Daily Archives: October 14, 2022 | LinksMedicus Free Medical News & Perspectives

RCTs | Thrombectomy improved recovery in basilar artery stroke but increased procedural complications and hemorrhages.

14 Oct, 2022 | 14:20h | UTC

Study 1: Trial of Endovascular Treatment of Acute Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)

Study 2: Trial of Thrombectomy 6 to 24 Hours after Stroke Due to Basilar-Artery Occlusion – New England Journal of Medicine (link to abstract – $ for full-text)

Registry-based cohort study: Endovascular treatment vs. best medical management in acute basilar artery occlusion strokes.

RCT: Endovascular therapy for stroke due to basilar-artery occlusion – “endovascular therapy and medical therapy did not differ significantly with respect to a favorable functional outcome”.

Commentary on Twitter

In 340 Chinese patients with basilar-artery occlusion, endovascular treatment resulted in better neurologic outcomes than medical care. Approximately one third of patients underwent intravenous thrombolysis. https://t.co/ZqHirYnjoH pic.twitter.com/fuRV3rFWX7

— NEJM (@NEJM) October 13, 2022

Review | Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease.

14 Oct, 2022 | 14:19h | UTC

Facing the challenge of polypharmacy when prescribing for older people with cardiovascular disease. A review by the European Society of Cardiology Working Group on Cardiovascular Pharmacotherapy – European Heart Journal – Cardiovascular Pharmacotherapy

Deprescribing in Older Adults with Cardiovascular Disease – Journal of the American College of Cardiology

Multimorbidity in Older Adults with Cardiovascular Disease – American College of Cardiology, Latest in Cardiology

Deprescribing medicines in older people living with multimorbidity and polypharmacy: the TAILOR evidence synthesis – Health Technology Assessment

Antihypertensive Deprescribing in Older Adults: a Practical Guide – Current Hypertension Reports

How-to guide for medication reviews in older adults with cancer: A Young International Society of Geriatric Oncology and Nursing & Allied Health Interest Group initiative – Journal of Geriatric Oncology

Deprescribing in Palliative Cancer Care – Life

Less is More: Deprescribing Medications in Older Adults with Kidney Disease: A Review – Kidney360

Process evaluation of implementation strategies to reduce potentially inappropriate medication prescribing in older population: A scoping review – Research in Social and Administrative Pharmacy

AGA Clinical Practice Update on De-Prescribing of Proton Pump Inhibitors: Expert Review – Gastroenterology

Development of a Metric to Detect and Decrease Low-Value Prescribing in Older Adults – JAMA Network Open

The MedSafer Study—Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial – JAMA Internal Medicine

Quantifying Anticholinergic Burden and Sedative Load in Older Adults with Polypharmacy: A Systematic Review of Risk Scales and Models – Drugs & Aging

Deprescribing in palliative patients with cancer: a concise review of tools and guidelines – Supportive Care in Cancer

Prescribing practices, patterns, and potential harms in patients receiving palliative care: A systematic scoping review – Exploratory Research in Clinical and Social Pharmacy

A narrative review of evidence to guide deprescribing among older adults – Journal of General and Family Medicine

Polypharmacy, inappropriate prescribing, and deprescribing in older people: through a sex and gender lens – The Lancet Health Longevity

Polypharmacy Management in Older Patients – Mayo Clinic Proceedings

Psychopharmacological Treatment in Older People: Avoiding Drug Interactions and Polypharmacy – Deutsches Ärzteblatt international

Eliminating Medication Overload: A National Action Plan – Lown Institute

International Group for Reducing Inappropriate Medication Use & Polypharmacy (IGRIMUP): Position Statement and 10 Recommendations for Action – Drugs & Aging

Common ED Medication Errors: Polypharmacy – emDocs

Current and future perspectives on the management of polypharmacy – BMC Family Practice

Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety

Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international

Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety

Special Statement | Postpartum visit checklists for normal pregnancy and complicated pregnancy.

14 Oct, 2022 | 14:18h | UTC

Society for Maternal-Fetal Medicine Special Statement: Postpartum visit checklists for normal pregnancy and complicated pregnancy – American Journal of Obstetrics & Gynecology

Original Guideline: ACOG Postpartum Toolkit (PDF)

Position Statement | Chronic kidney disease as cardiovascular risk factor in routine clinical practice.

14 Oct, 2022 | 14:17h | UTC

Chronic kidney disease as cardiovascular risk factor in routine clinical practice: a position statement by the Council of the European Renal Association – Nephrology Dialysis Transplantation

Position Statement | Home blood pressure monitoring.

14 Oct, 2022 | 14:16h | UTC

Home blood pressure monitoring: a position statement from the Korean Society of Hypertension Home Blood Pressure Forum – Clinical Hypertension

2021 European Society of Hypertension practice guidelines for office and out-of-office blood pressure measurement – Journal of Hypertension

Current applications and limitations of European guidelines on blood pressure measurement: implications for clinical practice – Internal and Emergency Medicine

Randomized Diagnostic Study: home blood pressure measurements correlate better with 24-h ambulatory monitoring measurements compared to clinic, and kiosk measurements.

