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Randomized Trials

RCT: Reloxaliase vs. placebo in enteric hyperoxaluria.

9 May, 2022 | 01:30h | UTC

Randomized Placebo-Controlled Trial of Reloxaliase in Enteric Hyperoxaluria – NEJM Evidence

 

Commentary on Twitter

 

RCT: Efficacy and safety of Difelikefalin in patients with moderate to severe pruritus receiving hemodialysis.

9 May, 2022 | 01:21h | UTC

Efficacy and Safety of Difelikefalin in Japanese Patients With Moderate to Severe Pruritus Receiving Hemodialysis: A Randomized Clinical Trial – JAMA Network Open

 

Commentary on Twitter

 

Non-Inferiority Trials: Understanding the concepts.

1 May, 2022 | 23:33h | UTC

Non-Inferiority Trials: Understanding the Concepts – Students 4 Best Evidence

Related:

Non-inferiority trials in cardiology: what clinicians need to know – Heart

Non-Inferiority Trials in Medicine: Practice Changing or a Self-Fulfilling Prophecy? – Journal of General Internal Medicine

Challenges in the Design and Interpretation of Noninferiority Trials – New England Journal of Medicine

Users’ guide to the surgical literature: how to assess a noninferiority trial – Canadian Journal of Surgery

 

RCT: Hybrid vs. open surgical reconstruction for iliofemoral occlusive disease.

1 May, 2022 | 23:28h | UTC

Editor’s Choice – Hybrid vs. Open Surgical Reconstruction for Iliofemoral Occlusive Disease: A Prospective Randomised Trial – European Journal of Vascular & Endovascular Surgery

 

RCT: Substrate ablation vs. antiarrhythmic drug therapy for symptomatic ventricular tachycardia.

20 Apr, 2022 | 09:46h | UTC

Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia – Journal of the American College of Cardiology (link to abstract – $ for full-text)

Podcast: Substrate Ablation vs Antiarrhythmic Drug Therapy for Symptomatic Ventricular Tachycardia

 

RCT: Sintilimab vs. placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic esophageal squamous cell carcinoma.

20 Apr, 2022 | 09:28h | UTC

Sintilimab versus placebo in combination with chemotherapy as first line treatment for locally advanced or metastatic oesophageal squamous cell carcinoma (ORIENT-15): multicentre, randomised, double blind, phase 3 trial – The BMJ

 

Commentary on Twitter

 

RCT: Allopurinol is noninferior to febuxostat for controlling gout flares.

19 Apr, 2022 | 02:05h | UTC

Comparative Effectiveness of Allopurinol and Febuxostat in Gout Management – NEJM Evidence (link to abstract – $ for full-text)

 

Cluster RCT: BABEL (Better tArgeting, Better outcomes for frail ELderly patients) advance care planning: a comprehensive approach to advance care planning in nursing homes.

19 Apr, 2022 | 01:26h | UTC

BABEL (Better tArgeting, Better outcomes for frail ELderly patients) advance care planning: a comprehensive approach to advance care planning in nursing homes: a cluster randomised trial – Age and Ageing

 

10-year results of a phase 3 RCT: High-dose radiotherapy and risk-adapted androgen deprivation in localized prostate cancer.

19 Apr, 2022 | 01:22h | UTC

High-dose radiotherapy and risk-adapted androgen deprivation in localised prostate cancer (DART 01/05): 10-year results of a phase 3 randomised, controlled trial – The Lancet Oncology (link to abstract – $ for full-text)

 

RCT: Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children.

14 Apr, 2022 | 08:43h | UTC

Efficacy, safety, and immunogenicity of an inactivated, adjuvanted enterovirus 71 vaccine in infants and children: a multiregion, double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet (link to abstract – $ for full-text)

 

RCT: A home-based, walking exercise behavior change intervention increased walking distance in adults with peripheral artery disease.

13 Apr, 2022 | 11:02h | UTC

Effect of a Home-Based, Walking Exercise Behavior Change Intervention vs Usual Care on Walking in Adults With Peripheral Artery Disease: The MOSAIC Randomized Clinical Trial – JAMA (free for a limited period)

 

Commentary on Twitter

 

RCT: In patients undergoing knee replacement surgery, the administration of periarticular liposomal bupivacaine did not improve postoperative recovery or pain compared with bupivacaine hydrochloride alone.

13 Apr, 2022 | 10:16h | UTC

Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement: A Randomized Clinical Trial – JAMA Surgery

 

RCT: Prophylactic Rivaroxaban for 30 days to prevent left ventricular thrombus after anterior ST-Segment Elevation Myocardial Infarction.

13 Apr, 2022 | 09:56h | UTC

Prophylactic Rivaroxaban Therapy for Left Ventricular Thrombus After Anterior ST-Segment Elevation Myocardial Infarction – JACC: Cardiovascular Interventions (link to abstract – $ for full-text)

 

RCT: Efficacy and safety of AbobotulinumtoxinA in patients with neurogenic detrusor overactivity incontinence performing regular clean intermittent catheterization.

12 Apr, 2022 | 08:42h | UTC

Efficacy and Safety of AbobotulinumtoxinA in Patients with Neurogenic Detrusor Overactivity Incontinence Performing Regular Clean Intermittent Catheterization: Pooled Results from Two Phase 3 Randomized Studies (CONTENT1 and CONTENT2) – European Urology

 

RCT: Efficacy and safety of weekly somatrogon vs. daily somatropin in children with growth hormone deficiency.

12 Apr, 2022 | 08:34h | UTC

Efficacy and safety of weekly somatrogon vs daily somatropin in children with growth hormone deficiency: a phase 3 study – The Journal of Clinical Endocrinology & Metabolism

 

RCT: Prophylactic Penehyclidine inhalation for prevention of postoperative pulmonary complications in high-risk patients.

