Archives
RCT: Durvalumab plus gemcitabine and cisplatin in advanced biliary tract cancer.
2 Jun, 2022 | 10:49h | UTCDurvalumab plus Gemcitabine and Cisplatin in Advanced Biliary Tract Cancer – NEJM Evidence
Commentary on Twitter
Durvalumab, with gemcitabine plus cisplatin, increased median overall survival, 12.8 months versus 11.5 months, in patients with previously untreated unresectable, recurrent or metastatic biliary tract cancer. https://t.co/SaeUxfGfWd#OncTwitter #MedTwitter #Cholangiocarcinoma pic.twitter.com/NZeVljWnyu
— NEJM Evidence (@NEJMEvidence) June 1, 2022
RCT: Effect of reflectance confocal microscopy for suspect lesions on diagnostic accuracy in melanoma.
2 Jun, 2022 | 10:41h | UTC
Commentary on Twitter
In this RCT, adjunctive use of reflectance confocal microscopy for suspicious lesions is proven to reduce unnecessary excisions and removes all aggressive melanomas at baseline in a real-life, prospective clinical decision making setting. https://t.co/cWJu9TlaEH
— JAMA Dermatology (@JAMADerm) June 1, 2022
Randomized Crossover Trial: Effect of a ketogenic diet vs. Mediterranean diet on HbA1c in individuals with prediabetes and type 2 diabetes mellitus.
2 Jun, 2022 | 10:37h | UTC
Commentary from one of the authors on Twitter (thread – click for more)
The results of the #KetoMedStudy are finally out! How low-carb do you need to go for glucose control? Is keto better than a low-carb Mediterranean diet with no refined grains (Med-Plus)? 👉 https://t.co/XHUqahXL2m#keto #ketodiet #MediterraneanDiet #ketomedstudy #luciaaronica
— Dr Aronica (@LuciaAronica) June 1, 2022
Survey: Do people with symptoms of an infectious illness follow advice to stay at home?
2 Jun, 2022 | 10:30h | UTCRelated:
This flu season, physicians need to scrap the ‘martyr culture’ of working while sick – STAT
Phase 2 RCT: Efficacy of epigallocatechin-3-gallate in preventing dermatitis in patients with breast cancer receiving postoperative radiotherapy.
2 Jun, 2022 | 10:34h | UTCEfficacy of Epigallocatechin-3-Gallate in Preventing Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy: A Double-Blind, Placebo-Controlled, Phase 2 Randomized Clinical Trial – JAMA Dermatology (free for a limited period)
Visual Abstract: Efficacy of Epigallocatechin-3-Gallate on Dermatitis in Patients With Breast Cancer Receiving Postoperative Radiotherapy
Essential components of postnatal care – a systematic literature review and development of signal functions to guide monitoring and evaluation.
2 Jun, 2022 | 10:29h | UTC
M-A: Association between benign ovarian tumors and ovarian cancer risk.
2 Jun, 2022 | 10:18h | UTC
M-A: Antidepressants in children and adolescents with major depressive disorder and the influence of placebo response.
2 Jun, 2022 | 10:32h | UTCAntidepressants in children and adolescents with major depressive disorder and the influence of placebo response: A meta-analysis – Journal of Affective Disorders (link to abstract – $ for full-text)
Commentaries:
Antidepressant Effect Sizes Modest for Pediatric Major Depressive Disorder – Consultant360
Commentary on Twitter
MA: The SMD among all studies of antidepressants in C&A with MDD was 0.12 (0.08-0.17), a very small ES, lower than that seen in studies of adults with MDD. When the MA was limited to studies with a low mean placebo response, the SMD increased to 0.19 https://t.co/hPYvta4rgf
— P𝘧OL (@psychopharmacol) March 23, 2022
Effectiveness and characteristics of physical fitness training on aerobic fitness in vulnerable older adults: an umbrella review of systematic reviews.
2 Jun, 2022 | 10:16h | UTC
Cohort Study: Evaluation of neurologic and psychiatric outcomes after hospital discharge among adult survivors of cardiac arrest.
2 Jun, 2022 | 10:15h | UTC
Network meta-analysis: Comparing efficacy and safety in catheter ablation strategies for atrial fibrillation.
2 Jun, 2022 | 10:13h | UTC
Expert Analysis: Cardiotoxicity and the evolving landscape of HER2-targeted breast cancer treatment.
2 Jun, 2022 | 10:11h | UTC
ERAS Guidelines for perioperative care in elective abdominal and pelvic surgery at primary and secondary hospitals in low–middle-income countries.
1 Jun, 2022 | 12:08h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Exercise and acute respiratory infections: might regular exercise help protect us?
2 Jun, 2022 | 10:10h | UTCOriginal Study: Exercise versus no exercise for the occurrence, severity, and duration of acute respiratory infections – Cochrane Library
M-A: Effectiveness of weight management interventions for adults delivered in primary care.
1 Jun, 2022 | 12:04h | UTCCommentary from the authors: Weight loss advice from GPs really can help people slim down and stay that way – new research – The Conversation
BSR guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs.
1 Jun, 2022 | 12:05h | UTCExecutive summary: The 2022 British Society for Rheumatology guideline for the treatment of psoriatic arthritis with biologic and targeted synthetic DMARDs – Rheumatology
Retrospective Cohort Study: Racial and ethnic discrepancy in pulse oximetry and delayed identification of treatment eligibility among patients with COVID-19.
