TOP 10 Medical News Stories
Tue, August 7 – 10 Stories of The Day!
7 Aug, 2018 | 02:42h | UTC
News release: New tools, old rules: limit screen-based recreational media at home – AHA/ASA Newsroom (free)
5 – Patient–physician gender concordance and increased mortality among female heart attack patients – PNAS (link to abstract – $ for full-text)
Commentaries: Women More Likely to Survive Heart Attacks If Treated by Female Doctors – The Atlantic (free) AND Women survive a heart attack more often when their doctor is female, study finds – STAT (free) AND Women survive heart attacks better with women doctors – Washington University in St. Louis, via ScienceDaily (free)
6 – Review: Oxygen Treatment in Intensive Care and Emergency Medicine – Deutsches Ärzteblatt International (free)
7 – Review: Liver enzymes: No trivial elevations, even if asymptomatic – Cleveland Clinic Journal of Medicine (free)
8 – Opinion: Anti-Vaccine Activists Have Taken Vaccine Science Hostage – The New York Times (10 articles per month are free)
“Should researchers not publish findings when there’s a chance they might be misinterpreted and scare the public?” (via @NYTHealth see Tweet)
9 – Red blood cell transfusion to treat or prevent complications in sickle cell disease: an overview of Cochrane reviews – Cochrane Library (link to abstract – $ for full-text)
Summary: An overview of Cochrane Reviews on red blood cell transfusions to treat or prevent sickle cell disease-related complications – Cochrane Library (free)
10 – Microvascular Outcomes in Patients With Diabetes After Bariatric Surgery Versus Usual Care: A Matched Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Bariatric Surgery for Diabetes May Halve the Risk for Microvascular Disease – NEJM Physician’s First Watch (free) AND Bariatric surgery linked to significant reduction in microvascular complications of type 2 diabetes – MedicalXpress (free)
Fri, August 3 – 10 Stories of The Day!
3 Aug, 2018 | 00:22h | UTC
4 – The Top 10 Pulmonary Pearls for Primary Care Physicians – Mayo Clinic Proceedings (free for a limited period)
5 – Cardiovascular and Other Health Benefits of Sauna Bathing: A Review of the Evidence – Mayo Clinic Proceedings (free for a limited period)
Commentaries: Regular sauna users may have fewer chronic diseases – Reuters (free) AND Saunas Linked to Numerous Health Benefits – Medscape (free registration required) AND Frequent sauna bathing has many health benefits – Elsevier, via ScienceDaily (free)
6 – No proof that moderate drinking prevents dementia – NHS Choices (free)
See original study: Alcohol consumption and risk of dementia (free text, editorial and commentaries)
“”Middle aged drinking may reduce dementia risk, new study finds,” is the misleading and irresponsible headline in The Daily Telegraph.”
7 – Viewpoint: Lyme Disease in 2018: What Is New (and What Is Not) – JAMA (free for a limited period)
8 – ACG Clinical Guideline: Management of Crohn’s Disease in Adults – The American Journal of Gastroenterology (free)
Commentary: New Crohn Disease Management Guidelines: Top Five Takeaways – Medscape (free registration required)
Commentaries: Study suggests obesity may increase flu spread – CIDRAP (free) AND Beyond Disease Severity: The Impact of Obesity on Influenza A Virus Shedding – The Journal of Infectious Diseases (free) AND Study suggests obesity may also impact flu transmission, not just severity of illness – Infectious Diseases Society of America, via EurekAlert (free) AND Obesity extends duration of influenza A virus shedding – NIH News (free)
10 – Increasing tolerance of hospital Enterococcus faecium to handwash alcohols – Science Translational Medicine (link to abstract – $ for full-text)
Commentaries: Study finds increased alcohol tolerance in common hospital pathogen – CIDRAP (free) AND Superbugs now also becoming resistant to alcohol disinfectants – Reuters (free) AND Some Bacteria Are Becoming ‘More Tolerant’ Of Hand Sanitizers, Study Finds – NPR (free)
“Researchers found that E faecium isolates collected in 2 Australian hospitals after 2009 were 10x more tolerant to alcohol than those collected before 2004, and that the date of isolation was a much better predictor of survival than the genotype” (via @CIDRAP_ASP see Tweet)
Wed, August 1 – 10 Stories of The Day!
1 Aug, 2018 | 00:01h | UTC
1 – Report: Capture the moment – Early initiation of breastfeeding: the best start for every newborn – World Health Organization (free)
News Release: 3 in 5 babies not breastfed in the first hour of life (free)
Commentaries: When it comes to breastfeeding, ‘timing is everything’ in saving newborn lives – UNICEF chief – UN News (free) AND 60% of babies ‘at risk due to breastfeeding delay after birth’ – The Guardian (free)
2 – Evidence Synopsis: Aspirin Plus Clopidogrel vs Aspirin Alone for Preventing Cardiovascular Events Among Patients at High Risk for Cardiovascular Events – JAMA (free for a limited period)
“Clopidogrel+ASA: Reduced risk for MI and ischemic stroke – Increased risk for major bleeding compared with aspirin alone. Combined therapy is NOT associated with lower mortality.” (via @ehlJAMA see Tweet)
Commentaries: Risk factors in septic revisions following total hip arthroplasty – The Lancet Infectious Diseases (free) AND Several factors associated with hip replacement revision due to prosthetic joint infection – ACP Internist Weekly (free)
4 – Choosing Wisely: Society for the Advancement of Blood Management: Five Things Physicians and Patients Should Question (free)
Commentary: Choosing Wisely: Five Anemia, Transfusion Practices to Avoid – Physician’s First Watch (free)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
5 – Perspective: Europe Expanded the “No Elsevier Deal” Zone & This Could Change Everything – Hilda Bastian, in Absolutely Maybe Blog (free)
6 – Perspective: Assisted suicide is controversial, but palliative sedation is legal and offers peace – The Washington Post (free)
7 – Perspective: A Fear of Lawsuits Really Does Seem to Result in Extra Medical Tests – The New York Times (10 articles per month are free)
“Doctors are known for complaining about how the malpractice system adds costs. But it has been hard to prove, until now.”
8 – Review: Differential diagnosis, investigation and therapy of bilateral adrenal incidentalomas – European Journal of Endocrinology (free)
Commentary: New Consensus Statement: NOAC and Clopidogrel for Most A-fib Patients Treated With PCI – TCTMD (free)
10 – Association of Statin Exposure With Histologically Confirmed Idiopathic Inflammatory Myositis in an Australian Population – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Rare Inflammatory Muscle Inflammation Increased With Statin Exposure – MedicalResearch.com (free) AND Statin Associated with an Increase in Inflammatory Myopathy – RheumNow (free) AND Statin use may increase risk for idiopathic inflammatory myositis – Healio (free registration required)
Thu, August 2 – 10 Stories of The Day!
2 Aug, 2018 | 03:15h | UTC
Related Article: Safety and Side Effects of Rifampin versus Isoniazid in Children – New England Journal of Medicine (free)
Quick Take Video Summary: Rifampin or Isoniazid for Latent Tuberculosis (free)
Commentaries: New tuberculosis treatment could help tackle global epidemic – The Guardian (free) AND Rifampin Promising for Latent TB in Phase 3 Trials – Medscape (free registration required)
2 – Clinical Report: Physician’s Role in Coordinating Care of Hospitalized Children – American Academy of Pediatrics (free)
News Release: Report guides pediatricians in improving care coordination of hospitalized children – AAP News (free)
3 – Prospective Validation of the 0/1-h Algorithm for Early Diagnosis of Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Validation of ESC 0/1-h Algorithm for MI – American College of Cardiology (free) AND ESC Algorithm Safely Rules Out NSTEMI, But Caution May Be Warranted in the US – TCTMD (free)
Related Review: High-Sensitivity Cardiac Troponin in the Evaluation of Possible AMI – American College of Cardiology (free)
Commentary: Omitting ACE inhibitor before surgery reduced intraoperative hypotension, study finds – ACP Hospitalist (free)
Commentaries: New Ebola outbreak declared in DRC a week after earlier one declared over – STAT (free) AND DRC confirms new Ebola cluster days after outbreak declared over – CIDRAP (free) AND Congo declares new Ebola outbreak in eastern province – Reuters (free) AND Deadly Ebola Strikes Anew, a Week After Previous Outbreak Was Extinguished – The New York Times (10 articles per month are free)
6 – Association of orthostatic hypotension with incident dementia, stroke, and cognitive decline – Neurology (link to abstract – $ for full-text)
Commentary: People who frequently feel dizzy on standing ‘at future risk of dementia’ – NHS Choices (free)
Related Research: Orthostatic hypotension and symptomatic subclinical orthostatic hypotension increase risk of cognitive impairment: an integrated evidence review and analysis of a large older adult hypertensive cohort – European Heart Journal (free)
7 – A Consensus Statement on acromegaly therapeutic outcomes – Nature Reviews Endocrinology (free)
Commentary: Consensus statement: optimizing acromegaly management – Univadis (free registration required)
Editorial: Relation between alcohol consumption in midlife and dementia in late life (free)
Commentaries: Expert reaction to long term abstinence and heavy drinking associated with dementia – Science Media Centre (free) AND Middle-aged non-drinkers may have ‘higher risk’ of dementia – The Guardian (free)
9 – Efficacy and Safety of Further Lowering of Low-Density Lipoprotein Cholesterol in Patients Starting With Very Low Levels: A Meta-analysis – JAMA Cardiology (free for a limited period)
Author Interview: Efficacy and Safety of Further Lowering of LDL Cholesterol in Patients Starting With Very Low Levels (free)
10 – MRI-defined White Matter Microstructural Alteration Associated with Soccer Heading Is More Extensive in Women than Men – Radiology (free for a limited period)
Commentaries: Soccer Heading May Be Riskier for Female Players – RSNA (free) AND Heading May Be Riskier For Female Soccer Players Than Males – NPR (free)
Mon, July 30 – 10 Stories of The Day!
