M-A: Antidepressants in children and adolescents with major depressive disorder and the influence of placebo response.

Antidepressants in children and adolescents with major depressive disorder and the influence of placebo response: A meta-analysis – Journal of Affective Disorders (link to abstract – $ for full-text)

Commentaries:

Antidepressants Have Small Effect Sizes for the Treatment of Major Depressive Disorder Among Children – Psychiatry Advisor

Antidepressant Effect Sizes Modest for Pediatric Major Depressive Disorder – Consultant360

Commentary on Twitter

MA: The SMD among all studies of antidepressants in C&A with MDD was 0.12 (0.08-0.17), a very small ES, lower than that seen in studies of adults with MDD. When the MA was limited to studies with a low mean placebo response, the SMD increased to 0.19 https://t.co/hPYvta4rgf

— PfOL (@psychopharmacol) March 23, 2022