Systematic Reviews & Meta-analysis
Systematic Review: Disease‐modifying treatments for primary autoimmune hemolytic anemia
28 Apr, 2021 | 08:09h | UTCDisease‐modifying treatments for primary autoimmune haemolytic anaemia – Cochrane Library
Summary: Treatment for primary autoimmune haemolytic anaemia – Cochrane Library
M-A: Effectiveness of intrapartum fetal surveillance to improve maternal and neonatal outcomes – “none of the newer surveillance methods seem to significantly reduce emergency cesarean deliveries in labor or neonatal morbidity compared with using simple intermittent auscultation of the fetal heart”
28 Apr, 2021 | 08:08h | UTC
M-A: Helicobacter pylori eradication therapy to prevent gastric cancer – H. pylori eradication may reduce the incidence of gastric cancer in healthy individuals in East Asian countries
27 Apr, 2021 | 09:21h | UTCHelicobacter pylori eradication therapy to prevent gastric cancer: systematic review and meta-analysis (link to abstract – $ for full-text – free article here)
M-A: Lidocaine lubricant jelly does not reduce pain perception during female urethral catheterization
27 Apr, 2021 | 09:11h | UTCLidocaine lubricant jelly does not reduce pain perception during female urethral catheterization: A systematic review with meta‐analysis and trial sequential analysis – The International Journal of Clinical Practice (link to abstract – $ for full-text)
M-A: Comparative Efficacy of 6 Topical Pharmacological Agents for Preventive Interventions of Postoperative Sore Throat After Tracheal Intubation
27 Apr, 2021 | 09:13h | UTC
Systematic Review: Dopamine agonists for preventing ovarian hyperstimulation syndrome
27 Apr, 2021 | 09:08h | UTCDopamine agonists for preventing ovarian hyperstimulation syndrome – Cochrane Library
Systematic review: Surgical or radiological treatment for varicoceles in subfertile men
27 Apr, 2021 | 09:09h | UTCSurgical or radiological treatment for varicoceles in subfertile men – Cochrane Library
Systematic review shows there is insufficient evidence on the best approaches to stop long‐term antidepressant use – “Future studies should distinguish carefully between relapse and withdrawal symptoms”
23 Apr, 2021 | 08:19h | UTCAuthor interview: Stopping long-term antidepressants in people with depression or anxiety – Cochrane Library
Commentary: ‘Urgent’ need for more evidence on safely stopping antidepressants, say experts – Metro
“Future studies should distinguish carefully between relapse and withdrawal symptoms and follow emerging guidance to use taper schemes of many weeks or months (or longer for long-term users) down to very low doses before stopping. Such studies would give us a clearer idea of the ability of antidepressants to prevent relapse.”
Commentary on Twitter (thread – click for more)
Outline of the Cochrane study a bit for those scared of its length. Metro article: https://t.co/3c32xjGJsr Lead author: the dauntless Ellen van Leuween. Co-author @tony_kendrick https://t.co/tt4Lzyacq4 While there are hundreds of studies looking at starting antidepressants(1/n)
— Mark Horowitz @markhoro.bsky.social (@markhoro) April 22, 2021
Systematic Review: PARP (Poly ADP‐Ribose Polymerase) inhibitors for locally advanced or metastatic breast cancer
23 Apr, 2021 | 08:16h | UTCSummary: PARP inhibitors for locally advanced or metastatic breast cancer – Cochrane Library
Systematic review: Venoarterial Extracorporeal Membrane Oxygenation in Massive Pulmonary Embolism-Related Cardiac Arrest
22 Apr, 2021 | 08:18h | UTCSummary: VA ECMO for Massive PE + Cardiac Arrest – Journal Feed
M-A: Aspirin alone better than dual antiplatelet therapy after transcatheter aortic valve implantation
22 Apr, 2021 | 08:20h | UTC
Maternal, Fetal, and Child Outcomes of Mental Health Treatments in Women: A Systematic Review of Perinatal Pharmacologic Interventions
22 Apr, 2021 | 08:19h | UTCSee also: Final Report AND Evidence Summary
Systematic review: Thrombolytic therapy for acute massive or submassive pulmonary embolism