30 Jul, 2018 | 00:05h | UTC
See also: World Hepatitis Day (28 July 2018) – World Health Organization (free manuals, guidelines and campaign resources)
Invited Commentary: Should we screen women for abdominal aortic aneurysm? – The Lancet (free)
Invited Commentary: Should aspirin and PPIs be recommended for patients with Barrett’s oesophagus? – The Lancet (free)
5 – Effect of Escitalopram vs Placebo Treatment for Depression on Long-term Cardiac Outcomes in Patients With Acute Coronary Syndrome: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Treating Depression May Improve Cardiac Outcomes, Research Finds – AJMC (free) AND Treating depression may prevent repeat heart attack, study says – UPI (free)
6 – Opinion: How Do You Want to Die? – The New York Times (10 articles per month are free)
“Are we turning sudden cardiac death into a longer, winding path? Defibrillators can prevent sudden death but they also can take away the sudden-death option.” (via @RasoiniR see Tweet)
7 – Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)
Summary: Treatment for HIV-associated cryptococcal meningitis – Cochrane Library (free)
8 – Protease Inhibitors and Cardiovascular Outcomes in Patients With HIV and Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Protease inhibitors may increase risk of death in people with HIV and heart failure – OnMedica (free) AND Protease inhibitors may increase risk of death in people with HIV and heart failure – Massachusetts General Hospital, via EurekAlert (free)
9 – Prevalence of Depression Among Fathers at the Pediatric Well-Child Care Visit – JAMA Pediatrics (link to abstract – $ for full-text)
Commentaries: New dads need depression screening, too – Reuters (free) AND New Dads as Likely to Suffer From Depression as Moms, Study Suggests – Medscape (free registration required)
Commentary: Pediatric hypertension: ACEi/ARBs look like the best choice – Univadis (free)
“According to the present analysis, angiotensin-converting enzyme inhibitors and angiotensin receptor blockers could represent the best choice as antihypertensive treatment for pediatric hypertension. However, because of the paucity of available data for the other classes of antihypertensive drugs, definitive conclusions are not allowed and further randomized controlled trials are warranted.”
Tue, July 31 – 10 Stories of The Day!
31 Jul, 2018 | 00:01h | UTC
News Release: Limit low-calorie sodas and drinks, and stick to water instead, researchers advise (free)
2 – Health Collection: Strategic review of child health – The BMJ (free articles)
“About 5.6m children died before their 5th birthday in 2016. The new global child health collection launching today explores how we can work together to safeguard the health and wellbeing of children across the world.”
3 – Guideline: PSA-Based Prostate Cancer Screening in Men Aged 55-69 – American Academy of Family Physicians (free)
News Release: AAFP Updates Its PSA Screening Recommendation (free)
Related Guidelines with conflicting viewpoints: American Cancer Society Guideline for the Early Detection of Prostate Cancer (free) AND USPSTF Recommendation Statement: Screening for Prostate Cancer (free guideline, editorial and commentaries)
4 – The association between suicide deaths and putatively harmful and protective factors in media reports – Canadian Medical Association Journal (free) (via @IrfanDhalla)
Invited Commentary: Responsible reporting to prevent suicide contagion (free for one week)
5 – Richard Lehman’s journal reviews, 30 July 2018 – The BMJ Opinion (free)
Richard Lehman’s final review of the latest research in the top medical journals.
6 – Viewpoint: Gaps in the Clinical Management of Influenza: A Century Since the 1918 Pandemic – JAMA (free)
News Release: How and when to counsel at-risk patients about fertility preservation, sexual function – AAP News (free)
8 – Drinking or Smoking While Breastfeeding and Later Cognition in Children – Pediatrics (free)
Commentaries: Study: Drinking while breastfeeding linked with children’s reasoning deficits – AAP News (free) AND Alcohol in breast milk may lead to lower cognition in kids, study finds – CNN (free) AND Fuel For Mommy Shaming: Breastfeeding And Alcohol Study Deeply Misleading – Forbes (free)
9 – LOw dose MAGnesium sulfate versus HIgh dose in the early management of rapid atrial fibrillation: randomised controlled double blind study – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentaries: Low-dose vs. High-dose Magnesium in Rapid Afib – The PharmERToxGuy (free) AND Magnesium to treat rapid Afib in the ED – Univadis (free registration required)
10 – A Systematic Review and Meta‐analysis of Ketamine as an Alternative to Opioids for Acute Pain in the Emergency Department – Academic Emergency Medicine (link to abstract – $ for full-text)
Commentaries: Low-Dose Ketamine Offers Effective Alternative to Opioids in Treatment of Acute Pain, Meta-Analysis Suggests – Psychiatric News Alert (free) AND Ketamine vs Opioids for Acute Pain in the Emergency Department – MedicalResearch.com (free) AND Low-Dose Ketamine May Be a Safe Opioid Alternative, Review Confirms – Medscape (free registration required) AND Ketamine could help reduce opioid use in the ER – Medical News Today (free)
Fri, July 27 – 10 Stories of The Day!
27 Jul, 2018 | 01:16h | UTC
1 – Medications that reduce emergency hospital admissions: an overview of systematic reviews and prioritisation of treatments – BMC Medicine (free) (via @OxPrimaryCare)
Commentary: The eleven best medications for reducing pressure on emergency care services – University of Oxford (free)
2 – First Latin American clinical practice guidelines for the treatment of systemic lupus erythematosus: Latin American Group for the Study of Lupus (GLADEL, Grupo Latino Americano de Estudio del Lupus)–Pan-American League of Associations of Rheumatology (PANLAR) – Annals of Rheumatic Diseases (free) (via @Abraham_RMI)
Commentary: Latin American Clinical Practice Guidelines for Lupus – RheumNow (free)
Related Guideline: The British Society for Rheumatology guideline for the management of systemic lupus erythematosus in adults (free) AND Executive Summary (free)
Related Guidelines: Intravenous fluid therapy in adults in hospital – National Institute for Health and Care Excellence (free) AND Intravascular volume therapy in adults: Guidelines from the Association of the Scientific Medical Societies in Germany – European Journal of Anaesthesiology (free)
Related Reviews: Principles of fluid management and stewardship in septic shock: it is time to consider the four D’s and the four phases of fluid therapy – Annals of Intensive Care (free) AND A rational approach to fluid therapy in sepsis – British Journal of Anaesthesia (free)
Source: Critical Care Reviews Newsletter
4 – Timing of intervention in aortic stenosis: a review of current and future strategies – Heart (free)
See also: No, A Big NIH Trial Did Not Show That Lowering Blood Pressure Will Prevent Dementia – Cardiobrief (free)
6 – Opinion: Physicians aren’t ‘burning out.’ They’re suffering from moral injury – STAT (free)
Related: The Burnout Crisis in American Medicine (free commentaries on the subject) AND Physician Burnout Can Lead to Major Medical Errors (link to abstract and free commentaries)
7 – Choosing Wisely: American Academy of Pediatrics – Section on Nephrology and the American Society of Pediatric Nephrology: Five Things Physicians and Patients Should Question (free)
AAP News Release: Choosing Wisely Offers Advice on Appropriate Nephrology Testing in Children (free)
Commentary: AAP offers guidance on pediatric nephrology tests, procedures – Univadis (free registration required)
See complete lists of low-value practices: Choosing Wisely U.S. / Choosing Wisely UK / Choosing Wisely Australia AND Choosing Wisely Canada
8 – Mirror therapy for improving motor function after stroke – Cochrane Library (link to abstract – $ for full-text)
Summary: Mirror therapy for improving movement after stroke – Cochrane Library (free)
Commentaries: Osteoporosis Treatment After Hip Fracture: Bad News and Getting Worse – JAMA Network Open (free) AND Rate of Osteoporosis Drug Treatment to Prevent Recurrent Fractures Dropping – AJMC (free) AND Osteoporosis treatment often not started after hip fracture in elderly patients, study finds – ACP Internist (free)
Commentary: Consumption of Fast Food Linked with Asthma and Other Allergic Diseases – Wiley (free) AND Study Links Fast Food Consumption to Severe Asthma – AJMC (free)
Thu, July 26 – 10 Stories of The Day!
