Randomized Trials
RCT | Myosin inhibition in patients with obstructive hypertrophic cardiomyopathy referred for septal reduction therapy.
13 Jul, 2022 | 11:52h | UTC
Long-term follow up of a RCT | Physical therapy noninferior to early arthroscopic partial meniscectomy in patients with degenerative meniscal tears.
12 Jul, 2022 | 12:57h | UTC
RCT | Adjunctive transdermal cannabidiol no better than placebo for drug-resistant focal epilepsy.
12 Jul, 2022 | 12:54h | UTC
Commentary on Twitter
In this randomized clinical trial, transdermal cannabidiol was well-tolerated and safe, but did not decrease seizure frequency at week 12 of the double-blind period among the placebo, 195-mg cannabidiol, and 390-mg cannabidiol treatments. https://t.co/lR3kEzPE5T
— JAMA Network Open (@JAMANetworkOpen) July 8, 2022
RCT | Leflunomide vs. azathioprine for maintenance therapy of lupus nephritis.
12 Jul, 2022 | 12:51h | UTC
Commentary on Twitter
🆕🔥Leflunomide versus azathioprine for maintenance therapy of lupus nephritis
🫘LEF=AZR in maintenance for SLE-LN
🫘Induction with NIH-CYC
🫘Chinese seem to love Lefno
🫘Generalisability difficult
Would have loved an MMF vs LEF#Rheumtwitter #Nephtwitterhttps://t.co/N2gTYISibM pic.twitter.com/nlP2LkSu8c— EnvisionRheumat (@ERheumat) July 5, 2022
Under a http://creativecommons.org/licenses/by-nc/4.0/ license
Designing and conducting adaptive trials to evaluate interventions in health services and implementation research: practical considerations.
12 Jul, 2022 | 12:27h | UTC
Commentary on Twitter
Practical considerations in designing and conducting adaptive #trials to evaluate interventions in #healthservices and implementation research. ▶️ https://t.co/0kGY6nOSza
@jlauffen #MedTwitter #BMJMedicine pic.twitter.com/Dot9XT1KDu
— BMJMedicine (@BMJMedicine) July 11, 2022
RCT | First-line catheter ablation of monomorphic ventricular tachycardia in cardiomyopathy concurrent with defibrillator implantation.
11 Jul, 2022 | 12:21h | UTC
Commentary on Twitter
#OriginalResearch: In #PAUSE_SCD RCT, early first-line catheter ablation performed concurrent with ICD implantation for monomorphic VT significantly reduced the composite primary outcome of VT recurrence, CV hospitalization, or death @DrRoderickTung https://t.co/ifQvG9A4j5 pic.twitter.com/5WAcPz3Mlm
— Circulation (@CircAHA) May 5, 2022
RCT | 20% albumin vs. plasmalyte in patients with cirrhosis and sepsis-induced hypotension.
11 Jul, 2022 | 12:16h | UTC
RCT | Non-fasting vs. fasting for cardiac implantable electronic device procedures.
11 Jul, 2022 | 12:03h | UTCA randomized trial of non-fasting vs. fasting for cardiac implantable electronic device procedures (Fast-CIED Study) – EP Europace (link to abstract – $ for full-text)
Commentary: Non-fasting yields better well-being, safety in patients getting implantable device – Healio (free registration required)
Commentary from one of the authors on Twitter
The first RCT to assess the benefits of a non-fasting strategy for #ICD/PM implantation has been published today @ESC_Journals
It is my honor to design and conduct this RCT together with Dr. Bode, Dr. Gerhard and @GerdHindricks. Big thanks to the team…https://t.co/YKQXf1YeRa pic.twitter.com/tzq2hel2MJ— Alireza Sepehri Shamloo (@ShamlooSepehri) June 23, 2022
RCT | Sacral neuromodulation for neurogenic lower urinary tract dysfunction.
8 Jul, 2022 | 11:47h | UTCSacral Neuromodulation for Neurogenic Lower Urinary Tract Dysfunction – NEJM Evidence
Commentary on Twitter
Pts with neurogenic lower urinary tract dysfunction had sacral neuromodulators implanted and optimized. They were then randomized to have the device either remain ON or switched OFF for 2 months. The success rate was 76% in the ON group vs 42% in the OFF. https://t.co/dhteW70jXp pic.twitter.com/1c0w8HOMJm
— NEJM Evidence (@NEJMEvidence) July 7, 2022
RCT | Effect of electroacupuncture on insomnia in patients with depression.
