Daily Archives: October 19, 2021
Long-term consequences of the misuse of ivermectin data.
19 Oct, 2021 | 09:56h | UTCLong-term consequences of the misuse of ivermectin data – The Lancet Infectious Diseases
Related:
Ivermectin: How false science created a Covid ‘miracle’ drug.
Fraudulent ivermectin studies open up new battleground between science and misinformation.
The lesson of ivermectin: meta-analyses based on summary data alone are inherently unreliable.
Ivermectin: Cochrane’s most talked about review so far, ever. Why?
Flawed ivermectin preprint highlights challenges of COVID drug studies.
Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.
Why was a major study on ivermectin for covid-19 just retracted?
RCT: Ivermectin does not prevent hospitalizations in patients with COVID-19.
RCT: Ivermectin does not improve time to resolution of symptoms among adults with mild COVID-19
Commentary on Twitter
Ivermectin's data for Covid, checkered with inconsistencies, small/low quality clinical trials, and fraud, have long-term consequences for the drug's established and essential useshttps://t.co/NG6vpej8GP @TheLancetInfDis pic.twitter.com/Oz0FxUJetK
— Eric Topol (@EricTopol) October 18, 2021
RECOVERY Trial: In patients admitted to hospital with COVID-19, Colchicine did not reduce 28-day mortality, duration of hospital stay, or risk of progressing to invasive mechanical ventilation or death.
19 Oct, 2021 | 10:14h | UTCRelated:
Systematic Review: Colchicine for the treatment of COVID‐19 – not beneficial for hospitalized patients; inconclusive evidence for the treatment of non-hospitalized patients, “probably slightly reduces the need for hospitalization or death within 28 days compared to placebo”.
19 Oct, 2021 | 10:13h | UTCColchicine for the treatment of COVID‐19 – Cochrane Library
Related:
Commentary on Twitter
JUST PUBLISHED – Is #colchicine (often used to treat #gout) an effective treatment for people with #COVID19? ➡️ https://t.co/IF1enksFpn New @CochraneHaem systematic review includes evidence from 4 RCTS with 11,525 hospitalised & 4488 non‐hospitalised people.
— The Cochrane Library (@CochraneLibrary) October 18, 2021
China’s COVID vaccines have been crucial — now immunity is waning.
19 Oct, 2021 | 09:53h | UTCChina’s COVID vaccines have been crucial — now immunity is waning – Nature
Related:
Editorial | Covid-19 vaccination: evidence of waning immunity is overstated.
COVID vaccine effects wane over time but still prevent death and severe illness.
Perspective | What we actually know about waning immunity.
Another study shows Pfizer mRNA vaccine immunity is reduced over time.
Studies: COVID vaccine protection waning against infection but not hospitalization.
BJS commission on surgery and perioperative care post-COVID-19.
19 Oct, 2021 | 09:52h | UTCBJS commission on surgery and perioperative care post-COVID-19 – British Journal of Surgery
Commentary on Twitter
The @BJSurgery commission on surgery and perioperative care post #Covid_19
? Global surgical community involved
? Pandemic uncovers problems in healthcare systems
?? Training severely damaged
? Ethics committee needed at surgical oncology centreshttps://t.co/CfNk9vBPjV pic.twitter.com/vomtZ3zcql
— Giovanni Marchegiani (@Gio_Marchegiani) October 16, 2021
Editorial: Preparing for “Disease X”.
19 Oct, 2021 | 09:54h | UTCPreparing for “Disease X” – Science
Another observational study suggests Rivaroxaban is associated with higher rates of gastrointestinal bleeding than other direct oral anticoagulants.
19 Oct, 2021 | 09:47h | UTCRivaroxaban Is Associated with Higher Rates of Gastrointestinal Bleeding Than Other Direct Oral Anticoagulants: A Nationwide Propensity Score–Weighted Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentary: Rivaroxaban Again Linked to More Bleeding vs Other DOACs – TCTMD
Commentary on Twitter
A new study from @uni_iceland and @Landspitali finds that #Rivaroxaban is associated with a higher risk of GI bleeding compared to other direct oral anticoagulants. https://t.co/2J451CN5dD #afib #bleedingrisk #DOAC pic.twitter.com/Q6VSv5Taqg
— Annals of Int Med (@AnnalsofIM) October 13, 2021
Cluster RCT: An exercise intervention may improve academic achievement among children.
19 Oct, 2021 | 09:45h | UTC
Commentary on Twitter
Physical inactivity is an important health concern worldwide. This study examined the effects of an exercise intervention on children’s academic achievement, cognitive function, physical fitness, and other health-related outcomes: https://t.co/Pdd0qZqYNN #Pediatrics pic.twitter.com/VkyPba3Sv2
— AAP Journals (@AAPJournals) October 18, 2021
Guideline: Management of anticoagulants and antiplatelet agents in cutaneous surgery.
19 Oct, 2021 | 09:50h | UTC
Systematic Review: Calcium channel blockers versus other classes of drugs for hypertension – “there is moderate certainty evidence that diuretics reduce major cardiovascular events and congestive heart failure more than CCBs”.
19 Oct, 2021 | 08:56h | UTCSummary: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Original Study: Calcium channel blockers versus other classes of drugs for hypertension – Cochrane Library
Commentary on Twitter
How do calcium channel blockers compare to other #antihypertensive drugs for #hypertension??
Our @CochraneLibrary systematic review looks at evidence from 23 RCTs involving 153,849 participants with #highbloodpressure
??https://t.co/dDLCY1RoOT#SystematicReviews #SysRev pic.twitter.com/zJ4JNRRf0L
— Cochrane Hypertension (@CochraneHTN) October 17, 2021
Urolithiasis: ED presentations, evaluation, management, and disposition.
19 Oct, 2021 | 08:53h | UTCUrolithiasis: ED Presentations, Evaluation, Management, and Disposition – emDocs
Podcast: Diagnosis and treatment of Celiac Disease.
19 Oct, 2021 | 08:54h | UTC#300 Celiac Disease with Dr. Amy Oxentenko – The Curbsiders
Preoperative hypertension: perioperative implications and management.
19 Oct, 2021 | 08:51h | UTCPreoperative hypertension: perioperative implications and management – BJA Education
Bioethics | The Reluctant Patient and the Insistent Doctor.
19 Oct, 2021 | 08:50h | UTCThe Reluctant Patient and the Insistent Doctor – The American Journal of Medicine
Review: Wilms Tumor.
19 Oct, 2021 | 08:44h | UTCWilms tumour – Nature Reviews Disease Primers (free for a limited period)
Infographic: Wilms tumour
Commentary on Twitter
This is a schematic showing the timeline of key advances that established the modern clinical management of children with #Wilms tumour https://t.co/lT9ECVeuiZ pic.twitter.com/7KbMSo7qY3
— Nature Reviews Disease Primers (@DiseasePrimers) October 15, 2021
Opinion | Multi-cancer screening tests: communicating about risks should be prioritized.
19 Oct, 2021 | 08:49h | UTC
Review: Stroke prevention after cryptogenic stroke.
19 Oct, 2021 | 08:46h | UTCStroke Prevention After Cryptogenic Stroke – Current Cardiology Reports
Related:
Canadian Stroke Best Practice Recommendations for Acute Stroke Management
M-A: Risk factors for invasive candida infection in critically ill patients – The risk factors associated with the highest risk for ICI were broad spectrum antibiotics (OR 5.6), blood transfusion (OR 4.9), Candida colonization (OR 4.7), central venous catheter (OR 4.7) and total parenteral nutrition (OR 4.6).
19 Oct, 2021 | 08:47h | UTC