RCT: In patients undergoing knee replacement surgery, the administration of periarticular liposomal bupivacaine did not improve postoperative recovery or pain compared with bupivacaine hydrochloride alone. 13 Apr, 2022 | 10:16h | UTC Efficacy of Liposomal Bupivacaine and Bupivacaine Hydrochloride vs Bupivacaine Hydrochloride Alone as a Periarticular Anesthetic for Patients Undergoing Knee Replacement: A Randomized Clinical Trial – JAMA Surgery