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Randomized Trials

Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis

2 Mar, 2021 | 01:24h | UTC

Phase 3 Trials of Tirbanibulin Ointment for Actinic Keratosis – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: 3-Year outcomes of transcatheter mitral valve repair in patients with heart failure

2 Mar, 2021 | 01:20h | UTC

3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Commentary: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Heart Failure – American College of Cardiology

 

Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice

28 Feb, 2021 | 21:25h | UTC

News release: Targeted spraying to prevent malaria in low-transmission setting halves cost of current practice – Wits University

Original study: Effectiveness and cost-effectiveness of reactive, targeted indoor residual spraying for malaria control in low-transmission settings: a cluster-randomised, non-inferiority trial in South Africa – The Lancet

 

Commentary on Twitter

 

Turning houses into ‘lethal mosquito lures’ nearly halves incidence of malaria in children

28 Feb, 2021 | 21:26h | UTC

News release: Turning houses into ‘lethal mosquito lures’ nearly halves incidence of malaria in children – London School of Hygiene & Tropical Medicine

Original Study: Impact and cost-effectiveness of a lethal house lure against malaria transmission in central Côte d’Ivoire: a two-arm, cluster-randomised controlled trial – The Lancet

 

Commentary on Twitter (thread – click for more)

https://twitter.com/EDSternberg/status/1365083598538362882

 

RCT: Baclofen reduces agitation in patients with unhealthy alcohol use receiving mechanical ventilation, but results in a longer time receiving mechanical ventilation and more extended ICU stay

28 Feb, 2021 | 21:09h | UTC

Effect of High-Dose Baclofen on Agitation-Related Events Among Patients With Unhealthy Alcohol Use Receiving Mechanical Ventilation: A Randomized Clinical Trial – JAMA

Editorial: Baclofen to Prevent Agitation Caused by Alcohol Withdrawal in the ICU

Video presentation: Effect of Baclofen on Agitation-Related Events Among Mechanically Ventilated Patients With Alcohol Use Disorder

 

Commentary on Twitter

 

RCT: Balanced opioid-free anesthesia with Dexmedetomidine resulted in a greater incidence of serious adverse events, especially hypoxemia and bradycardia

28 Feb, 2021 | 21:03h | UTC

Balanced Opioid-free Anesthesia with Dexmedetomidine versus Balanced Anesthesia with Remifentanil for Major or Intermediate Noncardiac Surgery: The Postoperative and Opioid-free Anesthesia (POFA) Randomized Clinical Trial – Anesthesiology

 

RCT: similar outcomes in patients with heart failure with preserved ejection fraction randomized to high-intensity interval training vs. moderate continuous training vs. guideline-based physical activity advice

28 Feb, 2021 | 21:06h | UTC

Effect of High-Intensity Interval Training, Moderate Continuous Training, or Guideline-Based Physical Activity Advice on Peak Oxygen Consumption in Patients With Heart Failure With Preserved Ejection Fraction: A Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)

Commentary: Hold Off on HIIT for Patients with Heart Failure with Preserved EF – Physician’s Weekly

 

Commentary on Twitter

 

RCT: An intensive blood pressure lowering strategy after successful endovascular therapy in acute ischemic stroke did not reduce radiographic intraparenchymal hemorrhage rates

28 Feb, 2021 | 20:59h | UTC

Safety and efficacy of intensive blood pressure lowering after successful endovascular therapy in acute ischaemic stroke (BP-TARGET): a multicentre, open-label, randomised controlled trial – The Lancet Neurology (link to abstract – $ for full-text)

 

RCT: Endoscopic surgery improves survival compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma

28 Feb, 2021 | 20:45h | UTC

Endoscopic surgery compared with intensity-modulated radiotherapy in resectable locally recurrent nasopharyngeal carcinoma: a multicentre, open-label, randomised, controlled, phase 3 trial – The Lancet Oncology

Commentary: Endoscopic Nasopharyngectomy vs IMRT for Previously Treated, Resectable, Locally Recurrent Nasopharyngeal Carcinoma – The ASCO Post

 

Conflicting results from 2 randomized trials testing Tocilizumab for Covid-19

26 Feb, 2021 | 08:48h | UTC

Study 1: Tocilizumab in Hospitalized Patients with Severe Covid-19 Pneumonia – New England Journal of Medicine

Study 2: Interleukin-6 Receptor Antagonists in Critically Ill Patients with Covid-19 – New England Journal of Medicine

Editorial: Interleukin-6 Receptor Inhibition in Covid-19 — Cooling the Inflammatory Soup – New England Journal of Medicine

 

Commentary on Twitter

 

Phase 2 trial: Muscarinic cholinergic receptor agonist and peripheral antagonist for schizophrenia

26 Feb, 2021 | 08:30h | UTC

Muscarinic Cholinergic Receptor Agonist and Peripheral Antagonist for Schizophrenia – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Phase II Results Promising for New Schizophrenia Drug Combo – MedPage Today

 

RCT: Topical intranasal tranexamic acid does not reduce the need for nasal packing in epistaxis

