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Systematic Reviews & Meta-analysis

M-A | Various exercise training modes reduce resting blood pressure, isometric exercise most effective

31 Jul, 2023 | 14:35h | UTC

Exercise training and resting blood pressure: a large-scale pairwise and network meta-analysis of randomised controlled trials – British Journal of Sports Medicine

News Release: Static isometric exercise, such as wall sits, best for lowering blood pressure – BMJ Newsroom

Commentary: Wall squats and planks best at lowering blood pressure – BBC

 

M-A | Cardiovascular events in patients treated with bempedoic acid versus placebo

31 Jul, 2023 | 14:06h | UTC

Cardiovascular events in patients treated with bempedoic acid versus placebo: systematic review and meta-analysis – European Heart Journal – Cardiovascular Pharmacotherapy

 

Commentary on Twitter

 

Systematic Review | Organizational changes likely decrease physical restraint usage in long-term care

31 Jul, 2023 | 13:53h | UTC

Interventions for preventing and reducing the use of physical restraints for older people in all long‐term care settings – Cochrane Library

Summary: Interventions for preventing and reducing the use of physical restraints in all long-term care settings – Cochrane Library

 

Systematic Review | Probiotics’ potential in preventing necrotizing enterocolitis in very preterm, VLBW infants warrants further research

31 Jul, 2023 | 13:51h | UTC

Probiotics to prevent necrotising enterocolitis in very preterm or very low birth weight infants – Cochrane Library

 

RCT | Combined endovenous ablation and compression speeds up venous leg ulcers healing

31 Jul, 2023 | 13:49h | UTC

Endovenous ablation for venous leg ulcers – Cochrane Library

Summary: What are the benefits and risks of endovenous ablation (using heat or medication to permanently close veins) for treating venous leg ulcers – Cochrane Library

 

M-A | P2Y12 monotherapy after 1-3 months DAPT safely reduces bleeding in PCI patients with CAD and CKD

26 Jul, 2023 | 13:18h | UTC

P2y12 inhibitor monotherapy after 1–3 months dual antiplatelet therapy in patients with coronary artery disease and chronic kidney disease undergoing percutaneous coronary intervention: a meta-analysis of randomized controlled trials – Frontiers in Cardiovascular Medicine

Related:

De-escalation or abbreviation of dual antiplatelet therapy in acute coronary syndromes and percutaneous coronary intervention: a Consensus Statement from an international expert panel on coronary thrombosis – Nature Reviews Cardiology (if the link is paywalled, try this one)

RCT | 3-6 month DAPT noninferior to 12 month DAPT in patients undergoing PCI with third-generation DES

Short Duration of DAPT Versus De-Escalation After Percutaneous Coronary Intervention for Acute Coronary Syndromes – JACC: Cardiovascular Interventions

Long-term Effects of P2Y12 Inhibitor Monotherapy After Percutaneous Coronary Intervention: 3-Year Follow-up of the SMART-CHOICE Randomized Clinical Trial – JAMA Cardiology (link to abstract – $ for full-text)

Effect of 1-Month Dual Antiplatelet Therapy Followed by Clopidogrel vs 12-Month Dual Antiplatelet Therapy on Cardiovascular and Bleeding Events in Patients Receiving PCI: The STOPDAPT-2 Randomized Clinical Trial – JAMA

Effect of P2Y12 Inhibitor Monotherapy vs Dual Antiplatelet Therapy on Cardiovascular Events in Patients Undergoing Percutaneous Coronary Intervention: The SMART-CHOICE Randomized Clinical Trial – JAMA

Comparison of Clopidogrel Monotherapy After 1 to 2 Months of Dual Antiplatelet Therapy With 12 Months of Dual Antiplatelet Therapy in Patients With Acute Coronary Syndrome: The STOPDAPT-2 ACS Randomized Clinical Trial – JAMA Cardiology

