Psychiatry
RCT: Levothyroxine does not reduce the risk of developing depressive symptoms in older adults with subclinical hypothyroidism
18 Feb, 2021 | 02:46h | UTCRelated Studies: Association Between Levothyroxine Treatment and Thyroid-Related Symptoms Among Adults Aged 80 Years and Older With Subclinical Hypothyroidism – JAMA AND Thyroid Hormone Therapy for Older Adults with Subclinical Hypothyroidism – New England Journal of Medicine AND L-Thyroxine Therapy for Older Adults With Subclinical Hypothyroidism and Hypothyroid Symptoms: Secondary Analysis of a Randomized Trial – Annals of Internal Medicine
Guidelines (conflicting viewpoints): BMJ Guideline: Treatment of Subclinical Hypothyroidism AND Society for Endocrinology & British Thyroid Association issue statement against new treatment recommendations for subclinical hypothyroidism
Commentary on Twitter
Ancillary study of the TRUST RCT of levothyroxine therapy finds it does not reduce depression risk among older adults with subclinical hypothyroidism and shouldn't be prescribed for this purpose. #VisualAbstract https://t.co/yu3EChdkm1
— JAMA Network Open (@JAMANetworkOpen) February 10, 2021
For patients with schizophrenia, five variables associated with everyday functioning
15 Feb, 2021 | 00:41h | UTC
Commentary on Twitter
A longitudinal study in more than 600 people with #schizophrenia documented that social and non-social cognition, avolition and positive symptoms are the main factors impacting on real-life functioning at follow-up https://t.co/xoBt5DAVfQ #ItalianNetworkforResearchonPsychoses
— JAMA Psychiatry (@JAMAPsych) February 11, 2021
[Preprint] Six-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19
12 Feb, 2021 | 02:14h | UTCSix-month Neurological and Psychiatric Outcomes in 236,379 Survivors of COVID-19 – medRxiv
Commentary: Covid linked to risk of mental illness and brain disorder, study suggests – The Guardian
COVID’s mental-health toll: how scientists are tracking a surge in depression
5 Feb, 2021 | 01:36h | UTCCOVID’s mental-health toll: how scientists are tracking a surge in depression – Nature
Related: Trends in US Emergency Department Visits for Mental Health, Overdose, and Violence Outcomes Before and During the COVID-19 Pandemic – JAMA Psychiatry AND Mental Health, COVID-19, and the Invisible Pandemic on the Horizon – Mayo Clinic Proceedings
One in three adults report anxiety, depression related to COVID-19
3 Feb, 2021 | 01:35h | UTCOne in three adults report anxiety, depression related to COVID-19 – Duke-NUS Medical School
Meta-analysis of longitudinal studies: Frequent or dependent cannabis use in youth linked to decline IQ
2 Feb, 2021 | 01:02h | UTC
Blood test to detect psychogenic nonepileptic seizures shows promise
1 Feb, 2021 | 01:37h | UTCBlood Test to Detect Psychogenic Nonepileptic Seizures Shows Promise – Physician’s Weekly
Original study: Association of Epileptic and Non-epileptic Seizures and Changes in Circulating Plasma Proteins Linked to Neuroinflammation – Neurology (link to abstract – $ for full-text)
Cohort study: Schizophrenia linked to increased mortality among patients with COVID-19
29 Jan, 2021 | 01:47h | UTCAssociation of Psychiatric Disorders With Mortality Among Patients With COVID-19 – JAMA Psychiatry
Commentaries: Expert reaction to COVID and schizophrenia – Science Media Centre AND Schizophrenia Second Only To Age as Greatest Risk Factor for COVID-19 Death – NYU Langone Health
Long Covid: Respiratory and psychophysical sequelae among patients with COVID-19 four months after hospital discharge
28 Jan, 2021 | 01:31h | UTCCommentary: Lung, mobility problems plague COVID-19 patients months after recovery – UPI
Randomized trial: Clozapine vs. Olanzapine vs. Haloperidol in the treatment of violence in schizophrenia
26 Jan, 2021 | 00:33h | UTCThe Importance of Conduct Disorder in the Treatment of Violence in Schizophrenia: Efficacy of Clozapine Compared With Olanzapine and Haloperidol – American Journal of Psychiatry (link to abstract – $ for full-text)
Commentary on Twitter (thread – Click for more)
RCT: In physically assaultive schizophrenia patients clozapine was superior to haloperidol and olanzapine in reducing assaults; olanzapine was superior to haloperidol https://t.co/RrX6VPubgL
— P𝘧OL (@psychopharmacol) January 25, 2021
Study confirms well-known suicide risk factors, identifies new risks
22 Jan, 2021 | 08:17h | UTCStudy Confirms Well-Known Suicide Risk Factors, Identifies New Risks – Psychiatric News Alert
Original study: Identification of Suicide Attempt Risk Factors in a National US Survey Using Machine Learning – JAMA Psychiatry (link to abstract – $ for full-text)
International consensus on a standard set of outcome measures for child and youth anxiety, depression, obsessive-compulsive disorder, and post-traumatic stress disorder
22 Jan, 2021 | 08:11h | UTCInternational consensus on a standard set of outcome measures for child and youth anxiety, depression, obsessive-compulsive disorder, and post-traumatic stress disorder – The Lancet Psychiatry (free registration required)
Commentary on Twitter (Thread – Click for more)
1) Delighted to announce the publication of our @TheLancetPsych paper presenting first international consensus on outcomes to track in routine care for children & youth with anxiety/depression. @ICHOM_ORG @mirandarwolpert #MHOutcomes.https://t.co/izFD2j9J2f pic.twitter.com/8as1npIpKE
— Karolin Krause (@KrauseKarolin) December 18, 2020
Randomized trial: Repeated Ketamine administration for chronic posttraumatic stress disorder
21 Jan, 2021 | 01:03h | UTCA Randomized Controlled Trial of Repeated Ketamine Administration for Chronic Posttraumatic Stress Disorder – The American Journal of Psychiatry (link to abstract – $ for full-text)
Commentaries: Repeated Ketamine Infusions Reduce Symptom Severity in Individuals With Chronic Post-Traumatic Stress Disorder – Mount Sinai AND Repeated Ketamine Infusions May Rapidly Reduce Chronic PTSD Symptoms – Psychiatry News Alert
Commentary on Twitter
Patients with chronic PTSD given repeated infusions of ketamine over 2 weeks showed significantly greater symptom improvement than those given a psychoactive placebo control infusion, the first evidence of efficacy.