26 Jul, 2018 | 00:36h | UTC
1 – UNDETECTABLE = UNTRANSMITTABLE: Public Health and HIV Viral Load Suppression – UNAIDS Explainer (free PDF)
News Release: Undetectable = Untransmittable – UNAIDS (free)
Related: Science Validates Undetectable = Untransmittable HIV Prevention Message – National Institute of Allergy and Infectious Diseases (free) AND The “Undetectable = Untransmittable” message goes global: I=I, N=N and B=B – Aidsmap (free)
2 – Rapid Recommendations: Patent foramen ovale closure, antiplatelet therapy or anticoagulation therapy alone for management of cryptogenic stroke? A clinical practice guideline – The BMJ (free)
4 – Prehospital Plasma during Air Medical Transport in Trauma Patients at Risk for Hemorrhagic Shock – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Giving Plasma to Trauma Patients with Severe Bleeding During Air Transport Saves Lives – Health Sciences at the University of Pittsburgh, via NewsWise (free)
Source: Critical Care Reviews Newsletter
See also: Full Report (free PDF)
See also: Full Report (free PDF) AND Evidence Summary (free PDF)
8 – Radiation Exposure From Pediatric CT Scans and Subsequent Cancer Risk in the Netherlands – JNCI: Journal of the National Cancer Institute (link to abstract – $ for full-text)
Commentary: Pediatric CT Scans and Subsequent Malignancy Risk – The ASCO Post (free)
9 – Sexual transmission of Zika virus and other flaviviruses: A living systematic review – PLOS Medicine (free) (via @NIAIDNews)
Commentary: Study suggests smaller window for Zika sexual transmission – CIDRAP (free)
10 – Association Between the New York Sepsis Care Mandate and In-Hospital Mortality for Pediatric Sepsis – JAMA (link to abstract – $ for full-text)
Commentaries: Pediatric sepsis care within an hour increases chances of survival, shows study – News Medical (free) AND “Rory’s Regulations” Improves Pediatric Sepsis Care – MedicalResearch.com (free) AND Sepsis Survival Higher in Kids With Quick Bundle Completion – Medscape (free registration required)
Wed, July 25 – 10 Stories of The Day!
25 Jul, 2018 | 01:08h | UTC
Editorial: 2018 IAS-USA Recommendations for the Use of Antiretroviral Therapy for HIV: Building on Decades of Progress (free)
Commentary: International Organization Releases New Guidelines for Treatment and Prevention of HIV Infection in Adults – University of Alabama at Birmingham, via NewsWise (free)
2 – Clinical Review Audio: Working on the Precipice: On the Frontlines of the AIDS Epidemic at the CDC, Part I – JAMA (free)
Related Perspective: Anthony Fauci, MD: Working to End HIV/AIDS – JAMA (free)
Related – Part I: Trending Cardiovascular Nutrition Controversies – Journal of the American College of Cardiology (free)
Commentary: Chew on This: Review Tackles Controversies in Nutrition for CV Health – TCTMD (free) AND Separating health from hype for a diet that’s kind on your heart – ABC News (free)
Commentaries: Deadly Ebola outbreak in Congo is declared over by health ministry – STAT (free) AND Congo declares Ebola flare-up over after rapid response – Reuters (free) AND DRC declares end to Ebola outbreak – CIDRAP (free)
Related: An Ebola Outbreak Has Just Been Stopped. Here’s What It Tells Us About Containing Epidemics – Harvard Business Review (free) AND Ebola: How a killer disease was stopped in its tracks – BBC (free) AND Congo’s Ebola outbreak is all but over. Did an experimental vaccine help? – Science Magazine (free)
6 – Persistence of Ebola virus after the end of widespread transmission in Liberia: an outbreak report – The Lancet Infectious Diseases (link to abstract – $ for full-text)
Commentaries: Flare-up of Ebola in Liberian family highlights virus persistence – CIDRAP (free) AND For the First Time, a Female Ebola Survivor Infects Others – The New York Times (10 article per month are free)
7 – Antidepressant Withdrawal Syndrome – Therapeutics Initiative (free)
Related Perspective: Many People Taking Antidepressants Discover They Cannot Quit – The New York Times (10 articles per month are free)
“Antidepressants should be added to the list of drugs associated with tolerance, dependence and a withdrawal syndrome.”
“Withdrawal symptoms occur in at least one-third of patients who stop.”
See also: Heart Attack & Stroke Calculator (free tool)
Commentaries: New health calculator can help predict heart disease risk, estimate heart age – CMAJ, via ScienceDaily (free) AND Calculator can predict heart age, risk for heart disease – UPI (free) AND Algorithm Allows Patients To Calculate Their Risk of Stroke and Heart Disease – MedicalResearch.com (free)
Related Calculators: ACC/AHA CV Risk Calculator (free) AND QRISK3-2017 Cardiovascular Disease Risk Calculator (free)
9 – When We Eat, or Don’t Eat, May Be Critical for Health – The New York Times (10 articles per month are free)
Original Article: Early Time-Restricted Feeding Improves Insulin Sensitivity, Blood Pressure, and Oxidative Stress Even without Weight Loss in Men with Prediabetes – Cell Metabolism (link to abstract – $ for full-text)
Commentaries: Study: 5:2 diet as effective at controlling diabetes as monitoring daily caloric intake – UPI (free) AND HbA1c improves just as much on dieting only two days a week – OnMedica (free) AND Two-Day Fast Per Week vs Daily Calorie Restriction in Diabetes – MedicalResearch.com (free)
Mon, July 23 – 10 Stories of The Day!
23 Jul, 2018 | 00:04h | UTC
1 – Guideline: Early and locally advanced breast cancer: diagnosis and management – National Institute for Health and Care Excellence (free)
Summary: Blood pressure targets in people with cardiovascular disease – Cochrane Library (free)
“Insufficient evidence to justify lower than standard blood pressure targets in people with hypertension + CVD” (via @CochraneHTN see Tweet)
4 – Opinion: Paramedic 2: Epinephrine harms/helps in out of hospital cardiac arrest – First10EM (free)
See Also: Original Article (free study and editorial) AND Expert Reaction (free commentaries)
“Paramedic 2 quick summary:
If 1000 people treated with epinephrine:
– 246 extra ROSC (return of spontaneous circulation)
– 158 extra admissions
– 8 extra survivors (5 with bad neuro outcomes, 3 with good neuro outcomes)
– What those numbers mean is a value question, not a science question.” (via @First10EM see Tweet)
5 – Guideline: Human Immunodeficiency Virus Drug Resistance: 2018 Recommendations of the International Antiviral Society–USA Panel – Clinical Infectious Diseases (free) (via @CarlosdelRio7)
6 – Report: Miles to go—closing gaps, breaking barriers, righting injustices – UNAIDS (free PDF)
Press Release: UNAIDS warns that progress is slowing and time is running out to reach the 2020 HIV targets (free)
Commentary: U.N. says global fight against AIDS is at ‘precarious point’ – Reuters (free)
Source: International Health Policies Newsletter
7 – Advancing global health and strengthening the HIV response in the era of the Sustainable Development Goals: the International AIDS Society—Lancet Commission (free articles and commentaries – registration required)
Commentaries: Report Warns Of ‘Dangerous Complacency’ In The Fight Against HIV – NPR (free) AND ‘Dangerous complacency’ to global HIV epidemic risks resurgence – BBC (free) AND Experts warn approach to HIV/AIDS is complacent – OnMedica (free)
Related Study: The burden of Neglected Tropical Diseases in Brazil, 1990-2016: A subnational analysis from the Global Burden of Disease Study 2016 – PLOS Neglected Tropical Diseases (free)
9 – Definitions and pathophysiology of vasoplegic shock – Critical Care (free)
Commentary: Enhanced recovery programmes after stomach cancer surgery reduce hospital stay without increasing complications – NIHR Signals (free)
See also: Enhanced Recovery After Surgery Guidelines and Reviews (all free)
Tue, July 24 – 10 Stories of The Day!