Six months versus 12 months dual antiplatelet therapy after drug-eluting stent implantation in ST-elevation myocardial infarction (DAPT-STEMI): randomised, multicentre, non-inferiority trial – The BMJ

6-month versus 12-month or longer dual antiplatelet therapy after percutaneous coronary intervention in patients with acute coronary syndrome (SMART-DATE): a randomised, open-label, non-inferiority trial – The Lancet

Dual Antiplatelet Therapy Duration Based on Ischemic and Bleeding Risks After Coronary Stenting – Journal of the American College of Cardiology

 

M-A | Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals

26 Jul, 2023 | 13:15h | UTC

Vegetarian Dietary Patterns and Cardiometabolic Risk in People With or at High Risk of Cardiovascular Disease: A Systematic Review and Meta-analysis – JAMA Network Open

Commentary: M-A: Vegetarian diets may modestly improve cardiometabolic profile in high-risk individuals – HCP Live

 

M-A | Oral isotretinoin and triple topical therapies found most effective in acne vulgaris treatment

26 Jul, 2023 | 13:13h | UTC

Comparative Efficacy of Pharmacological Treatments for Acne Vulgaris: A Network Meta-Analysis of 221 Randomized Controlled Trials – Annals of Family Medicine

News Release: Meta-analysis of research on acne reveals that oral isotretinoin, followed by topical antibiotic, benzoyl peroxide and retinoid, are most effective treatments – American Academy of Family Physicians

 

M-A | Early initiation of renal replacement therapy fails to improve survival rates in AKI patients

25 Jul, 2023 | 13:46h | UTC

Early strategy vs. late initiation of renal replacement therapy in adult patients with acute kidney injury: an updated systematic review and meta-analysis of randomized controlled trials – European Review for Medical and Pharmacological Sciences

 

Systematic Review | Rapamycin and rapalogs for tuberous sclerosis complex

25 Jul, 2023 | 13:43h | UTC

Rapamycin and rapalogs for tuberous sclerosis complex – Cochrane Library

 

M-A | Early NIPPV likely reduces the risk of respiratory failure and intubation in very preterm infants

25 Jul, 2023 | 13:39h | UTC

Early nasal intermittent positive pressure ventilation (NIPPV) versus early nasal continuous positive airway pressure (NCPAP) for preterm infants – Cochrane Library

 

Systematic Review | Existing research on post-stroke depression interventions lacks conclusive results

25 Jul, 2023 | 13:37h | UTC

Pharmacological, non‐invasive brain stimulation and psychological interventions, and their combination, for treating depression after stroke – Cochrane Library

Summary: Pharmacological, non-invasive brain stimulation and psychological interventions for treating depression after stroke – Cochrane Library

 

M-A | Comparison of systemic treatments for chronic plaque psoriasis – Anti-IL17 stands out

25 Jul, 2023 | 13:27h | UTC

Systemic pharmacological treatments for chronic plaque psoriasis: a network meta‐analysis – Cochrane Library

 

Systematic Review | Low-level HIV viremia (below 1000 copies/mL) linked to minimal sexual transmission risk

24 Jul, 2023 | 13:15h | UTC

The risk of sexual transmission of HIV in individuals with low-level HIV viraemia – The Lancet

Editorial: HIV is sexually untransmittable when viral load is undetectable – The Lancet

Related: Study: Growing Acceptability of “Undetectable = Untransmittable” but Widespread Misunderstanding of HIV Transmission Risk Persists (several texts on the subject)

 

Commentary on Twitter

 

Systematic Review | Dual therapy of Rifaximin and lactulose potentially reduces risk in hepatic encephalopathy

24 Jul, 2023 | 12:57h | UTC

Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

Summary: Rifaximin for prevention and treatment of hepatic encephalopathy in people with cirrhosis – Cochrane Library

 

Systematic Review | Insufficient evidence for ACEi/ARB’s impact on early non-diabetic CKD

24 Jul, 2023 | 12:56h | UTC

Angiotensin‐converting enzyme inhibitors and angiotensin receptor blockers for adults with early (stage 1 to 3) non‐diabetic chronic kidney disease – Cochrane Library

