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Daily Archives: March 21, 2022

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis.

21 Mar, 2022 | 10:01h | UTC

EASL Clinical Practice Guidelines on prevention and management of bleeding and thrombosis in patients with cirrhosis – Journal of Hepatology

 

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity.

21 Mar, 2022 | 09:47h | UTC

Antigenic evolution will lead to new SARS-CoV-2 variants with unpredictable severity – Nature Reviews Microbiology

 

Commentary on Twitter

 

Future of clinical trial methodology.

21 Mar, 2022 | 09:59h | UTC

Future of Clinical Trial Methodology – Anesthesia & Analgesia

Commentary: Looking to the Future of Clinical Research Methodology – Anesthesia & Analgesia

 

Guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care.

21 Mar, 2022 | 10:02h | UTC

PEER simplified chronic pain guideline: Management of chronic low back, osteoarthritic, and neuropathic pain in primary care – Canadian Family Physician

 

Infographic: IDSA COVID-19 outpatient treatment guidelines roadmap.

21 Mar, 2022 | 09:51h | UTC

COVID-19 Outpatient Treatment Guidelines Roadmap – Infectious Diseases Society of America

 

Commentary on Twitter

 

CDC Report: Effectiveness of mRNA vaccination in preventing COVID-19–associated invasive mechanical ventilation and death in the US.

21 Mar, 2022 | 09:38h | UTC

Effectiveness of mRNA Vaccination in Preventing COVID-19–Associated Invasive Mechanical Ventilation and Death — United States, March 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Related Study: COVID-19–Associated Hospitalizations Among Adults During SARS-CoV-2 Delta and Omicron Variant Predominance, by Race/Ethnicity and Vaccination Status — COVID-NET, 14 States, July 2021–January 2022 – CDC Morbidity and Mortality Weekly Report

Commentary: Studies show vaccines protect against serious Omicron illness – CIDRAP

 

Commentary on Twitter

 

Effectiveness of the Johnson & Johnson vaccine in health-care workers in South Africa in a period when the beta and then the delta SARS-CoV-2 variants of concerns were dominant.

21 Mar, 2022 | 09:43h | UTC

Effectiveness of the Ad26.COV2.S vaccine in health-care workers in South Africa (the Sisonke study): results from a single-arm, open-label, phase 3B, implementation study – The Lancet

Invited Commentary: Sisonke: reaching several goals together – The Lancet

 

Commentary on Twitter (thread – click for more)

 

RCT: Efficacy and acceptability of dietary therapies in non-constipated irritable bowel syndrome: a randomized trial of traditional dietary advice, the low FODMAP diet and the gluten-free diet.

21 Mar, 2022 | 08:53h | UTC

Efficacy and Acceptability of Dietary Therapies in Non-Constipated Irritable Bowel Syndrome: A Randomized Trial of Traditional Dietary Advice, the Low FODMAP Diet and the Gluten-Free Diet – Clinical Gastroenterology and Hepatology

Commentary: Traditional Dietary Advice Optimal as an Irritable Bowel Syndrome Therapy – HCPLivre

Related:

10 mistakes in dietary management of irritable bowel syndrome and how to avoid them.

Supplement: Irritable bowel syndrome and related conditions.

RCT: FODMAPs, but not gluten, elicit modest symptoms of irritable bowel syndrome.

RCT: Among patients with diarrhea-predominant irritable bowel syndrome, a low FODMAP diet achieved earlier symptomatic improvements in stool frequency and excessive wind.

British Society of Gastroenterology guidelines on the management of irritable bowel syndrome

Guidelines for the treatment of irritable bowel syndrome

ACG Clinical Guideline: Management of irritable bowel syndrome

M-A: Efficacy of a low-FODMAP diet in adult irritable bowel syndrome

 

Myocarditis following a third Pfizer vaccination dose in military recruits in Israel.

21 Mar, 2022 | 09:37h | UTC

Myocarditis Following a Third BNT162b2 Vaccination Dose in Military Recruits in Israel – JAMA

Related:

Myocarditis following COVID-19 BNT162b2 vaccination among adolescents in Hong Kong.

[Preprint] Post-marketing active surveillance of myocarditis and pericarditis following vaccination with COVID-19 mRNA vaccines in persons aged 12-39 years in Italy.

Myocarditis after BNT162b2 vaccination in Israeli adolescents.

Myocarditis cases reported after mRNA-Based COVID-19 vaccination in the US from December 2020 to August 2021.

A case-control study showed an increased risk of myocarditis after COVID-19 vaccination with a messenger RNA vaccine compared to an inactivated virus vaccine.

[Preprint] Risk of myocarditis following sequential COVID-19 vaccinations by age and sex.

Risks of myocarditis, pericarditis, and cardiac arrhythmias associated with COVID-19 vaccination vs. SARS-CoV-2 infection.

Case series with 139 adolescents and young adults with suspected myocarditis following mRNA vaccination showed most cases had a mild clinical course and rapid resolution of symptoms.

Heart-inflammation risk from Pfizer COVID vaccine is very low.

Large cohort study with over 2.5 million individuals showed the incidence of myocarditis after the Pfizer vaccine was 2.13 cases per 100,000 persons.

Study with over 5.1 million vaccinated individuals showed the incidence of myocarditis after the receipt of the Pfizer vaccine was low and more common after the second dose in young male recipients.

Large Observational study shows Pfizer Covid vaccine is mostly safe but is associated with increased risk of myocarditis, adenopathy, appendicitis, and herpes zoster.

 

Guideline: Umbilical cord management in preterm and term infants.

