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Daily Archives: August 6, 2021

[Preprint] RCT: non-invasive respiratory strategies in acute respiratory failure in patients with COVID-19 – CPAP reduced the composite outcome of intubation or death within 30 days; high-flow nasal oxygenation was not associated with better outcomes.

6 Aug, 2021 | 10:18h | UTC

An adaptive randomized controlled trial of non-invasive respiratory strategies in acute respiratory failure patients with COVID-19 – medRxiv

Commentary: Covid: Pressured oxygen reduces ventilator need – BBC

 

Commentary on Twitter (thread – click for more)

 

Systematic Review: “Remdesivir probably has little or no effect on all‐cause mortality at up to 28 days in hospitalized adults with SARS‐CoV‐2 infection. We are uncertain about the effects of remdesivir on clinical improvement and worsening”.

6 Aug, 2021 | 10:15h | UTC

Remdesivir for the treatment of COVID‐19 – Cochrane Library

Summary: Remdesivir for the treatment of COVID-19 – Cochrane Library

 

Commentary on Twitter (thread – click for more)

 

Flawed ivermectin preprint highlights challenges of COVID drug studies.

6 Aug, 2021 | 10:07h | UTC

Flawed ivermectin preprint highlights challenges of COVID drug studies – Nature

Related:

Systematic review: no evidence to support the use of Ivermectin for treating or preventing COVID-19.

Why was a major study on ivermectin for covid-19 just retracted?

 

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients.

6 Aug, 2021 | 10:13h | UTC

Dexamethasone and tocilizumab treatment considerably reduces the value of C-reactive protein and procalcitonin to detect secondary bacterial infections in COVID-19 patients – Critical Care

 

Clinical Picture: Mucormycosis after COVID-19 in a patient with diabetes.

6 Aug, 2021 | 10:09h | UTC

Mucormycosis after COVID-19 in a patient with diabetes – The Lancet

Related:

COVID-19 and mucormycosis superinfection: the perfect storm.

ECMM/ISHAM recommendations for clinical management of COVID -19 associated mucormycosis in low- and middle-income countries.

The “Black Fungus” in India: The Emerging Syndemic of COVID-19–Associated Mucormycosis – careful use of antibiotics and corticosteroids and closely monitoring blood glucose levels are some of the strategies suggested by the authors.

Multicenter Epidemiologic Study of Coronavirus Disease–Associated Mucormycosis, India – Uncontrolled diabetes mellitus was the most common underlying disease; improper glucocorticoid use was independently associated with the disease.

Opinion | “Doctors have been blamed for the rise in black fungus in India, but the COVID treatment guidelines could be contributing” – improper use of antibiotics and higher than usual doses of corticosteroids may be contributing to the emergence of mucormycosis and other fungal co-infections.

What is mucormycosis, the fungal infection affecting COVID patients in India?

[Preprint] The Emergence of COVID-19 Associated Mucormycosis: Analysis of Cases From 18 Countries.

Mucormycosis: The ‘black fungus’ maiming Covid patients in India

Global Guideline for the Diagnosis and Management of Mucormycosis

 

M-A: Chest radiograph findings in COVID-19.

6 Aug, 2021 | 10:03h | UTC

Systematic review and meta-analysis of chest radiograph (CXR) findings in COVID-19 – Clinical Imaging

 

Review of COVID-19: Abdominal manifestations in adults and multisystem inflammatory syndrome in children.

6 Aug, 2021 | 10:05h | UTC

Review of COVID-19, part 1: Abdominal manifestations in adults and multisystem inflammatory syndrome in children – Clinical Imaging

 

PIDS-IDSA Guideline on diagnosis and management of acute hematogenous osteomyelitis in pediatrics.

6 Aug, 2021 | 09:58h | UTC

Clinical Practice Guideline by the Pediatric Infectious Diseases Society and the Infectious Diseases Society of America: 2021 Guideline on Diagnosis and Management of Acute Hematogenous Osteomyelitis in Pediatrics – Journal of the Pediatric Infectious Diseases Society

News release: New PIDS-IDSA guideline on bone infections in children addresses key diagnostic and treatment questions – Pediatric Infectious Diseases Society

 

Fibrotic interstitial lung abnormalities at 1-year follow-up CT after severe COVID-19.