24 Jul, 2018 | 00:06h | UTC
4 – Reports from the task force on tropical diseases by the World Federation of Societies of Intensive and Critical Care Medicine:
– Intensive care in severe malaria
Source: Critical Care Reviews Newsletter
5 – Policy statement: Food Additives and Child Health – American Academy of Pediatrics (free)
Technical Report: Food Additives and Child Health (free)
Commentaries: Chemicals in Food May Harm Children, Pediatricians’ Group Says – The New York Times (10 articles per month are free) AND Pediatrics Group Issues Statement on Food Additives and Child Health – Physician’s First Watch (free) AND Report: Common food additives may pose danger to kids – University of Washington Medicine (free)
6 – Honey for cough in children: can it help? – Evidently Cochrane (free)
Original Cochrane Review: Honey for acute cough in children – Cochrane Library (free) AND Summary: Honey for acute cough in children (free)
7 – Richard Lehman’s journal reviews, 23 July 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Commentaries: Mums with healthy habits ‘less likely’ to have obese children – NHS Choices (free) AND Mother’s lifestyle influences child’s obesity risk – Cardiovascular Business (free) AND 5 habits for moms that help prevent childhood obesity – Harvard Medical School (free)
Fri, July 20 – 10 Stories of The Day!
20 Jul, 2018 | 01:07h | UTC
1 – Expert reaction to trial looking at adrenaline for cardiac arrests – Science Media Centre (free)
See original article in yesterday’s issue: A Randomized Trial of Epinephrine in Out-of-Hospital Cardiac Arrest (see #1)
Related Review: The role of adrenaline in cardiopulmonary resuscitation – Critical Care (free)
2 – A Phase 3 Trial of l-Glutamine in Sickle Cell Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Quick Take Video Summary: Glutamine to Treat Sickle Cell Disease (free)
Commentary: Drug may ease pain, lessen hospitalization from sickle cell disease – UPI (free)
Commentary: Most common shoulder operation is no more beneficial than placebo surgery – University of Helsinki, via EurekAlert (free)
Related research with similar results: Arthroscopic subacromial decompression for subacromial shoulder pain (free article, editorial and commentaries)
Commentaries: A Spike In Liver Disease Deaths Among Young Adults Fueled By Alcohol – NPR (free) AND Alcohol-related liver failure deaths rising among U.S. young adults – Reuters (free) AND More Americans Are Dying of Cirrhosis and Liver Cancer – The New York Times (10 articles per month are free)
5 – Complementary Medicine, Refusal of Conventional Cancer Therapy, and Survival Among Patients With Curable Cancers – JAMA Oncology (free for a limited period)
Commentary: Association of complementary medicine, cancer treatment, survival – eCancer News (free)
6 – Clinical Evidence Synopsis: Probiotics to Prevent Clostridium difficile Infection in Patients Receiving Antibiotics – JAMA (free for a limited period)
Original Article: Probiotics for the prevention of Clostridium difficile-associated diarrhea in adults and children – Cochrane Library (link to abstract – $ for full-text) AND Summary: The use of probiotics to prevent Clostridium difficile diarrhea associated with antibiotic use (free)
Related Meta-Analysis: Timely Use of Probiotics in Hospitalized Adults Prevents Clostridium difficile Infection (free) AND Probiotics for the Prevention of Clostridium difficile (link to abstract and commentaries)
7 – To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (link to abstract – $ for full-text)
Summary: To continue taking or to stop taking antiplatelet drugs for a few days before non-cardiac surgery in adults – Cochrane Library (free)
“We found low-certainty evidence that either continuation or discontinuation of antiplatelet therapy before non-cardiac surgery may make little or no difference to mortality, bleeding requiring surgical intervention, or ischaemic events”.
Commentaries: Poor air quality does not offset exercise’s heart benefits – AHA/ASA Newsroom (free) AND Why smog should not be your excuse to skip workouts – Reuters (free)
“A reduced risk of hypertension is observed in metformin users in a dose‐response pattern”.
Editorial: Sulfonylureas as second line treatment for type 2 diabetes – The BMJ (free for a limited period)
Commentaries: Diabetes: Switching to Sulfonylureas from Metformin Linked to Increased Side Effects – MedicalResearch.com (free) AND Switching diabetes patients to sulfonylurea linked with complications – Pulse (free) AND Raised risk of MI and mortality when starting sulfonylurea – OnMedica (free)
Wed, July 18 – 10 Stories of The Day!
18 Jul, 2018 | 00:35h | UTC
1 – Association of Digital Media Use With Subsequent Symptoms of Attention-Deficit/Hyperactivity Disorder Among Adolescents – JAMA (link to abstract – $ for full-text)
Commentaries: More Screen Time For Teens Linked To ADHD Symptoms – NPR (free) AND Digital media use linked to behavioral problems in kids – University of Southern California, via ScienceDaily (free) AND Screen time linked to ADHD symptoms in teens – Reuters (free) AND ADHD study links teens’ symptoms with digital media use – CNN (free) AND Expert reaction to association of digital media use and ADHD symptoms among teenagers – Science Media Centre (free)
2 – Perspective: “Is There a Doctor on the Plane?” – JAMA (free for a limited period)
Interview: “Is There a Doctor on the Plane?” (free)
4 – Report: Open Science by Design: Realizing a Vision for 21st Century Research (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)
News Release: Report Proposes Recommendations and New Framework to Speed Progress Toward Open Science (free)
5 – Clinical Trial Evidence Supporting FDA Approval of Drugs Granted Breakthrough Therapy Designation – JAMA (link to abstract – $ for full-text)
Commentaries: Are ‘breakthrough’ drugs as safe as other FDA-approved medicines? – CNN (free) AND Evidence to support ‘breakthrough’ drugs often very limited: study – Reuters (free)
6 – Head To Head: Does evidence based medicine adversely affect clinical judgment? – The BMJ (free) (via @michelaccad)
7 – Harms Reporting in Randomized Controlled Trials of Interventions Aimed at Modifying Microbiota: A Systematic Review – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Reporting on risks often inadequate for prebiotics, probiotics, synbiotics – ACP Internist (free) AND Probiotics studies often don’t disclose safety data or risks, report finds – STAT (free) AND Safety of Probiotic Supplements Is Not Guaranteed, Study Says – Consumer Reports (free)
“How to make an intervention safe? Don’t report the adverse events”. (via @EricTopol see Tweet)
8 – Review: Noninvasive ventilation in acute respiratory failure: which recipe for success? – European Respiratory Review (free)
Source: Critical Care Reviews Newsletter
Editorial: It’s not a gut feeling: don’t listen to the bowels (free PDF)
Source: Critical Care Reviews Newsletter
10 – Occult blood in faeces is associated with all-cause and non-colorectal cancer mortality – Gut (free)
Commentaries: FOB associated with rise in all-cause mortality – OnMedica (free) AND 3 key findings from Gut study on all-cause mortality associated with occult blood in stool – GI & Endoscopy (free) AND Fecal Occult Blood Flags Risks Beyond Colon Cancer – MedPage Today (free)
Thu, July 19 – 10 Stories of The Day!
19 Jul, 2018 | 01:45h | UTC
Editorial: Testing Epinephrine for Out-of-Hospital Cardiac Arrest (free)
Commentary: Using adrenaline in cardiac arrests results in less than 1 percent more people leaving hospital alive – University of Warwick, via EurekAlert (free)
See also: Infographic detailing result findings (free)
“A clinical trial of the use of adrenaline in cardiac arrests has found that its use results in less than 1% more people leaving hospital alive – but almost doubles the risk of severe brain damage for survivors of cardiac arrest”.