21 Mar, 2022 | 08:48h | UTC

Guideline No. 424: Umbilical Cord Management in Preterm and Term Infants – Journal of Obstetrics and Gynaecology Canada

 

ACS nutrition and physical activity guideline for cancer survivors.

21 Mar, 2022 | 08:51h | UTC

American Cancer Society nutrition and physical activity guideline for cancer survivors – CA: A Cancer Journal for Clinicians

Patient Page: Nutrition and Physical Activity Guideline for Cancer Survivors – CA: A Cancer Journal for Clinicians

 

M-A: Prevalence of coronary microvascular disease and coronary vasospasm in patients with nonobstructive coronary artery disease.

21 Mar, 2022 | 08:47h | UTC

Prevalence of Coronary Microvascular Disease and Coronary Vasospasm in Patients With Nonobstructive Coronary Artery Disease: Systematic Review and Meta‐Analysis – Journal of the American Heart Association

 

Review: How to manage a high-output stoma.

21 Mar, 2022 | 08:44h | UTC

How to manage a high-output stoma – Frontline Gastroenterology

 

Commentary on Twitter

 

Review: Challenging management dogma where evidence is non-existent, weak or outdated.

21 Mar, 2022 | 08:55h | UTC

Challenging management dogma where evidence is non-existent, weak or outdated – Intensive Care Medicine (if the link is paywalled, try this one)

 

Large sleep database from the UK Biobank reveals a landscape of human sleep phenotypes.

21 Mar, 2022 | 08:41h | UTC

The 103,200-arm acceleration dataset in the UK Biobank revealed a landscape of human sleep phenotypes – Proceedings of the National Academy of Sciences

Commentary: Half a million nights’ sleep reveal 16 kinds of snoozer – Nature

 

RCT: Imaging modality (CT vs. MRI) and frequency (seven scans over 60 months vs. three scans over 36 months) in surveillance of Stage I Seminoma Testicular Cancer.

21 Mar, 2022 | 08:39h | UTC

Imaging Modality and Frequency in Surveillance of Stage I Seminoma Testicular Cancer: Results From a Randomized, Phase III, Noninferiority Trial (TRISST) – Journal of Clinical Oncology (link to abstract – $ for full-text)

 

M-A: Hydroxyethyl starch for fluid management in patients undergoing major abdominal surgery.

21 Mar, 2022 | 08:35h | UTC

Hydroxyethyl Starch for Fluid Management in Patients Undergoing Major Abdominal Surgery: A Systematic Review With Meta-analysis and Trial Sequential Analysis – Anesthesia & Analgesia

 

M-A: Airway ultrasound as predictor of difficult direct laryngoscopy.

21 Mar, 2022 | 08:36h | UTC

Airway Ultrasound as Predictor of Difficult Direct Laryngoscopy: A Systematic Review and Meta-analysis – Anesthesia & Analgesia

 

Systematic Review: Strategies for using topical corticosteroids in children and adults with eczema.

21 Mar, 2022 | 08:33h | UTC

Strategies for using topical corticosteroids in children and adults with eczema – Cochrane Library

Summary: What is the best way to use topical corticosteroids to treat people with eczema? – Cochrane Library

 

Commentary on Twitter

 

Pro-Con Debate: Prehospital blood transfusion—should it be adopted for civilian trauma?

21 Mar, 2022 | 08:38h | UTC

Pro-Con Debate: Prehospital Blood Transfusion—Should It Be Adopted for Civilian Trauma? – Anesthesia & Analgesia

Infographic: Pre-Hospital Blood Transfusion: A Pro-Con Debate – Anesthesia & Analgesia

Related: RCT: In patients with trauma-related hemorrhagic shock receiving prehospital care, there was no benefit from resuscitation with blood products compared to 0.9% sodium chloride.

 

Editorial | BNP: Biomarker Not Perfect in heart failure with preserved ejection fraction.

21 Mar, 2022 | 08:31h | UTC

Editorial: BNP: Biomarker Not Perfect in heart failure with preserved ejection fraction – European Heart Journal

Original Study: Heart failure with preserved ejection fraction in patients with normal natriuretic peptide levels is associated with increased morbidity and mortality – European Heart Journal (link to abstract – $ for full-text)

 

Blood pressure hyperreactivity to standing: a predictor of adverse outcome in young hypertensive patients.

21 Mar, 2022 | 08:30h | UTC

Blood Pressure Hyperreactivity to Standing: a Predictor of Adverse Outcome in Young Hypertensive Patients – Hypertension (link to abstract – $ for full-text)

News Release: If blood pressure rises upon standing, so may risk for heart attack – American Heart Association

Commentaries:

BP Hyperreactivity to Standing Tied to CV, Renal Events – HealthDay

Young hypertensives: increase in blood pressure on standing linked to increase in adverse events – MedicalResearch

 

Valoctocogene Roxaparvovec gene therapy for Hemophilia A.

21 Mar, 2022 | 08:27h | UTC

Valoctocogene Roxaparvovec Gene Therapy for Hemophilia A – New England Journal of Medicine (link to abstract – $ for full-text)

Commentaries:

Valoctocogene Roxaparvovec Evaluated in Severe Hemophilia A – HealthDay

Hemophilia A Gene Therapy Reduced Bleeding Events, Need for Clotting Factors – AJMC

 

Opinion: Health-related artificial intelligence needs rigorous evaluation and guardrails.

21 Mar, 2022 | 08:29h | UTC

Health-related artificial intelligence needs rigorous evaluation and guardrails – STAT

 

RCT: Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis.

21 Mar, 2022 | 08:26h | UTC

Early symptomatic improvement after ustekinumab therapy in patients with ulcerative colitis: 16-week data from the UNIFI trial – Clinical Gastroenterology and Hepatology (link to abstract – $ for full-text)

 

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