Psychiatry
Antidepressant Switching vs Augmentation in Resistent Depression?
12 Jul, 2017 | 15:24h | UTCEffect of Antidepressant Switching vs Augmentation on Remission Among Patients With Major Depressive Disorder Unresponsive to Antidepressant Treatment: The VAST-D Randomized Clinical Trial – JAMA (link to abstract – $ for full-text)
Commentaries: Study Compares Switching Meds vs an Additional Med for Patients Unresponsive to an Antidepressant – The Jama Network (free) AND For Treatment-Resistant Depression, Add an Antipsychotic or Switch Antidepressants? – Physician’s First Watch (free)
Augmentation with aripiprazole led to a modestly increased likelihood of remission, but with more adverse effects. “Given the small effect size and adverse effects associated with aripiprazole, further analysis including cost-effectiveness is needed to understand the net utility of this approach”.
Deutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia
11 Jul, 2017 | 16:44h | UTCDeutetrabenazine for treatment of involuntary movements in patients with tardive dyskinesia (AIM-TD): a double-blind, randomised, placebo-controlled, phase 3 trial – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentaries: Drug Eases Tardive Dyskinesia Linked to Antipsychotic Use – Medscape (free registration required) AND Second Tardive Dyskinesia Drug Works – MedPage Today (free registration required)
Vasomotor symptoms are associated with depressive symptoms in community-dwelling older women
9 Jul, 2017 | 00:20h | UTCVasomotor symptoms are associated with depressive symptoms in community-dwelling older women – Menopause (link to abstract – $ for full-text)
Commentary: Treatable menopause symptoms linked to depression in older women – Reuters (free)
Lithium Reduces Suicide Risk in Bipolar Patients
7 Jul, 2017 | 14:05h | UTCSuicidal Behavior During Lithium and Valproate Treatment: A Within-Individual 8-Year Prospective Study of 50,000 Patients With Bipolar Disorder – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Lithium Found to Decrease Suicide Risk in Bipolar Patients – Psychiatry News (free) AND Lithium protects against suicide – Karolinska Institutet News (free)
“Lithium, Not Valproate, Significantly Reduced Suicidal Behavior Among People With BD (an 8 y. Study)” (RT @psychopharmacol see Tweet)
Autism spectrum disorder and epileptic encephalopathy: common causes, many questions
7 Jul, 2017 | 13:25h | UTCReview: Autism spectrum disorder and epileptic encephalopathy: common causes, many questions – Journal of Neurodevelopmental Disorders (free)
Pain and Psychology – A Reciprocal Relationship
7 Jul, 2017 | 13:23h | UTCReview: Pain and Psychology – A Reciprocal Relationship – The Ochsner Journal (free)
Medication-Induced Tardive Dyskinesia
7 Jul, 2017 | 13:22h | UTCReview: Medication-Induced Tardive Dyskinesia: A Review and Update – The Ochsner Journal (free)
Treating Anxiety in 2017: Optimizing Care to Improve Outcomes
5 Jul, 2017 | 21:49h | UTCTreating Anxiety in 2017: Optimizing Care to Improve Outcomes – JAMA (free)
“Exercise, mindfulness-based stress reduction = 1st-line treatments for anxiety; move on to SSRIs and CBT as needed” (RT @JAMA_current see Tweet)
Prevalence and risk factors for HIV, hepatitis B, and hepatitis C in people with severe mental illness
5 Jul, 2017 | 18:08h | UTCInvited commentary: Ending HIV, hepatitis B, and hepatitis C: what about people with severe mental illness?
“People with severe mental illness have 3x the general pop risk of HIV & Hepatitis B, and 9x the risk of Hepatitis C” (RT @AllenFrancesMD and @in_psych see Tweet)
Depression following traumatic brain injury: prevalence, impact, and management challenges
3 Jul, 2017 | 17:37h | UTC
Association of Electroconvulsive Therapy With Psychiatric Readmissions
3 Jul, 2017 | 17:02h | UTCEditorial: Modern Electroconvulsive Therapy: Vastly Improved Yet Greatly Underused – JAMA Psychiatry (free) (RT @JAMA_current see Tweet)
In this observational study, electroconvulsive therapy was associated with reduced 30-day readmission risk among psychiatric inpatients with severe affective disorders (RR=0.54;0.28-0.81).
