Urology
Long-term data: No difference in cardiovascular mortality or morbidity with transdermal estradiol vs. LHRH agonists for androgen suppression in prostate cancer
15 Feb, 2021 | 00:31h | UTCTransdermal oestradiol for androgen suppression in prostate cancer: long-term cardiovascular outcomes from the randomised Prostate Adenocarcinoma Transcutaneous Hormone (PATCH) trial programme – The Lancet (link to abstract – $ for full-text)
RCT: Among patients undergoing transurethral resection of the prostate, it is safe to withhold antimicrobial prophylaxis for those without pre-operative pyuria or a pre-operative, indwelling catheter
11 Feb, 2021 | 01:52h | UTC
RCT: MRI-targeted biopsy safely reduces the need for biopsy in more than one-third of men at risk for prostate cancer
5 Feb, 2021 | 01:27h | UTCCommentary: Clinical trial: Using MRI for prostate cancer diagnosis equals or beats current standard – Ontario Institute for Cancer Research AND Another Win for MRI and Targeted Prostate Biopsy – MedPage Today (free registration required)
Related: MRI-Targeted, Systematic, and Combined Biopsy for Prostate Cancer Diagnosis – New England Journal of Medicine (study and commentaries) Negative Predictive Value of Multiparametric Magnetic Resonance Imaging in the Detection of Clinically Significant Prostate Cancer in the Prostate Imaging Reporting and Data System Era: A Systematic Review and Meta-analysis – European Urology AND Meta-Analysis: MRI plus Targeted Biopsy vs. Systematic Biopsy Alone for the Diagnosis of Prostate Cancer (studies and commentaries)
Small study shows feasibility of MRI-guided focused ultrasound ablation for localized intermediate-risk prostate cancer
3 Feb, 2021 | 01:09h | UTCCommentary: Study: MRI-guided ultrasound treats prostate cancer with few side effects – UPI
Randomized trial: Prostate-only versus whole-pelvic radiation therapy in high-risk and very high-risk prostate cancer
28 Jan, 2021 | 01:09h | UTC
Commentary on Twitter
🚨 POP-RT P3 RCT in @ASCO_pubs
High-risk prostate cancer & pelvic LN risk ≥20% ➡️
-Prostate only
-Pelvic RTIG-IMRT w/ SIB
-50 Gy/25 fxn to Pelvis
-68 Gy to P+SV⬆️bFFS 95% v 81%
⬆️DFS ~90% v 77%
⬆️DMFS 96% v 89%
✅Low S/Ehttps://t.co/r6YjqWl8Cr#pcsm #radonc #oncoalert pic.twitter.com/d9EL02edcd— Mudit Chowdhary, MD (@DrChowdharyMD) January 27, 2021
ASCO Guideline Update: Initial management of noncastrate advanced, recurrent, or metastatic prostate cancer
28 Jan, 2021 | 01:17h | UTC
[Abstract Only] Meta-analysis: Ablation of aldosterone producing adenoma is associated with a reduced operative duration, decreased intraoperative blood loss, and faster postoperative recovery compared to laparoscopic adrenalectomy
21 Jan, 2021 | 00:50h | UTCAblation versus laparoscopic adrenalectomy for the treatment of aldosterone‑producing adenoma: a meta-analysis – Abdominal Radiology (link to abstract – $ for full-text)
AUA/ASRM Guideline: Diagnosis and treatment of infertility in men
19 Jan, 2021 | 01:21h | UTCDiagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline Part I – The Journal of Urology
Diagnosis and Treatment of Infertility in Men: AUA/ASRM Guideline PART II – The Journal of Urology
Randomized trial: Ultra-hypofractionated vs. conventionally fractionated radiotherapy for prostate cancer
19 Jan, 2021 | 01:14h | UTCUltra-hypofractionated versus conventionally fractionated radiotherapy for prostate cancer (HYPO-RT-PC): patient-reported quality-of-life outcomes of a randomised, controlled, non-inferiority, phase 3 trial – The Lancet Oncology (link to abstract – $ for full-text)
Postdischarge virtual visits for low-risk surgeries: A randomized noninferiority clinical trial
17 Jan, 2021 | 21:57h | UTCPostdischarge Virtual Visits for Low-risk Surgeries: A Randomized Noninferiority Clinical Trial – JAMA Surgery (free for a limited period)
Commentary: Surgical Centers Warm Up to Video Chats, Texts for Patient Follow-Up – MedPage Today (free registration required)
Systematic review: Prostatic arterial embolization for men with symptomatic benign prostatic hyperplasia provides similar short term (up to 12 months) improvement in urologic symptom scores and quality of life, but with an increase in re-treatment rates
15 Jan, 2021 | 08:11h | UTC
Systematic review: Adding abiraterone acetate to androgen deprivation therapy for the treatment of metastatic hormone-sensitive prostate cancer
15 Jan, 2021 | 08:10h | UTC
Randomized trial: In kidney transplantation, oxygenated cold perfusion preservation is safe and reduces post-transplant complications compared to standard cold perfusion preservation in kidney transplantation
