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In this study, American Indian or Alaska Native and Black populations experienced high rates or excess deaths from external causes (transportation fatalities homicide, and drug-related deaths) during the early #COIVD19 pandemic. https://t.co/RaatdoaFzI

— JAMA Internal Medicine (@JAMAInternalMed) May 11, 2022

Pharmacist-led review tied to better antimicrobial prescribing at discharge.

13 May, 2022 | 10:59h | UTC

Commentary: Pharmacist-led review tied to better antimicrobial prescribing at discharge – CIDRAP

Original Study: Pharmacist-Driven Transitions of Care Practice Model for Prescribing Oral Antimicrobials at Hospital Discharge – JAMA Network Open

Risk factors associated with Alzheimer disease and related dementias by sex and race and ethnicity in the US.

13 May, 2022 | 10:55h | UTC

Risk Factors Associated With Alzheimer Disease and Related Dementias by Sex and Race and Ethnicity in the US – JAMA Neurology (free for a limited period)

Commentaries:

Alzheimer’s and Dementia Linked to Eight Modifiable Risk Factors – Psychiatric News Alert

The 3 Midlife Factors That Raise Your Odds for Alzheimer’s – HealthDay

M-A: Impact of the WHO Surgical Safety Checklist relative to its design and intended use.

13 May, 2022 | 10:49h | UTC

Impact of the WHO Surgical Safety Checklist Relative to Its Design and Intended Use: A Systematic Review and Meta-Meta-Analysis – Journal of the American College of Surgeons

RCT: Treatment with Etirinotecan pegol for patients with metastatic breast cancer and brain metastases.

13 May, 2022 | 10:51h | UTC

Treatment With Etirinotecan Pegol for Patients With Metastatic Breast Cancer and Brain Metastases: Final Results From the Phase 3 ATTAIN Randomized Clinical Trial – JAMA Oncology (free for a limited period)

Commentary on Twitter

Treatment with etirinotecan pegol showed no statistically significant improvement in survival among patients with #BreastCancer & brain metastases, but study represents larged published study for this understudied population. https://t.co/AVKeo1BWQV #BCSM #BTSM

— JAMA Oncology (@JAMAOnc) May 12, 2022

Sci-Hub downloads show countries where pirate paper site is most used.

13 May, 2022 | 10:47h | UTC

Sci-Hub downloads show countries where pirate paper site is most used – Nature

Review: Eponyms in medical oncology.

13 May, 2022 | 10:45h | UTC

Eponyms in medical oncology – Cancer Treatment and Research Communications

M-A: Direct oral anticoagulants not as effective as vitamin K antagonists in patients with antiphospholipid syndrome.

13 May, 2022 | 10:43h | UTC

Direct oral anticoagulants versus vitamin K antagonists in patients with antiphospholipid syndrome: systematic review and meta-analysis – RMD Open

Special Issue | Multicancer early detection: accelerating progress through international collaboration.

13 May, 2022 | 10:46h | UTC

Homepage: Multicancer Early Detection: Accelerating Progress Through International Collaboration

Multicancer early detection: International summit to Clarify the Roadmap

Multicancer early detection test: Preclinical, translational, and clinical evidence–generation plan and provocative questions

International perspectives on the development, application, and evaluation of a multicancer early detection strategy

Development and evaluation of safety and effectiveness of novel cancer screening tests for routine clinical use with applications to multicancer detection technologies

Evaluating the impact of multicancer early detection testing on health and economic outcomes: Toward a decision modeling strategy

Patient engagement and advocacy considerations in development and implementation of a multicancer early detection program

Industry engagement: Accelerating discovery, application, and adoption through industry partnerships

Opinion | Liquid biopsy: misplaced faith in early cancer detection?

Liquid Biopsy: Still Early Days for Early Detection

Opinion: New cancer test isn’t ready for prime time

Detection of Surgically Resectable Cancers with a Multi-analyte Blood Test

Review: Vertebroplasty for osteoporotic vertebral fracture – Three among four double-blind studies which used a sham procedure did not confirm the benefit suggested by previous studies.

13 May, 2022 | 10:44h | UTC

Vertebroplasty for osteoporotic vertebral fracture – RMD Open

Phase 2/3 RCT: Tocilizumab in patients with new onset polymyalgia rheumatica reduces flares in a protocol of rapid glucocorticoid tapering (from 20 mg to 0 mg over 11 weeks).

13 May, 2022 | 10:42h | UTC

Tocilizumab in patients with new onset polymyalgia rheumatica (PMR-SPARE): a phase 2/3 randomised controlled trial – Annals of Rheumatic Diseases (link to abstract – $ for full-text)

Limiting resident-physician work hours may improve patient safety outcomes.

12 May, 2022 | 10:30h | UTC

News Release: Limiting resident-physician work hours improved patient safety outcome – Brigham and Women’s Hospital

Original Study: National improvements in resident physician-reported patient safety after limiting first-year resident physicians’ extended duration work shifts: a pooled analysis of prospective cohort studies – BMJ Quality & Safety

New guideline for low-risk, recurrent abdominal pain in the emergency department.

12 May, 2022 | 10:31h | UTC

Guidelines for Reasonable and Appropriate Care in the Emergency Department 2 (GRACE-2): Low-risk, recurrent abdominal pain in the emergency department – Academic Emergency Medicine

News Release: New guideline for low-risk, recurrent abdominal pain in the emergency department – Society for Academic Emergency Medicine

Opinion: Why preprints are good for patients.

