Archives
Research: Incidence of STI Before and After Pre-Exposure Prophylaxis for HIV
25 Jan, 2018 | 20:51h | UTCIncidence of sexually transmitted infections before and after Pre-Exposure Prophylaxis for HIV: a cohort study – AIDS (link to abstract – $ for full-text)
Commentary: Preexposure Prophylaxis for HIV Tied to Increased STI Rates – Medscape (free registration required)
Gene Editing – And What it Really Means to Rewrite the Code of Life
25 Jan, 2018 | 20:53h | UTCGene editing – and what it really means to rewrite the code of life – The Guardian (free)
Related: Correction of a pathogenic gene mutation in human embryos (free articles and commentaries) AND Simple guide to CRISPR, one of the biggest science stories of the decade – VOX (free)
Research: Socioeconomic Outcomes of Women Who Receive and Women Who Are Denied Wanted Abortions
25 Jan, 2018 | 20:52h | UTCCommentary: Opinion: Restricting access to abortion makes poor women poorer – LA Times (free)
Review: Biology and Therapy of Medullary Thyroid Carcinoma
25 Jan, 2018 | 20:46h | UTCRecent advances in the biology and therapy of medullary thyroid carcinoma – F1000 Research (free)
Research: Association of Depression With Mortality in Older Adults Undergoing TAVR and SAVR
25 Jan, 2018 | 20:50h | UTCAssociation of Depression With Mortality in Older Adults Undergoing Transcatheter or Surgical Aortic Valve Replacement – JAMA Cardiology (link to abstract – $ for full-text)
Commentaries: Depression May Increase Risk of Death Following Heart Procedure, Study Suggests – Psychiatric News Alert (free) AND One-Third of TAVR and SAVR Patients Are Depressed, Upping Mortality Risk – TCTMD (free) AND Association of Depression With Mortality After SAVR and TAVR – American College of Cardiology, Latest in Cardiology (free)
Review: Sleep Apnea and its Role in Transportation Safety
25 Jan, 2018 | 20:45h | UTCSleep apnea and its role in transportation safety – F1000 Research (free)
Review: Vancomycin-resistant Enterococcus Infection in the Hematopoietic Stem Cell Transplant Recipient
25 Jan, 2018 | 20:48h | UTC
Wed, January 24 – 10 Stories of The Day!
24 Jan, 2018 | 01:18h | UTC
1 – Report: Public Health Consequences of E-Cigarettes – National Academies of Sciences, Engineering, and Medicine (free PDF)
Press release: New Report One of the Most Comprehensive Studies on Health Effects of E-Cigarettes; Finds That Using E-Cigarettes May Lead Youth to Start Smoking, Adults to Stop Smoking (free)
Commentaries: E-Cigarettes Likely Encourage Kids To Try Tobacco But May Help Adults Quit – NPR (free) AND 4 big takeaways from the most comprehensive report on e-cigarettes yet – VOX (free) AND Vaping Can Be Addictive and May Lure Teenagers to Smoking, Science Panel Concludes – The New York Times (10 articles per month are free)
See prognostic calculator: Prediction models for 3 month outcome after aSAH
3 – Antithyroid Drugs and Congenital Malformations: A Nationwide Korean Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: First trimester exposure to antithyroid drugs associated with increased risk of birth defects – 2 Minute Medicine (free) AND Use of Antithyroid Drugs Early in Pregnancy Tied to Birth Defect Risk – Physician’s First Watch (free) AND First trimester exposure to antithyroid drugs linked with birth defects – OnMedica (free)
Commentary: AAP Issues Recommendations for Improving Early-Childhood Nutrition – Physician’s First Watch (free) AND These Are the Best Foods for a Baby’s Brain – TIME (free)
5 – Robust research needs many lines of evidence – Nature (free)
Source: Critical Care Reviews Newsletter
8 – Choosing Wisely Campaign: American Society of Breast Surgeons – Benign Breast Disease: Five Things Physicians and Patients Should Question (free)
Commentary: Choosing Wisely: 5 Procedures to Avoid in Benign Breast Disease – Physician’s First Watch (free)
See more on the Choosing Wisely initiative in our April 5 issue (see #6)
9 – Reduction of PTSD Symptoms With Pre-Reactivation Propranolol Therapy: A Randomized Controlled Trial – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Propranolol May Help Patients With PTSD – Psychiatric News Alert (free) AND Propranolol May Fill ‘Dire’ Treatment Need for PTSD – Medscape (free registration required)
10 – Starting antiretroviral therapy immediately after HIV diagnosis reduces transmission of the virus – NIHR Signal (free)
Original article: Implications for a policy of initiating antiretroviral therapy in people diagnosed with human immunodeficiency virus: the CAPRA research programme – Programme Grants for Applied Research (free)
Review: Predictors of Outcome in Phaeochromocytomas and Paragangliomas
25 Jan, 2018 | 20:42h | UTCPredictors of outcome in phaeochromocytomas and paragangliomas – F1000 Research (free)
Thu, January 25 – 10 Stories of The Day!