12 Apr, 2022 | 08:18h | UTC

Prophylactic Penehyclidine Inhalation for Prevention of Postoperative Pulmonary Complications in High-risk Patients: A Double-blind Randomized Trial – Anesthesiology

 

RCT: For adults with HIV, a 4-days-on and 3-days-off treatment strategy is noninferior to standard treatment for maintaining viral suppression.

11 Apr, 2022 | 01:56h | UTC

A 4-days-on and 3-days-off maintenance treatment strategy for adults with HIV-1 (ANRS 170 QUATUOR): a randomised, open-label, multicentre, parallel, non-inferiority trial – The Lancet HIV (link to abstract – $ for full-text)

Commentary: Intermittent Treatment Strategy Is Effective for HIV – Consultant360

 

Commentaries on Twitter

 

RCT: Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough.

11 Apr, 2022 | 01:22h | UTC

Efficacy and safety of gefapixant, a P2X3 receptor antagonist, in refractory chronic cough and unexplained chronic cough (COUGH-1 and COUGH-2): results from two double-blind, randomised, parallel-group, placebo-controlled, phase 3 trials – The Lancet (link to abstract – $ for full-text)

 

Commentary on Twitter

 

Study Commentary | To Bougie or not to Bougie: Bougie vs. Stylet for first-pass intubation success.

8 Apr, 2022 | 10:07h | UTC

To Bougie or Not to Bougie: Bougie versus Stylet for First-Pass Intubation Success – Annals of Emergency Medicine

Original Study: RCT: In critically ill adults undergoing tracheal intubation, use of a bougie did not significantly increase the incidence of successful first attempt intubation vs. with use of an endotracheal tube with stylet.

 

Study Commentary | Advanced glaucoma: surgery lowers pressure in the eye more effectively than eye drops.

8 Apr, 2022 | 10:06h | UTC

Advanced glaucoma: surgery lowers pressure in the eye more effectively than eye drops – National Institute for Health Research

Original Study: Pragmatic RCT: Among patients with advanced glaucoma, primary trabeculectomy resulted in similar quality of life and safety outcomes and achieved a lower intraocular pressure compared with primary medication.

 

RCT: Among patients with complicated urinary tract infection, oral Tebipenem Pivoxil Hydrobromide was noninferior to intravenous Ertapenem and showed a similar safety profile.

7 Apr, 2022 | 09:53h | UTC

Oral Tebipenem Pivoxil Hydrobromide in Complicated Urinary Tract Infection – New England Journal of Medicine (link to abstract – $ for full-text)

 

Commentary on Twitter

 

RCT: Effect of different corticosteroid dosing regimens on clinical outcomes in boys with Duchenne Muscular Dystrophy.

7 Apr, 2022 | 08:53h | UTC

Effect of Different Corticosteroid Dosing Regimens on Clinical Outcomes in Boys With Duchenne Muscular Dystrophy: A Randomized Clinical Trial – JAMA (free for a limited period)

Related:

RCT: Routine lung volume recruitment is not beneficial for boys with Duchenne muscular dystrophy.

Phase 2 RCT: Repeated intravenous cardiosphere-derived cell therapy in late-stage Duchenne muscular dystrophy.

Research: Long-term effects of glucocorticoids in patients with Duchenne muscular dystrophy

 

Commentary on Twitter

 

Randomized, sham-controlled trial: Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs.

7 Apr, 2022 | 09:49h | UTC

Long-term efficacy and safety of renal denervation in the presence of antihypertensive drugs (SPYRAL HTN-ON MED): a randomised, sham-controlled trial – The Lancet (link to abstract – $ for full-text)

Commentary: Three-year trial of SPYRAL HTN-ON MED shows blood pressure reductions – MedicalXpress

Related:

Systematic Review: Renal denervation may have a modest effect in improving 24h ambulatory blood pressure monitoring (reduction in SBP by 5.29 mmHg and DBP by 3.75 mmHg) but does not improve major cardiovascular outcomes and renal function.

M-A: Renal denervation for hypertension is associated with a modest reduction in ambulatory blood pressure control (3.61 mm Hg reduction in ambulatory systolic BP and 1.85 mm Hg reduction in ambulatory diastolic BP).

#ACC21 – RCT: Among patients with resistant hypertension, ultrasound renal denervation resulted in a modest improvement in systolic BP (–4.5 mm Hg) vs. sham procedure.

Meta-Analysis: Sham-Controlled Randomized Trials of Catheter-Based Renal Denervation in Patients with Hypertension

 

Commentary on Twitter

 

RCT: Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anesthetic injection for hip osteoarthritis.

7 Apr, 2022 | 08:37h | UTC

Clinical effectiveness of one ultrasound guided intra-articular corticosteroid and local anaesthetic injection in addition to advice and education for hip osteoarthritis (HIT trial): single blind, parallel group, three arm, randomised controlled trial – The BMJ

News Release: Steroid injections may provide longer lasting benefits for hip pain than current best care – BMJ

 

Commentary on Twitter

 

RCT: Pain outcomes following mechanochemical ablation vs. cyanoacrylate adhesive for the treatment of primary truncal saphenous vein incompetence.

7 Apr, 2022 | 08:28h | UTC

Pain Outcomes Following Mechanochemical Ablation vs Cyanoacrylate Adhesive for the Treatment of Primary Truncal Saphenous Vein Incompetence: The MOCCA Randomized Clinical Trial – JAMA Surgery (free for a limited period)

Invited Commentary: Relevant Outcomes in Superficial Venous Ablation Treatments – JAMA Surgery (free for a limited period)

 

Commentary on Twitter

 

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