Systematic Reviews & Meta-analysis
[Abstract Only] Meta-Analysis: Safety and Efficacy of Testosterone for Postmenopausal Women with Low Sexual Desire Causing Distress
29 Jul, 2019 | 20:45h | UTCSafety and efficacy of testosterone for women: a systematic review and meta-analysis of randomised controlled trial data – The Lancet Diabetes & Endocrinology (link to abstract – $ for full-text)
Commentaries: Testosterone may significantly improve sexual function and sexual well-being in postmenopausal women – The Lancet (free) AND Testosterone can enhance libido in postmenopausal women, new research says – CNN (free)
Related Commentary on Twitter
Just online: Safety and efficacy of #testosterone for #women: a systematic review and meta-analysis of randomised controlled trial data https://t.co/xKp6RCKd0g #postmenopausal #menopause #sexual desire pic.twitter.com/wqfMGHL37T
— The Lancet Diabetes & Endocrinology (@TheLancetEndo) July 26, 2019
Meta-Analysis: Very Early Mobilization After Stroke Does Not Improve Outcomes
29 Jul, 2019 | 20:32h | UTCVery Early Versus Delayed Mobilization After Stroke: Systematic Review and Meta-Analysis – Stroke (free PDF)
[Abstract Only] Meta-Analysis: Effect of Extending the Interval After Long‐course Chemoradiotherapy Before Surgery in Locally Advanced Rectal Cancer
27 Jul, 2019 | 20:03h | UTCMeta‐analysis of the effect of extending the interval after long‐course chemoradiotherapy before surgery in locally advanced rectal cancer – British Journal of Surgery (link to abstract – $ for full-text)
Source: EvidenceAlerts
Meta-analysis: Diagnosis of Elevated Intracranial Pressure in Critically Ill Adults
26 Jul, 2019 | 01:08h | UTCCommentary: Review examines methods for diagnosis of elevated ICP in critically ill – MedicalXpress (free)
Related Guidelines: Management of severe traumatic brain injury (first 24 hours) – Anaesthesia Critical Care & Pain Medicine (free) AND Consensus statement from the International Consensus Meeting on the Role of Decompressive Craniectomy in the Management of Traumatic Brain Injury – Acta Neurochirurgica (free)
Related Reviews: Emergency Neurological Life Support: Intracranial Hypertension and Herniation – Neurocritical Care (free) AND Acute Management of Traumatic Brain Injury – Surgical Clinics of North America (free)
Related Commentary on Twitter
A question we often ask in the ED/ICU: Does this patient have increased ICP?
Our @bmj_latest study found that traditional physical exam and CT signs had poor accuracy for elevated ICP. If suspected, consider treatment & transfer for invasive monitoring.https://t.co/1Eb8PtYLFJ pic.twitter.com/bQFIgWnuur
— Shannon Fernando (@shanfernands) July 25, 2019
Meta-Analysis: Risk of Recurrent Thromboembolism after Discontinuation of Anticoagulant Treatment for First Unprovoked Venous Thromboembolism Event
26 Jul, 2019 | 01:06h | UTCCommentary: Long-Term Risk for Recurrent VTE Significant After Stopping Anticoagulation – NEJM Journal Watch (free)
“the risk of recurrent VTE was 10% in the first year after treatment, 16% at two years, 25% at five years, and 36% at 10 years, with 4% of recurrent VTE events resulting in death.”