2 – Omega-3 fatty acids for the primary and secondary prevention of cardiovascular disease – Cochrane Library (link to abstract – $ for full-text)
Cochrane Summaries: New Cochrane health evidence challenges belief that omega 3 supplements reduce risk of heart disease, stroke or death (free) AND Omega-3 intake for cardiovascular disease (free)
Commentaries: Expert reaction to Cochrane review on omega-3 fatty acids and risk of heart disease, stroke and death – Science Media Centre (free) AND Omega 3 supplements don’t protect against heart disease – new review – The Conversation (free)
Related Meta-Analysis: Omega-3 Fatty Acid Supplements Don’t Reduce Cardiovascular Risk (free article and commentary)
Commentaries: Virtual counseling helps lower blood pressure – AHA News (free) AND E-counseling can lower blood pressure, heart disease risk – Medical News Today (free)
4 – Guideline: Diagnosis, assessment and management of constipation in advanced cancer: ESMO Clinical Practice Guidelines – Annals of Oncology (free)
Commentary: Nurse staffing levels linked to reports of missed care in adult wards – NIHR Signal (free)
Commentaries: HIV infection doubles risk of heart disease – University of Edinburgh, via ScienceDaily (free) AND Global Burden of HIV-Related CVD Has Tripled Over Two Decades – TCTMD (free)
7 – Report: Feeding in the first year of life – Scientific Advisory Committee on Nutrition (SACN) (free)
Commentaries: SACN publishes ‘Feeding in the first year of life’ report – Public Health England (free) AND Too many babies overfed, experts fear – BBC (free)
Original Article: Why all randomised controlled trials produce biased results – Annals of Medicine (free)
Source: Nature Briefing Newsletter
9 – CBT for anxiety: new meta-analysis confirms significant improvements to target symptoms – The Mental Elf (free) (via @AllenFrancesMD)
Original article: Cognitive behavioral therapy for anxiety and related disorders: A meta-analysis of randomized placebo-controlled trials – Depression and Anxiety (free)
Commentaries: More Than 90 Percent Of Smokers Using E-cigarettes Still Smoking A Year Later – Georgia State University (free) AND Study casts doubt on effectiveness of e-cigs for smoking cessation – National Institutes of Health (free) AND Vaping May Not Help Smokers Kick the Habit – MedPage Today (free registration required)
Mon, July 16 – 10 Stories of The Day!
16 Jul, 2018 | 00:01h | UTC
Commentaries: Weight-adjusted aspirin for cardiovascular prevention – The Lancet (free) AND One dose of aspirin doesn’t fit all – University of Oxford (free)
Practice Changing Article. “Low doses of aspirin (75–100 mg) were only effective in preventing vascular events in patients weighing less than 70 kg, and had no benefit in the 80% of men and nearly 50% of all women weighing 70 kg or more. By contrast, higher doses of aspirin were only effective in patients weighing 70 kg or more.”
2 – Vulnerability to snakebite envenoming: a global mapping of hotspots – The Lancet (free)
Commentaries: Addressing the global challenge of snake envenoming – The Lancet (free) AND New study maps the areas where people are most vulnerable to death following snakebite – London School of Tropical Medicine (free) AND New study finds 93 million people vulnerable to death from snakebites – Institute for Health Metrics and Evaluation (free)
Commentaries: Inferior Vena Cava Filters and Mortality: Is It the Underlying Process, the Patient, or the Device? (free)
“Could IVC filters be causing harm? They began being used before @US_FDA started approving devices. This article raises possibility of increased mortality. Maybe where we need trials to determine safety and effectiveness”. (via @hmkyale see Tweet)
Related Guidelines: 2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation (free) AND 2014 AHA/ACC Guideline for the Management of Patients With Non–ST-Elevation Acute Coronary Syndromes (free)
Commentaries: New digital chemical screening tool could help eliminate animal testing – Science (free) AND Database Analysis More Reliable Than Animal Testing For Toxic Chemicals – Johns Hopkins Bloomberg School of Public Health (free) AND Software beats animal tests at predicting toxicity of chemicals – Nature News (free)
8 – Review: Cardiac rehabilitation: A class 1 recommendation – Cleveland Clinic Journal of Medicine (free)
Related Guidelines: Cardiac rehabilitation – Scottish Intercollegiate Guidelines Network (free) AND Myocardial infarction: cardiac rehabilitation and prevention of further cardiovascular disease – National Institute for Health and Care Excellence (free)
Commentaries: 800,000 More Adolescents Classified as Hypertensive Under New Guidelines – NEJM Physician’s First Watch (free) AND New guidelines label 795K more US children as hypertensive – Cardiovascular Business (free)
10 – Serial measures of circulating biomarkers of dairy fat and total and cause-specific mortality in older adults: the Cardiovascular Health Study – American Journal of Clinical Nutrition (free for a limited period)
Commentaries: Study finds no significant link between whole dairy products and heart disease, stroke – News Medical (free) AND Full-fat dairy may actually benefit heart health – Medical News Today (free)
Related Studies: Meta-Analysis: Cheese consumption and risk of cardiovascular disease (link to abstract and commentaries) AND Milk and dairy consumption and risk of cardiovascular diseases and all-cause mortality (free study and commentaries)
Tue, July 17 – 10 Stories of The Day!
17 Jul, 2018 | 01:52h | UTC
1 – Systematic Review: Nurses as substitutes for doctors in primary care – Cochrane Library (free)
Summary: Nurses as substitutes for doctors in primary care – Cochrane Library (free)
“This updated Cochrane Review indicates that nurses can effectively expand the capacity of the primary care workforce”.
2 – Comparison of Antibiotic Prescribing in Retail Clinics, Urgent Care Centers, Emergency Departments, and Traditional Ambulatory Care Settings in the United States – JAMA Internal Medicine (free for a limited period)
Commentaries: Overprescription in Urgent Care Clinics—The Fast and the Spurious – JAMA Internal Medicine (free for a limited period) AND Urgent care centers often prescribe unnecessary antibiotics – Reuters (free) AND Study spotlights inappropriate prescribing in urgent care – CIDRAP (free)
3 – Clinical Review: Novel therapies for diabetes mellitus in pregnancy – The BMJ (free for a limited period)
4 – 9 in 10 infants worldwide received vaccinations in 2017 – World Health Organization (free)
Commentaries: National Academies target opioid abuse and infectious disease consequences – Emory Health Sciences (free) AND Within opioid abuse epidemic, infectious disease epidemic emerges – Reuters (free)
6 – Richard Lehman’s journal review, 16 July 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Commentaries: No association found between fertility treatment, some types of cancer – ACP Internist (free) AND Fertility treatment does not appear to raise serious cancer risk – OnMedica (free)
Commentaries: Strengthening eye health evidence for children in low-income and middle-income countries (free) AND App screening boosts children’s eye health – Medical Health News (free)
Related: Polypharmacy Guidance, Realistic Prescribing 3 rd Edition, 2018 – Scottish Government Polypharmacy Model of Care Group (free PDF) AND The Challenge of Polypharmacy: From Rhetoric to Reality – Royal Pharmaceutical Society and Royal College of General Practitioners Partnership (free PDF) AND Common ED Medication Errors: Polypharmacy – emDocs (free) AND Current and future perspectives on the management of polypharmacy – BMC Family Practice (free) AND The other big drug problem: Older people taking too many pills – The Whashington Post (free) AND Routine deprescribing of chronic medications to combat polypharmacy – Therapeutic Advances in Drug Safety (free) AND Polypharmacy—an Upward Trend with Unpredictable Effects – Deutsches Ärzteblatt international (free) AND Clinical Consequences of Polypharmacy in Elderly – Expert Opinion on Drug Safety (free) AND Too Many Meds? America’s Love Affair With Prescription Medication – Consumer Reports (free) AND CaDeN Deprescribing Guidelines and Algorithms (free)
Thu, July 12 – 10 Stories of The Day!
12 Jul, 2018 | 01:44h | UTC
1 – Guideline: Rheumatoid arthritis in adults: management – National Institute for Health and Care Excellence (free)
2 – Guideline: Brain tumours (primary) and brain metastases in adults – National Institute for Health and Care Excellence (free)
4 – Efficacy of short-course antibiotic treatments for community-acquired pneumonia in adults: A systematic review and meta-analysis – Antimicrobial Agents and Chemotherapy (link to abstract – $ for full-text)
Commentary: Is Short-Course Antibiotic Treatment for CAP Effective? – MPR (free)
5 – News Release: Trial wipes out more than 80 per cent of disease-spreading mozzie – Commonwealth Scientific and Industrial Research Organisation (CSIRO), Australian Government (free)
Commentary: Australian experiment wipes out over 80% of disease-carrying mosquitoes – CNN (free)
6 – Perspective: Fractional-Dose Yellow Fever Vaccination — Advancing the Evidence Base – New England Journal of Medicine (free)
Related Research: Immunogenicity of Fractional-Dose Vaccine during a Yellow Fever Outbreak — Preliminary Report – The New England Journal of Medicine (free)
Commentaries: Most black adults have high blood pressure before age 55 – AHA / ASA Newsroom (free) AND New CARDIA Data: 75% of African-Americans Have Hypertension by Age 55 – TCTMD (free)
8 – News Release: FDA updates warnings for fluoroquinolone antibiotics on risks of mental health and low blood sugar adverse reactions – U.S. Food and Drug Administration (free)
Commentaries: FDA Strengthens Warnings for Fluoroquinolone Antibiotics – MPR (free) AND FDA Announces Labeling Changes for Fluoroquinolones Due to Mental Health AEs, Blood Sugar Disturbances – MD Magazine (free)
Commentaries: A painful lesson: are we repeating previous mistakes in pain management? – The Lancet Public Health (free) AND Use of illicit cannabis does not reduce chronic pain, according to new Australian study – RACGP (free)
Related: Efficacy and adverse effects of medical marijuana for chronic noncancer pain: Systematic review of randomized controlled trials – Canadian Family Physician (free) AND Benefits and Harms of Cannabis in Chronic Pain or Post-traumatic Stress Disorder: A Systematic Review – VA Evidence-based Synthesis Program (free) AND Cannabis products for adults with chronic neuropathic pain – Cochrane Library (free)
10 – Marijuana Use, Respiratory Symptoms, and Pulmonary Function: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Smoking Marijuana May Be Tied to Cough, Sputum Production – HealthDay (free) AND Regular marijuana use is associated with development of respiratory issues – 2 Minute Medicine (free)
Wed, July 11 – 10 Stories of The Day!