Practice: I am your trans patient
2 Jul, 2017 | 21:06h | UTCPractice: I am your trans patient – The BMJ (free)
Related infographic: Managing disclosure of gender dysphoria – The BMJ (free PDF)
“Five transgender authors share their experiences of healthcare & the important messages they’d like doctors to know” (RT @bmj_latest see Tweet)
When Anxiety or Depression Masks a Medical Problem
30 Jun, 2017 | 15:09h | UTCWhen Anxiety or Depression Masks a Medical Problem – New York Times (10 articles month are free)
Related: Managing Anxiety in the Medically Ill – Psychiatric Times (free)
“Very 1st differential before making a psych diagnosis should be – is this due to medical problem? 2nd question – medication/substance/alcohol? (RT @AllenFrancesMD see Tweet)
Trial of Electrical Direct-Current Therapy versus Escitalopram for Depression
29 Jun, 2017 | 00:34h | UTCTrial of Electrical Direct-Current Therapy versus Escitalopram for Depression – New England Journal of Medicine (link to abstract – $ for full-text)
Commentary: A New Brain-Stimulation Treatment Disappoints – Physician’s First Watch (free)
“For depression, new transcranial direct current stimulation treatment is not as effective as escitalopram” (RT @JWatch see Tweet)
Spasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers
23 Jun, 2017 | 14:41h | UTCSpasticity Drug Cuts Alcohol Consumption in High-Risk Drinkers – Medscape (free registration required)
Unpublished results, presented at the 13th World Congress of Biological Psychiatry, suggesting baclofen is an effective alternative for high-risk alcohol consumption.
Co-morbid OSA and insomnia increases depression prevalence and severity in men
23 Jun, 2017 | 00:55h | UTCCo-morbid OSA and insomnia increases depression prevalence and severity in men – Respirology (link to abstract – $ for full-text)
Commentaries: Combo of sleep apnea and insomnia linked to depression in men – Forbes (free) AND Sleep apnea and insomnia combination linked with depression – Wiley, via EurekAlert (free)
Why are doctors killing themselves
19 Jun, 2017 | 12:55h | UTCWhy are doctors killing themselves? – by Anne Malatt, via MJA Insight (free)
Related: Why are doctors plagued by depression and suicide? A crisis comes into focus – STAT News (free)
Social media and mental health
16 Jun, 2017 | 01:05h | UTCSocial media and mental health
1 – Quit Social Media Every Other Day – The Atlantic (free)
2 – Social media is as harmful as alcohol and drugs for millennials – The Conversation (free)
3 – Point of view: Is ‘Internet Addiction’ Real? – NPR Health News (free)
4 – Report: #StatusOfMind Social media and young people’s mental health and wellbeing – Royal Society of Public Health (link to introduction – free PDF)
Commentaries: Instagram ‘worst for young mental health’ – BBC News (free) AND Instagram worst social media app for young people’s mental health – CNN news (free)
Lithium Markedly Cuts Hospital Readmission in Depression
16 Jun, 2017 | 00:57h | UTCPharmacological treatments and risk of readmission to hospital for unipolar depression in Finland: a nationwide cohort study – The Lancet Psychiatry (link to abstract – $ for full-text)
Commentary: Lithium Markedly Cuts Hospital Readmission in Depression – Medscape (free registration required)
Doctors are prone to burn-out and depression. We need to take care
16 Jun, 2017 | 00:58h | UTCDoctors are prone to burn-out and depression. We need to take care – World Economic Forum (free)
Real-World Effectiveness of Antipsychotic Treatments
15 Jun, 2017 | 00:44h | UTCReal-World Effectiveness of Antipsychotic Treatments in a Nationwide Cohort of 29 823 Patients With Schizophrenia – JAMA Internal Medicine(link to abstract – $ for full-text)
Commentaries: Oral clozapine, long-acting injectables tied to lower relapse risk in schizophrenia – Clinical Psychiatry News (free registration required) AND Long-Acting Antipsychotics Tied to Superior Outcomes – Medscape (free registration required)
“The risk of rehospitalization is about 20% to 30% lower during long-acting injectable treatments compared with equivalent oral formulations”
More Treatments on Deck for Alcohol Use Disorder
14 Jun, 2017 | 00:40h | UTCMedical News & Perspectives: More Treatments on Deck for Alcohol Use Disorder – JAMA (free)
Guidelines for the recognition and management of mixed depression
13 Jun, 2017 | 20:01h | UTCGuidelines for the recognition and management of mixed depression – CNS Spectrums (free)
Commentary: First-Ever Guideline for Mixed Depression Released – Medscape (free registration required)
Moderate alcohol consumption as risk factor for adverse brain outcomes and cognitive decline
8 Jun, 2017 | 15:58h | UTCEditorial: Alcohol consumption and brain health (free)
Commentaries: Even moderate drinking linked to a decline in brain health, finds study – Oxford’s Department of Psychiatry (free) AND Moderate drinking may alter brain, study says – CNN (free) AND Even moderate drinking may speed brain decline – STAT News (free) AND Even moderate drinking linked to changes in brain structure, study finds – Reuters (free)
Prenatal antidepressant use and risk of attention-deficit/hyperactivity disorder in offspring
7 Jun, 2017 | 15:07h | UTCEditoral: The safety of antidepressants in pregnancy (free)
Commentary: Kids’ ADHD Risk May Be Linked to Mother’s Underlying Mental Health, Not Prenatal Antidepressant Use – Physician’s First Watch(free)