21 Apr, 2021 | 06:20h | UTCThrombolytic therapy for pulmonary embolism – Cochrane Library
Summary: Drugs to dissolve pulmonary embolism (blood clot in the lungs) – Cochrane Library
M-A: Corticosteroids in COVID-19 and non-COVID-19 ARDS
20 Apr, 2021 | 06:11h | UTC
M-A: Progestogens for preventing miscarriage
21 Apr, 2021 | 06:22h | UTCProgestogens for preventing miscarriage: a network meta‐analysis – Cochrane Library
Summary: Are progestogen treatments effective in preventing miscarriage? – Cochrane Library
Related Meta-analysis: Evaluating Progestogens for Preventing Preterm birth International Collaborative (EPPPIC): meta-analysis of individual participant data from randomised controlled trials – The Lancet (link to abstract – $ for full-text)
M-A: Portal venous system thrombosis after bariatric surgery
21 Apr, 2021 | 06:16h | UTCPortal venous system thrombosis after bariatric surgery: A systematic review and meta-analysis – Surgery (link to abstract – $ for full-text)
M-A: Diagnostic performance of different sampling approaches for SARS-CoV-2 RT-PCR testing
20 Apr, 2021 | 06:09h | UTCCommentary: Beyond COVID-19—will self-sampling and testing become the norm? – The Lancet Infectious Diseases
Related Meta-analysis: Saliva and nasopharyngeal swab nucleic acid amplification have similar diagnostic accuracy for the detection of SARS-CoV-2 AND Saliva vs. nasopharyngeal swabs equally sensitive for Covid-19 diagnosis
Therapies for Clinically Localized Prostate Cancer: A Comparative Effectiveness Review
18 Apr, 2021 | 21:16h | UTC
M-A: Nonantibiotic Strategies for the Prevention of Infectious Complications following Prostate Biopsy
18 Apr, 2021 | 21:14h | UTC
M-A: Long-acting injectable vs. oral antipsychotics for the maintenance treatment of schizophrenia
15 Apr, 2021 | 06:31h | UTC
Commentary on Twitter
https://twitter.com/TheLancetPsych/status/1382314592609693703
M-A: Treatment with hydroxychloroquine is associated with increased mortality in COVID-19 patients
16 Apr, 2021 | 06:30h | UTC
Commentaries on Twitter
The use of hydroxychloroquine in COVID19 will be remembered as one of the worst examples of medicine going against its core principle:
First Do No Harm. https://t.co/PGq4D5pJ1H— Maurizio Cecconi (@DrMCecconi) April 15, 2021
What collaboration can achieve
Just out in @NatureComms our meta-analysis of 14 unpublished & 14 published RCTs on Hydroxychloroquine/ Choloroquine
Thanks so much to the great team – and special thanks for rapidly sharing the data of unpublished trials!https://t.co/Dg1DmAx1Kq
— Lars G. Hemkens (@LGHemkens) April 15, 2021
Systematic review: Excessive nurse work hours is associated with increased adverse patient outcomes
15 Apr, 2021 | 06:19h | UTCRelationships between comprehensive characteristics of nurse work schedules and adverse patient outcomes: A systematic literature review – Journal of Clinical Nursing (link to abstract – $ for full-text)
M-A: Chemotherapy and radiotherapy in locally advanced head and neck cancer
15 Apr, 2021 | 06:29h | UTC
Commentary on Twitter
What is the best treatment in locally advanced HN Cancer?
Our latest individual patient data network meta-analysis available here for free @TheLancetOncol: https://t.co/UuFvjpKO6I
Many limitations but by far the largest work on the topic (115 RCT, 29000 pts).
#radonc #hncsm pic.twitter.com/eNYHbxsB4Q
— Pierre Blanchard, MD (@PBlanchardMD) April 14, 2021
M-A: Effectiveness of treatments for acute and subacute mechanical non-specific low back pain
14 Apr, 2021 | 01:39h | UTC
Commentary on Twitter
Just published in BJSM 🔥🔥🔥
Effectiveness of treatments for acute and subacute mechanical non-specific low back pain: a systematic review with network meta-analysis
👀👀👇👇🔎https://t.co/bx06RPLTbT pic.twitter.com/RzHkwN2nTp
— Physio Meets Science (@PhysioMeScience) April 13, 2021
M-A: Post-extubation oxygenation strategies in acute respiratory failure – NPPV or HFNC may reduce the risk of endotracheal reintubation but not mortality
12 Apr, 2021 | 00:42h | UTC