Randomized Trials
Randomized controlled trial compared three antiretroviral regimens started in pregnant women with HIV
2 Apr, 2021 | 09:15h | UTCCommentary: ART in pregnant women living with HIV – The Lancet
RCT: Reduced-sodium added-potassium salt substitute reduces blood pressure in hypertensive patients
1 Apr, 2021 | 03:32h | UTC
Commentaries on Twitter
https://twitter.com/Dr_WuJ/status/1376715405553590275
Salt substitution (70% sodium chloride/30% potassium chloride blend) is an effective, low-cost intervention for BP controlhttps://t.co/EemPEY9T2k pic.twitter.com/xVITnGLEip
— K Pavithran (@drkpavithran) March 31, 2021
RCT: Second-line FOLFOX chemotherapy vs. active symptom control for advanced biliary tract cancer
1 Apr, 2021 | 03:21h | UTCCommentary: Treating patients with advanced biliary tract cancers: Changing tactics – Cancer Research UK
RCT: Adjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer
1 Apr, 2021 | 03:19h | UTCAdjuvant Nivolumab in Resected Esophageal or Gastroesophageal Junction Cancer – New England Journal of Medicine (link to abstract – $ for full-text)
RCT: The effect of external ventricular drain tunneling length on CSF infection rate in pediatric patients
1 Apr, 2021 | 03:16h | UTC
Commentary on Twitter
In this randomized, double-blind, controlled trial in @TheJNS:
External ventricular drain tunnel lengths of 5 cm and longer did not show a difference in the CSF infection rate in pediatric patients. https://t.co/RohLQpttCZ
— Saleh Almenawer, MD (@SalehAlmenawer) March 25, 2021
Opinion | COVID-19: underpowered randomized trials, or no randomized trials?
1 Apr, 2021 | 03:42h | UTCCOVID-19: underpowered randomised trials, or no randomised trials? – Trials
Commentary on Twitter
One important reason why we don’t see any randomised trials of non-pharmaceutical interventions is that they need to have thousands of participants to be sufficiently “powered”, statistically. I think underpowered trials are better than no trials. https://t.co/UsYfPO12kX
— Atle Fretheim (@AtleFretheim) March 31, 2021
Higher-Calorie Refeeding in Anorexia Nervosa: 1-Year Outcomes From a Randomized Controlled Trial
31 Mar, 2021 | 03:04h | UTCRelated Randomized trial: In patients with anorexia nervosa, a higher-calorie refeeding approach promotes earlier recovery with no increase in safety events during hospitalization
RCT: Using low-pressure pneumoperitoneum in laparoscopic colonic resection improves postoperative recovery compared to standard pressure pneumoperitoneum
28 Mar, 2021 | 22:11h | UTC
Commentary on Twitter
Low-pressure in colorectal lap surgery impacts pain / LOHS Our randomized trial just published in @BJSurgery @CHUBordeaux @univbordeaux Low-pressure versus standard pressure laparoscopic colorectal surgery (PAROS trial): a phase III randomized control… https://t.co/VWvT76ibey pic.twitter.com/rufjLPAsDa
— Quentin Denost (@QDenost) March 24, 2021
RCT: Abrocitinib vs. Placebo or Dupilumab for Atopic Dermatitis
26 Mar, 2021 | 08:27h | UTCAbrocitinib versus Placebo or Dupilumab for Atopic Dermatitis – New England Journal of Medicine
RCT: Metoclopramide + diphenhydramine more efficacious than placebo for acute post-traumatic headache in the ED
26 Mar, 2021 | 08:24h | UTCRandomized Study of Metoclopramide Plus Diphenhydramine for Acute Posttraumatic Headache – Neurology (link to abstract – $ for full-text)
Commentary: Drug Combo Superior to Placebo for Posttraumatic Headache – HealthDay
RCT: Fixed (40 mg twice daily) or variable (0.5 mg/kg twice daily) dosing of prophylactic enoxaparin after surgical procedures
26 Mar, 2021 | 08:23h | UTCOptimal Dosing of Prophylactic Enoxaparin after Surgical Procedures: Results of the Double-Blind, Randomized, Controlled FIxed or Variable Enoxaparin (FIVE) Trial – Plastic and Reconstructive Surgery (link to abstract – $ for full-text)
Covid: The London bus trip that saved maybe a million lives (about the creation of the RECOVERY Trial)
26 Mar, 2021 | 08:53h | UTCCovid: The London bus trip that saved maybe a million lives – BBC
Related: Covid-19: The Inside Story of the RECOVERY Trial
Commentary on Twitter
Very cool story by @JamesTGallagher about a convo on a London bus that led to the creation of the RECOVERY trial, which has been a shining (& too rare) example of how to do critical research in a pandemic. Bravo @PeterHorby & @MartinLandray h/t @hildabast https://t.co/BRSJLSFXdc
— Helen Branswell 🇨🇦 (@HelenBranswell) March 25, 2021
RCT: Effect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures
25 Mar, 2021 | 08:04h | UTCEffect of Intrawound Vancomycin Powder in Operatively Treated High-risk Tibia Fractures: A Randomized Clinical Trial – JAMA Surgery (free for a limited period)
RCT: Effect of continued weekly subcutaneous Semaglutide vs. placebo on weight loss maintenance in adults with overweight or obesity
24 Mar, 2021 | 08:05h | UTCEffect of Continued Weekly Subcutaneous Semaglutide vs Placebo on Weight Loss Maintenance in Adults With Overweight or Obesity: The STEP 4 Randomized Clinical Trial – JAMA (free for a limited period)
Commentaries: Continuing Semaglutide Leads to Further Weight Loss – NEJM Journal Watch AND STEP 4: Long-term treatment needed for full semaglutide benefit – MedwireNews
Podcast: Semaglutide for Weight Loss – JAMA
Commentary on Twitter