1 Jun, 2022 | 11:58h | UTCEditorial: Racial and Ethnic Bias in Pulse Oximetry and Clinical Outcomes
Related:
Racial Bias in Pulse Oximetry Measurement – New England Journal of Medicine
FDA issues alert on ‘limitations’ of pulse oximeters, without explicit mention of racial bias – STAT
Pulse Oximeter Accuracy and Limitations: FDA Safety Communication – U.S. Food & Drug Administration
Commentary on Twitter
This cohort study found overestimation of arterial oxygen saturation levels by pulse oximetry occurred in Asian, Black, and Hispanic patients with #COVID19 and delayed care compared with White patients. https://t.co/ptOVwuUewr @AshFawzyMD @GoldenSherita @AmandaBradke @BTGaribaldi
— JAMA Internal Medicine (@JAMAInternalMed) May 31, 2022
M-A: The collateral damage of COVID-19 to cardiovascular services.
1 Jun, 2022 | 11:56h | UTCNews Release: COVID-19’s toll on global cardiac services – University of Leeds
Commentary: COVID-19 severely disrupted global cardiac care, increasing deaths – CIDRAP
Commentary on Twitter
Conclusions from a recent meta-analysis now in EHJ online. "There was substantial global collateral CV damage during the COVID-19 pandemic with disparity in severity by country income classification."#COVID19 #EHJhttps://t.co/jb8bFDL4JP pic.twitter.com/g3oQSP9gFg
— EHJ Editor-in-Chief (@ehj_ed) May 31, 2022
WHO Updated Report: Multi-country monkeypox outbreak in non-endemic countries.
1 Jun, 2022 | 11:46h | UTCMulti-country monkeypox outbreak in non-endemic countries: Update – World Health Organization
Commentary: Monkeypox outbreak reaches 257 confirmed cases worldwide, WHO says – CNN
Related:
Monkeypox outbreaks: 4 key questions researchers have – Nature
Study reports first use of antivirals in monkeypox patients – Lancet
Surveillance, case investigation and contact tracing for Monkeypox – World Health Organization
Laboratory testing for the monkeypox virus: Interim guidance – World Health Organization
A Novel International Monkeypox Outbreak – Annals of Internal Medicine
EU health agency warns monkeypox could become endemic in Europe if outbreak continues – STAT
Monkeypox cases increase across Europe, North America – CIDRAP
Multi-country monkeypox outbreak in non-endemic countries – World Health Organization
Monkeypox goes global: why scientists are on alert – Nature
Monkeypox: What do we know about the outbreaks in Europe and North America? – The BMJ
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – STAT
Monkeypox: Time to worry or one to ignore? – BBC
UK, Spain, Portugal report more monkeypox cases – CIDRAP
U.S. monkeypox case reported, as Spain, Portugal report infections in growing outbreak – STAT
Monkeypox – United Kingdom of Great Britain and Northern Ireland – World Health Organization
Monkeypox cases confirmed in England – latest updates – UK Health Security Agency
Seven Confirmed Monkeypox Cases in UK Includes Sexually Transmitted Cluster – Health Policy Watch
European outbreak of monkeypox: what you need to know – The Conversation
Rare monkeypox outbreak in U.K., Europe and U.S.: What is it and should we worry – NPR
Monkeypox cases under investigation in Canada as outbreak spreads in Europe, U.S. – CBC News
Network Meta-Analysis: Effectiveness of heterologous and homologous covid-19 vaccine regimens.
1 Jun, 2022 | 12:00h | UTCNews Release: Three doses of the same or mixed covid jabs work equally well against infections – BMJ
Commentary: Three jabs best for preventing Covid infections, global analysis finds – The Guardian
Cohort Study: Association of prenatal exposure to antiseizure medication with risk of autism and intellectual disability.
1 Jun, 2022 | 11:44h | UTCAuthor Interview: Prenatal Exposure to Antiseizure Medication With Risk of Autism and Intellectual Disability – JAMA
Commentaries:
Prenatal Exposure to Certain Antiseizure Meds Linked to Autism – HealthDay
Related:
Risks of 23 specific malformations associated with prenatal exposure to 10 antiepileptic drugs – Neurology (link to abstract – $ for full-text)
Educational attainment of children born to mothers with epilepsy – Journal of Neurology, Neurosurgery, and Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter
Nordic study of 4.5 million children found an association between prenatal exposure to topiramate and valproate and child intellectual disability and #autism. https://t.co/UH2THznPiV
— JAMA Neurology (@JAMANeuro) May 31, 2022
Guideline: Early mobilization and rehabilitation of critically ill burn patients.
1 Jun, 2022 | 11:40h | UTC
Systematic Review: SARS-CoV-2 saliva testing using RT-PCR.
1 Jun, 2022 | 11:42h | UTC
ASCO Guideline Update: Systemic therapy for advanced human epidermal growth factor receptor 2–positive breast cancer.
1 Jun, 2022 | 11:38h | UTC
Commentary on Twitter
Out on JCO the latest @ASCO Guidelines Update on the treatment of HER2-positive ABC. Key points: standard first line remains THP, new second line is T-DXd, no standard after progression to T-DXd, a setting for which we urgently need data.https://t.co/2mMxBLACmf pic.twitter.com/2sXpzqz4ym
— Paolo Tarantino (@PTarantinoMD) June 1, 2022
Understanding base excess (BE): merits and pitfalls.
1 Jun, 2022 | 11:33h | UTCUnderstanding base excess (BE): merits and pitfalls – Intensive Care Medicine (if the link is paywalled, try this one)
Commentary on Twitter
Understanding base excess
🧪 valuable quantitative estimate of metabolic acid-base derangements, but not info on underlying mechanisms
🧪 standard BE composite marker: several components contribute; interpretation of isolated value very difficult#FOAMcc
🖇️https://t.co/T8pcVRrTgR pic.twitter.com/6TEFsFTJR1— Intensive Care Medicine (@yourICM) May 31, 2022