25 Jan, 2018 | 00:56h | UTC
Commentaries: More stroke patients eligible for crucial treatments under new guidelines – American Heart Association News (free) AND More stroke patients may receive crucial treatments under new guideline – AHA/ASA Newsroom (free)
“A new guideline for treating acute ischemic stroke recommends an increased treatment window for mechanical clot removal from six hours to up to 24 hours in certain patients with clots in large vessels”. (from AHA/ASA Newsroom)
Commentaries: Brain-scan guided emergency stroke treatment can save more lives – NIH News Releases (free) AND Study confirms late clot extraction can save brain cells of stroke victims – Reuters (free) AND New Findings Could Save Lives of More Stroke Patients – The New York Times (10 articles per month are free)
Related article: Thrombectomy 6 to 24 Hours after Stroke with a Mismatch between Deficit and Infarct – New England Journal of Medicine (link to abstract – $ for full-text)
3 – Perspectives: To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians (free)
Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free)
4 – Association of Time to Treatment With Short-term Outcomes for Pediatric Patients With Refractory Convulsive Status Epilepticus – JAMA Neurology (free for a period)
Editorial: Time May Be of the Essence in the Treatment of Pediatric Patients With Refractory Convulsive Status Epilepticus (free)
Commentary: Delays Raise Death Risk in Kids with Status Epilepticus – MedPage Today (free registration required)
“These findings may change the perception of acute seizure and status epilepticus treatment, tentatively converting it into an extremely time-sensitive emergency that is similar to stroke or other cardiovascular events”.
Related: Canadian Deprescribing Network (CaDeN) (free) AND CaDeN Deprescribing Guidelines and Algorithms (free) AND Deprescribing guidelines for the elderly – Ontario Pharmacy Evidence Network (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
7 – Guideline: Oesophago-gastric cancer: assessment and management in adults – National Institute for Health and Care Excellence (NICE) (free)
8 – Guideline: Age-related macular degeneration – National Institute for Health and Care Excellence (NICE) (free)
Commentaries: Largest Study to Date Supports Surgical LAA Closure in A-fib Patients – TCTMD (free) AND Thromboembolism Less Likely With LAA Closure Added to Cardiac Surgery – MedPage Today (free registration required)
Randomized trials are needed to confirm these interesting findings.
10 – Trends in Survival After In-Hospital Cardiac Arrest During Nights and Weekends – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Survival From In-Hospital Cardiac Arrest Improves But Still Worse on Nights and Weekends – MedicalResearch.com (free)
AND Hospital patients less likely to survive ‘off-hours’ cardiac arrest – Reuters (free) AND You are still more likely to die in a hospital on the weekend – CNN (free)
See also a recent meta-analysis showing the “weekend effect” in surgical patients
Review: Electroanalgesia and Laser Therapies for Pain Management
25 Jan, 2018 | 20:44h | UTC
Guideline Synopsis: Management of High Blood Pressure in Adults
23 Jan, 2018 | 16:57h | UTCRelated: Redefining Hypertension: Assessing the New Blood-Pressure Guidelines – New England Journal of Medicine (free) AND AAFP Decides to Not Endorse AHA/ACC Hypertension Guideline – American Academy of Family Physicians (free)
Research: Adjunctive Glucocorticoid Therapy in Patients with Septic Shock
23 Jan, 2018 | 16:58h | UTCAdjunctive Glucocorticoid Therapy in Patients with Septic Shock – New England Journal of Medicine (free)
Commentaries: The Definitive Word on Steroids in Septic Shock – Emergency Medicine Literature of Note (free) AND Adrenal – The Bottom Line (free)
“For the primary outcome, there was no statistically significance difference in mortality at 90 days – 27.9% in the hydrocortisone cohort, and 28.8% with placebo. Looking at secondary outcomes, the results here tended to favor hydrocortisone – a slightly faster resolution of shock, shorter ICU stays, and, oddly, decreased transfusion requirements”. (from Emergency Medicine Literature of Note Blog)