Related Commentary on Twitter
Excited to share my first study published today in @bmj_latest on recurrence risk after stopping #anticoagulation for unprovoked #VTE. Big thanks to the MARVELOUS collaborators, @CIHR_IRSC for funding/support & @RodgerMarc for continued mentorship https://t.co/jnT86dRzHK#phdlife pic.twitter.com/SSVTYwkXth
— Faizan Khan, PhD (@FaizanK91) July 25, 2019
Meta-Analysis: Impact of Furosemide on Mortality and the Requirement for Renal Replacement Therapy in Acute Kidney Injury
26 Jul, 2019 | 00:45h | UTC
Systematic Review: Interventions for Preventing Obesity in Children
26 Jul, 2019 | 00:32h | UTCInterventions for preventing obesity in children – Cochrane Library (free)
Summary: Do diet and physical activity strategies help prevent obesity in children (aged 0 to 18 years)? – Cochrane Library (free)
Systematic Review: Palliative Care for People with Dementia Living at Home
25 Jul, 2019 | 01:32h | UTC
Meta-Analysis: Plant-Based Dietary Patterns Linked to Lower Risk of Type 2 Diabetes
23 Jul, 2019 | 01:45h | UTCAssociation Between Plant-Based Dietary Patterns and Risk of Type 2 Diabetes: A Systematic Review and Meta-analysis – JAMA Internal Medicine (free for a limited period)
Commentaries: Following a healthy plant-based diet may lower type 2 diabetes risk – JAMA Internal Medicine (free) Eating a plant-based diet might help prevent type 2 diabetes, study suggests – CNN (free) AND Healthy plant-based diets could reduce diabetes risk, study says – UPI (free) AND Expert reaction to study on the vegetarian diet and diabetes risk – Science Media Centre (free)
Meta-Analysis: Diagnostic Performance of PET or PET/CT Using 18F-FDG Labeled White Blood Cells in Infectious Diseases
23 Jul, 2019 | 01:22h | UTC
Cochrane Review: Buffered Solutions Do Not Improve Mortality in Critically Ill Adults and Children Compared to 0,9% Saline
20 Jul, 2019 | 18:35h | UTCBuffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Summary: Buffered solutions versus 0.9% saline for resuscitation in critically ill adults and children – Cochrane Library (free)
Related Meta-Analysis: Choice of Intravenous Crystalloid Fluid and Mortality in Critically Ill Adult Patients – Southern Medical Journal (link to abstract – $ for full-text)
Related Randomized Trials: Balanced Crystalloids vs Saline in Hospitalized Patients (free studies and commentary)
“The three ongoing studies once published and assessed may alter the conclusions of the review.”
Systematic Review: Incentives for Smoking Cessation
19 Jul, 2019 | 09:47h | UTCIncentives for smoking cessation – Cochrane Library (free)
Summaries: Can rewards help smokers to quit in the long term? – Cochrane Library (free) AND Featured Review: Incentives for smoking cessation – Cochrane Library (free)
Commentaries: Helping smokers quit: financial incentives work – The Conversation (free) AND NHS could save billions by offering cash reward to quit smoking – The Guardian (free)
Related Commentary on Twitter
https://twitter.com/CochraneUK/status/1151846093061312515
Meta-Analysis: Preventable Patient Harm Across Medical Care Settings
18 Jul, 2019 | 10:54h | UTCEditorial: Preventable harm: getting the measure right (free)
Commentaries: One in 20 patients exposed to preventable harm in medical care – OnMedica (free) AND Half of All Patient Harms ‘Preventable’ – Medscape (free registration required)
Related Commentary on Twitter
Around one in 20 patients are affected by preventable harm in medical care, of which around 12% causes permanent disability or death, finds a study published by @bmj_latest today – take a look at the research https://t.co/oHxTBlh4s1 and linked editorial https://t.co/MBW6moT3pE pic.twitter.com/gxoL4V435w
— BMJ Group (@bmj_company) July 18, 2019
Meta-Analysis: Menstrual Cup Use, Leakage, Acceptability, Safety, and Availability
18 Jul, 2019 | 10:05h | UTCCommentaries: Inserting informed choice into global menstrual product use and provision – The Lancet Public Health (free) AND Menstrual Cups: Study Finds They’re Safe To Use — And People Like Them – NPR (free) AND Menstrual cups ‘as reliable as tampons’ – BBC (free) AND A Better Way to Manage Your Period? Try the Menstrual Cup, Scientists Say – The New York Times (free)
Meta-Analysis: Antiplatelet Therapy After Noncardioembolic Stroke
17 Jul, 2019 | 10:47h | UTCSource: EvidenceAlerts
“Results favor clopidogrel and aspirin/dipyridamole combination for long-term secondary prevention after noncardioembolic stroke or transient ischemic attack”.