11 Jul, 2018 | 01:44h | UTC
Editorial: USPSTF Recommendations for Assessment of Cardiovascular Risk With Nontraditional Risk Factors: Finding the Right Tests for the Right Patients (free)
“The USPSTF concludes that the current evidence is insufficient to assess the balance of benefits and harms of adding the ankle-brachial index (ABI), high-sensitivity C-reactive protein (hsCRP) level, or coronary artery calcium (CAC) score to traditional risk assessment for cardiovascular disease (CVD) in asymptomatic adults to prevent CVD events”.
2 – Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free for a limited period)
Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
Commentaries: Study: Multivitamins Do Not Prevent Strokes, Heart Attacks or Cardiovascular Disease Deaths – University of Alabama at Birmingham, via NewsWise (free) AND Multivitamin-mineral supplements do not reduce heart disease, deaths – Reuters (free)
Related: Supplements Not Effective for CVD Prevention and Treatment (link to abstract and commentaries) AND Multivitamins are probably a waste of money (free commentaries)
3 – Comparative Benefits and Harms of Basal Insulin Analogues for Type 2 Diabetes: A Systematic Review and Network Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Newer, older insulin formulations may offer similar glucose-lowering effects – ACP Internist (free) AND HbA1c Reduction Similar in Old, New Basal Insulin Analogues – MedPage Today (free registration required)
Author Interview: Effects of Early Solid Food Introduction on Infant Sleep (free audio)
Commentaries: Babies fed solids earlier ‘sleep better’ – NHS Choices (free) AND Feeding your baby solids early may help them sleep, study suggests – The Guardian (free) AND Giving your baby solid food early won’t help them sleep better – The Conversation (free)
5 – Effect of a Home-Based Wearable Continuous ECG Monitoring Patch on Detection of Undiagnosed Atrial Fibrillation: The mSToPS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentary: If You Look For Atrial Fibrillation You Will Find Atrial Fibrillation – Cardiobrief (free)
Related: Wearable technology to screen for atrial fibrillation: does it raise more questions than it answers? (free commentaries)
6 – Review: Update on infection control practices in cancer hospitals – CA: A Cancer Journal of Clinicians (free)
7 – Review: Optimal pain management for patients with cancer in the modern era – CA: A Cancer Journal of Clinicians (free)
Commentary: Higher risk of heart defects in babies of mothers with type 1 diabetes – Karolinska Institutet, via EurekAlert (free)
10 – Consensus Report: Returning Individual Research Results to Participants: Guidance for a New Research Paradigm (2018) – National Academies of Sciences, Engineering, and Medicine (free PDF)
Commentaries: National Academies panel urges researchers to routinely share test results with study participants – STAT (free) AND If you give your DNA and tissues to science, should you get a peek at what they might contain? – Science (free) AND New report says individual research results should be shared with participants more often – National Academies of Sciences, Engineering, and Medicine (free)
Related Viewpoint: Return of Research Results to Study Participants: Uncharted and Untested – JAMA (free for a limited period)
Fri, July 13 – 10 Stories of The Day!
13 Jul, 2018 | 00:25h | UTC
1 – INSPIRE: Seven strategies for ending violence against children – World Health Organization (free resources)
Fact Sheet: Violence against children – World Health Organization (free)
The package includes the core document describing what the INSPIRE strategies and interventions are; an implementation handbook that provides details on how to implement the interventions, and a set of indicators to measure the uptake of INSPIRE and its impact on levels of violence against children.
2 – Comparison of the Safety Planning Intervention With Follow-up vs Usual Care of Suicidal Patients Treated in the Emergency Department – JAMA Psychiatry (free for a limited period)
Author Interview: Association of Safety Planning Intervention With Subsequent Suicidal Behavior Among ER-Treated Suicidal Patients (free)
Commentaries: ED Intervention with Follow-Up Appears to Reduce Suicidal Behaviors – NEJM Physician’s First Watch (free) AND A Simple Emergency Room Intervention Can Help Cut Suicide Risk – NPR (free)
Related Studies: Suicide Prevention in an Emergency Department Population (free study and commentaries) AND Strategies to prevent death by suicide (link to abstract and commentaries)
3 – Concomitant Oral Anticoagulant and Nonsteroidal Anti-Inflammatory Drug Therapy in Patients With Atrial Fibrillation – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Bleeding Risk Increased With NSAID Use in Anticoagulated A-fib Patients: RE-LY Analysis – TCTMD (free) AND NSAID, anticoagulant combo ups risk for bleeding events in AFib patients – Cardiovascular Business (free) Concomitant NSAIDs and Anticoagulants in Atrial Fibrillation – American College of Cardiology (free)
4 – Infographic: Testing for non-alcoholic fatty liver disease -The BMJ (free PDF)
5 – The right diet can boost potency of cancer drugs – Nature News (free)
Original article: Suppression of insulin feedback enhances the efficacy of PI3K inhibitors – Nature (link to abstract – $ for full-text)
Related: Top oncologist to study effect of diet on cancer drugs – The Guardian (free)
“Diets appear to matter in mouse cancer Rx – can these preclinical findings be translated to humans?” (via @Aiims1742 see Tweet)
6 – Report: Research into physiotherapy for musculoskeletal conditions – NIHR Dissemination Centre (free PDF)
This new NIHR report brings together key research relevant to those delivering musculoskeletal physiotherapy services.
7 – Last Month in Oncology with Dr. Bishal Gyawali: June 2018 – eCancer News (free)
This review has an interesting opinion on changing definitions of clinically meaningful endpoints in cancer research.
8 – Research Methods & Reporting: Reading Mendelian randomisation studies: a guide, glossary, and checklist for clinicians – The BMJ (free)
9 – Anticoagulation for perioperative thromboprophylaxis in people with cancer – Cochrane Library (free)
Summary: Blood thinners for the prevention of blood clots in people with cancer undergoing surgery – Cochrane Library (free)
10 – Effect of Alteplase vs Aspirin on Functional Outcome for Patients With Acute Ischemic Stroke and Minor Nondisabling Neurologic Deficits: The PRISMS Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Stopping the Alteplase Indication Creep – Emergency Medicine Literature of Note (free) AND Alteplase unlikely to reduce disability after mild stroke without disabling deficits – 2 Minute Medicine (free) AND Lytic No Better Than Aspirin for Mild Ischemic Stroke – MedPage Today (free registration required)
Tue, July 10 – 10 Stories of The Day!