12 May, 2022 | 10:25h | UTC

Why preprints are good for patients – Nature Medicine

Commentary on Twitter

.@PeterHorby on how rapid communication saved lives. "In the month between the public announcement of the [RECOVERY dexamethasone] result and the publication of the peer-reviewed manuscript, over 700,000 [new] COVID-19 cases were reported globally."https://t.co/5m3VVxjBBX

— Natalie E. Dean, PhD (@nataliexdean) May 11, 2022

Systematic Review: Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures.

12 May, 2022 | 10:24h | UTC

Antibiotic prophylaxis for preventing bacterial endocarditis following dental procedures – Cochrane Library

Summary: Antibiotics for the prevention of bacterial endocarditis (severe infection or inflammation of the lining of the heart chambers) in dentistry – Cochrane Library

Commentary on Twitter

Have a look at the evidence on antibiotics for preventing bacterial endocarditis in people undergoing dental treatment. Summary here: https://t.co/7uxnkbgt8t. Full review here: https://t.co/3Au3EsHZIU pic.twitter.com/RLsF3fHiZa

— Cochrane Oral Health (@CochraneOHG) May 11, 2022

Capsid inhibition with Lenacapavir in multidrug-resistant HIV-1 infection.

12 May, 2022 | 10:20h | UTC

Capsid Inhibition with Lenacapavir in Multidrug-Resistant HIV-1 Infection – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Lenacapavir for HIV Infection in a Multidrug-Resistant Study Cohort – ContagionLive

RCT: Evaluation of mRNA-1273 Covid-19 vaccine in children 6 to 11 years of age.

12 May, 2022 | 10:22h | UTC

Evaluation of mRNA-1273 Covid-19 Vaccine in Children 6 to 11 Years of Age – New England Journal of Medicine

Commentary on Twitter

Two 50-μg doses of mRNA-1273 vaccine were found to be safe and effective in inducing immune responses and preventing Covid-19 in children 6 to 11 years of age. https://t.co/A5SBK4zK6E pic.twitter.com/7x4JgOwK57

— NEJM (@NEJM) May 11, 2022

ASTRO Guideline: Radiation therapy for brain metastases.

12 May, 2022 | 10:11h | UTC

Radiation Therapy for Brain Metastases: An ASTRO Clinical Practice Guideline – Practical Radiation Oncology

News Release: ASTRO issues clinical guideline on radiation therapy for brain metastases – American Society for Radiation Oncology

Commentary on Twitter

ASTRO has released a guideline on #RadiationTherapy for brain metastases, which updates the original 2012 guideline. The publication in #PracticalRO includes treatment algorithms for limited & extensive brain metastases. Read here: https://t.co/5QRI0XqWHx #RadOnc pic.twitter.com/oNj2nzAKdm

— ASTRO (@ASTRO_org) May 10, 2022

Cohort Study: Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age.

12 May, 2022 | 10:14h | UTC

Impact of modifiable healthy lifestyle adoption on lifetime gain from middle to older age – Age and Ageing

Commentary on Twitter

https://twitter.com/EricTopol/status/1524446562545405952

Epidemiological update: Hepatitis of unknown etiology in children.

12 May, 2022 | 10:12h | UTC

Epidemiological update: Hepatitis of unknown aetiology in children – European Centre for Disease Prevention and Control

Unexplained hepatitis cases in kids rise to 348 in 20 nations – CIDRAP

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing 2 – UK Health Security Agency

With usual suspects ruled out, disease detectives try to crack mystery of viral hepatitis cases in kids – STAT

Acute Hepatitis and Adenovirus Infection Among Children — Alabama, October 2021–February 2022 – Morbidity and Mortality Weekly Report

The CDC and WHO Have Reported an Unusual Cluster of Severe Pediatric Hepatitis Cases – Science-Based Medicine

Investigation into acute hepatitis of unknown aetiology in children in England Technical briefing – UK Health Security Agency

Multi-Country – Acute, severe hepatitis of unknown origin in children – World Health Organization

WHO says 12 countries have reported unusual cases of hepatitis in kids – STAT

CDC Alerts Providers to Hepatitis Cases of Unknown Origin – Centers for Disease Control and Prevention

Recommendations for Adenovirus Testing and Reporting of Children with Acute Hepatitis of Unknown Etiology – Centers for Disease Control and Prevention

Could Mysterious Hepatitis Cases be Triggered by COVID-19? – Health Policy Watch

Increase in hepatitis (liver inflammation) cases in children under investigation – UK Health Security Agency

U.S., U.K. investigating unusual cases of hepatitis in young children – STAT

Acute hepatitis of unknown aetiology – the United Kingdom of Great Britain and Northern Ireland – World Health Organization

Increase in acute hepatitis of unknown origin among children – United Kingdom – European Centre for Disease Prevention and Control

Mysterious liver illness seen in kids in US, Europe – Associated Press

Commentary on Twitter (thread – click for more)

Update: #Hepatitis of unknown aetiology in children – 11 May 2022

Approximately 106 cases have been identified in 14 EU/EEA countries and 450 cases are reported worldwide.

The cause of the disease is still under investigation.
Read more: https://t.co/B0lLm7I0dV

— ECDC Outbreaks (@ECDC_Outbreaks) May 11, 2022