8 Jul, 2022 | 11:45h | UTCInvited Commentary: Effects of Electroacupuncture for Depression-Related Insomnia – JAMA Network Open
Commentary on Twitter
This randomized clinical trial found that an 8-weeek electroacupuncture with standard care improved sleep quality for patients with insomnia and depression, compared with sham acupuncture and/or standard care. https://t.co/nacnxEI4Ik
— JAMA Network Open (@JAMANetworkOpen) July 7, 2022
RCT | Cabozantinib plus atezolizumab vs. sorafenib for advanced hepatocellular carcinoma.
8 Jul, 2022 | 11:41h | UTCInvited Commentary: Cabozantinib plus atezolizumab in advanced hepatocellular carcinoma and the role of adjuvant antiviral therapy – The Lancet Oncology (free registration required)
Commentary on Twitter
In the phase III COSMIC-312 trial in 837 pts with advanced-stage HCC, mPFS was 6.8 vs 4.2 months (HR 0.63; P=.0012) & mOS was 15.4 vs 15.5 months (HR 0.90; P=.44) with cabozantinib+atezolizumab vs sorafenib; mPFS with cabozantinib alone was 5.8 months: https://t.co/eiZEqSxLAr
— NatureRevClinOncol (@NatRevClinOncol) July 6, 2022
RCT | Ustekinumab does not improve outcomes in patients with systemic lupus erythematosus.
8 Jul, 2022 | 11:39h | UTC
RCT | Balovaptan no better than placebo for social communication in childhood autism spectrum disorder.
8 Jul, 2022 | 11:38h | UTC
Commentary on Twitter
In this RCT, balovaptan did not demonstrate efficacy in improvement of socialization and communication in pediatric autism spectrum disorder (ASD), highlighting challenges faced in #ASD trial design, such as outcome measure sensitivity & placebo response. https://t.co/FFAJeu5xv0
— JAMA Psychiatry (@JAMAPsych) July 6, 2022
RCT | Dose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military.
8 Jul, 2022 | 11:26h | UTCDose-related effects of ketamine for antidepressant-resistant symptoms of posttraumatic stress disorder in veterans and active duty military: a double-blind, randomized, placebo-controlled multi-center clinical trial – Neuropsychopharmacology (if the link is paywalled, try this one)
Commentary on Twitter
Glad to see this work published. Contrary to predictions from small studies, #ketamine failed in the largest #PTSD clinical trial.
Future studies should test the lower dose and 3x/wk. @npp_journal @YalePsych @bcmhouston @netteaverillhttps://t.co/7NcFsNTMKw
— Chadi Abdallah (@ChadiAbdallah3) January 19, 2022
RCT | Efficacy and safety of upadacitinib for active ankylosing spondylitis refractory to biological therapy.
7 Jul, 2022 | 12:44h | UTC
Commentary on Twitter
SELECT-AXIS 2 trial – patients with #AS and inadequate response to #bDMARDs. #RCT of upadacitinb vs placebo 14 weeks:
Improved signs and symptoms of active AS and was well tolerated for 14 weeks of treatment in bDMARD-IR patients!https://t.co/Z7fuxiXMDb pic.twitter.com/kGZX9AsaVE— Annals of the Rheumatic Diseases (@eular_ARD) July 5, 2022
RCT | Odevixibat treatment in progressive familial intrahepatic cholestasis.
6 Jul, 2022 | 11:35h | UTCInvited Commentary: The first new drug for progressive familial intrahepatic cholestasis – The Lancet Gastroenterology & Hepatology (free registration required)
Commentary on Twitter
New research – Thompson et al – Odevixibat treatment in progressive familial intrahepatic cholestasis: a randomised, placebo-controlled, phase 3 trial (PEDFIC 1)https://t.co/hPLmPLMcDt#livertwitter #cholestasis #PFIC pic.twitter.com/oUMMh1H0kv
— The Lancet Gastroenterology & Hepatology (@LancetGastroHep) July 1, 2022
RCT | Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis.
