TOP 10 Medical News Stories
Fri, May 25 – 10 Stories of The Day!
25 May, 2018 | 00:19h | UTC
1 – Report: Diet, Nutrition, Physical Activity and Cancer: a Global Perspective – World Cancer Research Fund (free)
Commentaries: A blueprint to beat cancer – World Cancer Research Fund (free) AND 10-year study shows obesity increases risk for 12 cancers – UPI (free)
Related Guideline: Pancreatic cancer in adults: diagnosis and management – National Institute for Health and Care Excellence (free)
Related Systematic Review: Chemotherapy and radiotherapy for advanced pancreatic cancer – Cochrane Library (free)
Summary: ACEP Clinical Policy on Acute VTE 2018 – R.E.BE.L.em (free)
Related: Should We Anticoagulate Patients with Isolated Subsegmental Pulmonary Emboli? – NEJM Journal Watch (free)
4 – Review: The art of cardiovascular risk assessment – Clinical Cardiology (free)
5 – Review: Pitfalls on the replacement therapy for primary and central hypothyroidism in adults – European Journal of Endocrinology (free)
6 – Europe’s open-access drive escalates as university stand-offs spread – Nature News (free)
7 – Perspective: How Tech Can Turn Doctors Into Clerical Workers – The New York Times Magazine (10 articles per month are free)
“The threat that electronic health records and machine learning pose to physicians’ clinical judgment — and their well-being”.
8 – New Free Online Course: Introduction to Critical Care Medicine – University of Glasgow and FutureLearn (free) (via @classcentral)
Editorial: Atopic eczema and cardiovascular disease (free)
Commentaries: Severe eczema and increased risk of cardiovascular problems – The BMJ Opinion (free) AND Severe eczema linked to cardiovascular problems – OnMedica (free) AND People with severe eczema at higher risk of heart conditions – NHS Choices (free)
10 – Association Between Gestational Hypertension and Risk of Cardiovascular Disease Among 617 589 Norwegian Women – Journal of the American Heart Association (free for a limited period)
Editorial: Cardiovascular Sequels of Hypertension in Pregnancy (free for a limited period)
Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries)
Mon, May 28 – 10 Stories of The Day!
28 May, 2018 | 00:31h | UTC
News Release: HCV Guidance Updates Recommendations for Screening and Treating Key Populations (free)
Related Guideline: EASL Recommendations on Treatment of Hepatitis C 2018 – Journal of Hepatology (free)
2 – A1C Targets Should Be Personalized to Maximize Benefits While Limiting Risks – Diabetes Care (free) (via @Abraham_RMI)
Related guideline: Hemoglobin A1c Targets for Glycemic Control With Pharmacologic Therapy for Nonpregnant Adults With Type 2 Diabetes Mellitus: A Guidance Statement Update From the American College of Physicians (free)
“Clinicians should aim to achieve an HbA1c level between 7% and 8% in most patients with type 2 diabetes” (from ACP Guideline, prompting the Editorial)
3 – Latest Developments on the Ebola Outbreak in DRC:
Vaccinations set to begin in Ebola outbreak epicenter – STAT (free) AND Research during Ebola vaccine trial: It’s complicated – Science (free) AND New Ebola Tactics Raise Hope but May Sow Confusion – The New York Times (10 articles per month are free) AND Ebola outbreak in DRC on ‘epidemiological knife-edge,’ says WHO official – Devex (free) AND The success of the new Ebola vaccine will hinge on trust – VOX (free)
4 – Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) (via @Fluid_Academy)
Related Review: Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free)
5 – Perspective: QALYs in 2018—Advantages and Concerns – JAMA (free for a limited period)
Commentary: Appreciating Cardiovascular Disease Risk in South Asians: The Time is Now (free)
Top Ten Things to Know: Atherosclerotic Cardiovascular Disease in South Asians in the United States: Epidemiology, Risk Factors, and Treatments (free PDF)
AHA News: South Asians’ high risk of cardiovascular disease has been hidden by a lack of data (free)
News Release: South Asian Americans are at high risk for heart disease and stroke (free)
7 – Interactive Associations of Vascular Risk and β-Amyloid Burden With Cognitive Decline in Clinically Normal Elderly Individuals: Findings From the Harvard Aging Brain Study – JAMA Neurology (free for a limited period)
Commentaries: Vascular risk interacts with amyloid levels to increase age-related cognitive decline – Massachusetts General Hospital, via ScienceDaily (free) AND Bad Synergy—Together, Vascular Problems and Aβ Hasten Memory Slippage – AlzForum (free) AND Combo of vascular risk, brain amyloid could quicken mental decline – Cardiovascular Business (free)
Commentaries: Low-fat Diet May Improve Overall Survival in Newly Diagnosed Breast Cancer – Oncology Nurse Advisor (free) AND Low-fat diet reduces risk of breast cancer death – NHS Choices (free)
Editorial: Antidepressant induced weight gain (free)
Commentaries: Antidepressant therapy and risk of weight gain – The BMJ Opinion (free) AND Taking antidepressants could be linked to weight gain, according to a new study — and some drugs heighten the risk more than others – Business Insider (free) AND Antidepressants linked to risk of weight gain, study shows – OnMedica (free) AND Antidepressant use linked with weight gain – NHS Choices (free)
10 – Committee Opinion: Gynecologic Care for Adolescents and Young Women With Eating Disorders – American College of Obstetricians and Gynecologists (free)
News Release: Ob-Gyns Have Important Role on Care Team for Women with Eating Disorders – ACOG (free)
Commentary: OB/GYN Group Offers Advice on Caring for Teens, Young Women with Eating Disorders – Physician’s First Watch (free)
Thu, May 24 – 10 Stories of The Day!
24 May, 2018 | 00:05h | UTC
Commentaries: Money a better motivator to stop smoking than free e-cigs or quit aids – Reuters (free) AND E-cigarettes aren’t better at helping smokers quit than other strategies – Journalist’s Resource (free) AND For Smoking Cessation, Money Whispers Louder than Nicotine Replacement – MedPage Today (free registration required)
“Trial finds financial incentives most effective – but nothing very effective” (from MedPage Today)
Editorial: Nurse-Led Communication in the Intensive Care Unit (free)
Commentary: Team Approach to Support Families Improves ICU Patient-Centered Care and Lowers Costs – University of Pittsburg (free)
Summary: Advocating for Life Support Training of Children, Parents, Caregivers, School Personnel, and the Public (free)
News Release: AAP policy says more people need access to life support training, AEDs (free)
Commentary: AAP: Children can be educated in assisting those in cardiac arrest – Healio (free registration required)
5 – Estimating the Association of the 2017 and 2014 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults: An Analysis of National Data – JAMA Cardiology (free for a limited period)
Author Interview: Association of the 2014 and 2017 Hypertension Guidelines With Cardiovascular Events and Deaths in US Adults (free)
Commentary: Under 2017 Guideline, More Than 105 Million Americans Have Hypertension – AJMC (free)
The researchers estimated risk reductions of CVD and all-cause mortality, as well as associated harms from therapy, assuming the entire US adult population achieved guideline-recommended systolic BP treatment goals.
6 – Perspective: Ten dubious beliefs in neurocritical care – PulmCrit (free)
7 – A state of the art review on optimal practices to prevent, recognize, and manage complications associated with intravascular devices in the critically ill – Critical Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
8 – Endovascular ultrasound renal denervation to treat hypertension (RADIANCE-HTN SOLO): a multicentre, international, single-blind, randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)
Related Article: Effect of renal denervation on blood pressure in the presence of antihypertensive drugs: 6-month efficacy and safety results from the SPYRAL HTN-ON MED proof-of-concept randomised trial (link to abstract – $ for full-text)
Commentaries: Two Sham-Controlled Renal Denervation Studies Offer Hope in Hypertension – TCTMD (free) AND Renal denervation linked to significant drops in blood pressure – Cardiovascular Business (free) AND Novel Renal Denervation Catheters Showing Modest BP Reductions – MedPage Today (free registration required)
Commentaries: Medication-related harm is common in older adults after hospital discharge – OnMedica (free) AND Medication-related harm found to be common among older adults, but preventable – News Medical (free)
Commentaries: Avoiding the car for travel could significantly lower risk of illness and death – BMJ, via EurekAlert (free) AND Ditching the car may reduce your risk of dying from heart disease and stroke by almost a third – The Conversation (free)
Tue, May 22 – 10 Stories of The Day!