In this RCT, weekly subcutaneous subcutaneous semaglutide resulted in increased weight loss over 48 weeks vs placebo in adults with #overweight or #obesity https://t.co/Ze6zHCG1Fd
— JAMA (@JAMA_current) March 23, 2021
RCT: No benefit from marine Omega-3 fatty acid and Vitamin D supplementation on incident atrial fibrillation
17 Mar, 2021 | 02:38h | UTCEffect of Marine Omega-3 Fatty Acid and Vitamin D Supplementation on Incident Atrial Fibrillation: A Randomized Clinical Trial – JAMA (free for a limited period)
Editorial: Omega-3 Fatty Acids and Atrial Fibrillation – JAMA (free for a limited period)
RCT: No benefit from probiotic therapy in critical illness
16 Mar, 2021 | 01:30h | UTC
Commentary on Twitter
Early & sustained untargeted administration of probiotics to adults admitted to #ICU safe, but not associated with improved outcomes. ROCIT, restoration of gut microflora in critical illness, trial visual abstract full text open access #FOAMcc on @yourICM https://t.co/mP4bkHpqSs pic.twitter.com/bu3EGUyDCm
— Intensive Care Medicine (@yourICM) March 15, 2021
Platelet tests pre-CABG may safely shorten washout waits, cut costs
16 Mar, 2021 | 01:44h | UTCPlatelet Tests Pre-CABG May Safely Shorten Washout Waits, Cut Costs – TCTMD
RCT: Little benefit from osteopathic manipulative treatment on activity limitations in patients with nonspecific subacute and chronic low back pain
16 Mar, 2021 | 01:39h | UTCEffect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Visual abstract: Effect of Osteopathic Manipulative Treatment vs Sham Treatment on Activity Limitations in Patients With Nonspecific Subacute and Chronic Low Back Pain
Phase 2 RCT: Donanemab in early Alzheimer’s Disease
14 Mar, 2021 | 20:21h | UTCDonanemab in Early Alzheimer’s Disease – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Experimental Alzheimer’s drug could slow cognitive decline in patients, early results suggest – CNN AND Alzheimer’s study shows mixed results for Lilly’s donanemab on secondary outcomes – First World Pharma
Commentary on Twitter
In a phase 2 trial, patients with early Alzheimer’s disease who received donanemab, an antibody that targets amyloid deposits, showed a better composite score for cognition & ability to perform activities of daily living at 76 weeks than those who received placebo. #ADPD2021
— NEJM (@NEJM) March 13, 2021
Clinical trial shows alcohol use disorder recovery can start without sobriety
14 Mar, 2021 | 20:17h | UTC
Commentary on Twitter (thread – click for more)
1/A new trial found a harm reduction treatment effective in reducing drinking in persons experiencing homelessness – from @TheLancetPsych — I was happy to write the editorial—. Press summary here: https://t.co/WoLVWqinm6
— Stefan Kertesz, MD, MSc (@StefanKertesz) March 12, 2021
RCT: Efficacy of a combination of conservative therapies vs. an education comparator on clinical outcomes in thumb base osteoarthritis
14 Mar, 2021 | 20:13h | UTCEfficacy of a Combination of Conservative Therapies vs an Education Comparator on Clinical Outcomes in Thumb Base Osteoarthritis: A Randomized Clinical Trial – JAMA Internal Medicine (free for a limited period)
Commentary: Mix of treatments could be way to restore hand function in thumb-base osteoarthritis – University of Sydney
Commentary on Twitter
In people with thumb base #osteoarthritis, a combination of conservative treatments provided small beneficial effects on hand function at 6 weeks, but not pain, compared to an education control. Effects on hand function and pain were greater at 12 weeks https://t.co/lxaIubgTKT
— JAMA Internal Medicine (@JAMAInternalMed) March 9, 2021
70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age
14 Mar, 2021 | 20:07h | UTC70-gene signature as an aid for treatment decisions in early breast cancer: updated results of the phase 3 randomised MINDACT trial with an exploratory analysis by age – The Lancet Oncology (link to abstract – $ for full-text)
RCT: Effect of ventral vs. dorsal spinal surgery on patient-reported physical functioning in patients with cervical spondylotic myelopathy
10 Mar, 2021 | 08:26h | UTCEffect of Ventral vs Dorsal Spinal Surgery on Patient-Reported Physical Functioning in Patients With Cervical Spondylotic Myelopathy: A Randomized Clinical Trial – JAMA (free for a limited period)
RCT: 5 days of high-dose amoxicillin therapy noninferior to 10 days for the treatment of pediatric community-acquired pneumonia
9 Mar, 2021 | 02:29h | UTCShort-Course Antimicrobial Therapy for Pediatric Community-Acquired Pneumonia: The SAFER Randomized Clinical Trial – JAMA Pediatrics (free for a limited period)
Editorial: Rightsizing Treatment for Pneumonia in Children
Commentary: Five days of antibiotics fine for children with pneumonia – McMaster University
Commentary on Twitter (thread – click for more)
This is fantastic! In outpatient community acquired pneumonia (CAP) a 5 day course of amoxicillin is just as effective as a 10 day course. A small thread follow1/6https://t.co/ewceFEe4gw
— Ricardo Quiñonez, MD, FAAP, FHM (@QuinonezRicardo) March 8, 2021
3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure
9 Mar, 2021 | 02:22h | UTC3-Year Outcomes of Transcatheter Mitral Valve Repair in Patients With Heart Failure – Journal of the American College of Cardiology (link to abstract – $ for full-text)
Commentaries: 3-Year Outcomes of Transcatheter Mitral Valve Repair in Heart Failure – American College of Cardiology