Systematic Review: Tracheal Intubation in Critically ill Patients
23 Jan, 2018 | 16:56h | UTCTracheal intubation in critically ill patients: a comprehensive systematic review of randomized trials – Critical Care (free) (via @fpereirapa)
Guideline on Pre-operative Exercise Training in Patients Awaiting Major Non-cardiac Surgery
23 Jan, 2018 | 16:54h | UTC
Review: Treatment of Anxiety Disorders
23 Jan, 2018 | 16:55h | UTCReview: Treatment of anxiety disorders – Dialogues in Clinical Neuroscience (free)
Non-Inferiority Trials in Medicine
23 Jan, 2018 | 16:51h | UTCNon-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy? – Journal of General Internal Medicine (free for a period)
Related: Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine (free) AND Users’ guide to the surgical literature: how to assess a noninferiority trial – Canadian Journal of Surgery (free)
Research: Hyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer
23 Jan, 2018 | 16:52h | UTCHyperthermic Intraperitoneal Chemotherapy in Ovarian Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Hyperthermic intraperitoneal chemotherapy with surgery increases survival for epithelial ovarian cancer patients – 2 Minute Medicine (free) AND Add-On Hyperthermic Intraperitoneal Chemotherapy Assessed in Ovarian CA – MPR (free)
Patients treated with hyperthermic intraperitoneal chemotherapy associated with surgery had increased median overall survival compared to patients treated with surgery alone (45,7 months vs 33,9 months).
Richard Lehman’s journal review – 22 January 2018
23 Jan, 2018 | 16:51h | UTCRichard Lehman’s journal review, 22 January 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Guidelines for Fatigue Risk Management in Emergency Medical Services
23 Jan, 2018 | 16:49h | UTCCommentaries in the same issue: Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Significant Step Forward and a Model for Other High-Risk Industries (free) AND What an Evidence-based Guideline for Fatigue Risk Management Means for Us: Statements From Stakeholders (free) AND Proposed Performance Measures and Strategies for Implementation of the Fatigue Risk Management Guidelines for Emergency Medical Services (free) AND Evidence-Based Guidelines for Fatigue Risk Management in Emergency Medical Services: A Step in the Right Direction Toward Better Sleep Health (free)
Research: Medical Oncology Outpatients’ Perceptions of Location of End-of-Life Care
23 Jan, 2018 | 16:50h | UTCCommentary: Let’s Talk About End-of-Life Care – National Comprehensive Cancer Network, via NewsWise (free)
“…majority of people with cancer would like their physicians to ask them where they would prefer to receive end-of-life care” (from NewsWise).
Meta-Analysis: Weekend Surgical Care and Postoperative Mortality
23 Jan, 2018 | 16:47h | UTCCommentary: Evidence Supports ‘Weekend Effect’ for Mortality after Surgery – Wolters Kluwer, via NewsWise (free)
“The odds of postoperative mortality were 27 percent higher for patients admitted to the hospital on Saturday or Sunday, compared to those hospitalized on a weekday” (from NewsWise).
Critical Care Reviews Book 2018
23 Jan, 2018 | 16:48h | UTCCritical Care Reviews Book 2018 (free PDF)
“The Critical Care Reviews Book summarizes, critiques and puts in context the biggest trials of the year”.
Consensus: Integrating new Approaches to Atrial Fibrillation Management
23 Jan, 2018 | 16:42h | UTC
Research: Early Menarch and Menopause and Cardiovascular Risk
23 Jan, 2018 | 16:46h | UTCWomen’s reproductive factors and incident cardiovascular disease in the UK Biobank – Heart (link to abstract – $ for full-text)
Commentaries: Starting periods before age of 12 linked to heightened risk of heart disease and stroke – The BMJ, via EurekAlert (free) AND Early periods linked to heightened cardiovascular risk – OnMedica (free) AND Starting periods early linked to health risks later in life – Medical News Today (free) AND Early menarche and menopause linked to cardiovascular disease risk – The Guardian (free)