22 May, 2018 | 00:58h | UTC
Commentaries: Procalcitonin-Guided Care Doesn’t Reduce Antibiotics for Lower Respiratory Tract Infection – NEJM Journal Watch (free) AND Infection blood test of limited value in reducing antibiotic use – MedicalXpress (free)
Commentary: EMCrit Guest Post – The good, the bad, and the ugly of the Joint Statement on REBOA by Zaffer Qasim (free)
Source: Critical Care Reviews Newsletter
3 – Committee Opinion: Postpartum Pain Management – American College of Obstetricians and Gynecologists (free)
News Release: ACOG Recommends Postpartum Pain Management Approach Tailored to Patients (free)
Commentaries: ACOG: Postpartum Pain Management Requires Individualized Approach – MedPage Today (free registration required) AND OB/GYN Group Releases Guidance on Managing Postpartum Pain – NEJM Physician’s First Watch (free)
Commentaries: Experimental Ebola Vaccinations, Considered ‘Paradigm Shift,’ Begin In Congo – NPR (free) AND Ebola vaccine drive launches in DRC as cases rise to 49 – CIDRAP (free) AND Congo begins giving experimental Ebola vaccine to medics – Reuters (free)
See also: Frequently asked questions on Ebola virus disease vaccine – World Health Organization (free)
“Health workers operating in affected areas in the Democratic Republic of the Congo are being vaccinated today and community outreach has started to prepare for the ring vaccination” (via @WHO see Tweet)
5 – Health care is an essential human right – and so is a proper diagnosis – The Conversation (free)
Related Commentary: For First Time, W.H.O. Names Some Lab Tests ‘Essential’ – The New York Times (10 articles per month are free)
See Original WHO Report: List of Essential In Vitro Diagnostics First edition (2018) – World Health Organization (free report and news release)
6 – Review: Autism spectrum disorder: advances in diagnosis and evaluation – The BMJ (free for a limited period)
7 – Opinion: Don’t Put That in My Heart Until You’re Sure It Really Works – The New York Times (10 articles per month are free)
Commentary: Cardiologist wants more rigorous testing before devices, techniques are adopted – Cardiovascular Business (free)
See also: Commentaries (PRO and Con) on the CABANA Trial (all free)
8 – Richard Lehman’s weekly journal review, 21 May 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
9 – Review: Identifying and managing depression in patients with coronary artery disease – Journal of the American Academy of Pas (free)
Commentaries: Depression in Patients With CAD – American College of Cardiology (free) AND Early Depression Diagnosis is Deadly Serious for Patients with Coronary Artery Disease – Florida State University, via NewsWise (free)
Commentaries: Atrial Fibrillation Burden and Stroke Risk – American College of Cardiology (free) AND Greater burden of atrial fibrillation linked to higher stroke risk – Kaiser Permanente, via EurekAlert (free)
Wed, May 23 – 10 Stories of The Day!
23 May, 2018 | 00:05h | UTC
1 – Low-dose corticosteroids for adult patients with septic shock: a systematic review with meta-analysis and trial sequential analysis – Critical Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
“In adults with septic shock treated with low dose corticosteroids, short- and longer-term mortality are unaffected, adverse events increase, but duration of shock, mechanical ventilation and ICU stay are reduced”.
2 – Aldosterone Antagonist Therapy and Mortality in Patients With ST-Segment Elevation Myocardial Infarction Without Heart Failure: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Invited Commentary: Mineralocorticoid Receptor Antagonists in ST-Segment Elevation Myocardial Infarction – JAMA Internal Medicine (free for a limited period)
Aldosterone antagonists are beneficial for patients with STEMI and reduced ejection fraction. This meta-analysis suggests that patients with STEMI and LVEF greater than 40% or without heart failure also have improved outcomes with aldosterone antagonists.
3 – Effect of More vs Less Frequent Follow-up Testing on Overall and Colorectal Cancer–Specific Mortality in Patients With Stage II or III Colorectal Cancer: The COLOFOL Randomized Clinical Trial – JAMA (free for a limited period)
Related Trial: Association Between Intensity of Posttreatment Surveillance Testing and Detection of Recurrence in Patients With Colorectal Cancer (free for a limited period)
Commentaries: Surveillance intensity not associated with earlier detection of recurrence or improved survival in colorectal cancer – MedicalXpress (free) AND CRC: No Increase in Survival with Stepped-Up Surveillance – MedPage Today (free registration required) AND CRC recurrence surveillance studies: No benefit to high-intensity strategy – Oncology Practice (free)
Related Article: Dupilumab Efficacy and Safety in Moderate-to-Severe Uncontrolled Asthma – New England Journal of Medicine (free)
Editorial: New Biologics for Asthma (free)
Commentary: Dupilumab Improves Severe Asthma – NEJM Physician’s First Watch (free)
5 – Five-Year Outcomes with PCI Guided by Fractional Flow Reserve – New England Journal of Medicine (free)
Commentary: FFR in PCI for Stable CAD: Lasting Benefit Shown by FAME 2, SCAAR Data – TCTMD (free)
6 – Pro/Con Debate: CTA as the Initial Test in Stable Angina – American College of Cardiology
Pro: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)
Con: Coronary CTA Should Be the Initial Test in Most Patients with Stable Chest Pain (free)
7 – How PrEP, the pill to prevent HIV, may be fueling a rise in other STDs – Vox (free)
Original Meta-Analysis: Effects of Pre-exposure Prophylaxis for the Prevention of Human Immunodeficiency Virus Infection on Sexual Risk Behavior in Men Who Have Sex With Men: A Systematic Review and Meta-analysis – Clinical Infectious Diseases (link to abstract – $ for full-text)
See also: Guidelines on HIV Pre-exposure Prophylaxis (all free)
Commentaries: BMJ’s scrambled message on eggs and heart disease: a recipe for rotten news coverage – Health News Review (free) AND Expert reaction to eggs and CVD – Science Media Centre (free) AND No, Eating Eggs Will NOT Protect You From Cardiovascular Death – The Methods Man (free)
9 – Rapid Recommendations: Atraumatic (pencil-point) versus conventional needles for lumbar puncture: a clinical practice guideline – The BMJ (free)
“We issue a strong recommendation for use of atraumatic needles in all patients (adults and children) undergoing lumbar puncture because they decrease complications and are no less likely to work than conventional needles”
10 – New BMJ Series: Universal Health Coverage
“The BMJ in partnership with The Harvard Global Health Institute are launching a collection of articles that will explore how to achieve effective Universal Health Coverage (UHC)”
Analysis: Rethinking assumptions about delivery of healthcare: implications for universal health coverage (free)
Opinion: Non-communicable diseases must be part of Universal Health Coverage (free)
Opinion: Ensuring effective investments in Universal Health Coverage at the national level (free)
Opinion: Paying and investing in community health workers accelerates universal health coverage (free)
Mon, May 21 – 10 Stories of The Day!
21 May, 2018 | 00:05h | UTC
1 – Outbreaks Associated with Treated Recreational Water — United States, 2000–2014 – MMWR, CDC (free)
Commentaries: Hotel pools a factor in water-related illness outbreaks – CIDRAP (free) AND Crypto, Pseudomonas and Legionella responsible for most outbreaks in swimming venues – Outbreak News Today (free) AND Sparkling Pool Water May Hold Disease-Causing Parasites – The New York Times (10 articles per month are free) AND CDC: How To Avoid Getting Sick From A Hotel Swimming Pool – Forbes (free)
Commentary: One in Three Have Hypertension – AJP (free)
“What do we learn from checking blood pressure in >1.2 million people of 80 countries who have not had their BP measured in a year? 34% HTN, 46% not controlled, Saturday spikes and a lot more” (via @EricTopol see Tweet)
3 – Perspective: Trying to Put a Value on the Doctor-Patient Relationship – The New York Times Magazine (10 articles per month are free)
“In its push for profits, the U.S. health care system has made it difficult for patients to get personal attention from doctors. But what if hands-on medicine actually saves money — and lives?”
4 – E-cigarettes: A win or loss for public health? – Knowable Magazine (free)
Related Perspective: The Promise of Vaping and the Rise of Juul – The New Yorker (free)
See also: related guidelines, reports and commentaries on e-cigarettes (all free)
“Arguments over whether e-cigarettes are harmful or helpful seem gridlocked as emerging research underscores both the toxicity of vaping and its possible benefits”. (via @ghn_news see Tweet)
5 – Dose Increase Versus Unchanged Continuation of Antidepressants After Initial Antidepressant Treatment Failure in Patients With Major Depressive Disorder: A Systematic Review and Meta-Analysis of Randomized, Double-Blind Trials – The Journal of Clinical Psychiatry (link to abstract – $ for full-text)
Commentary: Depression: boosting SSRIs doesn’t work – Univadis (free registration required)
“Meta-analysis: there is evidence from RCTs against increasing the dose of SSRIs (with the possible exception of citalopram) in adult patients with major depression and antidepressant treatment failure” (via @psychopharmacol see Tweet)
Commentaries: WHO: Ebola in DRC not global emergency; ring vaccination starts in 2 days – CIDRAP (free) AND Ebola outbreak is concerning, but falls short of global emergency, WHO panel says – STAT (free)
7 – Effect of Use of a Bougie vs Endotracheal Tube and Stylet on First-Attempt Intubation Success Among Patients With Difficult Airways Undergoing Emergency Intubation: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: JC: Don’t blame it on the Bougie – St Emlyn’s (free) AND EM Nerd-The Peculiar Case of the Parallel Pathways – EmNerd (free) AND The humble bougie markedly boosts first-pass intubation success – Univadis (free registration required)
Commentaries: Emergency hospital admissions for alcohol a red flag for suicide risk – new study – Public Health Wales (free) AND Alcohol-Related Emergency Admissions: A Marker for Suicide Risk – NEJM Journal Watch (free for a limited period)
9 – Report: World Health Statistics 2018: Monitoring health for the SDGs – World Health Organization (free)
Commentary: World Health Statistics: Over Half Of World’s Population Lack Essential Healthcare – WHO – Vigil 360 (free)
News Release: Keep saying yes to fish twice a week for heart health (free)
AHA News: Eating fish twice a week reduces heart, stroke risk (free)
Commentary: Omega-3 Fatty Acids and Coronary Heart Disease: A Very Fishy Story (free)
Top Ten Things to Know: Seafood Long-Chain n-3 Polyunsaturated Fatty Acids and Cardiovascular Disease (free PDF)
Fri, May 18 – 10 Stories of The Day!
