Systematic Reviews & Meta-analysis
RCT | Effect of mifepristone vs. placebo for treatment of adenomyosis with pain symptoms
5 Jul, 2023 | 01:06h | UTCSee also: Visual Abstract
SR | Antibiotic strategies for eradicating Pseudomonas aeruginosa in people with cystic fibrosis
5 Jul, 2023 | 01:04h | UTC
M-A | Family screening for bicuspid aortic valve and aortic dilatation
5 Jul, 2023 | 01:01h | UTC
Commentary on Twitter
Family screening for bicuspid aortic valve and aortic dilatation: a meta-analysis https://t.co/8rc4Uysf5o @escardio #EHJ #ESCYoung pic.twitter.com/p4XRzb3mzb
— European Society of Cardiology Journals (@ESC_Journals) June 15, 2023
Scoping Review | High correlation of positive outcomes in oncology meta-analyses with industry funding
3 Jul, 2023 | 14:21h | UTC
M-A | Clinical tests for confirming tracheal intubation or excluding esophageal intubation
3 Jul, 2023 | 14:19h | UTC
SR | Polyclonal anti‐thymocyte globulins for the prophylaxis of GVHD after allogeneic stem cell or bone marrow transplantation
3 Jul, 2023 | 14:16h | UTC
SR | Gonadotropin‐releasing hormone analogues for endometriosis
3 Jul, 2023 | 14:14h | UTCGonadotropin‐releasing hormone analogues for endometriosis – Cochrane Library
Summary: Gonadotrophin-releasing hormone analogues for pain associated with endometriosis – Cochrane Library
SR | Oral contraceptives containing drospirenone for premenstrual syndrome
3 Jul, 2023 | 14:13h | UTCOral contraceptives containing drospirenone for premenstrual syndrome – Cochrane Library
Summary: Birth control pills with drospirenone for treating premenstrual syndrome – Cochrane Library
SR | Little to no impact of low glycemic index/glycemic load diets on weight loss in overweight or obese individuals
30 Jun, 2023 | 14:54h | UTCSummary: This systematic review examined the impact of low glycaemic index or load (GI/GL) diets on weight loss in overweight or obese individuals, analyzing data from 10 randomized controlled trials (RCTs), with 1,210 participants. The main outcomes included changes in body weight, body mass index (BMI), adverse events, health-related quality of life, and mortality. The study showed that low GI/GL diets probably result in little to no difference in body weight and BMI changes compared to higher GI/GL diets or other diets. The evidence suggests a lack of effect on all main outcomes and the possible positive influence on mood remains uncertain.
The studies included in this review had a small sample size with a moderate to very low certainty of evidence. This suggests more well-structured studies with larger sample sizes are needed for firmer conclusions. Limitations of this review included the risk of bias, as many of the studies did not adopt objective outcome measurements and some had a high degree of loss to follow-up. Furthermore, the researchers recommend that future studies focus on diverse demographic groups and include participants from low- and middle-income countries.
M-A | Metoclopramide effective in acute migraine relief, comparable to most active drugs, superior to placebo
30 Jun, 2023 | 14:51h | UTC
M-A | Tracheostomy timing not a key determinant of clinical outcomes in critically ill stroke patients
30 Jun, 2023 | 14:50h | UTC
SR | Medical equipment that improve safety and outcomes of inter-facility transportation of critically ill patients
30 Jun, 2023 | 14:48h | UTC
M-A | Effects of SGLT-2 inhibitors on adipose tissue distribution in patients with type 2 diabetes mellitus
30 Jun, 2023 | 14:47h | UTC
M-A | The effectiveness and safety of laparoscopic uterosacral ligament suspension
30 Jun, 2023 | 14:37h | UTC
SR | Drivers of emergency department use among oncology patients in the era of novel cancer therapeutics
30 Jun, 2023 | 14:35h | UTC
M-A | Prophylactic intravenous tranexamic acid and thromboembolism in non-cardiac surgery
29 Jun, 2023 | 14:03h | UTC
SR | Anti‐vascular endothelial growth factors in combination with vitrectomy for complications of proliferative diabetic retinopathy
29 Jun, 2023 | 13:49h | UTC
SR | Medically assisted hydration in palliative care: uncertain effects on quality of life and survival
27 Jun, 2023 | 13:47h | UTCSummary: The Cochrane Review analyzed Randomized Controlled Trials (RCTs) to evaluate the impact of Medically Assisted Hydration (MAH) on the Quality of Life (QoL) and survival of adults receiving palliative care. A total of four studies involving 422 participants, all diagnosed with advanced cancer, were considered. Two studies compared MAH with placebo, and two compared it with standard care.
The primary outcome was QoL, assessed through validated scales, with survival and adverse events being secondary outcomes. Mean differences (MD) and risk ratios (RR) were calculated for continuous and dichotomous outcomes, respectively. However, results were inconclusive due to a very low certainty of evidence. Hence, it is unclear whether MAH improves QoL, prolongs survival, or leads to adverse events when compared to placebo or standard care.
The findings are only applicable to inpatients with advanced cancer at the end of life and do not transfer to other adults in palliative care with non-cancer, dementia, or neurodegenerative diseases, or those with an extended prognosis. The lack of high-quality evidence leaves clinicians to make decisions based on perceived benefits and harms for individual circumstances.
Article: Medically assisted hydration for adults receiving palliative care – Cochrane Library
M-A | Risk factors for non-tuberculous mycobacterial pulmonary disease
27 Jun, 2023 | 13:27h | UTCCommentary: Comorbid respiratory disease key predictor of NTM-PD – MDedge
M-A | Lifetime burden of psychological symptoms, disorders, and suicide due to cancer in childhood, adolescent, and young adult years
26 Jun, 2023 | 00:39h | UTCLifetime Burden of Psychological Symptoms, Disorders, and Suicide Due to Cancer in Childhood, Adolescent, and Young Adult Years: A Systematic Review and Meta-analysis – JAMA Pediatrics (free for a limited period)
Editorial: Poor Mental Health Among Survivors of Childhood Cancer—Risk Factors and a Call for Intervention – JAMA Pediatrics (free for a limited period)
M-A | Effect of resistance exercise dose components for tendinopathy management
26 Jun, 2023 | 00:22h | UTC
M-A | No significant difference between thrombo-aspiration and stent-retrieval thrombectomy in ischemic stroke treatment
22 Jun, 2023 | 15:00h | UTCSummary: Different types of percutaneous endovascular treatments for acute ischemic stroke – Cochrane Library
M-A | Anticoagulation options for continuous renal replacement therapy in critically ill patients
22 Jun, 2023 | 14:54h | UTC
M-A | CRP at 5 mg/L cut-off efficient for tuberculosis screening in HIV outpatients
21 Jun, 2023 | 13:30h | UTC
Commentary on Twitter
ERR: C-reactive protein at a 5 mg cut-off and two newly developed clinical prediction models from this study show clinical utility for TB screening among outpatient PLHIV, while the WHO-recommended four-symptom screen showed suboptimal clinical utility https://t.co/msm13KXR0Y pic.twitter.com/O0wS1Xv4da
— ERS publications (@ERSpublications) June 11, 2023
M-A | Stenting or angioplasty show little to no improvement over best medical practice in acute DVT treatment
20 Jun, 2023 | 12:29h | UTC