16 Dec, 2020 | 10:06h | UTCOxygenated versus standard cold perfusion preservation in kidney transplantation (COMPARE): a randomised, double-blind, paired, phase 3 trial – The Lancet (link to abstract – $ for full-text)
Commentary: Oxygenated hypothermic perfusion reduces post-kidney transplant complications – 2 Minute Medicine
CDC Guidelines for Gonococcal Infection, 2020. CDC recommends a single 500 mg intramuscular dose of ceftriaxone for uncomplicated gonorrhea, with oral doxycycline for 7 days when chlamydial coinfection has not been excluded
18 Dec, 2020 | 09:40h | UTCCommentary: CDC Guidelines Recommend Ceftriaxone Monotherapy for Uncomplicated Gonorrhea – NEJM Journal Watch
Commentary on Twitter
https://twitter.com/GarrettHile/status/1339732944613720064
Review: Perioperative venous thromboembolism prophylaxis
3 Dec, 2020 | 08:28h | UTCPerioperative Venous Thromboembolism Prophylaxis – Mayo Clinic Proceedings
Safe surgery: A cluster randomized trial showed that the implementation of control charts with feedback on indicators to surgical teams was associated with concomitant reductions in major adverse events in patients
9 Nov, 2020 | 01:23h | UTC
Review: Management of common postoperative complications
4 Nov, 2020 | 09:26h | UTCManagement of Common Postoperative Complications – Mayo Clinic Proceedings
Randomized trial: Effectiveness of pelvic floor muscle training with and without electromyographic biofeedback for urinary incontinence in women
18 Oct, 2020 | 23:06h | UTCCommentary: For Urinary Incontinence, No Need to Add Biofeedback to Pelvic Floor Exercises – NEJM Journal Watch
Commentary on Twitter
This RCT did not find a statistically significant or clinically important difference in severity of urinary incontinence between women randomised to electromyographic biofeedback plus pelvic floor muscle training or to pelvic floor muscle training alonehttps://t.co/z8nxLplT57
— The BMJ (@bmj_latest) October 17, 2020
Advanced Prostate Cancer: AUA/ASTRO/SUO Guidelines
24 Sep, 2020 | 09:15h | UTCAdvanced Prostate Cancer: AUA/ASTRO/SUO Guideline PART I – The Journal of Urology
Advanced Prostate Cancer: AUA/ASTRO/SUO Guideline PART II – The Journal of Urology
Catheter-associated urinary tract infections in adults: diagnosis, treatment, and prevention
23 Sep, 2020 | 14:35h | UTCCatheter-Associated Urinary Tract Infections in Adults: Diagnosis, Treatment, and Prevention – Journal of Hospital Medicine (free for a limited period)
Systematic review: Therapies for clinically localized prostate cancer
20 Sep, 2020 | 21:15h | UTCTherapies for Clinically Localized Prostate Cancer – Agency for Healthcare Research and Quality
Final report: Therapies for Clinically Localized Prostate Cancer AND Evidence Summary
[Abstract Only] Survival with Olaparib in metastatic castration-resistant prostate cancer
20 Sep, 2020 | 21:13h | UTC
Commentary on Twitter
The PROfound trial showed that olaparib prolonged imaging-based progression-free survival among patients whose tumors contained defects in the BRCA1, BRCA2, or ATM. With longer follow-up, the trial now shows that olaparib prolonged overall survival in these patients. #ESMO20
— NEJM (@NEJM) September 20, 2020
[Abstract Only] Avelumab maintenance therapy for advanced or metastatic urothelial carcinoma
20 Sep, 2020 | 21:11h | UTC
Commentary on Twitter
Maintenance avelumab plus best supportive care significantly prolonged overall survival, as compared with best supportive care alone, among patients with urothelial cancer who had disease that had not progressed with first-line chemotherapy. #ESMO20
— NEJM (@NEJM) September 18, 2020
[Abstract Only] Study: Patient reported outcomes predicting spontaneous stone passage may not have acceptable accuracy
14 Sep, 2020 | 00:55h | UTCPatient Reported Outcomes Predicting Spontaneous Stone Passage May Not Have Acceptable Accuracy – Journal of Urology (link to abstract – $ for full-text)
Commentary: Predicting Spontaneous Passage of a Ureteral Stone – NEJM Journal Watch (free for a limited period)
[Abstract Only] Randomized trial: Antibiotics vs. no therapy in kidney transplant recipients with asymptomatic bacteriuria
11 Sep, 2020 | 01:10h | UTC
Commentary on Twitter
More data ❌ screening/Rxing asymptomatic bacteriuria in kidney transplantation
199 KTx recipients (>2 mo out) randomized to Rx/no Rx for ASB
Rx arm had
💊No ⬇️ in symptomatic UTI
💊5x more ABx exposure
💊subsequent bacteriuria w resistant bacteria #TxIDhttps://t.co/a7aVjIJj0z pic.twitter.com/ngTkJLHCfU— Ilan Schwartz is on🦋 (@GermHunterMD) September 10, 2020