18 May, 2018 | 02:10h | UTC
1 – Inhaled Combined Budesonide–Formoterol as Needed in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Inhaled Combined Therapy as Needed in Mild Asthma (free)
Related Trial: As-Needed Budesonide–Formoterol versus Maintenance Budesonide in Mild Asthma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: International Study Suggests Alternative Treatment for Mild Asthma – McMaster University, via NewsWise (free) AND On Demand as Effective as Maintenance Therapy for Mild Asthma – Medscape (free registration required)
Commentaries: Exercise Doesn’t Slow Cognitive Decline in Patients with Dementia – NEJM Physician’s First Watch (free) AND Rigorous exercise does not halt dementia decline, study concludes – The Guardian (free) AND Expert reaction to effects of exercise on dementia in old people – Science Media Centre (free) AND Exercise ‘doesn’t slow’ progression of dementia – NHS Choices (free)
Commentaries: As Ebola hits major DRC city, WHO convenes emergency panel – CIDRAP (free) AND WHO to weigh declaration of international emergency over Ebola outbreak – STAT (free) AND Congo and WHO race to prevent runaway Ebola outbreak – Reuters (free) AND Fears of Larger Contagion as Ebola Spreads to Major Congo City The New York Times (10 articles per month are free)
4 – Association of disrupted circadian rhythmicity with mood disorders, subjective wellbeing, and cognitive function: a cross-sectional study of 91 105 participants from the UK Biobank – The Lancet Psychiatry (link to abstract – for full-text)
Commentaries: Disrupted sleep-wake cycle linked to mental health problems – new study – The Conversation (free) AND Study: Body clock disruption linked to mood disorders – UPI (free) AND Body clock disruptions linked to mood disorders – NHS Choices (free) AND Maintaining a daily rhythm is important for mental health, study suggests – CNN (free)
5 – Psychological therapies for treatment-resistant depression in adults – Cochrane Library (free)
Summary: Are psychological therapies effective in treating depression that did not get better with previous treatment? – Cochrane Library (free)
6 – Chemotherapy-Induced Peripheral Neuropathy in Long-term Survivors of Childhood Cancer: Clinical, Neurophysiological, Functional, and Patient-Reported Outcomes – JAMA Neurology (free for a limited period)
Commentaries: Peripheral Neuropathy Common in Childhood Cancer Survivors – MPR (free) AND Chemo-Induced Neuropathy Common after Childhood Cancer – MedPage Today (free registration required)
7 – Opinion: The ten pitfalls of lactate clearance in sepsis – Intensive Care Medicine (free)
Source: Critical Care Reviews Newsletter
Commentary: EAS Consensus Document Examines Safety of Statins Beyond Muscle Symptoms – TCTMD (free)
10 – Summary: The Practice of Cardio-Oncology in Spain: Position Statement From Scientific Societies Involved in Cancer and Heart Disease – American College of Cardiology (free)
Original Guideline: Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Thu, May 17 – 10 Stories of The Day!
17 May, 2018 | 01:41h | UTC
#ESOC2018 – Highlights from the 4th European Stroke Organization Conference
Editorial: Haemostatic treatment for intracerebral haemorrhage (free)
Commentaries: Study: Drug to treat bleeding may reduce stroke deaths – UPI (free) AND Drug to treat bleeding may benefit some stroke patients, study finds – University of Nottingham, via EurekAlert (free)
Editorial: Antiplatelet Therapy after Ischemic Stroke or TIA (free)
Commentary: Dual Antiplatelet Therapy or Aspirin Alone After TIA or Minor Stroke? – NEJM Physician’s First Watch (free)
Editorial: MRI-Guided Intravenous Alteplase for Stroke — Still Stuck in Time (free)
Commentary: New treatment option for ‘wake-up’ stroke patients – University of Glasgow, via MedicalXpress (free)
Commentaries: NAVIGATE ESUS: Rivaroxaban Fails to Prevent More Recurrent Cryptogenic Strokes Than Aspirin – TCTMD (free) AND Rivaroxaban Not Superior to Aspirin for Patients with Embolic Stroke of Unknown Source – NEJM Physician’s First Watch (free)
Commentaries: Elevated Stroke Risk Continues for 5 Years After TIA – NEJM Physician’s First Watch (free) AND Five Years after TIA or Minor Stroke, Second-Event Risk Persists – MedPage Today (free)
6 – Manual: Managing epidemics: Key facts about major deadly diseases – World Health Organization (free)
“Managing epidemics. This @WHO manual provides concise, up-to-date knowledge on 15 infectious diseases that have the potential to become international threats, and tips on how to respond to each of them”. (via @Onisillos and @claireekt see Tweet)
7 – Report: Saving lives, spending less: a strategic response to noncommunicable diseases – World Health Organization (free PDF)
News Release: Investing in noncommunicable disease control generates major financial and health gains – World Health Organization (free)
“For every US$1 invested in each policy area, the following returns have been documented:
US$12.82 from promoting healthy diets
US$9.13 from reducing the harmful use of alcohol
US$7.43 from lower tobacco use
US$3.29 from providing drug therapy for cardiovascular disease
US$2.80 from increasing physical activity
US$2.74 from managing cancer”
8 – ASCO 2018: Shortening Adjuvant Trastuzumab to 6 Months in Patients With HER2-Positive Early Breast Cancer Is Effective and Reduces Cardiac Toxicities – The ASCO Post (free)
Commentaries: Test of Herceptin Finds Briefer Treatment Can Work, With Fewer Side Effects – NPR (free) AND Shorter drug treatment OK for many breast cancer patients – Associated Press (free) AND For Women With Early Breast Cancer, Herceptin Treatment Can Be Much Shorter – The New York Times (10 articles per month are free)
““For women with early-stage breast cancer who needed the drug Herceptin, 6 months of treatment were as good as 12, a major study found. Less risk of side effects, less cost, less time “being a patient.”” (via @NYTHealth see Tweet)
“Global incident cases of multiple myeloma more than doubled from 1990-2016 w/incident cases increasing by 126%. The largest increase was in middle-SDI countries, particularly E. Asia with a 262% increase in incidence cases”. (via @IHME_UW see Tweet)
Commentary: Ibuprofen alone not an option for simple UTIs, study finds – CIDRAP (free) AND Randomized trial finds ibuprofen not a safe alternative to antibiotics for UTIs – PLOS, via ScienceDaily (free)
Related Research: Symptomatic treatment of uncomplicated lower urinary tract infections in the ambulatory setting: randomised, double blind trial- The BMJ (free)
Wed, May 16 – 10 Stories of The Day!
16 May, 2018 | 00:04h | UTC
1 – News Release: First-ever WHO list of essential diagnostic tests to improve diagnosis and treatment outcomes (free) (via @Onisillos)
Executive summary: List of Essential In Vitro Diagnostics, First edition (2018) – World Health Organization (free PDF)
News release: Study by center for health security identifies characteristics of microorganisms most likely to cause a global pandemic (free)
Commentaries: Is this the face of Disease X? The deadly pathogens which could cause the next global pandemic – The Telegraph (free) AND The Next Deadly Pandemic Could Be Unlike Any Threats We Know, Say Experts – Science Alert (free) AND The Next Pandemic: Forget Zika Or Ebola, Airborne Viruses Like The Flu And The Common Cold Are The Real Threat – Inquisitr (free) AND Report: Next Pandemic Will Likely Be Respiratory-Based Virus – MedPage Today (free registration required)
Related: Are we prepared for the looming epidemic threat? (free commentaries and video)
3 – Position Paper: Pathways and mechanisms linking dietary components to cardiometabolic disease: thinking beyond calories – Obesity Reviews (free)
Commentary: Some calories more harmful than others – University of California, via EurekAlert (free)
4 – Review: Diagnostic workup, etiologies and management of acute right ventricle failure – Intensive Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
5 – Improving Prediction of Dementia in Primary Care – Annals of Family Medicine (free)
Commentaries: Screening Tool Improves Dementia Prediction – Medscape (free registration required) AND Visual Test Could Help Predict Dementia Risk in Elders – NEJM Physician’s First Watch (free)
Commentaries: Biomarkers, PET imaging may predict cognitive decline en route to Alzheimer’s – Health Imaging (free) AND Amyloid PET Scan Can Predict Progression to Alzheimer’s in Patients With Mild Cognitive Impairment – MedicalResearch.com (free)
Related Studies: Elevated Brain Amyloid and Subsequent Cognitive Decline Among Cognitively Normal Persons (link to abstract and free commentaries) AND Identifying incipient dementia individuals using machine learning and amyloid imaging (free full-text and commentaries) AND High performance plasma amyloid-β biomarkers for Alzheimer’s disease (link to abstract and free commentaries)
7 – Last Month in Oncology with Dr. Bishal Gyawali: April 2018 – eCancer News (free)
8 – Effect of Intravesical Instillation of Gemcitabine vs Saline Immediately Following Resection of Suspected Low-Grade Non–Muscle-Invasive Bladder Cancer on Tumor Recurrence: SWOG S0337 Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Intravesical Gemcitabine Therapy Cuts Bladder Cancer Recurrence – MPR (free) AND Simple post-surgery step reduces bladder cancer recurrence – SWOG, via EurekAlert (free)
9 – Drug-eluting stents versus bare-metal stents in saphenous vein grafts: a double-blind, randomised trial – The Lancet (link to abstract – $ for full-text)
Commentary: Outcomes similar with DES vs. BMS in saphenous vein graft lesions – Healio (free registration required)
10 – Association of Colonoscopy Adenoma Findings With Long-term Colorectal Cancer Incidence – JAMA (free for a limited period)
Related Reviews: Optimizing post‐polypectomy surveillance: A practical guide for the endoscopist – Digestive Endoscopy (free) AND Optimal Colonoscopy Surveillance Interval after Polypectomy – Clinical Endoscopy (free)
Related Guidelines: Guidelines for Colonoscopy Surveillance After Screening and Polypectomy: A Consensus Update by the US Multi-Society Task Force on Colorectal Cancer (free) AND Korean Guidelines for Postpolypectomy Colonoscopy Surveillance – Digestive Endoscopy (free) AND Colorectal cancer surveillance after index colonoscopy: Guidance from the Canadian Association of Gastroenterology (free) AND Post-polypectomy colonoscopy surveillance: European Society of Gastrointestinal Endoscopy (ESGE) Guideline (free)
Advanced adenomas are associated with subsequent increased risk for colorectal cancer, but nonadvanced adenomas don’t seem to be associated with increased risk.
