Psychiatry
The Pharmacologic Treatment of Schizophrenia—2021
13 Jan, 2021 | 01:53h | UTCThe Pharmacologic Treatment of Schizophrenia—2021 – JAMA (free for a limited period)
Commentary on Twitter
Available treatments have transformed lives of people with schizophrenia, allowing many to live in the community & function independently. However, considerable unmet needs remain due to symptoms refractory to treatment, and adverse effects. @nyulangone https://t.co/tRh1fG6DMD
— JAMA Psychiatry (@JAMAPsych) January 9, 2021
Randomized trial: Effect of therapeutic suggestions during general anesthesia on postoperative pain and opioid use
13 Jan, 2021 | 01:51h | UTCCommentaries: Can we sooth the subconscious during general anaesthesia? – The BMJ AND Ernil Hansen: Soothing words and music during surgery might reduce postoperative pain – The BMJ Opinion AND Soothing words and music during surgery might reduce postoperative pain – The BMJ
Commentary on Twitter
Therapeutic suggestions played through earphones during general anaesthesia could provide a safe, feasible, inexpensive, and non-drug technique to reduce postoperative pain and opioid use, suggests new research https://t.co/LpTBnBbcT9
— The BMJ (@bmj_latest) December 13, 2020
AASM Guideline: Behavioral and psychological treatments for chronic insomnia disorder in adults
13 Jan, 2021 | 01:58h | UTCCommentary: New guideline encourages use of cognitive behavioral therapy for insomnia in adults – ACP Internist
Long Covid: 6-month consequences of COVID-19 in patients discharged from hospital
10 Jan, 2021 | 20:43h | UTC6-month consequences of COVID-19 in patients discharged from hospital: a cohort study – The Lancet
Commentaries: Most patients hospitalized for Covid-19 still have symptoms six months later, China study finds AND Long-term follow-up of recovered patients with COVID-19 – The Lancet
Commentary on Twitter
Largest #LongCovid cohort @TheLancet just published:
6 months post-hospital,
—76% still had ≥ 1 symptom
—63% fatigue/muscle weakness
—sleep, anxiety, depression common
—Sig % w/CT lung abnormalities
—13% had abnormal kidney function https://t.co/zfRf7MGdxB pic.twitter.com/LI4DaJPis8— Eric Topol (@EricTopol) January 8, 2021
[Preprint] Characterizing Long COVID in an International Cohort: 7 Months of Symptoms and Their Impact
10 Jan, 2021 | 20:41h | UTCRelated: Explanations for ‘long Covid’ remain elusive. For now, believing patients and treating symptoms is the best doctors can do – STAT AND Long COVID: who is at risk? – The Conversation
Commentary on Twitter
How long is #LongCovid?
The most extensive symptom assessment and longest duration (7 months) of nearly 3,800 individuals shows how debilitating this is in young, predominantly women, w/ most unable to return to full prior work https://t.co/o0YUNse1EA @ahandvanish @AthenaAkrami pic.twitter.com/3miXJFdVp0— Eric Topol (@EricTopol) December 29, 2020
AAP Guideline: Identification and management of eating disorders in children and adolescents
10 Jan, 2021 | 20:30h | UTCIdentification and Management of Eating Disorders in Children and Adolescents – Pediatrics
Commentary: Pediatrics Group Offers Guidance on Managing Eating Disorders in Youth – NEJM Journal Watch
Systematic review: Melatonin may have a similar effect to benzodiazepines in reducing preoperative and postoperative anxiety in adults
10 Jan, 2021 | 20:14h | UTCMelatonin for preoperative and postoperative anxiety in adults – Cochrane Library
Summary: Melatonin for preoperative and postoperative anxiety in adults – Cochrane Library
Comprehensive overview of current pharmacological augmentation recommendations for major depression
17 Dec, 2020 | 08:55h | UTC
Commentary on Twitter
Pharmacological augmentation in unipolar depression – our new review of treatment guidelines compares current recommendations and discusses future guideline development @LindseyMarwood @valeriadeangel @roland_zahn @TCleare @ijnp_neuropsych https://t.co/ui5mGUP8nW
— Rachael Taylor (@rachael_wallis) June 5, 2020
Longer time spent at home during COVID-19 pandemic is associated with binge drinking among US adults
16 Dec, 2020 | 09:36h | UTCCommentaries: New study shows every week of lockdown increases binge drinking – MedicalXpress AND Study finds more binge drinking during stay-at-home lockdowns – MedicalXpress