6 Jul, 2022 | 11:31h | UTCCommentary: Does Azithromycin antagonize the effect of inhaled tobramycin in cystic fibrosis? – Medical Dialogues
Commentary on Twitter
Original research: Testing the effects of combining azithromycin with inhaled tobramycin for P. aeruginosa in cystic fibrosis: a randomised, controlled clinical trialhttps://t.co/z9dGX52dAe pic.twitter.com/tpiOqIIQjb
— ThoraxBMJ (@ThoraxBMJ) May 23, 2022
RCT | Enterosgel (polymethylsiloxane polyhydrate) for the treatment of irritable bowel syndrome with diarrhea.
6 Jul, 2022 | 11:33h | UTCRCT | Ozoralizumab vs. placebo in patients with active rheumatoid arthritis despite methotrexate therapy.
6 Jul, 2022 | 11:12h | UTCCommentary: Ozoralizumab shows promise in methotrexate-resistant RA – medwire News
RCT | Distal radial vs. conventional radial access for coronary angiography and intervention.
5 Jul, 2022 | 11:54h | UTCEditorial: Less Is More, But Not Always: Distal Transradial Access for Radial Artery Occlusion Prevention
Commentaries:
Distal Radial Access Doesn’t Lower Risk of Occlusion: DISCO RADIAL – TCTMD
Fancy Coronary Access Technique Disappoints in Preventing Radial Artery Occlusions — Distal radial approach did result in easier hemostasis, however – MedPage Today (free registration required)
Commentary on Twitter
New #JACCINT issue is out!
RCT shows no difference in radial artery occlusion between distal radial access and transradial access in patients undergoing diagnostic coronary angiography or #PCI using a 6-F Glidesheath Slender. https://t.co/kk5TKgf9rD#RadialFirst #RAO #RCT pic.twitter.com/484yOB9djM
— JACC Journals (@JACCJournals) June 20, 2022
Two new studies show no benefit of Enoxaparin for primary thromboprophylaxis in symptomatic outpatients with COVID-19.
1 Jul, 2022 | 11:49h | UTCCommentaries:
Antithrombotic Prophylaxis No Help in Outpatients With COVID — Two trials show no differences between patients who received enoxaparin vs standard of care – MedPage Today (free registration required)
Commentary on Twitter (thread – click for more)
Early in the pandemic we wondered whether antithrombotic therapy in outpatients with #COVID19 would prevent #thrombosis ❓
Several trials were started globally and the ACTIV-4B trial was previously reported⬇️ https://t.co/Q15WcZwDIA
Now, we publish the OVID and ETHIC trials🧵
— The Lancet Haematology (@TheLancetHaem) June 30, 2022
RCT: A single immediate dose of intravenous tenecteplase is noninferior to alteplase for the treatment of patients with acute ischemic stroke.
1 Jul, 2022 | 11:44h | UTCIntravenous tenecteplase compared with alteplase for acute ischaemic stroke in Canada (AcT): a pragmatic, multicentre, open-label, registry-linked, randomised, controlled, non-inferiority trial – The Lancet (link to abstract – $ for full-text)
News Release: UCalgary researchers with the Calgary Stroke Program make another breakthrough in the treatment of stroke
RCT: Effect of a community health worker intervention on acute care use, advance care planning, and patient-reported outcomes among adults with advanced stages of cancer.
1 Jul, 2022 | 10:58h | UTCEffect of a Community Health Worker Intervention on Acute Care Use, Advance Care Planning, and Patient-Reported Outcomes Among Adults With Advanced Stages of Cancer: A Randomized Clinical Trial – JAMA Oncology (free for a limited period)
See also: Visual Abstract
RCT: The effect of enhanced recovery after minimally invasive esophagectomy.
1 Jul, 2022 | 10:56h | UTCRelated:
Complete List of Enhanced Recovery After Surgery (ERAS) Society Guidelines
Visual abstract: ASO Visual Abstract: Guide to Enhanced Recovery for Cancer Patients Undergoing Surgery—ERAS and Esophagectomy
Enhanced recovery after surgery (ERAS) programs for esophagectomy – Journal of Thoracic Disease
RCT: Diclofenac–hyaluronate conjugate intra-articular injection for hip, ankle, shoulder, and elbow osteoarthritis.
1 Jul, 2022 | 10:55h | UTC