Tue, May 15 – 10 Stories of The Day!
15 May, 2018 | 01:28h | UTC
1 – News Release: WHO plan to eliminate industrially-produced trans-fatty acids from global food supply – World Health Organization (free)
See also: REPLACE Action package: Trans Fat Free by 2023 – World Health Organization (free resources)
Commentaries: Editorial Board Opinion: The World Doesn’t Need Trans Fats – The New York Times (10 articles per month are free) AND WHO calls for trans fats to be eliminated within five years – Reuters (free) AND Industrial trans fats must be removed from food supply, WHO says – The Guardian (free) AND The new global plan to eliminate the most harmful fat in food, explained – VOX (free)
2 – Experimental vaccine to be used against Ebola outbreak in the DRC – STAT (free)
Related: WHO to send vaccines to fight new Ebola outbreak – NBC News (free) AND The New Ebola Outbreak Could Take ‘Three, Maybe Four’ Months to Control – The Atlantic (free)
See also: WHO News: Ebola Outbreak Declared in Democratic Republic of the Congo (free news release and commentaries)
3 – Complete Revascularization During Primary Percutaneous Coronary Intervention Reduces Death and Myocardial Infarction in Patients With Multivessel Disease: Meta-Analysis and Meta-Regression of Randomized Trials – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)
Commentary: Complete Revascularization During PCI for Multivessel STEMI – American College of Cardiology (free)
Related: Meta-Analysis of Culprit-Only vs Multivessel PCI in Patients with STEMI and Multivessel Coronary Disease (link to abstract, commentaries and Cochrane Review on the subject)
4 – The Burnout Crisis in American Medicine – The Atlantic (free)
Related: Why Physician Burnout Is Endemic, and How Health Care Must Respond – NEJM Catalyst (free) AND Counting the costs: U.S. hospitals feeling the pain of physician burnout – Reuters (free) AND Panic, chronic anxiety and burnout: doctors at breaking point – The Guardian (free) AND To Care Is Human — Collectively Confronting the Clinician-Burnout Crisis – New England Journal of Medicine (free) AND Beyond Burnout — Redesigning Care to Restore Meaning and Sanity for Physicians – New England Journal of Medicine (free)
5 – Richard Lehman’s journal review, 14 May 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
6 – Perspective: Deployment of Preventive Interventions — Time for a Paradigm Shift – New England Journal of Medicine (free)
8 – Guideline: Deprescribing benzodiazepine receptor agonists – Canadian Family Physician (free) (via @Deprescribing)
Related: CaDeN Deprescribing Guidelines and Algorithms (free) AND 11 Drugs You Should Seriously Consider Deprescribing – Medscape Slideshow (free registration required) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free)
9 – NAP6 Report: Anaesthesia, Surgery and Life-Threatening Allergic Reactions: Report and findings of the Royal College of Anaesthetists’ 6th National Audit Project (free PDF)
News Release: RCoA undertakes largest ever study of anaphylaxis in anaesthesia and surgery (free)
Infographic: Anaesthesia, Surgery and Life-Threatening Allergic Reactions (free PDF)
“The study found teicoplanin is 17-fold more likely to cause anaphylaxis than penicillin and similar drugs. As 90 per cent of patients who report penicillin allergy are in fact not allergic, better identification of true allergy would reduce risk”. (from News Release)
10 – Guideline: Screening for impaired vision in community-dwelling adults aged 65 years and older in primary care settings – Canadian Task Force on Preventive Health Care (free)
See also: Summary of recommendations for clinicians and policy-makers (free)
Commentaries: Screening for impaired vision in older adults: New Canadian guideline – Canadian Medical Association Journal, via EurekAlert (free) AND Canadian Guideline Recommends Against Vision Screening of Older Adults in Primary Care Settings – NEJM Physician’s First Watch (free)
Mon, May 14 – 10 Stories of The Day!
14 May, 2018 | 00:11h | UTC
Editorial: Finding the Right Balance (free)
Commentaries: Restrictive fluids tied to kidney injury after major abdominal surgery – MDedge (free) AND Restricting Fluids During Abdominal Surgery Shows No Benefit, Possible Renal Risk – Medscape (free registration required)
2 – Investigational Testing for Zika Virus among U.S. Blood Donors – New England Journal of Medicine (free)
Quick Take Video Summary: Testing Blood Donations for Zika Virus (free)
Sounding Board: Revisiting Blood Safety Practices Given Emerging Data about Zika Virus (free)
Commentaries: Study: Zika blood donation screening costly, finds few cases – CIDRAP (free) AND Testing for Zika virus in blood donors finds few infections — at a cost of about $5.3 million each – STAT (free)
3 – Corticosteroids Reduce Risk of Death Within 28 Days for Patients With Severe Alcoholic Hepatitis, Compared With Pentoxifylline or Placebo—a Meta-analysis of Individual Data – Gastroenterology (link to abstract – $ for full-text)
Commentary: Severe alcoholic hepatitis: corticosteroids alone are best for short-term survival – Univadis (free registration required)
4 – Advice for Patients: Are blood pressure measurement mistakes making you chronically ill? – American Heart Association News (free text and infographic)
Commentary: BP measurement: you’re probably doing it wrong – Univadis (free registration required)
5 – Oral Antibiotic Exposure and Kidney Stone Disease – Journal of the American Society of Nephrology (link to abstract – $ for full-text)
Commentaries: Study suggests oral antibiotics may increase kidney stone risk – CIDRAP (free) AND Antibiotics May Raise the Risk for Kidney Stones – The New York Times (free) AND Oral Antibiotics May Raise Risk of Kidney Stones – Children’s Hospital of Philadelphia, via NewsWise (free)
6 – Viewpoint: Management Reasoning: Beyond the Diagnosis – JAMA (free for a limited Period)
7 – Association of Efficacy of Resistance Exercise Training With Depressive Symptoms: Meta-analysis and Meta-regression Analysis of Randomized Clinical Trials – JAMA Psychiatry (link to abstract – $ for full-text)
Commentaries: Resistance Exercise Might Improve Depression Symptoms – NEJM Physician’s First Watch (free) AND Resistance exercise may reduce depressive symptoms in adults – MedicalXpress (free) AND Resistance Exercise Training May Alleviate Some Depressive Symptoms – MedicalResearch.com (free)
8 – Global statistics on alcohol, tobacco and illicit drug use: 2017 status report – Addiction (free PDF)
Commentaries: Alcohol and tobacco are by far the biggest threat to human welfare of all addictive drugs – Society for the Study of Addiction, via ScienceDaily (free) AND Which drugs pose the biggest threat to public health? – Medical News Today (free)
9 – Methylphenidate for attention deficit hyperactivity disorder (ADHD) in children and adolescents – assessment of adverse events in non-randomised studies – Cochrane Library (link to abstract – $ for full-text)
“Our findings suggest that methylphenidate may be associated with a number of serious adverse events as well as a large number of non-serious adverse events in children and adolescents, which often lead to withdrawal of methylphenidate”.
10 – Cost-effectiveness of Electroconvulsive Therapy vs Pharmacotherapy/Psychotherapy for Treatment-Resistant Depression in the United States – JAMA Psychiatry (free for a limited period)
Author interview: Cost-effectiveness of Electroconvulsive Therapy for Treatment-Resistant Depression in the United States (free)
Commentaries: Study about ‘shock therapy’ for depression suggests more patients should try it sooner – Michigan Medicine – University of Michigan, via EurekAlert (free) AND Third-Line Electroconvulsive Therapy May Be Best for Patients With Treatment-Resistant Depression – Psychiatric News Alert (free) AND ECT Found Cost Effective Early in Depression Treatment – MedPage Today (free registration required)
Fri, May 11 – 10 Stories of The Day!