Increase in overdose-related cardiac arrests observed by emergency medical services during the US COVID-19 epidemic
16 Dec, 2020 | 09:39h | UTCCommentaries: Steady Increase Seen in Cardiac Arrest−Related Overdoses During COVID-19 Pandemic – AJMC AND Sharp rise in overdose deaths during Covid-19 pandemic – MedicalResearch AND Cardiac Arrests Tied to Overdoses Have Surged During the Pandemic – U.S News
Commentary on Twitter
The overdose crisis meets the #COVID19 pandemic: Using data from a large cohort of EMS agencies, @JosephRFriedman @LeoBeletsky and David Schriger observe a nearly 50% increase in EMS-observed cardiac arrests in 2020 as compared to prior years https://t.co/wnsmYfOf7r
— JAMA Psychiatry (@JAMAPsych) December 4, 2020
Study shows rise in childhood depression symptoms during the COVID-19 lockdown
16 Dec, 2020 | 09:41h | UTCCommentaries: Steep rise in depressive symptoms among 7-12 year olds during UK-wide lockdown – British Medical Journal AND Children’s Depression Symptoms Up During U.K. Lockdown – Physician’s Weekly AND Expert reaction to longitudinal study of depression symptoms in children during the COVID-19 lockdown – Science Media Centre
Randomized trial: Long-acting injectable antipsychotic use by patients with early-phase schizophrenia can significantly delay time to first hospitalization
11 Dec, 2020 | 09:14h | UTCCommentary: Long-Acting Injectable Antipsychotics vs. Usual Care for Early-Phase Schizophrenia – Physician’s Weekly
Commentary on Twitter
RCT: The mean survival time until 1st hospitalization was 613.7 days for patients with schizophrenia treated with aripiprazole once monthly vs. 530.6 days for those treated with usual care (HR=0.56; 0.34- 0.92; NNT=7) https://t.co/i3857D2ULQ
— PfOL (@psychopharmacol) December 5, 2020
One in five covid-19 patients are diagnosed with a mental illness within three months
2 Dec, 2020 | 07:24h | UTC
Commentary on Twitter
"Survivors of COVID-19 appear to be at increased risk of psychiatric sequelae, and a psychiatric diagnosis might be an independent risk factor for #COVID-19."
New #Free Researchhttps://t.co/i00uBVdV0O
— The Lancet Psychiatry (@TheLancetPsych) November 10, 2020
Cohort study: Higher dose Z-drug use in dementia is associated with increased fracture and stroke risks, similar or greater to that for higher dose benzodiazepines
1 Dec, 2020 | 08:25h | UTCCommentary: The danger of Z-drugs for dementia patients – University of Exeter
Meta-analysis: Among the treatment interventions to maintain abstinence from alcohol in primary care, acamprosate was the only intervention with enough evidence of benefit
26 Nov, 2020 | 08:55h | UTC
Commentary on Twitter
Acamprosate was the only intervention with enough evidence of benefit for maintaining alcohol abstinence and acceptability up to 12 months after detoxification in primary care settings, concludes new #BMJResearchhttps://t.co/K7FutIC3yd
— The BMJ (@bmj_latest) November 25, 2020
Randomized, placebo-controlled, crossover trial: Amantadine, modafinil, and methylphenidate are no better than placebo for fatigue in multiple sclerosis
24 Nov, 2020 | 09:02h | UTCSafety and efficacy of amantadine, modafinil, and methylphenidate for fatigue in multiple sclerosis: a randomised, placebo-controlled, crossover, double-blind trial – The Lancet Neurology (link to abstract – $ for full-text)
CDC Report: Mental health-related emergency department visits among children aged under 18 years raised during the COVID-19 Pandemic
17 Nov, 2020 | 09:48h | UTCCommentary: ER Data Indicates the Pandemic Is Harming Children’s Mental Health – U.S. News
Commentary on Twitter
New @CDCMMWR suggests that the #COVID19 pandemic may be negatively impacting children’s mental health. The proportion of emergency room visits for mental health concerns in children & adolescents increased substantially this past Mar.-Oct. Read the report: https://t.co/9FyLoCzrza pic.twitter.com/fIXMIZg7KK
— CDC (@CDCgov) November 12, 2020
Sleep problems in dementia: Despite many drugs being widely prescribed, systematic review finds lack of evidence and no randomized controlled trials to guide decisions about drug treatment
17 Nov, 2020 | 09:29h | UTCPharmacotherapies for sleep disturbances in dementia – Cochrane Library
[Abstract Only] Randomized trial: Intravenous haloperidol more effective than ondansetron for cannabis hyperemesis syndrome