Learn More: https://t.co/qqcIsNfCHC pic.twitter.com/r7Bggz4cIj— Journals of The American Psychiatric Association (@APAPubJournals) January 5, 2021
USPSTF Statement: Interventions for tobacco smoking cessation in adults
20 Jan, 2021 | 01:32h | UTCEditorial: A Comprehensive Approach to Increase Adult Tobacco Cessation – JAMA
Author Interview: USPSTF Recommendation: Tobacco Cessation in Adults
JAMA Patient Page: Interventions to Promote Tobacco Cessation
Guideline synopsis: Initiating Pharmacologic Treatment in Tobacco-Dependent Adults
20 Jan, 2021 | 01:31h | UTCInitiating Pharmacologic Treatment in Tobacco-Dependent Adults – JAMA (free for a limited period)
Author Interview: Pharmacologic Management of Tobacco Cessation
Systematic review: Insufficient evidence of benefit from immediate‐release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults
20 Jan, 2021 | 01:11h | UTCIR methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults – Cochrane Library
Original study: Immediate‐release methylphenidate for attention deficit hyperactivity disorder (ADHD) in adults – Cochrane Library
Cardiovascular complications of opioid use: JACC state-of-the-art review
17 Jan, 2021 | 22:04h | UTC
Randomized trial: Naltrexone-Bupropion combination may help some people (13.6% vs. 2.5% with placebo) with methamphetamine use disorder
15 Jan, 2021 | 08:39h | UTCBupropion and Naltrexone in Methamphetamine Use Disorder – New England Journal of Medicine (link to abstract – $ for full-text)
Commentaries: Combination of two drugs can help treat methamphetamine addiction for some, new clinical trial data shows – STAT AND Naltrexone-Bupropion Combination May Help People With Methamphetamine Use Disorder – Psychiatric News Alert
Perspective: For people with OCD — and fearful of germs — the pandemic is upending years of therapy
14 Jan, 2021 | 02:00h | UTCFor people with OCD — and fearful of germs — the pandemic is upending years of therapy – STAT
Systematic review: Does behavioral support help people to stop smoking?
14 Jan, 2021 | 01:46h | UTCSummary: Does behavioural support help people to stop smoking? – Cochrane Library
New study highlights cost-effectiveness of bans on pesticides as a suicide prevention strategy
14 Jan, 2021 | 01:35h | UTC
The Pharmacologic Treatment of Schizophrenia—2021
13 Jan, 2021 | 01:53h | UTCThe Pharmacologic Treatment of Schizophrenia—2021 – JAMA (free for a limited period)
Commentary on Twitter
Available treatments have transformed lives of people with schizophrenia, allowing many to live in the community & function independently. However, considerable unmet needs remain due to symptoms refractory to treatment, and adverse effects. @nyulangone https://t.co/tRh1fG6DMD
— JAMA Psychiatry (@JAMAPsych) January 9, 2021
Randomized trial: Effect of therapeutic suggestions during general anesthesia on postoperative pain and opioid use
13 Jan, 2021 | 01:51h | UTCCommentaries: Can we sooth the subconscious during general anaesthesia? – The BMJ AND Ernil Hansen: Soothing words and music during surgery might reduce postoperative pain – The BMJ Opinion AND Soothing words and music during surgery might reduce postoperative pain – The BMJ
Commentary on Twitter
Therapeutic suggestions played through earphones during general anaesthesia could provide a safe, feasible, inexpensive, and non-drug technique to reduce postoperative pain and opioid use, suggests new research https://t.co/LpTBnBbcT9
— The BMJ (@bmj_latest) December 13, 2020
AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults
13 Jan, 2021 | 01:58h | UTCCommentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist
Long Covid: 6-month consequences of COVID-19 in patients discharged from hospital
10 Jan, 2021 | 20:43h | UTC6-month consequences of COVID-19 in patients discharged from hospital: a cohort study – The Lancet
Commentaries: Most patients hospitalized for Covid-19 still have symptoms six months later, China study finds AND Long-term follow-up of recovered patients with COVID-19 – The Lancet
Commentary on Twitter
Largest #LongCovid cohort @TheLancet just published:
6 months post-hospital,
—76% still had ≥ 1 symptom
—63% fatigue/muscle weakness
—sleep, anxiety, depression common
—Sig % w/CT lung abnormalities
—13% had abnormal kidney function https://t.co/zfRf7MGdxB pic.twitter.com/LI4DaJPis8— Eric Topol (@EricTopol) January 8, 2021