10 Jul, 2018 | 00:01h | UTC
Editorial: Treating nosocomial pneumonia: what’s new (free)
Related Guidelines: International ERS/ESICM/ESCMID/ALAT guidelines for the management of hospital-acquired pneumonia and ventilator-associated pneumonia (free) AND Management of Adults With Hospital-acquired and Ventilator-associated Pneumonia: 2016 Clinical Practice Guidelines by the Infectious Diseases Society of America and the American Thoracic Society (free)
Source: Critical Care Reviews Newsletter
2 – Guideline: Recommendations on screening for asymptomatic bacteriuria in pregnancy – Canadian Task Force on Preventive Health Care (free)
See also: Summary of recommendations for clinicians and policy-makers / other resources from CTFPHC (all free)
3 – Draft Statement: Antibiotics should be restricted for COPD – National Institute for Health and Care Excellence (free)
Commentaries: Antibiotics should be restricted for COPD, says NICE – OnMedica (free) AND UK officials recommend limits on antibiotics for COPD – CIDRAP (free)
“The draft antimicrobial guidance recommends that antibiotics should be offered to people who have a severe flare up of symptoms, also known as a severe acute exacerbation”
4 – Oposition to Breast-Feeding Resolution by U.S. Stuns World Health Officials – The New York Times (10 articles per month are free)
5 – Richard Lehman’s journal review, 9 July 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals
6 – Cabozantinib in Patients with Advanced and Progressing Hepatocellular Carcinoma – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: Cabozantinib in Hepatocellular Carcinoma – NEJM Resident 360 (free)
Median overall survival was 10.2 months with cabozantinib and 8.0 months with placebo, but the rate of high-grade adverse events in the cabozantinib group was approximately twice that observed in the placebo group. (more on this study in Richard Leeman’s review above)
Original study: Percutaneous coronary intervention in stable angina (ORBITA) (link to abstract and commentaries)
Related commentaries: Viewpoint: Placebo Effect of the Heart (free) AND Sham Surgeries: A Tale of Medical Reversals & the Role of the Media (free)
Related research: Research: Physiology-Stratified Analysis of ORBITA (free research and commentaries)
8 – Richard Smith: Reducing global road traffic crashes and injuries – The BMJ Opinion (free)
Related reports: The High Toll of Traffic Injuries : Unacceptable and Preventable – The World Bank (free PDF) AND Save LIVES: a road safety technical package (free) AND Unfinished Journey: The Global Health Response to Children & Road Traffic – FIA Foundation (free PDF) AND Securing safe roads: the politics of change – World Resources Institute Ross Center for Sustainable Cities (free news release and PDF)
9 – Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Summary: Negative pressure wound therapy for open traumatic wounds – Cochrane Library (free)
Related Research: Randomized Trial: Negative Pressure Wound Therapy No Better Than Regular Dressing in Severe Open Fracture of the Lower Limb (link to abstract and commentaries)
10 – Physician Burnout, Well-being, and Work Unit Safety Grades in Relationship to Reported Medical Errors – Mayo Clinic Proceedings (link to abstract – $ for full-text)
Commentaries: Medical errors may stem more from physician burnout than unsafe health care settings – Stanford Medicine, via ScienceDaily (free) AND Physician burnout, depression can lead to major medical errors: Study – ABC News (free) AND Burnout Tied to Twofold Higher Risk for Medical Errors – Medscape (free registration required)
Related: Perspective: The Burnout Crisis in American Medicine (free commentaries on the subject)
Mon, July 9 – 10 Stories of The Day!
9 Jul, 2018 | 00:11h | UTC
1 – Guidelines On The Management Of Acute Respiratory Distress Syndrome – Intensive Care Society (free PDF) (via @CritCareReviews)
Related Guidelines: The clinical practice guideline for the management of ARDS in Japan – Journal of Intensive Care (free) AND An Official American Thoracic Society/European Society of Intensive Care Medicine/Society of Critical Care Medicine Clinical Practice Guideline: Mechanical Ventilation in Adult Patients with Acute Respiratory Distress Syndrome (free)
2 – WHO Manual: Preventing disease through a healthier and safer workplace – World Health Organization (free PDF)
Source: International Health Policies Newsletter
3 – Clinical Update: Long-acting Reversible Contraception—Highly Efficacious, Safe, and Underutilized – JAMA (free for a limited period)
Clinical Review Audio: Return of the IUD: Long-acting Reversible Contraception Is Safe and Effective (free)
4 – Seriously, Juice Is Not Healthy – The New York Times (10 articles per month are free)
“Would you take a multivitamin if it contained 10 teaspoons of sugar? No. Then why are you drinking juice?” (via @NYTHealth see Tweet)
5 – Effect of Screening With Primary Cervical HPV Testing vs Cytology Testing on High-grade Cervical Intraepithelial Neoplasia at 48 Months: The HPV FOCAL Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: For Women Over 30, There May Be A Better Choice Than The Pap Smear – NPR (free) AND Study Suggests HPV Test More Accurate Than Pap Smear for Cervical Cancer Screening – AJMC (free) AND HPV testing could be more accurate than smear tests for initial screening of cervical cancer – NHS Choices (free)
6 – The health benefits of the great outdoors: A systematic review and meta-analysis of greenspace exposure and health outcomes – Environmental Research (free) (via @Mental_Elf and @AllenFrancesMD)
Commentary: It’s official — spending time outside is good for you – University of East Anglia, via ScienceDaily (free)
Related Meta-Analysis: Liberal vs Conservative Oxygen Therapy in Acutely ill Adults (link to abstract and commentary)
Source: Critical Care Reviews Newsletter
8 – Disease Outbreak News: Ebola virus disease – Democratic Republic of the Congo – World Health Organization (free)
Related: Ebola virus outbreak likely over in Congo, WHO says – NBC News (free) AND Good news: the Ebola outbreak in DRC is contained – VOX (free)
9 – Use of ‘smart drugs’ on the rise – Nature (free)
Related: A ‘smart’ approach to performance drugs – ACP Internist (free) AND Growing use of smart drugs by students could be a recipe for disaster – The Conversation (free) AND Brain Hackers Seeking Peak Performance Use Risky Chemical Cocktails: “Smart drugs” are not clinically proven and could be dangerous – Scientific American (free) AND Universities must do more to tackle use of smart drugs, say experts – The Guardian (free) AND Tweaking brains with ‘smart drugs’ to get ahead in Silicon Valley – The Washington Post (free) AND Professors take same ‘smart drugs’ as students to keep up with workloads, claims academic – Independent (free)
Commentaries: Folic acid linked to healthy brain development through childhood – Reuters (free) AND Folic Acid Fortification May Have Role in Sustaining Mental Health – AJMC (free) AND Prenatal Exposure to Folic Acid Appears to Promote Healthy Brain Development – Psychiatric News Alert (free) AND Perinatal Folic Acid May Protect Against Serious Mental Illness in Young People – MedicalResearch.com (free)
Fri, July 6 – 10 Stories of The Day!
6 Jul, 2018 | 00:36h | UTC
1 – Report: Delivering quality health services: A global imperative for universal health coverage – World Health Organization (free)
News Release: Low quality healthcare is increasing the burden of illness and health costs globally (free)
Commentary: Universal quality healthcare coverage—a commitment to building a healthier and more productive society – The BMJ Opinion (free)
Commentaries: Up to half of childhood cancer survivors will develop hormone disorders – The Endocrine Society, via ScienceDaily (free) AND Guideline Addresses Endocrine Effects After Childhood Cancer – Medscape (free registration required)
Editorial: Implementation Challenges for Risk-Stratified Screening in the Era of Precision Medicine (free)
Author Interview: Cost-effectiveness and Benefit-to-Harm Ratio of Risk-Stratified Breast Cancer Screening (free)
Commentaries: New approach to breast cancer screening — tailoring guidelines for each patient — may save lives and money, study says – STAT (free) AND No screening is better for women with low breast cancer risk, finds study – Guardian (free) AND Breast Cancer Screening Only for Women at Higher Risk – Medscape (free registration required)
4 – Review: Heart failure with preserved ejection fraction: from mechanisms to therapies – European Heart Journal (free)
5 – Review: Anemia and Iron Deficiency in Heart Failure: Current Concepts and Emerging Therapies – Circulation (free)
6 – Hidden conflicts? – Science Magazine (free)
““Pay-later conflicts of interest” have gone largely unnoticed & entirely unpoliced”. (via @cpiller see Tweet)
Commentary: Analysis Finds Less Bleeding — But Potentially Greater Mortality Risk — with Some Newer Anticoagulants – NEJM Physician’s First Watch (free)
9 – Species-specific activity of antibacterial drug combinations – Nature (link to abstract – $ for full-text)
Commentaries: Study: For antibiotics, good things may come in pairs – CIDRAP (free) AND Combining antibiotics alters effectiveness, study says – UPI (free) AND As drug resistance grows, combining antibiotics could turn up new treatments – STAT (free)
Invited Commentary: Preventing urinary tract infections in patients with neurogenic bladder (free)
Thu, July 5 – 10 Stories of The Day!