11 Nov, 2020 | 09:08h | UTC
Commentary on Twitter
Excited to have been involved in this practice-changing RCT comparing Haloperidol (superior) to Ondansetron for Cannabis Hyperemesis Syndrome from @Qemerg @therealdraa_ron @savforrester Marco Sivilotti and others! Check it out!https://t.co/ylms5JIO9v
— Andrew Koch Hall (@AKHallMD) November 5, 2020
[Abstract Only] Randomized trial: In patients with anorexia nervosa, a higher-calorie refeeding approach promotes earlier recovery with no increase in safety events during hospitalization
6 Nov, 2020 | 09:31h | UTCShort-term Outcomes of the Study of Refeeding to Optimize Inpatient Gains for Patients With Anorexia Nervosa: A Multicenter Randomized Clinical Trial – JAMA Pediatrics (link to abstract – $ for full-text0
Commentaries: Higher calorie treatment for people hospitalized with anorexia – NIH News Releases AND Higher-calorie diets for patients with anorexia nervosa shorten hospital stays – University of California – San Francisco
Commentary on Twitter
Great paper by @AndreaGarber2 showing that higher-calorie refeeding in #anorexia nervosa does not come at a higher risk of refeeding syndrome and can shorten hospital stays which is advantageous for both the patients/families and the medical system.https://t.co/aFQZKycpTX
— Jonas Steinhäuser (@JoSte95) October 30, 2020
Hot off the presses! Largest clinical trial of refeeding in #anorexianervosa shows that a higher-calorie approach is more efficacious & less costly than lower-calorie refeeding, with no increase in safety events & significant savings in healthcare costs. https://t.co/F0ciJAORdq
— UCSF EatingDisorders (@UCSF_EDP) October 20, 2020
Analysis: Adversity in childhood is linked to mental and physical health throughout life
4 Nov, 2020 | 09:28h | UTCAdversity in childhood is linked to mental and physical health throughout life – The BMJ
Commentary on Twitter
Adversity in the first years of life may deleteriously affect the course of human development. This #BMJInfographic presents some of these challenges and the mechanisms by which they can affect health throughout childhood and into adulthoodhttps://t.co/9cJAgmhrcr @will_s_t pic.twitter.com/Qsfp0YR9fZ
— The BMJ (@bmj_latest) November 3, 2020
[Preprint] Cognitive deficits in people who have recovered from COVID-19 relative to controls: An N=84,285 online study
28 Oct, 2020 | 09:14h | UTCCommentaries: Recovered COVID-19 patients exhibit cognitive deficits – News Medical AND Expert reaction to preprint suggesting patients who recovered from COVID-19 could suffer serious cognitive decline – Science Media Centre
[Abstract Only] Study: Postpartum depression may persist three years after giving birth
28 Oct, 2020 | 08:46h | UTCPostpartum depression may persist three years after giving birth – NIH News Releases
Original Study: Trajectories of Maternal Postpartum Depressive Symptoms – Pediatrics (link to abstract – $ for full-text)
Cohort study: Exposure to modafinil and armodafinil during pregnancy linked to fetal malformations
20 Oct, 2020 | 01:31h | UTCPregnancy and Fetal Outcomes Following Exposure to Modafinil and Armodafinil During Pregnancy – JAMA Internal Medicine (free for a limited period)
Commentaries: Caution in Prescribing Modafinil and Armodafinil to Individuals Who Could Become Pregnant – JAMA Internal Medicine (free for a limited period) AND Narcolepsy Drugs Tied to Increased Risk for Birth Defects – NEJM Journal Watch
Randomized trial: Targeting rehabilitation to improve outcomes after total knee arthroplasty in patients at risk of poor outcomes
18 Oct, 2020 | 23:04h | UTCCommentary: Self-Directed Physical Therapy Effective After Total Knee Arthroplasty – NEJM Journal Watch
Commentaries on Twitter
Outpatient therapist led rehabilitation was not superior to a single physiotherapist review and home exercise based regimen in patients at risk of poor outcomes after total knee arthroplasty, finds new research by @df_hamiltonhttps://t.co/DOTv1q8VJ6
— The BMJ (@bmj_latest) October 13, 2020
This study suggests that targeting postoperative physiotherapy to those most in need is a feasible delivery method, but that the actual content of the rehabilitation seems to have minimal influence on patient outcomes@df_hamiltonhttps://t.co/JISOQE4pMr
— The BMJ (@bmj_latest) October 17, 2020