Daily Archives: November 14, 2021
[Preprint] Risk of severe COVID-19 is rare among fully vaccinated individuals in England.
14 Nov, 2021 | 20:10h | UTCCommentary: Risk of severe COVID-19 is rare among fully vaccinated individuals in England – News Medical
Phase 4 RCT: Concomitant administration of COVID-19 vaccines (AstraZeneca or Pfizer) with seasonal influenza vaccines in adults is safe and preserves antibody responses to both vaccines.
14 Nov, 2021 | 20:14h | UTC
Large populational study finds prior SARS-CoV-2 infection reduces the risk of breakthrough infection following mRNA vaccination.
14 Nov, 2021 | 20:12h | UTCCommentaries:
Vaccine plus previous infection may offer enhanced COVID-19 protection – CIDRAP
Commentary on Twitter
Study found prior #SARSCoV2 infection was associated with lower risk for breakthrough infection among persons receiving the SARS-CoV-2 mRNA vaccines; however, the observational study design precludes direct comparison of infection risk btwn the 2 vaccines https://t.co/1RLuKSGPjy
— JAMA (@JAMA_current) November 1, 2021
Populational study in Qatar showed the effectiveness against SARS-CoV-2 Delta-induced severe, critical or fatal disease was 93.4% for the Pfizer vaccine and 96.1% for Moderna.
14 Nov, 2021 | 20:11h | UTC
Commentary on Twitter
A study in @NatureMedicine shows that mRNA COVID-19 vaccines are highly effective at preventing severe outcomes and death caused by the SARS-CoV-2 Delta variant in Qatar despite substantially lower effectiveness at blocking infection. https://t.co/V09Ma583fy pic.twitter.com/QG2HaDsrCo
— Nature Portfolio (@NaturePortfolio) November 4, 2021
What influences people’s responses to public health messages for managing risks and preventing infectious diseases? A rapid systematic review of the evidence and recommendations.
14 Nov, 2021 | 20:06h | UTC
Commentary on Twitter
COVID-19 messages should:
1) be developed with communities
2) address uncertainty immediately + with transparency
3) focus on unifying messages from sources
4) frame messages aimed at increasing understanding, social responsibility + ind control https://t.co/faxtAgngAI— Caroline Tomes MFPH (@carotomes) November 12, 2021
SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study.
14 Nov, 2021 | 20:05h | UTCNews Release: SARS-CoV-2 vaccines are safe and immunogenic in most people with cancer, according to study – Harvard Medical School
Original study: Immunogenicity and Reactogenicity of SARS-CoV-2 Vaccines in Patients With Cancer: The CANVAX Cohort Study – Journal of Clinical Oncology
Commentary from the author on Twitter (thread – click for more)
The CANVAX study is out in @JCO_ASCO! https://t.co/WKrU6dQIEB
Grateful to >1000 CANVAX participants, study leads ( @JustinGainor, @MGHPathology, @BalazsLab) and so many co-authors incl. @arthur_kim_ID, @KimberlyBlumen1, @joanhowMD, @dradityabardia
Much more to come!— Vivek Naranbhai, MD, PhD, DPhil (@vivek_naranbhai) November 10, 2021
#AHA21 – RCT: Among children and adolescents who had screening echocardiograms and were identified as having latent rheumatic heart disease, secondary antibiotic prophylaxis with penicillin G benzathine for 2 years was associated with reduced echocardiographic progression (0.8 vs. 8.2% in the control group).
14 Nov, 2021 | 20:03h | UTCSecondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Secondary Antibiotic Prophylaxis for Latent Rheumatic Heart Disease – American College of Cardiology
Commentaries on Twitter
One of most important studies ever Rheumatic Heart Disease @NEJM https://t.co/U8FuNHLqCJ RCT evidence 2ry prophylaxis reduces progression latent RhD pic.twitter.com/UycTElr7QM
— Michael Marks (@dr_michaelmarks) November 13, 2021
Penicillin slowed the devastating impact of rheumatic heart disease among children in Uganda. Findings of a large-scale, randomized controlled trial were completed in Uganda. Group A strep underlies rheumatic heart disease. New England Journal of Medicine https://t.co/1PKFJ12FvC
— delthia ricks ? (@DelthiaRicks) November 13, 2021
#AHA21 – Pooled data from six prospective cohorts found higher sodium and lower potassium intakes were associated in a dose–response manner with a higher cardiovascular risk.
14 Nov, 2021 | 19:58h | UTC24-Hour Urinary Sodium and Potassium Excretion and Cardiovascular Risk – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Less sodium and more potassium could be key in lowering risk of cardiovascular disease – The Harvard Gazette
Related study: Cohort Study: Joint Association of Urinary Sodium and Potassium Excretion with Cardiovascular Events and Mortality
Commentary on Twitter
In a study involving 10,709 adults, higher sodium intake was significantly associated with higher cardiovascular risk in a dose–response manner with a daily sodium intake of approximately 2000 to 6000 mg. #AHA21 https://t.co/9LDWvDKeUU pic.twitter.com/28yK4mBfdH
— NEJM (@NEJM) November 13, 2021
Editorial: COVID is disrupting scientific careers around the world.
14 Nov, 2021 | 20:08h | UTCCOVID is disrupting scientific careers around the world – Nature
See also:
Scientists count the career costs of COVID – Nature
Potentially long-lasting effects of the pandemic on scientists – Nature
#AHA21 – RCT: Concomitant tricuspid repair in patients undergoing surgery for degenerative mitral regurgitation reduced tricuspid regurgitation progression but increased the need for permanent pacemaker implantation.
