw and Cooked Vegetable Consumption and Risk of Cardiovascular Disease: A Study of 400,000 Adults in UK Biobank – Frontiers in Nutrition

Commentaries:

Eating veggies won’t protect your heart, study says, but critics disagree – CNN

Study Finds No Heart Benefit From Veggies. Nutritionists Disagree – HealthDay

Eating vegetables does not protect against cardiovascular disease, finds large-scale study – Frontiers

 


In an observational analysis of adults (aged 18-50 years) who have undergone aortic valve surgery, the Ross procedure was associated with better outcomes compared to prosthetic aortic valve replacement.

22 Feb, 2022 | 08:44h | UTC

Propensity-Matched Comparison of the Ross Procedure and Prosthetic Aortic Valve Replacement in Adults – Journal of the American College of Cardiology (link to abstract – $ for full-text)

News Release: The ‘Ross procedure’ may be a more favorable option for aortic valve replacement in younger adults – News Medical / The Mount Sinai Hospital

‘Ross procedure’ leads to improved survival in adults undergoing aortic valve surgery – The Mount Sinai Hospital

 


Position Statement: a disease state approach to the pharmacological management of type 2 diabetes in primary care.

22 Feb, 2022 | 08:51h | UTC

2022 update to the position statement by Primary Care Diabetes Europe: a disease state approach to the pharmacological management of type 2 diabetes in primary care

Related:

NICE Updated Guidance: Management of Type 2 Diabetes.

Guideline: ADA 2022 Standards of Medical Care in Diabetes.

 


Podcast: Tips and tricks for healing up patients with helicobacter.

22 Feb, 2022 | 08:43h | UTC

Podcast: #322 H. Pylori Infection – The Curbsiders

 


Practice Guidance: The prevention of pressure injuries in the positioning and mobilization of patients in the ICU.

22 Feb, 2022 | 08:46h | UTC

The prevention of pressure injuries in the positioning and mobilization of patients in the ICU: a good clinical practice document by the Italian Society of Anesthesia, Analgesia, Resuscitation and Intensive Care (SIAARTI) – Journal of Anesthesia, Analgesia and Critical Care

 


M-A: Combining antidepressants vs. antidepressant monotherapy for treatment of patients with acute depression.

22 Feb, 2022 | 08:40h | UTC

Combining Antidepressants vs Antidepressant Monotherapy for Treatment of Patients With Acute Depression: A Systematic Review and Meta-analysis – JAMA Psychiatry (free for a limited period)

 


M-A: Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk.

22 Feb, 2022 | 08:39h | UTC

Interventions to prevent spontaneous preterm birth in women with singleton pregnancy who are at high risk: systematic review and network meta-analysis – The BMJ

 


M-A of randomized trials | Association between intensity of LDL cholesterol reduction with statin-based therapies and secondary stroke prevention.

22 Feb, 2022 | 08:37h | UTC

Association Between Intensity of Low-Density Lipoprotein Cholesterol Reduction With Statin-Based Therapies and Secondary Stroke Prevention: A Meta-analysis of Randomized Clinical Trials – JAMA Neurology

Editorial: Low-Density Lipoprotein Cholesterol Level After a Stroke—Reducing It by Any Means (free for a limited period)

 


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