6 Aug, 2021 | 10:01h | UTC

Fibrotic Interstitial Lung Abnormalities at 1-year Follow-up CT after Severe COVID-19 – Radiology

Related: Postacute Sequelae of COVID-19 Pneumonia: 6-month Chest CT Follow-up.

 

Commentary on Twitter

 

Guideline: Laboratory detection and initial diagnosis of monoclonal gammopathies.

6 Aug, 2021 | 09:56h | UTC

Laboratory Detection and Initial Diagnosis of Monoclonal Gammopathies: Guideline From the College of American Pathologists in Collaboration With the American Association for Clinical Chemistry and the American Society for Clinical Pathology – Archives of Pathology & Laboratory Medicine

 

ESPEN practical guideline: Clinical nutrition in surgery – “Preoperative fasting from midnight is unnecessary in most patients. Patients undergoing surgery, who are considered to have no specific risk of aspiration, shall drink clear fluids until 2 h before anesthesia. Solids shall be allowed until 6 h before anesthesia.”

6 Aug, 2021 | 09:59h | UTC

ESPEN practical guideline: Clinical nutrition in surgery – Clinical Nutrition

 

RCT: Decompression alone is non-inferior to decompression with fusion in patients with degenerative lumbar spondylolisthesis.

6 Aug, 2021 | 09:54h | UTC

Decompression with or without Fusion in Degenerative Lumbar Spondylolisthesis – New England Journal of Medicine

Commentary: Decompression Noninferior for Degenerative Spondylolisthesis – HealthDay

 

Review: Rational fluid resuscitation in sepsis for the hospitalist.

6 Aug, 2021 | 09:53h | UTC

A Narrative Review Rational Fluid Resuscitation in Sepsis for the Hospitalist: A Narrative Review – Mayo Clinic Proceedings

 

Mammographic features are associated with cardiometabolic disease risk and mortality.

6 Aug, 2021 | 09:04h | UTC

Mammographic features are associated with cardiometabolic disease risk and mortality – European Heart Journal

 

Viewpoint: Aligning payments, services, and quality in primary care.

6 Aug, 2021 | 09:08h | UTC

Aligning Payments, Services, and Quality in Primary Care – JAMA (free for a limited period)

 

M-A: Pharmacotherapy for the prevention of chronic pain after surgery in adults.

6 Aug, 2021 | 09:51h | UTC

Pharmacotherapy for the Prevention of Chronic Pain after Surgery in Adults: An Updated Systematic Review and Meta-analysis – Anesthesiology

 

Commentary on Twitter

 

Researchers tell doctors to avoid routine urinary tests for older patients with delirium.

6 Aug, 2021 | 09:01h | UTC

Researchers tell doctors to avoid routine urinary tests for older patients with delirium – Johns Hopkins University School of Medicine

Original article: Things We Do for No Reason™: Obtaining Urine Testing in Older Adults With Delirium Without Signs or Symptoms of Urinary Tract Infection – Journal of Hospital Medicine ($)

 

Commentary on Twitter (thread – click for more)

 

Establishment of an international collaborative network for N-of-1 trials and single-case designs.

6 Aug, 2021 | 09:02h | UTC

Establishment of an International Collaborative Network for N-of-1 Trials and Single-Case Designs – Contemporary Clinical Trials Communications

 

International, multicenter observational study: Outcomes with percutaneous dilatational tracheotomy in high-risk ICU patients.

6 Aug, 2021 | 08:59h | UTC

Percutaneous dilatational tracheotomy in high-risk ICU patients – Annals of Intensive Care

 

Pre-post study: The implementation of a pathway and care bundle for the management of acute occlusive arterial mesenteric ischemia reduced mortality.

6 Aug, 2021 | 08:55h | UTC

The implementation of a pathway and care bundle for the management of acute occlusive arterial mesenteric ischemia reduced mortality – Journal of Trauma and Acute Care Surgery

 

Commentary on Twitter

 

M-A: Effects of early mobilization on the prognosis of critically ill patients.

6 Aug, 2021 | 08:57h | UTC

Effects of early mobilization on the prognosis of critically ill patients: A systematic review and meta-analysis – International Journal of Nursing Studies (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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