11 May, 2018 | 02:05h | UTC
1 – AHA/ACOG Presidential Advisory: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists – Circulation (free PDF)
News Releases: OB-GYNs, cardiologists join to fight the No. 1 killer of women (free) AND Annual well woman visit to the OB/GYN can keep your heart healthy: AHA/ACOG Presidential Advisory (free)
Top Ten Things to Know: Promoting Risk Identification and Reduction of Cardiovascular Disease in Women Through Collaboration with Obstetricians and Gynecologists (free PDF)
Editorial: No more vertebroplasty for acute vertebral compression fractures? (free)
Related Systematic Review: Percutaneous vertebroplasty for osteoporotic vertebral compression fracture – Cochrane Library (link to abstract and summary)
3 – CABANA: No Outcomes Benefit In First Big Trial Of AF Ablation – Cardiobrief (free)
Related Commentaries: Catheter ABlation vs ANtiarrhythmic Drug Therapy in Atrial Fibrillation – CABANA – American College of Cardiology (free) AND CABANA Misses Primary Endpoint, but Electrophysiologists See Support for Ablation – TCTMD (free)
4 – Guideline: Erectile Dysfunction – American Urology Association (2018) (free)
Commentary: EULAR Releases Recommendations for Pain Management in OA, Inflammatory Arthritis – Rheumatology Advisor (free)
6 – Perspective: The Catch-22 of Mass-Prescribing Antibiotics – Wired (free)
Related Commentary: African study on pre-emptive antibiotics in kids spurs resistance debate – CIDRAP (free)
Related Study: Azithromycin to Reduce Childhood Mortality in Sub-Saharan Africa – New England Journal of Medicine (free)
Commentary: Higher risks associated with vaginal birth after cesarean, although absolute risk small – CMAJ, via ScienceDaily (free)
8 – New Online Course: An introduction to systematic searching in PubMed – University of Nottingham (free)
“This course shows you how you can construct a comprehensive, systematic search strategy in PubMed to answer a clinical question” (via @CochraneUK see Tweet)
9 – Systematic Review: Induction of labour for improving birth outcomes for women at or beyond term – Cochrane Library (free)
Summary: Induction of labour in women with normal pregnancies at or beyond term – Cochrane Library (free)
Commentaries: Tom Marshall: The importance of asking the right research question – BMJ Opinion (free) AND Patients who have had an irregular heart beat can’t ever be considered ‘cured’ – University of Birmingham (free)
Thu, May 10 – 10 Stories of The Day!
10 May, 2018 | 00:40h | UTC
News Release: Guttmacher-Lancet Commission Proposes a Bold, New Agenda for Sexual and Reproductive Health and Rights – Guttmacher Institute (free)
Executive Summary: Accelerate Progress: Sexual and Reproductive Health and Rights for All – Guttmacher Institute (free)
Invited commentaries: Sexual and reproductive health and rights for all: an urgent need to change the narrative (free) AND Addressing the unfinished agenda on sexual and reproductive health and rights in the SDG era (free) AND Defining sexual and reproductive health and rights for all (free)
Commentaries: Why it could cost less than R120 per year to save a life – Bhekisisa (free) AND Gender-based violence must be at the heart of global health agenda: expert comment – London School of Hygiene & Tropical Medicine (free)
2 – Prophylactic vaccination against human papillomaviruses to prevent cervical cancer and its precursors – Cochrane Library (link to abstract and summary – $ for full-text)
News Release: Does HPV vaccination prevent the development of cervical cancer? Are there harms associated with being vaccinated? – Cochrane Library (free)
Scientific Expert Reaction: Cochrane Review on HPV vaccine for cervical cancer prevention in girls and women – Cochrane Library (free)
Commentaries: HPV vaccine ‘safe and effective’, says review – NHS Choices (free) AND Experts welcome new evidence on HPV jab efficacy and safety – OnMedica (free)
With a median follow-up of 3.9 years, high-dose as compared with low-dose pitavastatin significantly reduced the risk of the primary end point (4.3% vs 5.4%; NNT = 90), a composite of cardiovascular death, nonfatal myocardial infarction, nonfatal ischemic stroke, or unstable angina requiring emergency hospitalization.
Original article: Mortality after Fluid Bolus in African Children with Severe Infection – New England Journal of Medicine (free)
Commentaries: Eat less saturated, trans fats to curb heart disease: WHO – Reuters (free) AND Eat Less Saturated and Trans Fats, World Health Organization Says – Consumer Reports (free) AND ‘Bad’ fats targeted in new global health guidelines – UN News (free)
“Adults and children should consume a maximum of 10 percent of their daily calories in the form of saturated fat such as meat and butter and one percent from trans fats to reduce the risk of heart disease, the World Health Organization said on Friday” (from Reuters)
Commentary: Hospital-to-home transitional care reduces deaths, readmissions for heart failure – Cardiovascular Business (free)
7 – Correction to: 2018 Guidelines for the Early Management of Patients With Acute Ischemic Stroke: A Guideline for Healthcare Professionals From the American Heart Association/American Stroke Association – Stroke (free PDF)
Commentaries: AHA Rescinds Large Sections of New Stroke Guidelines – Medscape (free registration required) AND AHA/ASA retracts large portion of new stroke guidelines – Cardiovascular Business (free)
8 – Editorial: All science should inform policy and regulation – PLOS Medicine (free) (via @RasoiniR)
9 – Association of Preprocedural Fasting With Outcomes of Emergency Department Sedation in Children – JAMA Pediatrics (free for a limited period)
Commentaries: Preprocedural Fasting Not Necessary for Children in ED – Medscape (free registration required) AND Pre-Sedation Guidelines for Kids May Be Too Strict – MedPage Today (free registration required)
Related: NPO for sedation? Don’t swallow the myth – First10Em (free)
10 – Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Author Interview: Association Between Psychological Interventions and Chronic Pain Outcomes in Older Adults (free)
Commentaries: Psychological interventions can help treat chronic pain in seniors – UPI (free) AND Not All In Your Head: Psychological Therapies Not a Panacea for Pain – MedicalResearch.com (free)
Tue, May 8 – 10 Stories of The Day!
8 May, 2018 | 01:19h | UTC
1 – Management of Type 1 Diabetes With a Very Low–Carbohydrate Diet – Pediatrics (free)
Commentaries: How Low Can You Go? Does Lower Carb Translate to Lower Glucose? – Pediatrics (free) AND Very-low-carb diet shows promise in type 1 diabetes – Boston Children’s Hospital, via ScienceDaily (free) AND How a Low-Carb Diet Might Aid People With Type 1 Diabetes – The New York Times (10 articles per month are free) AND Is Exceptional Control of Type 1 Diabetes Possible with a Low-Carbohydrate Diet? – Dr. David Ludwig Blog (free)
*Randomized controlled trials are warranted.
Commentaries: Every cancer patient should be prescribed exercise medicine – The Conversation (free) AND Cancer: ‘If exercise was a pill it would be prescribed to every patient’ – The Guardian (free)
3 – Guideline: Management of stable angina – Scottish Intercollegiate Guidelines Network (free)
4 – Guideline: Pharmacological management of migraine – Scottish Intercollegiate Guidelines Network (free)
5 – The Surviving Sepsis Campaign Bundle: 2018 update – Intensive Care Medicine (free)
Opinion Against this Guideline: Petition to retire the surviving sepsis campaign guidelines – PulmCrit (free) (via @emdocsdotnet)
6 – Review: Alternatives to the Swan–Ganz catheter – Intensive Care Medicine (free for a limited period) (via @f_g_zampieri)
7 – Perspective: Questionable Admissions – New England Journal of Medicine (free)
8 – Clinical Handbook: Care of girls and women living with female genital mutilation – World Health Organization (free)
9 – Summary: AHA Scientific Statement on Right Heart Failure – American College of Cardiology (free)
Original Guideline: Evaluation and Management of Right-Sided Heart Failure: A Scientific Statement From the American Heart Association (free PDF)
Wed, May 9 – 10 Stories of The Day!