21 Feb, 2021 | 22:02h | UTC

The Use of Tranexamic Acid to Reduce the Need for Nasal Packing in Epistaxis (NoPAC): Randomized Controlled Trial – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Five oral analgesics (including opioids) are equally effective for the treatment of acute musculoskeletal extremity pain in the emergency department

21 Feb, 2021 | 21:39h | UTC

A Randomized Trial Comparing the Efficacy of Five Oral Analgesics for Treatment of Acute Musculoskeletal Extremity Pain in the Emergency Department – Annals of Emergency Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Vitamin D3 does not improve outcomes in hospitalized patients with moderate to severe COVID-19

18 Feb, 2021 | 03:20h | UTC

Effect of a Single High Dose of Vitamin D3 on Hospital Length of Stay in Patients With Moderate to Severe COVID-19: A Randomized Clinical Trial – JAMA

Editorial: Vitamin D3 to Treat COVID-19: Different Disease, Same Answer

 

 

RCT: Levonorgestrel-releasing intrauterine system vs. endometrial ablation for heavy menstrual bleeding

18 Feb, 2021 | 02:38h | UTC

Levonorgestrel-releasing intrauterine system versus endometrial ablation for heavy menstrual bleeding – American Journal of Obstetrics & Gynecology

 

RCT: Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%

18 Feb, 2021 | 02:34h | UTC

Cemiplimab monotherapy for first-line treatment of advanced non-small-cell lung cancer with PD-L1 of at least 50%: a multicentre, open-label, global, phase 3, randomised, controlled trial – The Lancet

 

Commentary on Twitter

 

RCT: Among patients with knee osteoarthritis, high-intensity strength training was not associated with better outcomes compared with low-intensity strength training or an attention control

17 Feb, 2021 | 01:24h | UTC

Effect of High-Intensity Strength Training on Knee Pain and Knee Joint Compressive Forces Among Adults With Knee Osteoarthritis: The START Randomized Clinical Trial – JAMA

Commentary: No Benefit from High-Intensity Strength Training for Knee Osteoarthritis – NEJM Journal Watch

 

Commentary on Twitter

 

RCT: Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer

16 Feb, 2021 | 01:44h | UTC

Short-term outcomes of complete mesocolic excision versus D2 dissection in patients undergoing laparoscopic colectomy for right colon cancer (RELARC): a randomised, controlled, phase 3, superiority trial – The Lancet Oncology (link to abstract – $ for full-text)

 

How effective is magnesium in for the treatment of migraine?

16 Feb, 2021 | 01:48h | UTC

How Effective is Magnesium in your MAGraine Cocktail? – Journal Feed

Original study: MAGraine: Magnesium compared to conventional therapy for treatment of migraines – American Journal of Emergency Medicine

 

Opinion: RECOVERY confirms benefit of tocilizumab combined with dexamethasone

16 Feb, 2021 | 02:09h | UTC

PulmCrit – RECOVERY confirms benefit of toci combined with dexamethasone

Original study: RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19 (study and commentaries)

 

RCT: Delayed antibiotic prescription feasible for children with uncomplicated respiratory infections

12 Feb, 2021 | 02:02h | UTC

Delayed Antibiotic Prescription for Children With Respiratory Infections: A Randomized Trial – Pediatrics (link to abstract – $ for full-text)

Commentary: Data support delayed antibiotics in kids with respiratory infections – CIDRAP

 

RCT: Tocilizumab reduces deaths in patients hospitalized with COVID-19

12 Feb, 2021 | 02:25h | UTC

Tocilizumab in patients admitted to hospital with COVID-19 (RECOVERY): preliminary results of a randomised, controlled, open-label, platform trial – medRxiv

News release: Tocilizumab reduces deaths in patients hospitalised with COVID-19 – University of Oxford

Commentary: Tocilizumab cuts death rate in severe COVID-19, study finds – CIDRAP

 

Commentary on Twitter

 

RCT: Once-weekly, high-dose semaglutide is effective for improving overweight or obesity among non-diabetic adults

11 Feb, 2021 | 02:09h | UTC

Once-Weekly Semaglutide in Adults with Overweight or Obesity – New England Journal of Medicine (link to abstract – $ for full-text)

Commentary: Semaglutide Plus Lifestyle Change Shown Effective for Obesity – NEJM Journal Watch

 

Commentary on Twitter

 

Randomized, cross-over trial: Compared to Mediterranean diet, a Low-fat vegan diet is better at improving body weight, lipid concentrations, and insulin sensitivity

11 Feb, 2021 | 01:56h | UTC

A Mediterranean Diet and Low-Fat Vegan Diet to Improve Body Weight and Cardiometabolic Risk Factors: A Randomized, Cross-over Trial – Journal of the American College of Nutrition

Commentary: Vegan diet associated with more weight loss, better cholesterol control than Mediterranean diet – Cardiovascular Business

Commentary: Vegan diet associated with more weight loss, better cholesterol control than Mediterranean diet – Cardiovascular Business

 

Commentary on Twitter

 

RCT: The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults

11 Feb, 2021 | 01:58h | UTC

The effect of daily protein supplementation, with or without resistance training for 1 year, on muscle size, strength, and function in healthy older adults: A randomized controlled trial – The American Journal of Clinical Nutrition (link to abstract – $ for full-text)

 

Commentary on Twitter

 

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