Study suggests a 30-second interval between automated office blood pressure measurements is as accurate and reliable as a 60-second interval.

USPSTF Statement recommends screening for hypertension in adults 18 years or older with office blood pressure measurement – diagnostic confirmation with blood pressure measurements outside of the clinical setting is advised before starting treatment

Study suggests that 7 days of home blood pressure monitoring is likely better than 24h ambulatory monitoring or 3 office measurements

Recommendations for the diagnosis and treatment of patients with locally advanced and metastatic breast cancer.

14 Oct, 2022 | 14:12h | UTC

AGO Recommendations for the Diagnosis and Treatment of Patients with Locally Advanced and Metastatic Breast Cancer: Update 2022 – Breast Care

Expert Consensus | Cardiac computed tomographic imaging in cardio-oncology.

14 Oct, 2022 | 14:14h | UTC

Cardiac computed tomographic imaging in cardio-oncology: An expert consensus document of the Society of Cardiovascular Computed Tomography (SCCT). Endorsed by the International Cardio-Oncology Society (ICOS) – Journal of Cardiovascular Computed Tomography

Commentary on Twitter

New SCCT Expert Consensus co-endorsed by @ICOSociety: #YesCCT in Cardio-Oncology

This document fills existing gaps about CCT in Cardio-Oncology w experts in cardio-oncology, CCT imaging and cancer medicine @journalCCT 👉https://t.co/lNaQ37sKoQ @onco_cardiology @CardiacCTGuy pic.twitter.com/hILbBimfmZ

— Heart_SCCT (@Heart_SCCT) September 19, 2022

4-year follow-up of a RCT | Pembrolizumab with vs. without chemotherapy in recurrent or metastatic head and neck SCC.

14 Oct, 2022 | 14:11h | UTC

Pembrolizumab With or Without Chemotherapy in Recurrent or Metastatic Head and Neck Squamous Cell Carcinoma: Updated Results of the Phase III KEYNOTE-048 Study – Journal of Clinical Oncology

Original Study: Pembrolizumab alone or with chemotherapy versus cetuximab with chemotherapy for recurrent or metastatic squamous cell carcinoma of the head and neck (KEYNOTE-048): a randomised, open-label, phase 3 study – The Lancet (link to abstract – $ for full-text)

M-A | The prognostic value of CAC zero among individuals presenting with chest pain.

14 Oct, 2022 | 14:10h | UTC

The Prognostic Value of CAC Zero Among Individuals Presenting With Chest Pain: A Meta-Analysis – JACC: Cardiovascular Imaging (link to abstract – $ for full-text)

RCT | A low-intensity psychosocial intervention improved recovery from depression in older adults in Brazil.

14 Oct, 2022 | 14:09h | UTC

A task-shared, collaborative care psychosocial intervention for improving depressive symptomatology among older adults in a socioeconomically deprived area of Brazil (PROACTIVE): a pragmatic, two-arm, parallel-group, cluster-randomised controlled trial – The Lancet Health Longevity

Invited Commentary: Empowering older adults and their communities to cope with depression in resource-limited settings – The Lancet Health Longevity

Commentary on Twitter

Empowering older adults and their communities to cope with #depression in resource-limited settings https://t.co/8GShpxpcOX @clausuemoto #Geriatrics

Our commentary @LancetLongevity about the incredible PRO-ACTIVE intervention by @scazufca & cols https://t.co/x2UerUFAYY pic.twitter.com/IP0DqTmGdP

— Marlon Aliberti (@marlon_aliberti) October 3, 2022

Under a Creative Commons Attribution (CC BY 4.0) License

Cohort Study | Carotid plaque characteristics predict recurrent ischemic stroke and transient ischemic attack.

14 Oct, 2022 | 14:08h | UTC

Carotid Plaque Characteristics Predict Recurrent Ischemic Stroke and TIA: The PARISK (Plaque At RISK) Study – JACC: Cardiovascular Imaging

Cohort Study | Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality.

14 Oct, 2022 | 14:06h | UTC

Purpose in life (Ikigai) and employment status in relation to cardiovascular mortality: the Japan Collaborative Cohort Study – BMJ Open

Perspective | The case for mild stimulation for in vitro fertilization.

14 Oct, 2022 | 14:07h | UTC

The case for mild stimulation for IVF: recommendations from The International Society for Mild Approaches in Assisted Reproduction – Reproductive Biomedicine Online

Commentary on Twitter

New Review paper from @GeetaNargund & the #ISMAAR committee recommends mild ovarian stimulation for IVF should be considered in all clinical scenarios, for effective pregnancy outcomes

Safer, better tolerated and less expensive than conventional IVF.https://t.co/Jv2H2ucQUc pic.twitter.com/LtOSfE98PG

— Reproductive BioMedicine Online (@RBMOnline) September 9, 2022

Cohort Study | Elevated C-reactive protein and subsequent patient-reported cognitive problems in older breast cancer survivors.