9 May, 2018 | 00:37h | UTC
3 – Screening for Prostate Cancer: US Preventive Services Task Force Recommendation Statement – JAMA (free)
Editorials: Prostate-Specific Antigen (PSA) Screening for Prostate Cancer: Revisiting the Evidence (free) AND USPTF Prostate Cancer Screening Recommendations—A Step in the Right Direction (free) AND Implications of the New USPSTF Prostate Cancer Screening Recommendation—Attaining Equipoise (free) AND Prostate Cancer Screening—A New Recommendation for Meaningful Physician-Patient Conversations (free)
Author Interview: USPSTF Recommendation: Screening for Prostate Cancer (free)
Video Summary: PSA Screening for Prostate Cancer: The 2018 USPSTF Recommendation Statement (free)
Infographic with key Facts: Is Prostate Cancer Screening Right for You? Understanding the Potential Benefits vs. Harms for Men 55-69 (free)
Commentary: Prostate cancer screening: the decision is up to you – Reuters (free)
4 – Effect of Coaching to Increase Water Intake on Kidney Function Decline in Adults With Chronic Kidney Disease: The CKD WIT Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Drinking more water does not slow decline of kidney function for kidney disease patients – Lawson Health Research Institute, via EurekAlert (free) AND Study: Drinking more water doesn’t slow kidney disease – UPI (free)
5 – Association of Mild Traumatic Brain Injury With and Without Loss of Consciousness With Dementia in US Military Veterans – JAMA Neurology (free for a limited period)
Editorial: Risk of Dementia Outcomes Associated With Traumatic Brain Injury During Military Service (free)
Commentaries: Dementia Risk Doubles Following Concussion, UCSF Study Shows – University of California San Francisco (free) AND Vets with Head Injury More Likely To Develop Dementia – MedicalResearch.com (free)
See two recent cohort studies with similar results: Long-term risk of dementia among people with traumatic brain injury (link to abstract and free commentaries) AND Traumatic Brain Injury and the Risk of Dementia Diagnosis (free article and commentaries)
6 – New Ebola outbreak declared in Democratic Republic of the Congo – World Health Organization (free)
Commentaries: New Ebola outbreak confirmed in DR Congo: UN health agency scales up response – UN News (free) AND Seventeen deaths reported in Congo as Ebola outbreak confirmed – Reuters (free) AND DRC confirms 2 Ebola infections, probes suspected cases – CIDRAP (free)
7 – Guideline: Investigation and management of a raised serum ferritin – British Journal of Haematology (free)
8 – Richard Lehman’s journal review, 8 May 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
9 – Alzheimer’s? Your Paperwork May Not Be in Order – The New York Times (10 articles per month are free)
Related: New Document for Patients: Advanced Health Directive for Dementia (free document and commentaries)
10 – Platelet Count Affects Efficacy of Folic Acid in Preventing First Stroke – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Folic acid ‘may help reduce stroke risk in people with high blood pressure’ – NHS Choices (free) AND Folic Acid Supplements May Reduce Stroke Risk in Hypertensive Patients – American College of Cardiology (free) AND Folic Acid Cut Strokes in Hypertensive Patients on Enalapril – MedPage Today (free registration required) AND Folic acid supplementation may help prevent first stroke in high-risk patients with hypertension – ACP Internist (free)
Mon, May 7 – 10 Stories of The Day!
7 May, 2018 | 00:29h | UTC
1 – SAVE LIVES: Clean Your Hands, 5 May 2018 – World Health Organization Campaign (free guidelines, implementation tools, infographics, videos and more)
“It’s in your hands – prevent sepsis in health care”
2 – Consensus statement for cancer patients requiring intensive care support – Annals of Hematology (free)
Source: Critical Care Reviews Newsletter
Source: Critical Care Reviews Newsletter
4 – A Simple Way to Improve a Billion Lives: Eyeglasses – The New York Times (10 articles per month are free)
“It’s the biggest health crisis you’ve never heard of. Doctors, philanthropists and companies are trying to solve it”.
5 – Opinion: Can we say who has died because of the breast-screening appointment error? – by David Spiegelhalter (free) (via @RichardLehman1 and @d_spiegel, see Tweet with infographic)
Related opinions: Breast cancer screening scandal must prompt review of mammograms – The Guardian (free) AND Breast cancer screening programme ‘does more harm than good’ – BBC (free) AND Did Breast Cancer Screening Error Cause Major Health Harm? – Medscape (free registration required)
6 – Decisions, Decisions: HMS physicians review the many factors in choosing breast cancer screenings – Harvard Medical School (free commentary and video) (via @tlisboa79 and @brhospitalist)
Original article: Breast Cancer Screening in 2018: Time for Shared Decision Making – JAMA (link to abstract – $ for full-text)
8 – University of Twitter? Scientists give impromptu lecture critiquing nutrition research – CBC (free)
Related: Twitter-Based Medicine: How Social Media is Changing the Public’s View of Medicine – The Health Care Blog (free) AND What’s your doctor reading? How social media is disrupting medical education – National Post (free)
Commentary: Women who eat fast food may take longer to get pregnant – NHS Choices (free) AND Women Who Eat Fast Food Take Longer to Become Pregnant – University of Adelaide, via NewsWise (free) AND Want to increase fertility? Try dropping fast food – CNN (free)
10 – Sauna bathing reduces the risk of stroke in Finnish men and women: A prospective cohort study – Neurology (link to abstract – $ for full-text)
Commentaries: Daily saunas may reduce stroke risk – NHS Choices (free) AND Can Saunas Lower Stroke Risk? – MedPage Today (free registration required) AND Could saunas reduce stroke risk? – Medical News Today (free)
Fri, May 4 – 10 Stories of The Day!
4 May, 2018 | 01:05h | UTC
1 – Manual: Core Components for Infection Prevention and Control: Implementation tools and resources – World Health Organization (free) (via @julesstorr and @Onisillos)
2 – Outpatient Infection Prevention: A Practical Primer – Open Forum Infectious Diseases (free) (via @IDSAInfo see Tweet)
Commentary: Pioneering Paper Shows Infection Control and Prevention in Clinics Is in Everyone’s Hands – University of Texas Health Science Center at Houston, via NewsWise (free)
Editorial: New evidence challenges use of bath emollients for children with eczema (free)
Commentaries: Trial finds no benefit of bath emollients beyond standard eczema care for children – The BMJ, via ScienceDaily (free) AND Bath oils for childhood eczema provide ‘no clinical benefit’ – NHS Choices (free)
Commentary: The ongoing reduction in pain became the inspiration to never go back to “ground zero” – The BMJ Opinion (free)
5 – Plastic Surgery’s Contributions to Surgical Ethics – AMA Journal of Ethics (free)
“Important for plastic surgeons in particular to remember: just because you *can* perform an operation, which might or might not be medically indicated, does not mean you *should* perform the operation” (via @JournalofEthics see Tweet)
6 – Once-Daily Single-Inhaler Triple versus Dual Therapy in Patients with COPD – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Single-Inhaler Triple Therapy in Patients with COPD (free)
7 – Lecture: How Less Health Care Can (Sometimes) Be Better For You (free)
See also: CLUE Working Group Lecture Series (tweet with lecture links by @KariTikkinen)
“Editor-in-Chief of @JAMAInternalMed, professor Rita Redberg gave the 3rd CLUE Working Group lecture entitled “How Less Health Care Can (Sometimes) Be Better For You” at the Think Corner of the U of Helsinki” (via @KariTikkinen see Tweet)
Source: EvidenceAlerts
10 – Comparison of Early Intervention Services vs Treatment as Usual for Early-Phase Psychosis: A Systematic Review, Meta-analysis, and Meta-regression – JAMA Psychiatry (free for a limited period)
Commentaries: With Early Intervention, Patients With Schizophrenia Experience Greater Improvements in Health, Function – Psychiatric News Alert (free) AND Early Intervention Best for Early-Phase Psychosis – MedPage Today (free registration required)
Wed, May 2 – 10 Stories of The Day!
2 May, 2018 | 00:08h | UTC
Commentaries: Moderate to severe mid-life anxiety may be linked to later life dementia – BMJ Open Blog (free) AND Anxiety in middle age linked to dementia later – Reuters (free) AND Expert reaction to a review of the association between mid-life anxiety and later life dementia – Science Media Centre (free)
“The current study isn’t designed to explain how anxiety and dementia might be connected, Iadecola added. “We cannot say with confidence that anxiety is a cause (risk factor), an early manifestation of the dementia, or only coincidentally associated with it,”” (from Reuters)
3 – Report: Trends in Reported Vectorborne Disease Cases — United States and Territories, 2004–2016 – MMWR, CDC (free)
Commentaries: CDC reports tripling of vector-borne diseases since 2004 – CIDRAP (free) And Tick and Mosquito Infections Spreading Rapidly, C.D.C. Finds – The New York Times (10 articles per month are free) AND Tick- and mosquito-borne diseases more than triple, since 2004, in the US – CNN (free)
4 – Effectiveness of theta burst versus high-frequency repetitive transcranial magnetic stimulation in patients with depression (THREE-D): a randomised non-inferiority trial – The Lancet (link to abstract – $ for full-text)
Commentaries: Three-Minute Brain Stimulation Sessions Effectively Reduce Depression Symptoms, Study Finds – Forbes (free) AND Three Minute Version of Brain Stimulation Therapy Effective for Hard to Treat Depression – Neuroscience News (free)
Source: Critical Care Reviews Newsletter
6 – Systematic Reviews & Meta-Analyses: A 5-Step Checkup – Absolutely Maybe in PLOS Blogs (free)
Commentary: Incidental Pancreatic Cysts: Majority Don’t Progress to Cancer – Medscape (free registration required)
News release: New guidance issued for treating cardiac arrest in children with heart disease (free)
Top Ten Things to Know: Cardiopulmonary Resuscitation in Infants and Children with Cardiac Disease (free PDF)
Commentary: ASCO Clinical Practice Guideline Update: Fertility Preservation in Patients With Cancer – The ASCO Post (free)
Related guidelines: Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)
10 – USPSTF Draft Recommendation Statement: Intimate Partner Violence, Elder Abuse, and Abuse of Vulnerable Adults: Screening (free)
Commentaries: USPSTF urges abuse screening for reproductive-aged women – MedicalXpress (free) AND USPSTF Recommends Screening for Partner Violence in Reproductive-Aged Women – Clinical Advisor (free)
“The USPSTF recommends that clinicians screen for intimate partner violence (IPV) in women of reproductive age and provide or refer women who screen positive to ongoing support services.”
Mon, April 30 – 10 Stories of The Day!