5 Jul, 2018 | 01:37h | UTC
Related Guideline: Pneumonia: Diagnosis and Management of Community- and Hospital-Acquired Pneumonia in Adults – National Institute for Health and Care Excellence (free)
Editorial: Myocardial Infarction With Nonobstructive Coronary Arteries (MINOCA): It’s Time to Face Reality! (free)
5 – Treatment of Angina: Where Are We? – Cardiology (free)
Source: Critical Care Reviews Newsletter
Commentaries: Clocking up 45+ working hours/week linked to heightened risk of diabetes in women – BMJ, via ScienceDaily (free) AND Greater Risk of Diabetes in Women With Longer Work Week – MedicalResearch.com (free)
Related Study: Effect of Work Stressors on the Risk of Type 2 Diabetes (link to abstract and commentary)
7 – Miscarriage and stillbirth following maternal Zika virus infection in nonhuman primates – Nature Medicine (link to abstract – $ for full-text)
Commentaries: Pregnancy loss occurs in 26 percent of Zika-infected monkeys – NIH News Releases (free) AND Monkey studies suggest Zika role in miscarriage may be higher than thought – CIDRAP (free)
8 – Alarming polio outbreak spreads in Congo, threatening global eradication efforts – Science (free)
9 – Carbohydrate Replacement of Rice or Potato with Lentils Reduces the Postprandial Glycemic Response in Healthy Adults in an Acute, Randomized, Crossover Trial – The Journal of Nutrition (link to abstract – $ for full-text)
Commentaries: Lentils significantly reduce blood glucose levels – University of Guelph, via ScienceDaily (free) AND Replace Carbs With Lentils to Blunt Glucose Spike After Meals – Medscape (free registration required)
10 – Hypertensive Disorders of Pregnancy and Maternal Cardiovascular Disease Risk Factor Development: An Observational Cohort Study – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Hypertensive disorders during pregnancy associated with increased rates of later CVD – ACP Internist (free) AND High blood pressure in pregnancy tied to heart disease risk afterward – Reuters (free) AND Women who experience hypertensive disorders during pregnancy are at high risk for developing high blood pressure, diabetes, and high cholesterol later in life – 2 Minute Medicine (free)
Related Studies: All Hypertensive Disorders of Pregnancy Increase the Risk of Future Cardiovascular Disease (free PDF and commentaries) AND Hypertensive Disorders in Pregnancy and the Risk of Subsequent Cardiovascular Disease (link to abstract and free commentaries) AND Gestational Hypertension and Future Risk of Cardiovascular Disease (free research and editorial)
Tue, July 3 – 10 Stories of The Day!
3 Jul, 2018 | 00:06h | UTC
Commentary: Foleys Aren’t Fun: Patient Study Shows Catheter Risks – University of Michigan, via NewsWise (free)
“More than half of patients surveyed while they had a urinary catheter, and again weeks later, reported a complication – and infections were only part of the problem” (from NewsWise)
Source: Critical Care Reviews Newsletter
“Out-of-hours discharge from an ICU is strongly associated with both in-hospital death and ICU readmission. Whether these increases in mortality and readmission result from patient differences, differences in care, or a combination remains unclear”.
3 – Review: Chronic hyperkalemia in non-dialysis CKD: controversial issues in nephrology practice – Journal of Nephrology (free)
4 – Opinion: Endless Gaming May Be a Bad Habit. That Doesn’t Make It a Mental Illness – The New York Times (10 articles per month are free)
Related: Gaming addiction as a mental disorder: it’s premature to pathologise players – The Conversation (free)
“The World Health Organization has made “internet gaming” a diagnosable disorder. But many experts aren’t even sure it exists”.
5 – Richard Lehman’s journal review, 2 July 2018 – The BMJ Opinion (free)
Richard Lehman reviews the latest research in the top medical journals.
Invited Commentary: Ebola virus disease: 11 323 deaths later, how far have we come? (free)
Related: Ebola Outbreak in Congo ‘Largely Contained’, says WHO (free statement and commentary)
Commentaries: Patient-centred care for multimorbidity: an end in itself? – The Lancet (free) AND Results of the largest ever multimorbidity trial in primary care challenge current thinking -NIHR News (free)
Related: Designing a High-Performing Health Care System for Patients with Complex Needs: Ten Recommendations for Policymakers (series of free articles on the topic) AND Multimorbidity: A Priority for Global Health Research (free report and commentaries)
“In the largest ever trial of an intervention to treat people with multiple long-term conditions (multimorbidity) in primary care, NIHR-researchers found that the patient-centred approach taken improved patients’ experience of their care but did not improve their health-related quality of life. This is a challenge to current thinking on which UK and international guidelines are based”. (from NIHR News)
8 – Association of Coffee Drinking With Mortality by Genetic Variation in Caffeine Metabolism: Findings From the UK Biobank – JAMA Internal Medicine (link to abstract – $ for full-text)
Commentaries: Expert reaction to research association between coffee and lower risk of death – Science Media Centre (free) AND Fresh grounds for coffee: Study shows it may boost longevity – Associated Press (free) AND Coffee Drinkers Are More Likely To Live Longer. Decaf May Do The Trick, Too – NPR (free)
Related Studies: Meta-Analysis: Coffee consumption and health (free research and commentaries) AND Coffee Drinking and Mortality Studies (link to abstract and commentaries)
Another observational study showing possible benefits from drinking coffee.
Invited Commentary: Unmet Survivorship Care Needs of Adolescent and Young Adult Cancer Survivors (free)
Related Reviews: Endocrine late-effects of childhood cancer and its treatments – European Journal of Endocrinology (free) AND Metabolic syndrome induced by anticancer treatment in childhood cancer survivors – Annals of Pediatric Endocrinology & Metabolism (free) AND Screening and management of adverse endocrine outcomes in adult survivors of childhood and adolescent cancer – The Lancet Diabetes & Endocrinology (free)
Related Guidelines and Reviews: Prevention and Monitoring of Cardiac Dysfunction in Survivors of Adult Cancers: American Society of Clinical Oncology Clinical Practice Guideline (free) AND Cardio-Onco-Hematology in Clinical Practice. Position Paper and Recommendations – Revista Espanola de Cardiologia (free) AND 2016 ESC Position Paper on cancer treatments and cardiovascular toxicity developed under the auspices of the ESC Committee for Practice Guidelines (free) AND Canadian Cardiovascular Society Guidelines for Evaluation and Management of Cardiovascular Complications of Cancer Therapy (free) AND Cardiotoxicity of anticancer treatments: Epidemiology, detection, and management – CA: A Cancer Journal for Clinicians (free)
Wed, July 4 – 10 Stories of The Day!
4 Jul, 2018 | 00:20h | UTC
Commentaries: Class of drugs used as alternative to opioids for back pain are ineffective, have potentially serious side effects: report – The Globe and Mail (free) AND Anticonvulsant drugs ineffective for low back pain and can cause harm, despite increased prescribing – CMAJ, via EurekAlert (free)
Related Meta-Analysis: Benefits and safety of gabapentinoids in chronic low back pain (free research and commentaries)
2 – The Carbohydrate-Insulin Model of Obesity: Beyond “Calories In, Calories Out” – JAMA Internal Medicine (free for a limited period)
3 – Epinephrine Versus Norepinephrine for Cardiogenic Shock After Acute Myocardial Infarction – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: Epinephrine vs. Norepinephrine for Cardiogenic Shock – American College of Cardiology (free) AND Norepinephrine Bests Epinephrine in Battle of the Vasopressors in Cardiogenic Shock – TCTMD (free)
4 – Enzalutamide in Men with Nonmetastatic, Castration-Resistant Prostate Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
Related Perspective: Metastasis-free Survival — A New End Point in Prostate Cancer Trials – New England Journal of Medicine (free)
Commentaries: Enzalutamide: Now Also for Earlier Use in Prostate Cancer? – Medscape (free registration required) AND Enzalutamide Improves Outcomes for Aggressive Prostate Cancer – MPR (free) AND Enzalutamide Postpones Metastasis for a Subset of High-Risk Patients With Prostate Cancer – Cancer Therapy Advisor (free)
5 – Editorial: Immunotherapy: hype and hope – The Lancet Oncology (free) (via @OphiraG)
Related: What Precisely Is Precision Oncology—and Will It Work? – The ASCO Post (free) AND Hope and hype around cancer immunotherapy – CNN (free)
Related guidelines: Fertility Preservation in Patients With Cancer: ASCO Clinical Practice Guideline Update – Journal of Clinical Oncology (free) AND Fertility preservation for patients with gynecologic malignancies: The Korean Society for Fertility Preservation clinical guidelines – Clinical and Experimental Reproductive Medicine (free) AND Fertility preservation for medical reasons in girls and women: British fertility society policy and practice guideline – Human Fertility (free)
7 – Influenza vaccine for chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
Summary: Influenza vaccine for people with chronic obstructive pulmonary disease (COPD) – Cochrane Library (free)
8 – Maternal and infant outcomes associated with lithium use in pregnancy: an international collaborative meta-analysis of six cohort studies – The Lancet (link to abstract – $ for full-text)
Commentaries: Increased risk of birth defects in babies after first-trimester exposure to lithium – Mount Sinai School of Medicine, via ScienceDaily (free) AND Lithium in Pregnancy Tied to Infant Morbidity, Malformation Risk – Medscape (free)
In this large international, population-based database, no evidence was found of an overall increased risk of congenital anomalies after first trimester metformin exposure.
10 – Australia wins landmark WTO ruling on plain tobacco packaging – Reuters (free)
Other commentaries: WTO Tobacco Ruling Opens Door to New Plain-Packaging Laws – Bloomberg (free) AND ‘Resounding victory’: Australia wins tobacco plain packaging dispute – The Guardian (free) AND Australian Tobacco Plain Packaging Upheld In Decision At WTO – Intellectual Property Watch (free)
Source: International Health Policies Newsletter