14 Oct, 2022 | 14:03h | UTC

Elevated C-Reactive Protein and Subsequent Patient-Reported Cognitive Problems in Older Breast Cancer Survivors: The Thinking and Living With Cancer Study – Journal of Clinical Oncology

News Release: Long-term study supports link between inflammation and cognitive problems in older breast cancer survivors – University of California

Review | Heart failure after right ventricular myocardial infarction.

14 Oct, 2022 | 14:05h | UTC

Heart Failure After Right Ventricular Myocardial Infarction – Current Heart Failure Reports

Cluster RCT | Culturally sensitive vs. standard behavioral approach for promoting weight-loss maintenance in black women.

14 Oct, 2022 | 14:04h | UTC

Promoting weight-loss maintenance among Black women primary care patients: A cluster RCT of a culturally sensitive versus standard behavioural approach – Clinical Obesity

Review | Point-of-care ultrasound in pediatric nephrology.

14 Oct, 2022 | 14:03h | UTC

Point-of-care ultrasound in pediatric nephrology – Pediatric Nephrology (if the link is paywalled, try this one)

M-A | Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections.

14 Oct, 2022 | 14:02h | UTC

Efficacy of different preoperative skin antiseptics on the incidence of surgical site infections: a systematic review, GRADE assessment, and network meta-analysis – The Lancet Microbe

Antiseptic Skin Agents to Prevent Surgical Site Infection After Incisional Surgery: A Randomized, Three-armed Combined Non-inferiority and Superiority Clinical Trial (NEWSkin Prep Study) – Annals of Surgery (link to abstract – $ for full-text)

Alcoholic chlorhexidine skin preparation or triclosan-coated sutures to reduce surgical site infection: a systematic review and meta-analysis of high-quality randomised controlled trials – The Lancet Infectious Diseases

Reducing surgical site infections in low-income and middle-income countries (FALCON): a pragmatic, multicentre, stratified, randomised controlled trial – The Lancet

Commentary on Twitter

To reduce risk of surgical site infections.
👉 chlorhexidine in alcohol better than iodine (esp non-clean surgery)
👉 but only at 2-2.5%. Higher concentration not better!
👉 olanexidine possible alternative but only 1x RCT@LancetMicrobe https://t.co/C8FHtEdYlf pic.twitter.com/FXwEOIg4Pf

— Gabriele Pollara (@gpollara) August 22, 2022

Illustrations under a Creative Commons Attribution (CC BY 4.0) license

M-A | Incidence of cutaneous adverse events with Phosphoinositide 3-Kinase inhibitors as adjuvant therapy in patients with cancer.

14 Oct, 2022 | 14:01h | UTC

Incidence of Cutaneous Adverse Events With Phosphoinositide 3-Kinase Inhibitors as Adjuvant Therapy in Patients With Cancer: A Systematic Review and Meta-analysis – JAMA Oncology (free for a limited period)

RCT | Effect of exercise training or complex mental and social activities on cognitive function in adults with chronic stroke.

14 Oct, 2022 | 13:59h | UTC

Effect of Exercise Training or Complex Mental and Social Activities on Cognitive Function in Adults With Chronic Stroke: A Randomized Clinical Trial – JAMA Network Open

Commentary: For seniors who had a stroke and risk dementia, exercise can help, study says – UPI

Cohort Study | Association between osseointegration of lower extremity amputation and mortality among adults.

14 Oct, 2022 | 14:00h | UTC

Association Between Osseointegration of Lower Extremity Amputation and Mortality Among Adults – JAMA Network Open

RCT | In abortion surgery, Esketamine plus Propofol can reduce hypotension compared to Fentanyl plus Propofol.

14 Oct, 2022 | 13:58h | UTC

Effect of different doses of esketamine compared with fentanyl combined with propofol on hypotension in patients undergoing painless abortion surgery: a prospective, randomized, double-blind controlled clinical trial – BMC Anesthesiology

Commentary: Esketamine as an adjunct with propofol and fentanyl to avoid perioperative hypotension – Physician’s Weekly

RCT | Impact of vaping prevention advertisements on adolescents.

14 Oct, 2022 | 13:57h | UTC

Impact of Vaping Prevention Advertisements on US Adolescents: A Randomized Clinical Trial – JAMA Network Open

News Release: Researchers find FDA ‘Real Cost’ ads reduce teen openness to vaping – UNC Lineberger Comprehensive Cancer Center

Commentary on Twitter

RCT: Real Cost vaping prevention ads led to lower youth susceptibility to vaping and discouraged cigarette smoking. #OAReaserch https://t.co/ASl5oXbn5Z pic.twitter.com/9Uaj4zc7sK

— JAMA Network Open (@JAMANetworkOpen) October 13, 2022

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