30 Apr, 2018 | 00:18h | UTC
1 – Mortality and morbidity in acutely ill adults treated with liberal versus conservative oxygen therapy (IOTA): a systematic review and meta-analysis – The Lancet (link to abstract – $ for full-text)
Commentary: Too liberal use of oxygen increases risk of death in acutely ill adult patients – McMaster University, via EurekAlert (free)
Commentaries: What proportion of older adults in hospital are frail? – The Lancet (free) AND Research helps frail older people in hospitals – University of Leicester, via EurekAlert (free)
3 – Universal health care, worldwide, is within reach – The Economist (a few articles per month are free)
Source: International Health Policies Newsletter
See also: About the Guide (free) AND Infographic (free PDF) AND Quick Start Guide (free)
5 – Expert statement for the management of hypovolemia in sepsis – Intensive Care Medicine (free for a limited period)
Source: Critical Care Reviews Newsletter
Source: Critical Care Reviews Newsletter
7 – Improving Emergency Department Care for Low-Risk Chest Pain – NEJM Catalyst (free)
8 – Debate: Should we recommend e-cigarettes to help smokers quit? – The BMJ (free)
See also: related guidelines, reports and commentaries on e-cigarettes
“Experts debate: Should doctors recommend e-cigarettes to help smokers quit? Revelation in harm reduction or a way to keep people addicted and gateway to youth smoking?” (via @rich_hurley see Tweet)
9 – 28th ECCMID: The MERINO Trial: piperacillin-tazobactam versus meropenem for the definitive treatment of bloodstream infections caused by third-generation cephalosporin nonsusceptible Escherichia coli or Klebsiella spp.: an international multi-centre openlabel non-inferiority randomised controlled trial (free abstract)
Commentaries: Avoid piperacillin-tazobactam when treating BSI cause by ceftriaxone-resistant pathogens – European Society of Clinical Microbiology and Infectious Diseases, via EurekAlert (free) AND Combo antibiotic found inferior for MDR bloodstream infections – CIDRAP (free)
Commentary: Predictors of poststroke pneumonia clarified – Univadis (free)
Thu, May 3 – 10 Stories of The Day!
3 May, 2018 | 00:05h | UTC
Related Infographics: PHE Infographics: Air pollution (free)
Updated Fact Sheets: Ambient (outdoor) air quality and health (free) AND Household air pollution and health (free)
Commentaries: Air pollution inequality widens between rich and poor nations – The Guardian (free) AND Expert reaction to new WHO global air pollution data – Science Media Centre (free)
Commentary: New Expert Consensus Document Provides Best Practices For Ionizing Radiation Safety – American College of Cardiology (free)
3 – Long-Term Effects of Omitting Antibiotics in Uncomplicated Acute Diverticulitis – American Journal of Gastroenterology (link to abstract – $ for full-text)
Commentary: Uncomplicated acute diverticulitis: omitting antibiotics found safe in DIABOLO – Univadis (free registration required)
4 – Effect of Glyburide vs Subcutaneous Insulin on Perinatal Complications Among Women With Gestational Diabetes: A Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Glyburide Should Not Be First-Line for Gestational Diabetes – Medscape (free registration required) AND Glyburide Compared With Insulin for First-Line Tx of Gestational Diabetes – MPR (free)
5 – Clinical Practice Guideline: Chronic Asthma – Toward Optimized Practice (free PDF)
See also: Summary (free PDF)
Related: see all TOP Clinical Practice Guidelines, a practical resource for Family Physicians at the point of care.
6 – Viewpoint: In the Era of Precision Medicine and Big Data, Who Is Normal? – JAMA (free for a limited period)
Commentaries: Diet rich in fish and legumes may help to delay natural menopause – BMJ, via EurekAlert (free) AND Expert reaction to study looking at dietary intake and age at menopause – Science Media Centre (free) AND Oily fish and fresh beans may be linked to a later menopause – NHS Choices (free)
8 – Interventions for preventing occupational irritant hand dermatitis – Cochrane Library (link to abstract – $ for full-text)
Summary: Treatments to prevent hand skin irritation in the workplace – Cochrane Library (free)
Key Points to Remember: Indications for Intracranial Endovascular Procedures – American College of Cardiology (free)
10 – Preventability of Early Versus Late Hospital Readmissions in a National Cohort of General Medicine Patients – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Hospital care quality more likely a factor in early versus late readmissions – ACP Hospitalist (free) AND Hospital readmissions occurring within 7 days post-discharge may be more preventable than later readmissions – 2 Minute Medicine (free)
Tue, May 1 – 10 Stories of The Day!
1 May, 2018 | 01:13h | UTC
1 – Impact of Healthy Lifestyle Factors on Life Expectancies in the US Population – Circulation (free PDF)
Commentaries: Five healthy habits may add more than a decade to life – Circulation Journal Report (free) AND The five habits that can add more than a decade to your life – The Guardian (free) AND Following five healthy lifestyle habits may increase life expectancy by decade or more – Harvard T.H. Chan School of Public Health, via ScienceDaily (free)
2 – Meta-Analysis: Radial-Artery or Saphenous-Vein Grafts in Coronary-Artery Bypass Surgery – New England Journal of Medicine (free for a limited period)
Commentaries: More Data Show Benefits of Multiple Arterial Over Saphenous-Vein Grafting in CABG: Meta-analysis – TCTMD (free) AND Radial Artery or Saphenous Vein Grafts in CABG – American College of Cardiology (free)
3 – Tenecteplase versus Alteplase before Thrombectomy for Ischemic Stroke – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Stroke: Which Clot Buster Drug Works Best? – MedicalResearch.com (free) AND Tenecteplase Appears Superior to Alteplase After Ischemic Stroke – Cardiology Advisor (free)
4 – Report: Using Technology to Advance Global Health – National Academies of Sciences, Engineering, and Medicine. 2018 (free PDF, registration required)
Commentaries: Taxing sweet snacks may bring even greater health benefits than taxing sugar-sweetened drinks – London School of Hygiene & Tropical Medicine (free) AND Soda Tax Backers Eye Cookies and Candy – MedPage Today (free)
Related: Fiscal policies for diet and the prevention of noncommunicable diseases – World Health Organization (free) AND To improve global health, tax the things that are killing us (free articles, commentaries and reports) AND The Lancet taskforce on NCDs and economics (free series and commentaries)
“A 10% tax would reduce the purchase of chocolates and other candy by 7.4%, of cookies by 6.9%, and of cake-type snacks by 6.6%” (via @medpagetoday see Tweet)
6 – Physical Activity and Incident Depression: A Meta-Analysis of Prospective Cohort Studies – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Regular exercise may help lower your risk of depression – NHS Choices (free) AND Regular Exercise Lowers Odds of Developing Depression, Meta-Analysis Finds – Psychiatric News Alert (free)
7 – Report: Using dietary intake modelling to achieve population salt reduction – A guide to developing a country-specific salt reduction model (2018) – WHO Europe (free PDF)
“The Salt Reduction Model is a 5-step plan to help countries achieve a 30% reduction in population salt intake. Reducing salt consumption will help prevent and control noncommunicable diseases such as heart disease and stroke” (via @WHO_Europe see Tweet)
8 – Richard Lehman’s journal review, 30 April 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
9 – Economics of Palliative Care for Hospitalized Adults With Serious Illness: A Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentaries: Study: Palliative Care Reduces Hospital Stay, Cost of Sickest Patients – U.S. News (free) AND Prompt Palliative Care Saves Money, Especially in Sickest Patients – MedPage Today (free registration required)
“Are #infographic / #visualabstract summaries of literature preferred to abstracts? Do they decrease cognitive load? Do they increase retention? Check out our latest!” (via @Brent_Thoma see Tweet and Visual Abstract)
Fri, April 27 – 10 Stories of The Day!
