Daily Archives: July 5, 2023

ASA Consensus Guidance | Preoperative management of patients on GLP-1 agonists

5 Jul, 2023 | 01:17h | UTC

American Society of Anesthesiologists Consensus-Based Guidance on Preoperative Management of Patients (Adults and Children) on Glucagon-Like Peptide-1 (GLP-1) Receptor Agonists – American Society of Anesthesiologists

Commentary: Anesthesiologists Say Ozempic, Wegovy Should Be Halted Prior to Surgery – HealthDay

 

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RCT | Opioids not more effective than placebo for acute low back and neck pain

5 Jul, 2023 | 01:15h | UTC

Opioid analgesia for acute low back pain and neck pain (the OPAL trial): a randomised placebo-controlled trial – The Lancet (link to abstract – $ for full-text)

News Releases:

Opioids no more effective than placebo for acute back and neck pain – University of Sidney

Opioid pain relievers do not reduce acute lower back and neck pain, study suggests – The Lancet

Commentary from the authors: Opioids don’t relieve acute low back or neck pain – and can result in worse pain, new study finds – The Conversation

 

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RCT | Transcranial direct current stimulation fails to outperform sham in major depressive disorder treatment

5 Jul, 2023 | 01:12h | UTC

Transcranial direct current stimulation as an additional treatment to selective serotonin reuptake inhibitors in adults with major depressive disorder in Germany (DepressionDC): a triple-blind, randomised, sham-controlled, multicentre trial – The Lancet (link to abstract – $ for full-text)

 

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RCT | No statistically significant impact of vitamin D on major cardiovascular events

5 Jul, 2023 | 01:11h | UTC

Vitamin D supplementation and major cardiovascular events: D-Health randomised controlled trial – The BMJ

Related:

2ry analysis of a RCT | Vitamin D supplementation does not affect cognitive function in older adults

RCT: Oral Vitamin D supplementation (60.000 IU per month) did not reduce mortality in patients 60 years or older (unscreened individuals in Australia, many without insufficiency, average 30ng/mL). Exploratory analyses pointed towards an increased risk of death from cancer.

Randomized Trial: Vitamin D Supplements and Prevention of Cancer and Cardiovascular Disease

Meta-Analysis: Vitamin D Not Effective for Cardiovascular Disease Prevention

Association between vitamin D supplementation and mortality: systematic review and meta-analysis – The BMJ

USPSTF Draft Statement: Insufficient evidence to recommend multivitamin supplements for the prevention of CVD or cancer. The statement also recommends against the use of beta-carotene (increases risk of CVD mortality and lung cancer) or vitamin E (clear evidence of no benefit)

Vitamin D, calcium, other vitamins, and supplements do not prevent cardiovascular diseases

 

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RCT | Lower rates of treatment failure with standard-course vs. short-course therapy in pediatric UTIs

5 Jul, 2023 | 01:09h | UTC

Short-Course Therapy for Urinary Tract Infections in Children: The SCOUT Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text)

See also: Visual Abstract

Commentary: Treatment Failure Down With Standard-Course Therapy in Pediatric UTI – HealthDay

 

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Review | Pathogenesis and management of abdominal aortic aneurysm

5 Jul, 2023 | 01:07h | UTC

Pathogenesis and management of abdominal aortic aneurysm – European Heart Journal

See also: Visual Abstract

 

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RCT | Effect of mifepristone vs. placebo for treatment of adenomyosis with pain symptoms

5 Jul, 2023 | 01:06h | UTC

Effect of Mifepristone vs Placebo for Treatment of Adenomyosis With Pain Symptoms: A Randomized Clinical Trial – JAMA Network Open

See also: Visual Abstract

 

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GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency

5 Jul, 2023 | 01:05h | UTC

GRADE guidance 36: updates to GRADE’s approach to addressing inconsistency – Journal of Clinical Epidemiology

 

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SR | Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis

5 Jul, 2023 | 01:04h | UTC

Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis – Cochrane Library

 

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RCT | FOLFOXIRI-Bevacizumab shows promise as first-line treatment in unresectable colorectal cancer metastases

5 Jul, 2023 | 01:02h | UTC

First-line systemic treatment strategies in patients with initially unresectable colorectal cancer liver metastases (CAIRO5): an open-label, multicentre, randomised, controlled, phase 3 study from the Dutch Colorectal Cancer Group – The Lancet Oncology (link to abstract – $ for full-tetxt)

 

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M-A | Family screening for bicuspid aortic valve and aortic dilatation

5 Jul, 2023 | 01:01h | UTC

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis – European Heart Journal

 

Commentary on Twitter

Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis https://t.co/8rc4Uysf5o @escardio #EHJ #ESCYoung pic.twitter.com/p4XRzb3mzb

— European Society of Cardiology Journals (@ESC_Journals) June 15, 2023

 

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Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management

5 Jul, 2023 | 01:00h | UTC

Myelodysplastic syndromes: 2023 update on diagnosis, risk-stratification, and management – American Journal of Hematology

 

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