14 Nov, 2021 | 20:00h | UTCConcomitant Tricuspid Repair in Patients with Degenerative Mitral Regurgitation – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries:
Tricuspid Repair During Mitral Surgery Slows Disease Progression at 2 Years – TCTMD
CTCR-MVS: Concomitant Tricuspid Repair in Patients With MR – American College of Cardiology
#AHA21 – RCT: In asymptomatic patients with severe aortic stenosis, early surgery improved outcomes compared to conservative treatment.
14 Nov, 2021 | 20:01h | UTCAortic Valve ReplAcemenT versus Conservative Treatment in Asymptomatic SeveRe Aortic Stenosis: The AVATAR Trial – Circulation (free for a limited period)
News release: Surgery to replace heart valve beneficial even with no symptoms of severe aortic stenosis – American Heart Association
Commentaries:
AVATAR Supports Early SAVR in Asymptomatic Severe AS Patients – TCTMD
Related study: #AHA19 – Randomized Trial: Early Surgery Improves Outcomes in Asymptomatic Patients with Very Severe Aortic Stenosis
Commentary on Twitter
#OriginalResearch SimPub#AHA21: The #AVATAR RCT of 157 patients with asymptomatic severe #AS and normal LVEF found that early #SAVR associated w/reduced composite outcome of death, MI, stroke or HF hospitalization compared to mgmt. https://t.co/SdMiWHOPnp #AHAJournals pic.twitter.com/jCcWVZfzse
— Circulation (@CircAHA) November 13, 2021
#AHA21 – RCT: Among patients undergoing cardiac surgery, routine posterior left pericardiotomy can prevent postoperative atrial fibrillation.
14 Nov, 2021 | 19:53h | UTCPosterior left pericardiotomy for the prevention of atrial fibrillation after cardiac surgery: an adaptive, single-centre, single-blind, randomised, controlled trial – The Lancet (free registration required)
Commentaries:
A short cut to prevent postoperative atrial fibrillation – The Lancet (free registration required)
#AHA21 – [Not published Yet] A small, randomized study showed stopping ticagrelor only 2-3 days before bypass surgery may be safe.
14 Nov, 2021 | 19:56h | UTCCommentary: RAPID CABG: No Penalty to Early Surgery for ACS After Stopping Ticagrelor – TCTMD
Cohort study suggests low-dose vs. standard radiation dose CT have similar diagnostic accuracy in suspected acute appendicitis.
14 Nov, 2021 | 19:37h | UTCNews release: Doctors can use CT scans with less radiation to diagnose appendicitis – Oxford University
Original study: Diagnostic accuracy using low-dose versus standard radiation dose CT in suspected acute appendicitis: prospective cohort study – British Journal of Surgery (link to abstract – $ for full-text)
Global, regional, and national mortality among young people aged 10–24 years, 1950–2019: a systematic analysis for the Global Burden of Disease Study 2019.
14 Nov, 2021 | 19:45h | UTCCommentary: Nearly two-thirds of those who died young in 2019 were male, research finds – The Guardian
Commentary on Twitter (thread – click for more)
✨?✨#GBDStudy 2019 analysis published by @TheLancet examined the global, regional, and national #mortality among young people aged 10-24 between 1950-2019, finding that mortality increased in 2019 with age globally?, particularly in males
Read here ⤵https://t.co/6gprq6gM0Z
— Institute for Health Metrics and Evaluation (IHME) (@IHME_UW) October 29, 2021
Consensus practice guidelines on interventions for cervical spine (facet) joint pain.
14 Nov, 2021 | 19:34h | UTCNews release: Only certain patients with chronic neck pain need invasive procedures to treat it – BMJ
Viewpoint | How to Measure Progress in Addressing Physician Well-being: Beyond Burnout.
14 Nov, 2021 | 19:40h | UTCHow to Measure Progress in Addressing Physician Well-being: Beyond Burnout – JAMA
Related:
Physician Well-being 2.0: Where Are We and Where Are We Going?
[Abstract Only] Assessment of Risk Factors for Suicide Among US Health Care Professionals
Beyond Burnout: Docs Decry ‘Moral Injury’ From Financial Pressures of Health Care
Perspective: Hospital Administration Response to Physician Stress and Burnout
Opinion: It’s Time to Talk About Physician Burnout and Moral Injury
Systematic Review: Effect of Organization-Directed Workplace Interventions on Physician Burnout
Perspective: The 3 Causes Of Physician Burnout (And Why There’s No Simple Solution)
Physician Burnout: A Global Crisis (several resources on the subject)
Assessment of arsenic trioxide and all-trans retinoic acid for the treatment of pediatric acute promyelocytic leukemia.
14 Nov, 2021 | 19:32h | UTCNews release: Drug combination helps children with acute promyelocytic leukemia avoid conventional chemotherapy – NIH News Releases
Commentary on Twitter
Clinical trial showed that pediatric patients with acute promyelocytic leukemia (APL) have very high cure rates with treatment regimen that uses targeted therapy and no cytotoxic chemotherapy for standard risk APL or limited anthracycline for high risk APL https://t.co/V3mahhIb6Y
— JAMA Oncology (@JAMAOnc) November 11, 2021
Observational Study: In patients with shockable in-hospital cardiac arrest, epinephrine before defibrillation was associated with worse survival.
14 Nov, 2021 | 19:33h | UTC
Commentary on Twitter
Despite guidelines suggesting otherwise, 27% of patients with an in-hospital cardiac arrest with a shockable rhythm received epinephrine before defibrillation
– and had a lower survival rate
– were defibrillated later-> dont do that!https://t.co/BGtNW02hav pic.twitter.com/WCJd7vtnEc
— Konstantin Krychtiuk (@krychtiukmd) November 13, 2021