27 Apr, 2018 | 01:39h | UTC
Commentary: Probiotics may be safe, low-cost prevention tool for Clostridium difficile infections – News Medical (free)
Related Articles: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use – Cochrane Library (free) AND Probiotics for the Prevention of Antibiotic-Associated Diarrhea in Outpatients—A Systematic Review and Meta-Analysis – Antibiotics (free) AND Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection: A Systematic Review With Meta-Regression Analysis – Gastroenterology (free)
2 – Anticholinergic drugs and risk of dementia: case-control study – The BMJ (free)
Editorial: Anticholinergic drugs and dementia in older adults (free)
Commentaries: Expert reaction to study investigating the association between different types of anticholinergic drugs and risk of dementia – Science Media Centre (free) AND Anticholinergic drugs may be linked to increased risk of dementia – OnMedica (free)
“The effect of anticholinergic therapy is relatively small (odds ratio 1.1 – 1.2) and establishing an association does not prove a causal link. Nevertheless, the paper may act as a useful guide for future research and clinical practice”. (by Prof Les Iversen, in Science Media Centre)
3 – Age and sex of surgeons and mortality of older surgical patients: observational study – The BMJ (free)
Editorial: Links between age and sex of surgeons and patients’ outcomes (free)
Commentary: Study Suggests Older Surgeons Produce Lower Mortality Rates in Emergency Procedures – UCLA, via NewsWise (free)
4 – Uterotonic agents for preventing postpartum haemorrhage: a network meta-analysis – Cochrane Library (free for a limited period)
News Release: Featured Review: Uterotonic agents for preventing postpartum haemorrhage – Cochrane Library (free)
Commentary: Review finds more effective drugs to stop bleeding after childbirth – University of Birmingham (free)
“New Cochrane Review suggests ergometrine plus oxytocin; misoprostol plus oxytocin; & carbetocin on its own, are more effective drugs for reducing excessive bleeding at childbirth rather than the current standard use of oxytocin on its own” (via @CochraneUK see Tweet)
5 – Optimised care of elderly patients with acute coronary syndrome – European Heart Journal: Acute Cardiovascular Care (free) (via @krychtiukmd see Tweet)
6 – Perspective: The Mediterranean Diet’s Fight Against Frailty – JAMA (free for a limited period)
7 – Committee Opinion: Adolescents and Long-Acting Reversible Contraception: Implants and Intrauterine Devices – American College of Obstetrics and Gynecology (free)
Commentary: ACOG Committee Opinion: adolescents should be offered LARC – Univadis (free registration required)
Related guidelines: WHO implementation tool for pre-exposure prophylaxis of HIV infection – World Health Organization (free) AND Canadian guideline on HIV pre-exposure prophylaxis and nonoccupational postexposure prophylaxis – Canadian Medical Association Journal (free) AND Preexposure Prophylaxis for the Prevention of HIV Infection in the United States – 2017 Update: a Clinical Practice Guideline (free)
10 – NT-proBNP (N-Terminal pro-B-Type Natriuretic Peptide)-Guided Therapy in Acute Decompensated Heart Failure – Circulation (link to abstract – $ for full-text)
Related Systematic Review: Effectiveness and cost-effectiveness of serum B-type natriuretic peptide testing and monitoring in patients with heart failure in primary and secondary care: an evidence synthesis, cohort study and cost-effectiveness model – Health Technology Assessment (free) AND Commentary: Uncertain benefits of BNP blood tests to monitor heart failure treatment – NIHR Signal (free)
Related AHA Scientific Statement: Role of Biomarkers for the Prevention, Assessment, and Management of Heart Failure (free)
Source: EvidenceAlerts
“NT Pro BNP guided heart failure treatment no better than usual care”. (via @doctorvec)
Thu, April 26 – 10 Stories of The Day!
26 Apr, 2018 | 00:14h | UTC
1 – World Malaria Day, 25 April 2018 – World Health Organization (free resources)
Commentaries: Can improving access to care help to eliminate malaria? – The Lancet (free) AND Dose entire population with anti-malaria drugs to eradicate disease – study – The Guardian (free) AND Malaria studies show benefit of mass treatment, methylene blue – CIDRAP (free)
Related: Seminar: Malaria (free registration required) AND Series: Malaria in Pregnancy (free registration required)
Quick Take Video Summary: Azithromycin to Reduce Childhood Mortality (free)
Commentaries: Giving Antibiotics To Healthy Kids In Poor Countries: Good Idea Or Bad Idea? – NPR (free) AND Infant Deaths Fall Sharply in Africa With Routine Antibiotics – The New York Times (free)
4 – Guideline: Pharmacologic Glycemic Management of Type 2 Diabetes in Adults – Canadian Journal of Diabetes (free)
Related Guidelines: ADA 2018 Standards of Medical Care in Diabetes (free) AND ACP Guideline: Hemoglobin A1c Targets for Glycemic Control in Type 2 Diabetes (free)
In this new guideline Hemoglobin A1c Targets are similar from ADA 2018 Standards.
5 – Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) (via @trishgreenhalgh)
Related Reviews: Current and future perspectives on the management of polypharmacy – BMC Family Medicine (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free)
Source: Hospital Medicine Virtual Journal Club (free)
7 – Guideline Update: Depression in adults: recognition and management – National Institute for Health and Care Excellence (free)
8 – Things We Do For No Reason: Periprocedural Bridging Anticoagulation – Journal of Hospital Medicine (free)
9 – A cancer drug tailored to your tumor? Experts trade barbs over ‘precision oncology’ – Science (free)
See also: Audio and slides on the meeting webcast (free) (via @barttels2 and @AACRPres see Tweet)
10 – Physicians’ Compassion, Communication Skills, and Professionalism With and Without Physicians’ Use of an Examination Room Computer: A Randomized Clinical Trial – JAMA Oncology (link to abstract – $ for full-text)
Commentaries: Patients Prefer Doctors Who Engage in Face-to-Face Visits – Physician’s Briefing (free) AND Docs Behind Screen Seen as Less Compassionate – MedPage Today (free registration required) AND Patients value eye contact from physicians: study – Univadis (free registration required)
Wed, April 25 – 10 Stories of The Day!
25 Apr, 2018 | 00:49h | UTC
Commentary: Early treatment for leg ulcers gets patients back on their feet – Imperial College London (free)
2 – Committee Opinion: Optimizing Postpartum Care – American College of Obstetricians and Gynecologists (free)
Commentary: Redesigning Maternal Care: OB-GYNs Are Urged to See New Mothers Sooner and More Often – ProPublica (free)
Source: Kaiser Health News Morning Brief
3 – Long-Term Effectiveness of Sigmoidoscopy Screening on Colorectal Cancer Incidence and Mortality in Women and Men: A Randomized Trial – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Sigmoidoscopy reduces colon cancer risk for men, but not women – American College of Physicians, via MedicalXpress (free) AND Sigmoidoscopy reduces colon cancer risk for men, but not women – 2 Minute Medicine (free)
Commentary: Soccer Heading—Not Collisions—Cognitively Impairs Players – Albert Einstein College of Medicine (free)
Related Review: Effects of Soccer Heading on Brain Structure and Function – Frontiers in Neurology (free)
5 – Teaching Computers to “See” the Invisible in Living Cells – NIH Director’s Blog (free)
Original Study: In Silico Labeling: Predicting Fluorescent Labels in Unlabeled Images (free) AND Commentary: Scientists teach computers how to analyze brain cells – NIH News Release (free)
6 – Pasta Is Good For You, Say Scientists Funded By Big Pasta – BuzzFeed News (free)
7 – Domain Management Approach to Heart Failure in the Geriatric Patient: Present and Future – Journal of the American College of Cardiology (free for a limited period) (via @monicaAGrinberg)
8 – Viewpoint: David Oliver: Tube feeding and deteriorating patients—guidelines can take us only so far – The BMJ (free)
Related Guidelines: American Geriatrics Society Feeding Tubes in Advanced Dementia Position Statement (free) AND ESPEN guideline on ethical aspects of artificial nutrition and hydration (free)
Related Reviews: Artificial nutrition and hydration in advanced dementia – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 1: goals of care, decision-making process, and family education – Canadian Family Physician (free) AND End-of-life issues in advanced dementia: Part 2: management of poor nutritional intake, dehydration, and pneumonia – Canadian Family Physician (free) AND Advanced Dementia – New England Journal of Medicine (free)
Commentary: Prolonged acetaminophen use during pregnancy linked to increased ASD and ADHD risk – The Hebrew University of Jerusalem, via EurekAlert (free)
Commentaries: Fetal exposure to moderate/high caffeine levels linked to excess childhood weight gain – BMJ Open Blog (free) AND Caffeine in pregnancy linked to risk of child overweight – OnMedica (free) AND Expert reaction to study looking at caffeine in pregnancy and weight gain in children – Science Media Centre (free)
Tue, April 24 – 10 Stories of The Day!
24 Apr, 2018 | 01:43h | UTC
1 – World Immunization Week, 24-30 April 2018 – World Health Organization (free resources)
2 – The vaccine dilemma: how experts weigh benefits for many against risks for a few – STAT (free)
3 – Why do we need vaccines? – Welcome Trust (free) (via @greg_folkers)
Other commentaries: Regular exercise after heart attack might halve risk of death over next few years – OnMedica (free) AND It’s not too late: Exercise after heart attack cuts mortality risk – Cardiovascular Business (free) AND Remaining Active After MI May Help Stave Off Mortality – TCTMD (free)
“Becoming more physically active after a myocardial infarction halves the risk of dying within 4 years, study finds”
“Compared with triple antithrombotic therapy, dual antithrombotic therapy shows a reduction in major or minor bleeding by 47% with comparable outcomes of major adverse cardiac events”.
See also: Related Physician Tools and Materials (free clinician summary, slides and more)
Commentaries: New guideline: Start taking MS drugs early on – American Academy of Neurology, via EurekAlert (free) AND New MS Guideline Addresses Starting, Switching, and Stopping Disease-modifying Therapy – MD Magazine (free) AND Start MS Drugs Early, New Guideline Says – MedPage Today (free registration required)
8 – Richard Lehman’s journal review, 23 April 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
9 – State of the Art Review: Increased cardiovascular risk in rheumatoid arthritis: mechanisms and implications – The BMJ (free for a limited period)
Commentary: Commonly prescribed heartburn drug linked to Pneumonia in Older Adults – University of Exeter (free)
Related: Proton Pump Inhibitors: Review of Emerging Concerns – Mayo Clinic Proceedings (free) AND Complications of Proton Pump Inhibitor Therapy – Gastroenterology (free) AND Adverse effects of proton-pump inhibitor use in older adults: a review of the evidence – Therapeutic Advances in Drug Safety (free) AND Deprescribing proton pump inhibitors: Evidence-based clinical practice guideline – Canadian Family Physician (free)
Source: Hospital Medicine Virtual Journal Club