Meta-Analysis: Risks of Stillbirth and Neonatal Death with Advancing Gestation at Term
16 Jul, 2019 | 09:46h | UTCCommentaries: New stillbirth risk figures help women’s decisions on timing delivery – Queen Mary University of London (free) AND Higher risk of stillbirth in longer pregnancies, study finds – PLOS (free) AND Expert reaction to study on longer pregnancies and risk of stillbirth – Science Media Centre (free)
Related Cochrane Review: Induction of Labor for Improving Birth Outcomes for Women at or Beyond Term (free)
Related Randomized Trials: Labor Induction vs. Expectant Management in Low-Risk Nulliparous Women (free) AND Induction of Labor at 41 Weeks vs. Expectant Management Until 42 Weeks (free)
Related WHO Recommendations: Induction of Labor at or Beyond Term (free)
[Abstract Only] Little Evidence for Nutritional Supplements to Improve Cardiovascular Outcomes
9 Jul, 2019 | 10:19h | UTCEffects of Nutritional Supplements and Dietary Interventions on Cardiovascular Outcomes: An Umbrella Review and Evidence Map – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Little evidence supports nutritional supplements for protection against cardiovascular disease, death – ACP Internist (free) AND Nutritional supplements and diets not always protective, WVU research suggests – West Virginia University (free) AND Supplements and Diets for Heart Health Show Limited Proof of Benefit – The New York Times (10 articles per month are free)
Related Study: Association of Multivitamin and Mineral Supplementation and Risk of Cardiovascular Disease: A Systematic Review and Meta-Analysis – Circulation: Cardiovascular Quality and Outcomes (free) AND Editorial: Multivitamins Do Not Reduce Cardiovascular Disease and Mortality and Should Not Be Taken for This Purpose: How Do We Know That? (free)
Meta-Analysis: Quadruple vs. Triple Combination Antiretroviral Therapies for Treatment-Naive People with HIV
9 Jul, 2019 | 09:41h | UTC
Cochrane Review: Pay for Performance for Hospitals
8 Jul, 2019 | 10:10h | UTCPay for performance for hospitals – Cochrane Library (free)
Summary: Pay for performance (payment or penalty methods to encourage hospitals to increase quality of care) – Cochrane Library (free)
Related Systematic Review: The Effects of Pay-for-Performance Programs on Health, Health Care Use, and Processes of Care: A Systematic Review – Annals of Internal Medicine (free)
See also: Impact of Financial Incentives on Early and Late Adopters among US Hospitals – The BMJ (free study and commentaries) AND Research: Pay-for-performance fails to perform (link to abstract and commentaries) AND Value-Based Purchasing: Time for Reboot or Time to Move On? – The JAMA Forum (free)
“We found either no difference at all or only a very slight effect for most P4P programs.”
Meta-Analysis: Duration of Dual Antiplatelet Therapy after Percutaneous Coronary Intervention with Drug-eluting Stent
30 Jun, 2019 | 17:52h | UTCRelated Randomized Trials: Shorter Duration of Dual Antiplatelet Therapy May be an Option for Patients Undergoing Percutaneous Coronary Intervention (free studies and commentaries)
Meta-Analysis: Routine Urinary Screening Not Indicated Prior To Elective Total Joint Arthroplasty
30 Jun, 2019 | 17:14h | UTCIs Routine Urinary Screening Indicated Prior To Elective Total Joint Arthroplasty? A Systematic Review and Meta-Analysis – The Journal of Arthroplasty (free for a limited period)
Meta-Analysis: Impact of Sugar‐sweetened Beverage Taxes on Purchases and Dietary Intake
27 Jun, 2019 | 09:05h | UTCRelated: Cochrane Review: Environmental Interventions to Reduce the Consumption of Sugar‐sweetened Beverages and Their Effects on Health (free study and commentaries) AND Soda Tax Linked to a 50 Percent Reduction in Sugary Drink Consumption (link to abstract and several resources on the subject) AND AAP/AHA Policy Statement: Public Policies to Reduce Sugary Drink Consumption in Children and Adolescents (free statement and commentaries) AND Taxes on Sugar-Sweetened Beverages Associated with Reduced Consumption (link to abstract and commentaries)
Meta-Analysis: Incidence of New Onset Diabetes Mellitus Secondary to Acute Pancreatitis
26 Jun, 2019 | 01:07h | UTC
Working While Sick: A Systematic Review of Infectious Illness Presenteeism
25 Jun, 2019 | 06:25h | UTCRelated Study: Working with influenza-like illness: Presenteeism among US health care personnel during the 2014-2015 influenza season – American Journal of Infection Control (link to abstract – $ for full-text) AND Commentaries: This flu season, physicians need to scrap the ‘martyr culture’ of working while sick – STAT (free) AND Healthcare Providers Shouldn’t Come to Work While Sick, but They Do — Here’s Why – HIV and ID Observations, Journal Watch Blog (free)
Infectious illness presenteeism (working while sick) prevalence ranged from 35 to 97%.
[Abstract Only] Meta-Analysis: Natural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess
25 Jun, 2019 | 06:33h | UTCNatural History of Adrenal Incidentalomas With and Without Mild Autonomous Cortisol Excess: A Systematic Review and Meta-analysis – Annals of Internal Medicine (link to abstract – $ for full-text)
Commentaries: Incidentally discovered adrenal tumors rarely grow or affect hormonal function, review finds – ACP Internist (free) AND Healthcare guidelines should be updated for patients with certain adrenal tumors – University of Birmingham (free)
Related Guideline: Management of adrenal incidentalomas: European Society of Endocrinology Clinical Practice Guideline in collaboration with the European Network for the Study of Adrenal Tumors – European Journal of Endocrinology (free)