Summary: Blood pressure lowering medication for adults with early stages of chronic kidney disease (without diabetes) – Cochrane Library

 

Systematic Review | Medical treatment of eosinophilic esophagitis

21 Jul, 2023 | 13:27h | UTC

Medical treatment of eosinophilic esophagitis – Cochrane Library

Summary: Medical treatments for eosinophilic esophagitis – Cochrane Library

Related:

RCT | Study finds both one-food and six-food elimination diets are effective initial options for eosinophilic esophagitis

M-A | Efficacy of elimination diets in eosinophilic esophagitis

RCT | Dupilumab in adults and adolescents with eosinophilic esophagitis

A meta-analysis on randomized controlled trials of treating eosinophilic esophagitis with budesonide – Annals of Medicine

A Clinical Severity Index for Eosinophilic Esophagitis: Development, Consensus, and Future Directions – Gastroenterology

British Society of Gastroenterology (BSG) and British Society of Paediatric Gastroenterology, Hepatology and Nutrition (BSPGHAN) joint consensus guidelines on the diagnosis and management of eosinophilic oesophagitis in children and adults – Gut

 

Systematic Review | Platinum doublet therapy outperforms non-platinum for advanced NSCLC, performance status 2 patients

20 Jul, 2023 | 10:56h | UTC

Best first‐line therapy for people with advanced non‐small cell lung cancer, performance status 2 without a targetable mutation or with an unknown mutation status – Cochrane Library

Summary: Best therapy for people with advanced non-small cell lung cancer who have not been treated without a targetable mutation and moderately impaired performance status – Cochrane Library

 

M-A | Adverse effects of antipsychotics on sleep in patients with schizophrenia

18 Jul, 2023 | 13:45h | UTC

Adverse effects of antipsychotics on sleep in patients with schizophrenia. Systematic review and meta-analysis – Frontiers in Psychiatry

 

M-A | One-year usage of elastic compression stockings comparable to two for post-thrombotic syndrome prevention

17 Jul, 2023 | 13:49h | UTC

Is it necessary to wear compression stockings and how long should they be worn for preventing post thrombotic syndrome? A meta-analysis of randomized controlled trials – Thrombosis Research

Commentary: Are Compression Stockings Beneficial for Preventing Post-Thrombotic Syndrome After Deep Venous Thrombosis? – NEJM Journal Watch

 

Systematic Review | Criteria to achieve safe antimicrobial intravenous-to-oral switch in hospitalized adult populations

17 Jul, 2023 | 13:34h | UTC

Criteria to achieve safe antimicrobial intravenous-to-oral switch in hospitalised adult populations: a systematic rapid review – BMJ Open

 

M-A | First-line thiazide diuretics show reduced cardiovascular events, comparable mortality vs. other antihypertensive drugs

14 Jul, 2023 | 12:55h | UTC

First‐line diuretics versus other classes of antihypertensive drugs for hypertension – Cochrane Library

Summary: What are the benefits and harms of diuretics given as a first treatment compared to other drug classes for hypertension (high blood pressure)? – Cochrane Library

 

M-A | Drug therapies for treatment of idiopathic pulmonary fibrosis

14 Jul, 2023 | 12:40h | UTC

Drug therapies for treatment of idiopathic pulmonary fibrosis: a systematic review, Bayesian network meta-analysis, and cost-effectiveness analysis – eClinicalMedicine

 

A guide and pragmatic considerations for applying GRADE to network meta-analysis

12 Jul, 2023 | 13:44h | UTC

A guide and pragmatic considerations for applying GRADE to network meta-analysis – The BMJ

 

Commentary on Twitter

 

M-A | Cognitive rehabilitation may improve everyday activities in mild to moderate dementia

12 Jul, 2023 | 13:34h | UTC

Cognitive rehabilitation for people with mild to moderate dementia – Cochrane Library

 

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